Gene: ATM

472
AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1
ATM serine/threonine kinase
protein-coding
11q22.3
Ensembl:ENSG00000149311 MIM:607585 Vega:OTTHUMG00000166480 UniprotKB:Q13315
NG_009830.1
PubMed
CD|ND|AD
37   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.874e-3 (AD)  3.991e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELF20.873
VPS13C0.864
ZFC3H10.862
AGO30.858
DIP2A0.858
ZBTB260.856
PBRM10.855
MSH60.854
PCF110.85
ZC3H11A0.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.424
OR4F29-0.393
HES5-0.314
TNNT1-0.304
WNT7B-0.3
PLA2G5-0.291
DIO2-0.26
ARSF-0.252
SLC13A5-0.251
ENDOU-0.247

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
ID Drug Name Action PubMed
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of ATM protein26208482
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)ureaATM mutant form results in increased susceptibility to 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea26208482
C1087311'-(hydroxymethyl)eugenol1'-(hydroxymethyl)eugenol results in increased phosphorylation of ATM protein28818686
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM protein"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of ATM mRNA"26988655
C5461932-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide"2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [potassium chromate(VI) results in increased expression of ATM protein modified form]"25977998
C5461932-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide"2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide results in decreased activity of ATM protein"25977998
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATM mRNA"19114083
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein"26451628
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein modified form"26451628
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein]"26451628
C4166532-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased expression of and results in increased phosphorylation of ATM protein23523585
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM protein"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM protein"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM protein"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM protein"25510870
C1177762,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form"26630137
C1177762,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form]"26630137
C1177762,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form]"26630137
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of ATM protein20469912
C0312782-chloroethyl ethyl sulfideATM protein affects the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]19111594
C0312782-chloroethyl ethyl sulfideATM protein affects the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein]19111594
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of ATM protein20469912
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one"2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form]"26630137
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin results in increased phosphorylation of ATM protein]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [BRCA1 results in increased expression of ATM mRNA]22832221
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased activity of ATM protein]22927544
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]18347191
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [IGF1 protein results in increased activity of ATM protein]20053781
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [INS1 protein results in increased activity of ATM protein]20053781
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein]22119920
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [potassium chromate(VI) results in increased expression of ATM protein modified form]25977998
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of ATM protein]]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol results in increased phosphorylation of ATM protein]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Sterigmatocystin results in increased expression of ATM protein modified form]26914363
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein22194930|2597799
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased expression of ATM protein modified form26914363
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [INS1 protein results in increased activity of ATM protein]20053781
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein16556909
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRIM28 protein]22003191
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]22003191
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRIM28 protein]22003191
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]22003191
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-onePARP1 protein affects the reaction [2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein]16556909
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein21186350
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein19182866|2141379
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]"24933654
C5534733-(3-dimethylaminopropylamino)-8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile"3-(3-dimethylaminopropylamino)-8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile results in increased activity of ATM protein"19182866
C5534723-(4-methylpiperazin)-8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile"3-(4-methylpiperazin)-8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carbonitrile results in increased activity of ATM protein"19182866
C0251603-aminobenzamide3-aminobenzamide inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of ATM protein]22226932
C0006147253'-oxomethylisoeugenol3'-oxomethylisoeugenol results in increased phosphorylation of ATM protein28818686
C0865384-amino-1,8-naphthalimide"4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein"16556909
C0865384-amino-1,8-naphthalimide"ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]"16556909
C0865384-amino-1,8-naphthalimide"ATM protein affects the susceptibility to 4-amino-1,8-naphthalimide"16556909
C0865384-amino-1,8-naphthalimide"PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]"16556909
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ATM mRNA19191707
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA21882252
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA]21882252
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of ATM mRNA26988655
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of ATM protein"23274516
