Gene: RERE

473
ARG|ARP|ATN1L|DNB1|NEDBEH
arginine-glutamic acid dipeptide repeats
protein-coding
1p36.23
Ensembl:ENSG00000142599 MIM:605226 Vega:OTTHUMG00000001765 UniprotKB:Q9P2R6
NG_047035.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.901e-1 (AD)  1.102e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00423486chr1:8491132RERE4.600e-10Smoking27651444
cg00546117chr1:8445545RERE7.330e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLASP10.924
SPATA20.919
AHDC10.917
TADA2B0.915
IP6K10.915
STK350.914
PRPF80.912
NMT10.911
SEC16A0.91
FOXO30.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.709
OR4F29-0.662
TFPI2-0.339
SH2D1A-0.327
CD8B-0.319
KLRB1-0.317
CD3G-0.316
C9orf135-0.313
GZMK-0.313
CTNNA3-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RERE mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RERE mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RERE mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RERE mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RERE mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RERE mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RERE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RERE mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of RERE mRNA"28073004
D000082AcetaminophenAcetaminophen results in decreased expression of RERE mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of RERE mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RERE gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RERE mRNA16483693
D001151ArsenicArsenic affects the methylation of RERE gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of RERE mRNA15761015
C006632arsenic trioxidearsenic trioxide results in increased sumoylation of RERE protein28318385
C547126AZM551248AZM551248 results in decreased expression of RERE mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of RERE mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of RERE gene22576693
C006780bisphenol Abisphenol A affects the methylation of RERE promoter27334623
C006780bisphenol Abisphenol A affects the expression of RERE mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RERE gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RERE mRNA28628672
D019327Copper SulfateCopper Sulfate results in increased expression of RERE mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of RERE mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RERE mRNA28628672
C000944dicrotophosdicrotophos results in increased expression of RERE mRNA28302478
D004237DiuronDiuron results in decreased expression of RERE mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RERE mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RERE mRNA16174780|2409603
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RERE mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RERE mRNA16174780|2409603
D005839GentamicinsGentamicins results in increased expression of RERE mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RERE mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RERE mRNA28628672
D048628KetolidesKetolides analog results in increased expression of RERE mRNA24967691
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of RERE mRNA"24972896
D008727MethotrexateMethotrexate results in increased expression of RERE mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RERE mRNA23103053
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of RERE mRNA19812364
C016340o,p'-DDT"o,p'-DDT results in decreased expression of RERE mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in decreased expression of RERE mRNA"24096037
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RERE mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RERE mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of RERE mRNA23948077
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of RERE mRNA18692542
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RERE mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of RERE mRNA18301758
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of RERE mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RERE mRNA19073995
C025462sulindac sulfidesulindac sulfide results in decreased expression of RERE mRNA12734198
D013629TamoxifenTamoxifen affects the expression of RERE mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RERE mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RERE mRNA17942748
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RERE mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of RERE gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of RERE mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of RERE mRNA28973697
D014520UrethaneUrethane results in increased expression of RERE mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RERE mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RERE mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RERE mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of RERE gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RERE mRNA21427059
C025643vinclozolinvinclozolin affects the expression of RERE mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of RERE mRNA18042343

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0003677DNA binding-IBA21873635  
GO:0003682chromatin binding-IEA-  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0005515protein binding-IPI16713569  18451879  19131340  
GO:0008267poly-glutamine tract binding-TAS10814707  
GO:0008270zinc ion binding-IEA-  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006338chromatin remodeling-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006607NLS-bearing protein import into nucleus-TAS10814707  
GO:0021691cerebellar Purkinje cell layer maturation-IEA-  
GO:0021930cerebellar granule cell precursor proliferation-IEA-  
GO:0021942radial glia guided migration of Purkinje cell-IEA-  
GO:0048755branching morphogenesis of a nerve-IEA-  
GO:0048813dendrite morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-NAS10814707  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23287867Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors. (2013 Feb 21)Cohen KSBlood