Gene: NDUFA1

4694
CI-MWFE|MWFE|ZNF183
NADH:ubiquinone oxidoreductase subunit A1
protein-coding
Xq24
Ensembl:ENSG00000125356 MIM:300078 Vega:OTTHUMG00000022287 UniprotKB:O15239
NG_009381.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBL50.976
COX7C0.973
UQCRQ0.971
NDUFS50.962
UQCR100.961
PARK70.96
NDUFA130.956
COX5B0.954
SNRPD20.952
COX4I10.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.864
OR4F29-0.851
ZC3H11B-0.187
MTRNR2L6-0.184
PZP-0.182
KRT73-0.18
C8orf74-0.18
OR51D1-0.176
IL18RAP-0.175
KCNJ15-0.172

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of NDUFA1 mRNA29078374
C0326681-nitropyreneNDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
C0326681-nitropyreneNDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]29078374
C0326681-nitropyrene[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]29078374
C0326681-nitropyrene1-nitropyrene results in decreased expression of NDUFA1 mRNA29078374
C0326681-nitropyrene1-nitropyrene results in decreased expression of NDUFA1 protein29078374
C0326681-nitropyrene[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]29078374
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NDUFA1 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of NDUFA1 mRNA16788091
C0259463-methyladenine[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]29078374
C0259463-methyladenine[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]29078374
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of NDUFA1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of NDUFA1 mRNA25704631|2906747
C027696acipimoxacipimox results in decreased expression of NDUFA1 mRNA25352640
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]16964424
D001280AtrazineAtrazine results in increased expression of NDUFA1 mRNA25929836
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NDUFA1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NDUFA1 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of NDUFA1 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NDUFA1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of NDUFA1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of NDUFA1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of NDUFA1 mRNA18958704
D002104CadmiumCadmium results in increased expression of NDUFA1 mRNA26187450
C100187chloropicrinchloropicrin results in increased expression of NDUFA1 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in decreased expression of NDUFA1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of NDUFA1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of NDUFA1 mRNA25562108
D013759DronabinolDronabinol results in decreased expression of NDUFA1 mRNA18454173
C000944dicrotophosdicrotophos results in decreased expression of NDUFA1 mRNA28302478
D004317DoxorubicinNDUFA1 protein affects the susceptibility to Doxorubicin16217747
C108024emamectin benzoateemamectin benzoate results in decreased expression of NDUFA1 mRNA18786259
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of NDUFA1 mRNA20064776
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NDUFA1 mRNA17942748|2409603
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFA1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NDUFA1 mRNA24096037
D017313FenretinideFenretinide affects the expression of NDUFA1 mRNA16570282
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NDUFA1 mRNA17183730
D007213IndomethacinIndomethacin results in increased expression of NDUFA1 mRNA28201806
D007538IsoniazidIsoniazid affects the expression of NDUFA1 mRNA24848797
C410337K 7174K 7174 results in decreased expression of NDUFA1 mRNA24086573
C011890kojic acidkojic acid results in increased expression of NDUFA1 mRNA16595896
D008777MethyltestosteroneMethyltestosterone results in decreased expression of NDUFA1 mRNA29191790
C025589ochratoxin Aochratoxin A results in increased expression of NDUFA1 mRNA17316727
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NDUFA1 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of NDUFA1 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of NDUFA1 mRNA]"21673326
C016340o,p'-DDT"o,p'-DDT results in increased expression of NDUFA1 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of NDUFA1 mRNA"24096037
D010100OxygenOxygen deficiency results in decreased expression of NDUFA1 mRNA24205000
D017239PaclitaxelNDUFA1 protein affects the susceptibility to Paclitaxel16217747
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NDUFA1 mRNA20936131
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NDUFA1 mRNA22714537
C059514resveratrolresveratrol results in increased expression of NDUFA1 mRNA22610192
C059514resveratrolNiacinamide inhibits the reaction [resveratrol results in increased expression of NDUFA1 mRNA]23891692
C059514resveratrolresveratrol results in increased expression of NDUFA1 mRNA23891692
C089730rosiglitazonerosiglitazone affects the expression of NDUFA1 mRNA22013433
D012643SeleniumSelenium results in decreased expression of NDUFA1 mRNA19244175
D012969Sodium FluorideSodium Fluoride results in decreased expression of NDUFA1 protein28918527
D013654Taurine[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]29078374
D013654Taurine[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]29078374
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of NDUFA1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NDUFA1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFA1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NDUFA1 mRNA17942748
C066340tolcaponetolcapone results in decreased expression of NDUFA1 mRNA24136188
D014050TolueneToluene results in decreased expression of NDUFA1 mRNA22166486|2296774
D014212TretinoinTretinoin results in decreased expression of NDUFA1 mRNA16788091
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NDUFA1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of NDUFA1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NDUFA1 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of NDUFA1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of NDUFA1 mRNA29078374
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of NDUFA1 mRNA29078374
D014747VinblastineNDUFA1 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in decreased expression of NDUFA1 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of NDUFA1 mRNA22615374
D009536NiacinamideNiacinamide inhibits the reaction [resveratrol results in increased expression of NDUFA1 mRNA]23891692

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS9878551  
GO ID GO Term Qualifier Evidence PubMed
GO:0006120mitochondrial electron transport, NADH to ubiquinone-NAS9878551  
GO:0032981mitochondrial respiratory chain complex I assembly-IMP27626371  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA16729965  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  17209039  27626371  
GO:0005747mitochondrial respiratory chain complex I-NAS9878551  
GO:0005829cytosol-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0031966mitochondrial membrane-IDA17209039  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19494790Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. (2009 Jul)Sapag APharmacogenet Genomics