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"Acetylcysteine inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of ATM protein]"23274516
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"Caffeine inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of ATM protein]"23274516
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of ATM mRNA26988655
D000082AcetaminophenAcetaminophen results in decreased expression of ATM mRNA21420995
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein]"26451628
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of ATM protein]"23274516
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of ATM protein modified form]24792323
D000111AcetylcysteineAcetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]15489221
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]15489221
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]15489221
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]15489221
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]15489221
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]15489221
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]15489221
D020106Acrylamide[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide20734998
C027955aflatoxin G1aflatoxin G1 results in increased activity of ATM protein23907605
C027955aflatoxin G1aflatoxin G1 results in increased expression of ATM protein modified form23907605
C027955aflatoxin G1Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]23907605
C027955aflatoxin G1Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]23907605
D000393Air PollutantsAir Pollutants results in increased phosphorylation of ATM protein28389379
D000872AnthocyaninsAnthocyanins results in increased phosphorylation of ATM protein27444805
C010680antibiotic G 418antibiotic G 418 results in increased expression of ATM protein mutant form15498871
D016590Aphidicolin[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRIM28 protein]22003191
D016590Aphidicolin[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]22003191
D034341Aristolochic AcidsAcetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of ATM protein modified form]24792323
D034341Aristolochic AcidsAristolochic Acids results in increased expression of ATM protein modified form24792323
D001151ArsenicArsenic affects the methylation of ATM gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of ATM mRNA19763917|2047151
C006632arsenic trioxidearsenic trioxide results in decreased expression of ATM protein modified form28318385
C006632arsenic trioxidearsenic trioxide results in decreased expression of ATM mRNA19730151
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of ATM protein23337567
D001194AsbestosAsbestos affects the expression of ATM mRNA17297452
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of ATM protein"20855422
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [potassium chromate(VI) results in increased expression of ATM protein modified form]25977998
D001205Ascorbic Acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ATM mRNA17917374
D001241AspirinAspirin results in increased expression of ATM mRNA20457246
D001280Atrazine[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of ATM mRNA22515965
D001564Benzo(a)pyrene[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA21882252
D001564Benzo(a)pyreneATM protein affects the susceptibility to Benzo(a)pyrene22382310
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATM mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATM mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATM protein22266578
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased phosphorylation of and affects the localization of ATM protein28461126
D001564Benzo(a)pyreneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA]21882252
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of ATM mRNA]22266578
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of ATM protein]22266578
D001564Benzo(a)pyreneATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]20888899
D001564Benzo(a)pyreneATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]20888899
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATM mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATM mRNA20713471|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATM mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ATM mRNA"28593498
C403753benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketonebenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Bortezomib results in increased cleavage of ATM protein]12393500
D004958EstradiolEstradiol results in decreased expression of ATM mRNA24349563
D004958EstradiolEstradiol results in increased expression of ATM protein modified form25933419
D004958EstradiolEstradiol results in decreased expression of ATM mRNA22467019
C044887beta-methylcholinebeta-methylcholine affects the expression of ATM mRNA21179406
C095105bexarotenebexarotene results in increased activity of ATM protein19067706
C006780bisphenol Abisphenol A results in increased expression of ATM mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of ATM protein modified form25933419
C006780bisphenol Abisphenol A results in increased phosphorylation of ATM protein29275510
C006780bisphenol AMYC protein promotes the reaction [bisphenol A results in increased expression of ATM protein modified form]25933419
C006780bisphenol Abisphenol A results in decreased expression of ATM mRNA25181051
C006780bisphenol Abisphenol A results in increased activity of ATM protein24085620
C006780bisphenol Abisphenol A results in increased expression of ATM mRNA27208089|2757113
C006780bisphenol Abisphenol A results in increased phosphorylation of ATM protein27208089
D001761Bleomycin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]]24933654
D001761Bleomycin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin results in increased phosphorylation of ATM protein]24933654
D001761Bleomycin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of ATM protein]]24933654
D001761BleomycinBleomycin promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]24933654
D001761BleomycinBleomycin results in increased phosphorylation of ATM protein24933654
D001761Bleomycinresveratrol promotes the reaction [Bleomycin results in increased phosphorylation of ATM protein]24933654
C557045BO-1051ATM protein promotes the reaction [BO-1051 results in increased cleavage of CASP3 protein]21184746
C557045BO-1051ATM protein promotes the reaction [BO-1051 results in increased cleavage of CASP7 protein]21184746
C557045BO-1051ATM protein promotes the reaction [BO-1051 results in increased expression of CHEK2 protein modified form]21184746
C557045BO-1051ATM protein promotes the reaction [BO-1051 results in increased expression of MTOR protein modified form]21184746
