Gene: NEDD8

4738
NEDD-8
neural precursor cell expressed, developmentally down-regulated 8
protein-coding
14q12
Ensembl:ENSG00000129559 MIM:603171 Vega:OTTHUMG00000029325 UniprotKB:Q15843
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.390e-1 (AD)  6.025e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UQCRH0.977
MEA10.975
HINT10.962
MRPS210.96
TOMM220.955
PSMB70.954
NDUFAB10.951
COPRS0.951
NABP20.951
PDAP10.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.758
OR4F29-0.725
MTRNR2L6-0.326
CXCR2-0.326
MAGEA12-0.319
VNN3-0.31
KCNJ15-0.309
IL18RAP-0.302
P2RY14-0.301
CXCR1-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NEDD8 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NEDD8 mRNA"18648102
C014949acetylhydrazineacetylhydrazine results in decreased expression of NEDD8 mRNA15282401
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NEDD8 gene27153756
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of NEDD8 protein16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of NEDD8 protein19364129
D001280AtrazineAtrazine results in decreased expression of NEDD8 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEDD8 mRNA22228805
C020711beryllium sulfateberyllium sulfate results in increased expression of NEDD8 mRNA16314022
C006780bisphenol Abisphenol A affects the expression of NEDD8 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of NEDD8 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NEDD8 mRNA28628672
D002104CadmiumCadmium results in increased expression of NEDD8 mRNA24376830
C100187chloropicrinchloropicrin results in increased expression of NEDD8 mRNA26352163
D002995Clofibric AcidClofibric Acid affects the expression of NEDD8 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of NEDD8 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of NEDD8 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NEDD8 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of NEDD8 mRNA19770486
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NEDD8 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NEDD8 mRNA17361019
D004026DieldrinDieldrin affects the expression of NEDD8 mRNA22546817
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NEDD8 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD8 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NEDD8 mRNA16174780
D005485FlutamideFlutamide results in increased expression of NEDD8 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NEDD8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NEDD8 mRNA28628672
D008713MethimazoleMethimazole results in decreased expression of NEDD8 mRNA17403546
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NEDD8 mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of NEDD8 protein26558463
C502362N-butyrylglucosamineN-butyrylglucosamine results in increased expression of NEDD8 mRNA16142878
C012655nimesulidenimesulide results in increased expression of NEDD8 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of NEDD8 mRNA17616710
C494474perchlorateperchlorate results in decreased expression of NEDD8 mRNA17403546
C006253pirinixic acidpirinixic acid results in increased expression of NEDD8 mRNA23811191
D011441PropylthiouracilPropylthiouracil results in decreased expression of NEDD8 mRNA17403546
D011794QuercetinQuercetin results in increased expression of NEDD8 protein17292933
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of NEDD8 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of NEDD8 mRNA28595984
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD8 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEDD8 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NEDD8 mRNA18796159
D013974ThyroxineThyroxine affects the expression of NEDD8 mRNA17403546
D013974ThyroxineThyroxine results in increased expression of NEDD8 mRNA17399805
D014212TretinoinTretinoin results in decreased expression of NEDD8 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NEDD8 mRNA"26179874
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of NEDD8 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of NEDD8 mRNA19244175
D015032ZincZinc deficiency results in increased expression of NEDD8 mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12816948  15988528  17318178  17353931  18264111  18274552  
18723677  18805092  19713960  21102408  21474709  21765416  
22466964  24949976  25416956  
GO:0031386protein tag-IBA21873635  
GO:0031625ubiquitin protein ligase binding-IBA21873635  
GO:0031625ubiquitin protein ligase binding-IPI15694336  
GO:0070628proteasome binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006464cellular protein modification process-TAS9694792  
GO:0006508proteolysis-TAS9694792  
GO:0006511ubiquitin-dependent protein catabolic process-TAS9353319  
GO:0006879cellular iron ion homeostasis-TAS-  
GO:0008104protein localization-IEA-  
GO:0009653anatomical structure morphogenesis-TAS9694792  
GO:0014070response to organic cyclic compound-IEA-  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitinationNOTIBA21873635  
GO:0016579protein deubiquitination-TAS-  
GO:0019941modification-dependent protein catabolic process-IBA21873635  
GO:0030162regulation of proteolysis-IBA21873635  
GO:0043687post-translational protein modification-TAS-  
GO:0045116protein neddylation-IBA21873635  
GO:0045116protein neddylation-IDA10500095  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS9353319  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689603UCH proteinasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8951664NeddylationTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-917937Iron uptake and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26752167A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. (2016 Jan 11)Taylor JYSci Rep