Gene: ATIC

471
AICAR|AICARFT|HEL-S-70p|IMPCHASE|PURH
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
protein-coding
2q35
Ensembl:ENSG00000138363 MIM:601731 Vega:OTTHUMG00000133023 UniprotKB:P31939
NG_013002.1
PubMed
0   ANCO-SNPs
ND
3   
6.762e-1 (AD)  1.041e-2 (ND)   (Frontal_Cortex)
6.922e-1 (AD)  1.912e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSPAN30.915
PPT10.907
VPS450.905
FH0.904
NFS10.902
AMFR0.902
AIG10.901
AP3S20.9
ARFGAP20.894
ARL30.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.778
OR4F29-0.717
FCER2-0.318
CETP-0.314
TFPI2-0.308
OR6C74-0.307
FCRL1-0.304
PPBP-0.294
SIX1-0.288
CLEC6A-0.286

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
DB00642PemetrexedSmall Molecule137281-23-3Approved|InvestigationalTarget
DB01700AICA ribonucleotideSmall Molecule3031-94-5Experimental|InvestigationalTarget
DB01972Guanosine-5'-MonophosphateSmall Molecule85-32-5ExperimentalTarget
DB023095--Monophosphate-9-Beta-D-Ribofuranosyl XanthineSmall MoleculeExperimentalTarget
DB034422-[5-Hydroxy-3-Methyl-1-(2-Methyl-4-Sulfo-Phenyl)-1h-Pyrazol-4-Ylazo]-4-Sulfo-Benzoic AcidSmall MoleculeExperimentalTarget
DB04057Beta-Dadf, Msa, Multisubstrate Adduct InhibitorSmall MoleculeExperimentalTarget
DB00563MethotrexateSmall Molecule59-05-2ApprovedEnzyme
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ATIC mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ATIC mRNA"21346803
C0587062-desamino-2-methylaminopterin2-desamino-2-methylaminopterin analog binds to and results in decreased activity of ATIC protein1313737
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of ATIC protein26194647
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ATIC mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of ATIC mRNA21420995
C000188alachloralachlor results in increased expression of ATIC mRNA12419858
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ATIC mRNA16483693
C023650anilineaniline results in increased nitrosation of ATIC protein21708182
D001280AtrazineAtrazine results in increased expression of ATIC mRNA25929836
D001507BeclomethasoneBeclomethasone results in increased expression of ATIC mRNA23656298
C006780bisphenol Abisphenol A affects the expression of ATIC mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ATIC mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ATIC protein28903499
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATIC mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ATIC mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ATIC mRNA17484886
C100187chloropicrinchloropicrin results in increased expression of ATIC mRNA26352163|2847649
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ATIC mRNA28472532
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATIC mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of ATIC mRNA19320972
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ATIC mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of ATIC mRNA27594783
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATIC mRNA17602206
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ATIC mRNA24534155
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATIC protein20227414
D005485FlutamideFlutamide results in decreased expression of ATIC mRNA24793618
D005485FlutamideFlutamide results in increased expression of ATIC mRNA24136188
D019833GenisteinGenistein results in decreased expression of ATIC mRNA22228119
D005839GentamicinsGentamicins results in increased expression of ATIC mRNA22061828
D006046GoldGold analog results in decreased expression of ATIC protein24780912
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATIC protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of ATIC protein23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATIC protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ATIC protein23178681
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATIC mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ATIC mRNA25982114
C410337K 7174K 7174 results in decreased expression of ATIC mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of ATIC mRNA24967691
D008727MethotrexateATIC gene polymorphism affects the susceptibility to Methotrexate16947783|1753070
D008727MethotrexateATIC gene SNP affects the susceptibility to Methotrexate17410198
D008727MethotrexateMethotrexate results in decreased expression of ATIC mRNA23897011
D008727MethotrexateMethotrexate metabolite results in decreased activity of ATIC protein25575725
C014085methotrexate polyglutamate[ADORA2A gene SNP co-treated with ATIC gene SNP] affects the abundance of methotrexate polyglutamate20954192
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ATIC mRNA27544571
D009020MorphineMorphine results in decreased expression of ATIC protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ATIC mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ATIC mRNA"25554681
C051752nefazodonenefazodone results in increased expression of ATIC mRNA24136188
C012655nimesulidenimesulide results in increased expression of ATIC mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ATIC mRNA17616710
D052638Particulate MatterParticulate Matter results in increased expression of ATIC mRNA24769257
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ATIC mRNA23948077
D010416PentachlorophenolPentachlorophenol results in increased expression of ATIC mRNA23892564
D010936Plant ExtractsPlant Extracts results in decreased expression of ATIC mRNA24677778
D011441PropylthiouracilPropylthiouracil results in increased expression of ATIC mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of ATIC protein17337753
C010327salinomycinsalinomycin results in decreased expression of ATIC mRNA19682730
D012969Sodium FluorideSodium Fluoride results in decreased expression of ATIC mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATIC mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATIC protein19201780
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATIC mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ATIC mRNA23411599
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ATIC mRNA19042947
D014520UrethaneUrethane results in decreased expression of ATIC mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of ATIC mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of ATIC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ATIC mRNA19101580
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ATIC gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of ATIC mRNA20044591
D015032ZincZinc deficiency results in increased expression of ATIC mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003937IMP cyclohydrolase activity-TAS-  
GO:0004643phosphoribosylaminoimidazolecarboxamide formyltransferase activity-TAS-  
GO:0042803protein homodimerization activity-IPI14756553  14966129  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0003360brainstem development-IEA-  
GO:0006139nucleobase-containing compound metabolic process-TAS8567683  
GO:0006189'de novo' IMP biosynthetic process-IEA-  
GO:0009116nucleoside metabolic process-IEA-  
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TAS-  
GO:0010035response to inorganic substance-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0031100animal organ regeneration-IEA-  
GO:0046452dihydrofolate metabolic process-IEA-  
GO:0046654tetrahydrofolate biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-73817Purine ribonucleoside monophosphate biosynthesisTAS
R-HSA-8956320Nucleobase biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18242762EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (2008 Aug)Shinmura KLung Cancer
17530705A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. (2007 Jun)Wessels JAArthritis Rheum
27770044Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins. (2016 Dec)Soukup TInt J Immunopathol Pharmacol