C557045BO-1051BO-1051 results in increased expression of ATM protein modified form21184746
D000069286Bortezomibbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Bortezomib results in increased cleavage of ATM protein]12393500
D000069286BortezomibBortezomib results in increased cleavage of ATM protein12393500
D000069286Bortezomib[CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of ATM protein]12393500
C546611brevetoxin 2brevetoxin 2 results in increased expression of ATM mRNA20498034
C016274bromoacetatebromoacetate results in increased expression of ATM mRNA19753638
D002066Busulfan[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein20933509
D002083Butylated Hydroxyanisole[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of ATM mRNA25086368
C018475butyraldehydebutyraldehyde results in decreased expression of ATM mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ATM mRNA26525392
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATM mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of ATM protein20435356
D002110Caffeine"Caffeine inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of ATM protein]"23274516
D002110CaffeineCaffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]22927544
D002110CaffeineCaffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]18347191
D002110CaffeineCaffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
D002110CaffeineCaffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]19028473
D002110CaffeineCaffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]15975956
D002110CaffeineCaffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]15975956
D002110CaffeineCaffeine results in decreased activity of ATM protein10531013|1150724
D002110Caffeine[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide20734998
D002110CaffeineCaffeine inhibits the reaction [ATM results in increased phosphorylation of and results in increased activity of CHEK2 protein]10744722
D002110CaffeineCaffeine results in decreased activity of ATM protein10744722
D002110CaffeineATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]20888899
D002110CaffeineCaffeine results in decreased activity of ATM protein12811820|1506017
D002110CaffeineCaffeine results in decreased activity of [ATM protein co-treated with ATR protein]15975956
C553149camphorquinonecamphorquinone results in increased phosphorylation of ATM protein26658076
D002166CamptothecinCamptothecin results in decreased expression of ATM mRNA24792648
D002211Capsaicin3-aminobenzamide inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of ATM protein]22226932
D002211CapsaicinATG5 mutant form inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of ATM protein]22226932
D002211CapsaicinCapsaicin results in increased activity of ATM protein19502594
D002211CapsaicinCapsaicin results in increased expression of ATM mRNA19502594
D002211CapsaicinCapsaicin results in increased phosphorylation of and results in increased activity of ATM protein22226932
D002211CapsaicinCapsaicin results in increased phosphorylation of ATM protein19502594
D002219CarbamatesCarbamates analog promotes the reaction [ATM protein results in increased phosphorylation of and results in increased activity of TP53 protein]19376255
D002219CarbamatesCarbamates analog results in increased phosphorylation of and results in increased activity of ATM protein19376255
D002219CarbamatesCarbamates analog results in increased phosphorylation of ATM protein19111005
D002392CatechinCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of ATM mRNA]21882252
D002738ChloroquineChloroquine results in increased phosphorylation of ATM protein18089834
D004390Chlorpyrifos[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of ATM mRNA22515965
D004390ChlorpyrifosChlorpyrifos results in increased expression of ATM mRNA22515965
C074702chromium hexavalent ionchromium hexavalent ion affects the phosphorylation of and affects the expression of ATM protein25173789
D007464ClioquinolClioquinol results in increased phosphorylation of ATM protein22627294
C068329clofarabine[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein20933509
D003035CobaltCobalt results in increased expression of ATM mRNA22147119
D003042CocaineCocaine results in increased expression of ATM mRNA20056891
D003042CocaineEHMT2 inhibits the reaction [Cocaine results in increased expression of ATM mRNA]20056891
D019327Copper SulfateCopper Sulfate results in decreased expression of ATM mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of ATM mRNA21878529
C029892cupric chloridecupric chloride results in increased phosphorylation of and results in increased activity of ATM protein16959548
C029892cupric chloridecupric chloride results in increased phosphorylation of ATM protein20435356
D003471CuprizoneCuprizone results in decreased expression of ATM mRNA26577399
D003474CurcuminCurcumin results in increased phosphorylation of ATM protein19401701|2113407
D003474Curcumin[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein21134073
D016572CyclosporineCyclosporine results in decreased expression of ATM mRNA25562108
C017160cypermethrincypermethrin results in increased expression of ATM mRNA21142847
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of ATM mRNA29038839
D003630DaunorubicinDaunorubicin results in increased expression of ATM mRNA12656675
C114768decamethylcyclopentasiloxanedecamethylcyclopentasiloxane results in decreased expression of ATM mRNA27601420
C014347decitabineATM protein affects the reaction [decitabine results in increased expression of H2AFX protein]17991895
C014347decitabineATM protein affects the susceptibility to decitabine17991895
C014347decitabinedecitabine affects the localization of ATM protein modified form17991895
C014347decitabinedecitabine affects the methylation of ATM promoter17488656
D003676DeferoxamineDeferoxamine results in increased phosphorylation of and results in increased activity of ATM protein16959548
C107676deguelindeguelin results in decreased expression of ATM mRNA22227970
D003976DiazinonDiazinon results in increased methylation of ATM gene22964155
D003976DiazinonDiazinon affects the expression of ATM mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ATM mRNA17361019|2126653
D002945CisplatinATM protein results in increased susceptibility to Cisplatin21324906
D002945CisplatinCisplatin results in increased expression of ATM mRNA25450742
D002945CisplatinCisplatin results in increased expression of ATM protein modified form21184746
D002945CisplatinCisplatin results in increased phosphorylation of and results in increased activity of ATM protein20145152
