Gene: NEB

4703
NEB177D|NEM2
nebulin
protein-coding
2q23.3
Ensembl:ENSG00000183091 MIM:161650 Vega:OTTHUMG00000153784 UniprotKB:P20929
NG_009382.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.326e-1 (AD)  1.980e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13031275chr2:151489980 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XIRP20.815
TTN0.813
KLHL410.785
MYH10.763
AMPD10.743
MYL10.74
CKM0.729
MYPN0.727
MYH20.695
MYLPF0.686

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C4orf48-0.349
CLEC11A-0.307
LRRC26-0.287
FAM229A-0.284
C19orf81-0.275
TPGS1-0.266
TMEM160-0.264
CLDND2-0.26
HES4-0.259
CCL27-0.258

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of NEB mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NEB mRNA"22698814
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NEB mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEB mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NEB mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NEB mRNA22100608
D000393Air PollutantsAir Pollutants analog results in decreased expression of NEB mRNA21757418
D000447AldehydesAldehydes results in decreased expression of NEB mRNA25014914
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of NEB mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of NEB mRNA26377693
D004958EstradiolEstradiol results in decreased expression of NEB mRNA20106945
D004958EstradiolEstradiol results in decreased expression of NEB mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of NEB mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of NEB mRNA24134786
C018475butyraldehydebutyraldehyde results in decreased expression of NEB mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NEB mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NEB mRNA20938992
C031180chrysenechrysene results in increased expression of NEB mRNA26377693
D003042CocaineCocaine results in decreased expression of NEB mRNA17898221
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of NEB mRNA26033743
D003300CopperCopper deficiency results in increased expression of NEB mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of NEB mRNA20106945|2798913
C017160cypermethrincypermethrin results in decreased expression of NEB mRNA22528246
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NEB mRNA24317228
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of NEB mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of NEB mRNA25016146
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of NEB mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of NEB mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NEB mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of NEB mRNA24535843
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NEB mRNA"22485181
D004147DioxinsDioxins affects the expression of NEB mRNA20463971
D004726EndosulfanEndosulfan results in increased expression of NEB protein26615145
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NEB mRNA20938992
C010178heliotrineheliotrine results in decreased expression of NEB mRNA26100227
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NEB mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of NEB mRNA20003209
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NEB mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NEB mRNA23103053
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of NEB mRNA22401849
C028473N-acetyl-4-benzoquinoneimineNEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NEB mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NEB mRNA"25620056
C028007nickel monoxidenickel monoxide results in decreased expression of NEB mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NEB mRNA27935865
C046012pentanalpentanal results in decreased expression of NEB mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of NEB mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NEB mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NEB mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of NEB mRNA19482888|2309116
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NEB mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NEB mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of NEB mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of NEB mRNA20813756|2381119
D011192Potassium DichromatePotassium Dichromate results in increased expression of NEB mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of NEB mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of NEB mRNA26079696
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of NEB mRNA26100227
D011794QuercetinQuercetin results in decreased expression of NEB protein19207037
D011794QuercetinQuercetin results in increased expression of NEB mRNA21632981
C009237senecioninesenecionine results in decreased expression of NEB mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of NEB mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NEB mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of NEB gene28589171
D053260SootSoot results in increased expression of NEB mRNA26551751
D013096SpermineSpermine results in increased expression of NEB mRNA18673383
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEB mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEB mRNA26290441
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of NEB mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NEB mRNA25613284
C012589trichostatin Atrichostatin A results in decreased expression of NEB mRNA15901671
D014520UrethaneUrethane results in decreased expression of NEB mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of NEB mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEB mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of NEB mRNA24383497|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI12482578  16902413  18639526  23414517  23615443  
GO:0008307structural constituent of muscle-TAS7739042  
GO:0051015actin filament binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007517muscle organ development-TAS7739042  
GO:0007525somatic muscle development-NAS7739042  
GO:0030049muscle filament sliding-TAS-  
GO:0030832regulation of actin filament length-NAS7739042  
GO:0048747muscle fiber development-IBA21873635  
GO:0071691cardiac muscle thin filament assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-TAS7739042  
GO:0030018Z disc-IBA21873635  
GO:0030018Z disc-IDA9501083  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-390522Striated Muscle ContractionTAS
R-HSA-397014Muscle contractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28886123Increased medial olivocochlear reflex strength in normal-hearing, noise-exposed humans. (2017)Bhatt IPLoS One
19536509Recruitment of GABA(A) receptors in chemoreceptor pulmonary neuroepithelial bodies by prenatal nicotine exposure in monkey lung. (2009)Fu XWAdv Exp Med Biol
8885943Maternal smoking and pulmonary neuroendocrine cells in sudden infant death syndrome. (1996 Oct)Cutz EPediatrics