Gene: NEDD4

4734
NEDD4-1|RPF1
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
protein-coding
15q21.3
Ensembl:ENSG00000069869 MIM:602278 Vega:OTTHUMG00000132015 UniprotKB:P46934
NG_051072.1
PubMed
0   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.433e-1 (AD)  3.289e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKD30.865
KDELC20.861
ZNF2170.856
CMTM60.856
ANO60.853
CARD80.851
BNIP20.848
WWTR10.845
RP20.843
RBMS20.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.607
SLC7A4-0.605
ABCC12-0.605
TMEM179-0.599
LRTM2-0.592
DLK2-0.586
LRFN2-0.584
KCNB2-0.583
BCL11A-0.581
MYADML2-0.58

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of NEDD4 mRNA"19162173
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4 mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of NEDD4 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NEDD4 mRNA21420995
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NEDD4 mRNA16483693
D001151ArsenicArsenic affects the methylation of NEDD4 gene25304211
C015001arsenitearsenite results in decreased methylation of NEDD4 promoter23974009
D001372Aza CompoundsAza Compounds results in decreased expression of NEDD4 mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of NEDD4 mRNA20521778
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NEDD4 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of NEDD4 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of NEDD4 mRNA26271895
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEDD4 mRNA20127859
C006780bisphenol Abisphenol A affects the expression of NEDD4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NEDD4 mRNA24982889
C037123cadmium sulfatecadmium sulfate results in increased expression of NEDD4 mRNA12064557|1467641
D002118CalciumCalcium affects the expression of NEDD4 mRNA15913539
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NEDD4 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of NEDD4 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NEDD4 gene20938992
D003024ClozapineClozapine results in decreased expression of NEDD4 mRNA18797397
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of NEDD4 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of NEDD4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NEDD4 mRNA25562108
D003894Deamino Arginine VasopressinDeamino Arginine Vasopressin results in increased expression of NEDD4 protein21734099
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of NEDD4 mRNA26271895
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NEDD4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NEDD4 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of NEDD4 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of NEDD4 mRNA19030233|2501614
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of NEDD4 mRNA]19030233
D004178DiquatDiquat affects the expression of NEDD4 mRNA22814884
D004237DiuronDiuron results in decreased expression of NEDD4 mRNA25152437
D004726EndosulfanEndosulfan results in decreased expression of NEDD4 mRNA21036383
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NEDD4 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEDD4 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NEDD4 mRNA17555576
D011345FenofibrateFenofibrate results in increased expression of NEDD4 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of NEDD4 mRNA]21318169
D005472FluorouracilNEDD4 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in decreased expression of NEDD4 mRNA24793618
D005485FlutamideFlutamide results in increased expression of NEDD4 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NEDD4 gene20938992
C070081fulvestrantfulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]29180066
C070081fulvestrantSB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]29180066
D005944GlucosamineGlucosamine results in decreased expression of NEDD4 mRNA17109745
D006220HaloperidolHaloperidol results in decreased expression of NEDD4 mRNA18797397
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of NEDD4 mRNA"26377693
D007211IndolesIndoles results in decreased expression of NEDD4 mRNA20521778
D007211IndolesIndoles results in increased expression of NEDD4 mRNA20521778
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NEDD4 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NEDD4 mRNA27392435
C410337K 7174K 7174 results in increased expression of NEDD4 mRNA24086573
D018021Lithium ChlorideLithium Chloride results in increased expression of NEDD4 protein21734099
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NEDD4 gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of NEDD4 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NEDD4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NEDD4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NEDD4 mRNA"20188158
C017557nickel subsulfidenickel subsulfide results in increased expression of NEDD4 mRNA21086188
C076029olanzapineolanzapine results in decreased expression of NEDD4 mRNA18797397
C076029olanzapineolanzapine results in decreased expression of NEDD4 protein18797397
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NEDD4 mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of NEDD4 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEDD4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NEDD4 mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of NEDD4 mRNA22538082
D010795Phthalic AcidsPhthalic Acids results in increased expression of NEDD4 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of NEDD4 mRNA18445702
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEDD4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NEDD4 mRNA22079256|2271453
C059514resveratrolresveratrol results in increased expression of NEDD4 protein25505154
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of NEDD4 mRNA]19030233
C093642SB 203580SB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]29180066
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NEDD4 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of NEDD4 mRNA28595984
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of NEDD4 mRNA16214533
D013739TestosteroneTestosterone results in decreased expression of NEDD4 mRNA20600201|2166921
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEDD4 mRNA21570461
D014212TretinoinTretinoin results in increased expression of NEDD4 mRNA21934132
D014415TunicamycinTunicamycin results in increased expression of NEDD4 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased methylation of NEDD4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NEDD4 mRNA23179753|2915479
D014640VancomycinVancomycin results in decreased expression of NEDD4 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of NEDD4 mRNA20566332
C029297vinylidene chloridevinylidene chloride results in increased expression of NEDD4 mRNA26682919
D014873Water PollutantsWater Pollutants results in decreased expression of NEDD4 mRNA23591932
C009687wortmanninwortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]20100827
D019287Zinc SulfateZinc Sulfate results in increased expression of NEDD4 protein20100827
D019287Zinc Sulfatewortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]20100827
D019287Zinc SulfateZinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]20100827
D019287Zinc SulfateZinc Sulfate results in increased expression of NEDD4 mRNA20100827
D019287Zinc SulfateZinc Sulfate results in increased expression of NEDD4 protein20100827