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein alternative form binds to ATM promoter]21191146
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein alternative form results in increased expression of ATM protein]21191146
D002945CisplatinMIR630 mRNA inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATM protein]20145152
D002945Cisplatin[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRIM28 protein]22003191
D002945Cisplatin[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]22003191
D002945CisplatinCisplatin results in increased expression of ATM mRNA21151649
D002945CisplatinCisplatin results in increased expression of ATM protein26723870
D002945CisplatinCisplatin results in increased phosphorylation of ATM protein22006019
D002945CisplatinNQO1 gene mutant form inhibits the reaction [Cisplatin results in increased expression of ATM protein]26723870
D002945CisplatinCisplatin results in increased expression of ATM protein modified form26739623
D002945CisplatinLovastatin inhibits the reaction [Cisplatin results in increased expression of ATM protein modified form]26739623
D004006DichlorvosDichlorvos results in increased expression of ATM mRNA24369695
D004006DichlorvosDichlorvos results in increased expression of ATM protein24369695
D004006DichlorvosTEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of ATM mRNA]24369695
C000944dicrotophosdicrotophos results in decreased expression of ATM mRNA28302478
D001728Dicumarol"Dicumarol inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of ATM protein modified form]"26630137
D004026DieldrinDieldrin affects the expression of ATM mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ATM mRNA28115068
D004051Diethylhexyl PhthalateEthanol promotes the reaction [Diethylhexyl Phthalate results in increased expression of ATM mRNA]28115068
D004051Diethylhexyl PhthalatePQQ Cofactor inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ATM mRNA]28115068
C014476diethyl maleatediethyl maleate results in increased expression of ATM mRNA11875189
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased cleavage of and results in increased activity of CASP3 protein]19919837
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATR mRNA]19919837
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATR protein]19919837
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDKN2A protein]19919837
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 mRNA]19919837
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 protein]19919837
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRP53 protein]19919837
D004052DiethylnitrosamineATM protein promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]19919837
D004052DiethylnitrosamineATM protein promotes the reaction [Diethylnitrosamine results in increased expression of TERT protein]19919837
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ATM mRNA17917374
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ATM mRNA17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased phosphorylation of ATM protein18506893
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATM mRNA]17854601
D004052DiethylnitrosamineXRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of ATM protein]18506893
D004052DiethylnitrosamineATM protein affects the reaction [Diethylnitrosamine results in increased expression of TP53 protein]11751435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased activity of ATM protein11751435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ATM protein11751435
C534866digalloylresveratroldigalloylresveratrol results in increased activity of ATM protein23943154
D002117CalcitriolCalcitriol results in increased expression of ATM mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [A gene mutant form results in decreased expression of ATM mRNA]"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ATM mRNA"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ATM protein"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased phosphorylation of ATM protein"23969067
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ATM mRNA"23969067
D004317Doxorubicin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased activity of ATM protein]22927544
D004317Doxorubicin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]18347191
D004317DoxorubicinAcetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]15489221
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]15489221
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]15489221
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]15489221
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]15489221
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]15489221
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]15489221
D004317DoxorubicinATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]15489221
D004317DoxorubicinCaffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]22927544
D004317DoxorubicinCaffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]18347191
D004317DoxorubicinDoxorubicin inhibits the reaction [BRCA1 protein binds to ATM promoter]22832221
D004317DoxorubicinDoxorubicin inhibits the reaction [RBBP8 protein binds to ATM promoter]22832221
D004317DoxorubicinDoxorubicin inhibits the reaction [[RBBP8 protein binds to BRCA1 protein binds to E2F1 protein] which results in increased expression of ATM mRNA]22832221
D004317DoxorubicinDoxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]15489221
D004317DoxorubicinDoxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]15489221
D004317DoxorubicinDoxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]15489221
D004317DoxorubicinDoxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]15489221
D004317DoxorubicinDoxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]15489221
D004317DoxorubicinDoxorubicin promotes the reaction [E2F1 protein results in decreased expression of ATM mRNA]22832221
D004317DoxorubicinDoxorubicin results in decreased expression of ATM mRNA22832221
D004317DoxorubicinDoxorubicin results in increased activity of ATM protein22927544
D004317DoxorubicinDoxorubicin results in increased expression of ATM protein modified form21184746
D004317DoxorubicinDoxorubicin results in increased phosphorylation of and results in increased activity of ATM protein18347191
D004317DoxorubicinDoxorubicin results in increased phosphorylation of ATM protein15489221
D004317Doxorubicinwortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]15489221
D004317DoxorubicinDoxorubicin results in increased phosphorylation of and results in increased activity of ATM protein22242153
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ATM mRNA"23811387
D004642EmodinEmodin results in increased expression of ATM mRNA16045814
