Gene: NDUFA10

4705
CI-42KD|CI-42k
NADH:ubiquinone oxidoreductase subunit A10
protein-coding
2q37.3
Ensembl:ENSG00000130414 MIM:603835 Vega:OTTHUMG00000133350 UniprotKB:O95299
NG_031855.2
PubMed
0   ANCO-SNPs
ND
1   
8.491e-1 (AD)  1.632e-1 (ND)   (Frontal_Cortex)
9.460e-1 (AD)  3.122e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDH3B0.97
USP50.966
ZFYVE270.963
MICU10.963
ABCF30.962
UQCC10.96
RXRB0.958
NDUFS20.958
CD99L20.957
ENO20.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.616
MTRNR2L6-0.446
MTRNR2L9-0.437
TFPI2-0.425
MTRNR2L10-0.42
KCNJ15-0.418
KLRB1-0.415
CXCR2-0.398
PABPC4L-0.395

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of NDUFA10 protein"19033394
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of NDUFA10 protein"19033394
D000082AcetaminophenAcetaminophen results in decreased expression of NDUFA10 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of NDUFA10 mRNA17562736
C016601afimoxifeneNDUFA10 results in decreased susceptibility to afimoxifene21233418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of NDUFA10 protein26072098
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of NDUFA10 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NDUFA10 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of NDUFA10 mRNA22521957
C006780bisphenol Abisphenol A affects the expression of NDUFA10 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of NDUFA10 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of NDUFA10 protein28903499
D003042CocaineCocaine affects the expression of NDUFA10 protein19393250
D019327Copper SulfateCopper Sulfate results in decreased expression of NDUFA10 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NDUFA10 mRNA20106945
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA10 mRNA26873546
D004317DoxorubicinDoxorubicin affects the expression of NDUFA10 protein29385562
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA10 mRNA26873546
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NDUFA10 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFA10 mRNA17942748
D005472FluorouracilFluorouracil results in increased expression of NDUFA10 protein15585135|1680352
D005472FluorouracilNDUFA10 protein affects the susceptibility to Fluorouracil15548681
D005485FlutamideFlutamide results in decreased expression of NDUFA10 mRNA24793618
D005839GentamicinsGentamicins results in increased expression of NDUFA10 mRNA22061828
D017313FenretinideFenretinide affects the expression of NDUFA10 mRNA16570282
D007538IsoniazidIsoniazid affects the expression of NDUFA10 mRNA24848797
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NDUFA10 mRNA21641980
D008727MethotrexateMethotrexate results in increased expression of NDUFA10 protein24736981
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of NDUFA10 protein26558463
D009534NiclosamideNiclosamide results in decreased expression of NDUFA10 mRNA22576131
C025589ochratoxin Aochratoxin A results in increased expression of NDUFA10 mRNA17316727
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NDUFA10 mRNA"21673326
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NDUFA10 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of NDUFA10 mRNA23811191
C089730rosiglitazonerosiglitazone affects the expression of NDUFA10 mRNA22013433
D012402RotenoneRotenone results in increased expression of NDUFA10 mRNA18191903
D013311StreptozocinStreptozocin results in increased expression of NDUFA10 protein21136691
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of NDUFA10 protein]21136691
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NDUFA10 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NDUFA10 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFA10 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NDUFA10 mRNA20399798
C009495titanium dioxidetitanium dioxide results in decreased expression of NDUFA10 mRNA23557971
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of NDUFA10 protein]21136691
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NDUFA10 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS9878551  
GO:0019136deoxynucleoside kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006120mitochondrial electron transport, NADH to ubiquinone-IBA21873635  
GO:0006120mitochondrial electron transport, NADH to ubiquinone-NAS9878551  
GO:0032981mitochondrial respiratory chain complex I assembly-IMP27626371  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IBA21873635  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  27626371  
GO:0005747mitochondrial respiratory chain complex I-NAS9878551  
GO:0005759mitochondrial matrix-IEA-  
GO:0043209myelin sheath-IEA-  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26988295The influence of chronic nicotine treatment on proteins expressed in the mouse hippocampus and cortex. (2016 Jun 5)Matsuura KEur J Pharmacol