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9305852  9990509  10642508  11359767  11598133  12796489  
15105431  15231748  16000308  16118794  18305167  19345329  
20086093  20159449  20562859  20676133  21765395  22096579  
23686771  25588945  29455656  
GO:0019871sodium channel inhibitor activity-IDA10642508  
GO:0019904protein domain specific binding-IPI12907594  
GO:0031698beta-2 adrenergic receptor binding-IDA18544533  
GO:0043130ubiquitin binding-IDA9990509  
GO:0050815phosphoserine residue binding-ISS-  
GO:0050816phosphothreonine residue binding-ISS-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IDA17996703  20086093  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO:0070063RNA polymerase binding-IPI17996703  
GO:0070064proline-rich region binding-IMP15126635  
GO:0070064proline-rich region binding-IPI11342538  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0006511ubiquitin-dependent protein catabolic process-IDA20086093  
GO:0006511ubiquitin-dependent protein catabolic process-IMP17218260  17996703  
GO:0006622protein targeting to lysosome-IBA21873635  
GO:0006622protein targeting to lysosome-IDA17116753  
GO:0007041lysosomal transport-IDA18544533  
GO:0007528neuromuscular junction development-IBA21873635  
GO:0010766negative regulation of sodium ion transport-IDA10642508  
GO:0010768negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage-IMP17996703  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IMP17218260  
GO:0016241regulation of macroautophagy-TAS25809873  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IDA17996703  18305167  25631046  26280536  
GO:0019089transmission of virus-IMP15126635  
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway-ISS-  
GO:0031175neuron projection development-IBA21873635  
GO:0031175neuron projection development-IEP9990509  
GO:0031623receptor internalization-IBA21873635  
GO:0031623receptor internalization-IDA18544533  
GO:0032801receptor catabolic process-IBA21873635  
GO:0032801receptor catabolic process-IDA18544533  
GO:0034644cellular response to UV-IMP17996703  
GO:0034765regulation of ion transmembrane transport-IDA17289006  
GO:0042391regulation of membrane potential-IDA17289006  
GO:0042921glucocorticoid receptor signaling pathway-IDA8649367  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway-IMP20086093  
GO:0044111development involved in symbiotic interaction-IMP15126635  
GO:0045732positive regulation of protein catabolic process-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IDA14973438  
GO:0046824positive regulation of nucleocytoplasmic transport-IDA17218261  
GO:0048814regulation of dendrite morphogenesis-IBA21873635  
GO:0048814regulation of dendrite morphogenesis-ISS-  
GO:0050807regulation of synapse organization-IBA21873635  
GO:0050847progesterone receptor signaling pathway-IDA8649367  
GO:0051592response to calcium ion-TAS9405440  
GO:0070534protein K63-linked ubiquitination-ISS-  
GO:1901016regulation of potassium ion transmembrane transporter activity-IDA17289006  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IBA21873635  
GO:2000650negative regulation of sodium ion transmembrane transporter activity-IDA10642508  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-ISS-  
GO:0000785chromatin-IDA17996703  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA12796489  
GO:0005794Golgi apparatus-IDA16118794  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS9405440  
GO:0005886plasma membrane-IDA16118794  
GO:0005886plasma membrane-IMP15126635  
GO:0005938cell cortex-IDA9990509  
GO:0016327apicolateral plasma membrane-TAS9405440  
GO:0043197dendritic spine-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IDA9990509  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1253288Downregulation of ERBB4 signalingTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-8948747Regulation of PTEN localizationTAS
R-HSA-8948751Regulation of PTEN stability and activityTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26149443Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis. (2015 Oct)Stockton SD JrMol Cell Proteomics