D004642EmodinEmodin results in increased phosphorylation of ATM protein20855424
C007590emulphogene BC 720emulphogene BC 720 results in increased expression of ATM mRNA25398874
D004726Endosulfan[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of ATM mRNA22515965
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of ATM mRNA29038839
C109476epoxiconazoleepoxiconazole results in increased expression of ATM mRNA29038839
C007366erythritol anhydrideATM protein affects the reaction [erythritol anhydride results in increased phosphorylation of TP53 protein]20024960
C007366erythritol anhydrideATM protein results in increased susceptibility to erythritol anhydride20024960
C007366erythritol anhydrideerythritol anhydride results in increased phosphorylation of ATM protein25633853
D000431EthanolEthanol promotes the reaction [Diethylhexyl Phthalate results in increased expression of ATM mRNA]28115068
D005047EtoposideEtoposide results in increased phosphorylation of and affects the localization of ATM protein26259609
D005047Etoposidepifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein]26259609
D005047EtoposideEtoposide results in increased phosphorylation of and results in increased activity of ATM protein22242153
D015025ZearalenoneZearalenone results in increased expression of ATM mRNA27862621
C024555ferric chlorideferric chloride results in increased phosphorylation of and results in increased activity of ATM protein16959548
D044950FlavanonesFlavanones results in increased phosphorylation of ATM protein21616090
C024352fludarabine[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of ATM protein20933509
C061365flusilazoleflusilazole results in increased expression of ATM mRNA22382673
D005492Folic AcidFolic Acid affects the expression of ATM mRNA16361273
D005557FormaldehydeFormaldehyde results in increased expression of ATM mRNA22525295
C039281furanfuran results in decreased expression of ATM mRNA25539665
C039281furanfuran results in increased expression of ATM mRNA22079235
D005665FurosemideFurosemide affects the expression of ATM mRNA17497460
C064925gadodiamidegadodiamide results in increased expression of ATM mRNA20959327
D005688GalactosamineGalactosamine results in increased expression of ATM protein24565947
D005688Galactosamineglycine propionyl carnitine inhibits the reaction [Galactosamine results in increased expression of ATM protein]24565947
D005707Gallic AcidGallic Acid results in decreased expression of ATM mRNA21887735
D019833Genistein2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
D019833Genistein2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
D019833GenisteinATM protein affects the reaction [Genistein results in increased expression of and results in increased phosphorylation of TP53 protein]15177039
D019833GenisteinATM protein affects the reaction [Genistein results in increased phosphorylation of H2AFX protein]15177039
D019833GenisteinCaffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
D019833GenisteinGenistein results in increased phosphorylation of ATM protein15177039|1903823
D019833GenisteinU 0126 inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
D019833GenisteinATM protein affects the susceptibility to Genistein21177254
D019833GenisteinGenistein results in increased activity of ATM protein15177039
D005839GentamicinsGentamicins results in increased expression of ATM protein mutant form15498871
C000588486glycine propionyl carnitineglycine propionyl carnitine inhibits the reaction [Galactosamine results in increased expression of ATM protein]24565947
C001330hellebrigeninhellebrigenin results in increased phosphorylation of ATM protein24954031
C024035hexamethylcyclotrisiloxanehexamethylcyclotrisiloxane results in decreased expression of ATM mRNA27601420
D006861Hydrogen Peroxide2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]]24933654
D006861Hydrogen Peroxide2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]24933654
D006861Hydrogen Peroxide2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]]24933654
D006861Hydrogen Peroxide"3,3',4,5'-tetrahydroxystilbene promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]"24933654
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ATM mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]24933654
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ATM mRNA22539617
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of and results in increased phosphorylation of ATM protein25972194
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ATM25336634
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ATM mRNA18951874|2597219
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ATM protein25972194
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of ATM protein24933654|2533663
D006861Hydrogen PeroxideMIRLET7G mRNA inhibits the reaction [Hydrogen Peroxide results in increased expression of ATM protein]25972194
D006861Hydrogen Peroxideresveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]24933654
D006861Hydrogen PeroxideSELENOH mutant form promotes the reaction [Hydrogen Peroxide results in increased expression of ATM]25336634
D006861Hydrogen PeroxideSELENOH mutant form promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]25336634
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of and results in increased activity of ATM protein18608517
D006918HydroxyureaHydroxyurea results in increased expression of ATM mRNA27208086
C051890irinotecanirinotecan results in increased phosphorylation of ATM protein22898888
D007501IronATM protein affects the susceptibility to Iron16959548
D007501IronIron results in increased phosphorylation of and results in increased activity of ATM protein16959548
D007501IronATM protein affects the abundance of Iron15336622
D017953IsocyanatesIsocyanates analog results in increased phosphorylation of ATM protein19111005
D017953IsocyanatesIsocyanates results in increased expression of ATM protein19283680
D017953IsocyanatesIsocyanates results in increased phosphorylation of ATM protein19197993
D017953Isocyanates[Isocyanates results in increased phosphorylation of ATM protein] which results in increased phosphorylation of H2AFX protein19197993
D007529Isoflavones[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein21134073
C544151jinfukangjinfukang results in decreased expression of ATM mRNA27392435
C006552kaempferolCaffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]19028473
C006552kaempferolkaempferol results in increased phosphorylation of ATM protein19028473
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ATM mRNA17917374
C506643liposomal doxorubicinliposomal doxorubicin results in increased phosphorylation of ATM protein27923599
D008094LithiumLithium results in decreased expression of ATM mRNA19949822
D008148LovastatinLovastatin inhibits the reaction [Cisplatin results in increased expression of ATM protein modified form]26739623
D008345ManganeseManganese results in decreased expression of ATM mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of ATM mRNA17175027
D008687MetforminATM gene SNP affects the susceptibility to Metformin21186350
D008727MethotrexateATM mRNA results in decreased susceptibility to Methotrexate16918715
D008727MethotrexateATM protein results in decreased susceptibility to Methotrexate16918715
D008730MethoxsalenMethoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]23907605
C005223methyleugenolmethyleugenol results in increased phosphorylation of ATM protein28818686
C005223methyleugenolmethyleugenol results in decreased expression of ATM mRNA26011634
C000614724methyleugenol-2',3'-epoxide"methyleugenol-2',3'-epoxide results in increased phosphorylation of ATM protein"28818686
D008769MethylnitronitrosoguanidineATM gene mutant form results in increased susceptibility to Methylnitronitrosoguanidine15010311
D015741MetriboloneATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AFX protein]23272087
D015741Metribolone[ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AFX protein]] which results in increased expression of ERG mRNA23272087
D015741MetriboloneMetribolone results in increased phosphorylation of ATM protein23272087
D008942MitoxantroneMitoxantrone results in decreased expression of ATM mRNA22832221
D016686Monocrotaline[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA21224054
D016686Monocrotaline[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein21224054
C437683motexafin gadoliniummotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of ATM mRNA16357179
D009151Mustard Gas2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein]22119920
D009151Mustard GasMustard Gas results in increased phosphorylation of ATM protein22119920
D009151Mustard Gaswortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein]22119920
C005246myristicinmyristicin results in decreased expression of ATM mRNA24792648
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of ATM mRNA"25461557
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ATM mRNA"17450800
C000621033napabucasinnapabucasin results in decreased expression of ATM mRNA25605917
D009285NaphthoquinonesNaphthoquinones results in increased expression of ATM mRNA23811387
C498045NCX 4040NCX 4040 results in increased expression of ATM mRNA20188076
C022838nickel chloridenickel chloride results in increased expression of ATM mRNA12426141|1283993
C022838nickel chloridenickel chloride affects the expression of ATM mRNA22546817
C028007nickel monoxidenickel monoxide analog results in increased phosphorylation of and affects the localization of ATM protein24503009
D009538NicotineNicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form]23907605
D009569Nitric OxideATM protein affects the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]15177039
D026422S-NitrosoglutathioneATM results in increased susceptibility to S-Nitrosoglutathione8958160
C024064octamethylcyclotetrasiloxaneoctamethylcyclotetrasiloxane results in decreased expression of ATM mRNA27601420
D010126OzoneOzone results in increased expression of ATM mRNA27206323
D010269ParaquatParaquat results in increased expression of ATM mRNA20883675
D010303ParomomycinParomomycin results in increased expression of ATM protein mutant form15498871
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM mRNA"25510870
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATM protein"25510870
D010419PentamidinePentamidine affects the localization of ATM protein modified form20144237
D010419PentamidinePentamidine results in decreased activity of ATM protein20144237
C046012pentanalpentanal results in decreased expression of ATM mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of ATM mRNA23091169
D010672Phenytoin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA21224054
D010672Phenytoin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein21224054
C030090phosphoramide mustardphosphoramide mustard affects the expression of ATM mRNA25497287
C030090phosphoramide mustardphosphoramide mustard results in increased expression of ATM mRNA26708502
C030090phosphoramide mustardphosphoramide mustard results in increased expression of ATM protein25497287|2670850
C121565pifithrinpifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein]26259609
C006253pirinixic acidpirinixic acid results in decreased expression of ATM mRNA16985257
D011084Polycyclic Aromatic HydrocarbonsATM gene polymorphism affects the susceptibility to Polycyclic Aromatic Hydrocarbons21873372
C019536potassium bromatepotassium bromate results in decreased expression of ATM mRNA22539617
C027373potassium chromate(VI)"2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [potassium chromate(VI) results in increased expression of ATM protein modified form]"25977998
C027373potassium chromate(VI)2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [potassium chromate(VI) results in increased expression of ATM protein modified form]25977998
C027373potassium chromate(VI)Ascorbic Acid inhibits the reaction [potassium chromate(VI) results in increased expression of ATM protein modified form]25977998
C027373potassium chromate(VI)ATM protein promotes the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]25977998
C027373potassium chromate(VI)ATM protein promotes the reaction [potassium chromate(VI) results in increased phosphorylation of CHEK2 protein]25977998
C027373potassium chromate(VI)potassium chromate(VI) results in increased activity of ATM protein25977998
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ATM protein modified form25977998
D045542PQQ CofactorPQQ Cofactor inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ATM mRNA]28115068
C045362prochlorazprochloraz results in increased expression of ATM mRNA29038839
D011398PromethazinePromethazine results in decreased expression of ATM mRNA26011634
C045950propiconazolepropiconazole results in decreased expression of ATM mRNA21278054
C006068propylparaben[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of ATM mRNA25086368
D011794QuercetinQuercetin results in decreased expression of ATM mRNA20596804|2372791
D011794QuercetinQuercetin results in increased phosphorylation of ATM protein15177039
D011794QuercetinATM protein affects the susceptibility to Quercetin21177254
D011794QuercetinQuercetin results in decreased expression of ATM mRNA25862958
C059514resveratrol2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]]24933654
C059514resveratrol2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]]24933654
C059514resveratrol2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of ATM protein]]24933654
C059514resveratrol2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]]24933654
C059514resveratrol2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol results in increased phosphorylation of ATM protein]24933654
C059514resveratrolATM mutant form inhibits the reaction [resveratrol results in increased expression of MICA protein]23445485
C059514resveratrolATM mutant form inhibits the reaction [resveratrol results in increased expression of ULBP2 protein]23445485
C059514resveratrolBleomycin promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]24933654
C059514resveratrolCaffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]15975956
C059514resveratrolCaffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]15975956
C059514resveratrolHydrogen Peroxide promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]24933654
C059514resveratrolresveratrol promotes the reaction [Bleomycin results in increased phosphorylation of ATM protein]24933654
C059514resveratrolresveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of ATM protein]24933654
C059514resveratrolresveratrol results in increased acetylation of ATM protein25533949
C059514resveratrolresveratrol results in increased activity of ATM protein22029423|2344548
C059514resveratrolresveratrol results in increased activity of [ATM protein co-treated with ATR protein]15975956
C059514resveratrol[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]15975956
C059514resveratrol[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] which results in increased phosphorylation of H2AFX protein15975956
C059514resveratrolresveratrol results in increased phosphorylation of ATM protein23522185|2493365
C059514resveratrol[temozolomide co-treated with resveratrol] results in increased phosphorylation of ATM protein23522185
C059514resveratrolresveratrol results in increased activity of ATM protein24933654
D012176RetinoidsRetinoids results in increased activity of ATM protein19067706
C547185riccardin Driccardin D affects the phosphorylation of ATM protein24069304
C547185riccardin Driccardin D results in increased expression of ATM mRNA24069304
D012293RifampinRifampin results in decreased expression of ATM mRNA24552687
D012293Rifampin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA21224054
D012293Rifampin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein21224054
D012402RotenoneRotenone results in increased expression of ATM mRNA18191903
C028268satratoxin Gsatratoxin G results in increased phosphorylation of ATM protein20150440
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ATM mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ATM mRNA19073995
D012835Silver NitrateSilver Nitrate analog results in increased expression of ATM mRNA22831968
C440975silybinsilybin results in increased phosphorylation of and results in increased activity of ATM protein16777994
D019821SimvastatinSimvastatin results in increased phosphorylation of and results in increased activity of ATM protein20499237
C009277sodium arsenatesodium arsenate results in increased expression of ATM mRNA24349563
C017947sodium arseniteATM gene mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]11507245
C017947sodium arseniteATM gene mutant form inhibits the reaction [sodium arsenite results in increased expression of TP53 protein]11507245
C017947sodium arseniteATM gene mutant form results in increased susceptibility to sodium arsenite11507245
C017947sodium arseniteATM protein affects the reaction [sodium arsenite results in decreased expression of HSP90AB1 mRNA]18996350
C017947sodium arseniteATM protein affects the reaction [sodium arsenite results in increased phosphorylation of TRP53 protein]18996350
C017947sodium arsenitesodium arsenite results in increased phosphorylation of ATM protein18996350
C028982sodium chromate(VI)MUS81 protein mutant form inhibits the reaction [sodium chromate(VI) results in decreased expression of ATM protein modified form]28318385
C028982sodium chromate(VI)sodium chromate(VI) results in decreased expression of ATM protein modified form28318385
D012969Sodium FluorideSodium Fluoride results in increased expression of ATM mRNA22525295
D013241Sterigmatocystin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Sterigmatocystin results in increased expression of ATM protein modified form]26914363
D013241SterigmatocystinSterigmatocystin results in increased expression of ATM protein modified form26914363
D013605T-2 ToxinT-2 Toxin results in increased phosphorylation of ATM protein20150440
C047246temozolomide[temozolomide co-treated with resveratrol] results in increased phosphorylation of ATM protein23522185
C047246temozolomidetemozolomide results in increased phosphorylation of ATM protein23522185
C505333TEMPOL-HTEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of ATM mRNA]24369695
D013739TestosteroneTestosterone affects the expression of ATM mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of ATM protein22015590
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATM mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATM mRNA16922920
D013849ThimerosalThimerosal results in increased expression of ATM mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ATM mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ATM mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ATM mRNA28111298
D014212TretinoinTretinoin results in increased expression of ATM mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of ATM mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of ATM mRNA28973697
C113580U 0126U 0126 inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]19038232
D014635Valproic AcidValproic Acid results in decreased expression of ATM mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of ATM gene29154799
D014635Valproic AcidValproic Acid affects the expression of ATM mRNA17292431
C521013veliparibveliparib results in increased activity of ATM protein21917757
C521013veliparibveliparib results in increased phosphorylation of and results in increased activity of ATM protein21917757
C025643vinclozolinvinclozolin results in increased expression of ATM mRNA23034163
C111237vorinostatvorinostat results in increased expression of ATM mRNA27188386
C111237vorinostatvorinostat results in increased phosphorylation of ATM protein20679231
C009687wortmanninwortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]15489221
C009687wortmanninwortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein]22119920
C009687wortmanninATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]20888899
C009687wortmanninwortmannin results in decreased activity of ATM protein22119920
D015032ZincZinc results in decreased expression of ATM mRNA19071009
D019345Zinc Acetatemotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of ATM mRNA16357179
C023616zinc chromatezinc chromate affects the phosphorylation of and affects the expression of ATM protein25173789
C023616zinc chromatezinc chromate results in increased phosphorylation of ATM protein19027772

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0004674protein serine/threonine kinase activity-IDA9733515  11375976  20096447  26323318  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004677DNA-dependent protein kinase activity-IDA15790808  
GO:0005515protein binding-IPI9168117  11375976  12607005  15314656  16452482  17157788  
17525732  18160036  18449195  18583959  18667510  18710941  
19015526  19412162  20801936  20810650  20864032  22977523  
25640309  25895060  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IBA21873635  
GO:00163031-phosphatidylinositol-3-kinase activity-IMP11375976  
GO:0044877protein-containing complex binding-IDA15790808  
GO:0046983protein dimerization activity-IDA15790808  
GO:0047485protein N-terminus binding-IDA11375976  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IEA-  
GO:0000724double-strand break repair via homologous recombination-IEA-  
GO:0000729DNA double-strand break processing-TAS-  
GO:0001541ovarian follicle development-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0001756somitogenesis-IEA-  
GO:0002331pre-B cell allelic exclusion-ISS-  
GO:0002377immunoglobulin production-IEA-  
GO:0006260DNA replication-TAS-  
GO:0006281DNA repair-IBA21873635  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006468protein phosphorylation-IDA15916964  
GO:0006468protein phosphorylation-IMP17694070  
GO:0006974cellular response to DNA damage stimulus-IDA16213212  
GO:0006974cellular response to DNA damage stimulus-IMP15790808  17875758  24550317  
GO:0006975DNA damage induced protein phosphorylation-IDA9733515  
GO:0006975DNA damage induced protein phosphorylation-IMP27664052  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007050cell cycle arrest-IMP15149599  
GO:0007094mitotic spindle assembly checkpoint-IMP11943150  
GO:0007131reciprocal meiotic recombination-TAS7792600  
GO:0007140male meiotic nuclear division-IEA-  
GO:0007143female meiotic nuclear division-IEA-  
GO:0007165signal transduction-TAS7792600  
GO:0007420brain development-IEA-  
GO:0007507heart development-IEA-  
GO:0008340determination of adult lifespan-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0010212response to ionizing radiation-IDA9733515  11375976  
GO:0010506regulation of autophagy-IMP23878245  
GO:0016572histone phosphorylation-IEA-  
GO:0018105peptidyl-serine phosphorylation-IDA9733515  26323318  
GO:0030889negative regulation of B cell proliferation-IMP17875758  
GO:0032210regulation of telomere maintenance via telomerase-IGI26586433  
GO:0032212positive regulation of telomere maintenance via telomerase-ISS-  
GO:0033129positive regulation of histone phosphorylation-IEA-  
GO:0033151V(D)J recombination-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0036289peptidyl-serine autophosphorylation-IMP24550317  
GO:0042159lipoprotein catabolic process-IEA-  
GO:0042981regulation of apoptotic process-TAS-  
GO:0043065positive regulation of apoptotic process-IMP17875758  
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator-IMP9733515  
GO:0043525positive regulation of neuron apoptotic process-IEA-  
GO:0045141meiotic telomere clustering-IEA-  
GO:0046777protein autophosphorylation-IDA9733515  15790808  
GO:0046777protein autophosphorylation-IMP27664052  
GO:0048538thymus development-IEA-  
GO:0048599oocyte development-IEA-  
GO:0051402neuron apoptotic process-IEA-  
GO:0051972regulation of telomerase activityNOTIMP26586427  
GO:0071044histone mRNA catabolic process-IDA16086026  
GO:0071480cellular response to gamma radiation-IDA9925639  16213212  
GO:0071481cellular response to X-ray-IDA26323318  
GO:0071500cellular response to nitrosative stress-IDA23878245  
GO:0072434signal transduction involved in mitotic G2 DNA damage checkpoint-IMP15149599  
GO:0090399replicative senescence-IMP15149599  
GO:0097694establishment of RNA localization to telomere-IMP26586433  
GO:0097695establishment of protein-containing complex localization to telomere-IC26586433  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1903626positive regulation of DNA catabolic process-IEA-  
GO:1903978regulation of microglial cell activation-IEA-  
GO:1904262negative regulation of TORC1 signaling-IMP23878245  
GO:1904354negative regulation of telomere capping-IMP17694070  
GO:1904358positive regulation of telomere maintenance via telomere lengthening-IMP17694070  26586427  
GO:1904884positive regulation of telomerase catalytic core complex assembly-IMP26586433  
GO:1905843regulation of cellular response to gamma radiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric regioncolocalizes_withIDA15149599  
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withIC26586433  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA26323318  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA27829214  
GO:0005819spindle-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
GO:1990391DNA repair complex-IDA24217620  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04210Apoptosis
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1TAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693548Sensing of DNA Double Strand BreaksTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-6803207TP53 Regulates Transcription of Caspase Activators and CaspasesTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6804760Regulation of TP53 Activity through MethylationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25AIEA
R-HSA-69610p53-Independent DNA Damage ResponseIEA
R-HSA-69613p53-Independent G1/S DNA damage checkpointIEA
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69615G1/S DNA Damage CheckpointsIEA
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20404482DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes. (2010 Jun 1)Jorgensen EDCell Cycle
9722204Early liver dysfunction in schistosomiasis. (1998 Aug)Camacho-Lobato LJ Hepatol
24819391Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study. (2014)Shen LPLoS One
24023351Effects of ataxia telangiectasia mutated (ATM) genotypes and smoking habits on lung cancer risk in Taiwan. (2013 Sep)Hsia TCAnticancer Res
18502988ATM gene variants in patients with idiopathic perifoveal telangiectasia. (2008 Sep)Barbazetto IAInvest Ophthalmol Vis Sci
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