Gene: NEFH

4744
CMT2CC|NFH
neurofilament heavy
protein-coding
22q12.2
Ensembl:ENSG00000100285 MIM:162230 Vega:OTTHUMG00000151155 UniprotKB:P12036
NG_008404.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.260e-1 (AD)  8.254e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEFM0.964
VAMP10.935
NEFL0.934
EPDR10.928
INA0.924
ADAM230.922
ANXA60.918
PELI30.918
SMYD20.917
SPTSSB0.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.569
RAI14-0.566
YES1-0.565
WWTR1-0.548
MYL3-0.545
TFPI2-0.535
LRAT-0.528
CNN2-0.52
MBNL3-0.512
HEY2-0.51

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NEFH mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of NEFH protein"21673325
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NEFH mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NEFH mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NEFH mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NEFH mRNA"25510870
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of NEFH protein"19033394
C0713962-chloro-4-nitroaniline2-chloro-4-nitroaniline affects the expression of NEFH mRNA22954530
C0047262-dichlorobenzene2-dichlorobenzene affects the expression of NEFH mRNA22954530
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NEFH mRNA"23146750
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of NEFH mRNA16788091
C0259463-methyladenine3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFH protein]23743148
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEFH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEFH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEFH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEFH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEFH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEFH mRNA"27188386
C5605976,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide"6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of NEFH protein]"22096544
C032159acetonitrileacetonitrile affects the expression of NEFH mRNA22954530
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tributyltin results in decreased expression of NEFH protein]26079211
D000448AldicarbAldicarb results in increased phosphorylation of NEFH protein16256972
C103303alitretinoinalitretinoin results in increased expression of NEFH protein23500671
D024502alpha-Tocopherolalpha-Tocopherol results in increased expression of NEFH protein modified form18942769
D000535AluminumAluminum results in decreased expression of NEFH mRNA2496932|9215990
C104223aluminum lactatealuminum lactate results in decreased expression of NEFH mRNA1578268
D000638AmiodaroneAmiodarone results in decreased expression of NEFH mRNA25659768
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NEFH mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NEFH protein16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NEFH mRNA24449571
D001151ArsenicArsenic metabolite affects the expression of NEFH mRNA17553662
C030693AshwagandhaAshwagandha inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of NEFH protein]22096544
D001280AtrazineAtrazine results in decreased expression of NEFH mRNA25929836
D001280AtrazineAtrazine results in decreased expression of NEFH mRNA22378314
D001285AtropineAtropine affects the expression of NEFH mRNA22954530
C006723benzyl benzoatebenzyl benzoate affects the expression of NEFH mRNA22954530
D004958EstradiolEstradiol affects the expression of NEFH mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of NEFH mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of NEFH mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of NEFH protein27364615
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in decreased expression of NEFH protein]27364615
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of NEFH mRNA25270620
C013418bromfenacoumbromfenacoum results in decreased expression of NEFH protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of NEFH mRNA26079696
D002110CaffeineCaffeine affects the expression of NEFH mRNA22954530
D002220CarbamazepineCarbamazepine affects the expression of NEFH mRNA22954530
D012721CarbarylCarbaryl results in increased phosphorylation of NEFH protein16256972
D002246Carbon DisulfideCarbon Disulfide results in decreased expression of NEFH protein16474999|1712016
D002246Carbon DisulfideCarbon Disulfide results in increased expression of NEFH mRNA17120161|1916547
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of NEFH mRNA19395590
D004390ChlorpyrifosChlorpyrifos results in increased expression of NEFH mRNA28385489
D002994ClofibrateClofibrate results in decreased expression of NEFH mRNA25270620
D003042CocaineCocaine results in increased expression of NEFH protein19217266
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of NEFH mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of NEFH mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of NEFH mRNA26577399
D003513CycloheximideCycloheximide results in decreased expression of NEFH mRNA19146868
D016572CyclosporineCyclosporine results in decreased expression of NEFH mRNA25270620
D016572CyclosporineCyclosporine affects the expression of NEFH mRNA22954530
C014347decitabinedecitabine affects the expression of NEFH mRNA17145863
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of NEFH mRNA]21095227
D013759DronabinolDronabinol results in increased expression of NEFH mRNA17578508
C049098diallyl phthalatediallyl phthalate affects the expression of NEFH mRNA22954530
D003975DiazepamDiazepam affects the expression of NEFH mRNA22954530
D003976DiazinonDiazinon results in decreased expression of NEFH protein17239417
D003976DiazinonDiazinon affects the expression of NEFH mRNA17452286
D002945CisplatinCisplatin results in decreased expression of NEFH mRNA27594783
D004006DichlorvosDichlorvos affects the expression of NEFH mRNA22954530
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NEFH mRNA26924002
D004026DieldrinDieldrin results in decreased expression of NEFH mRNA18812211
D004041Dietary FatsDietary Fats results in increased expression of NEFH mRNA25016146
D004126DimethylformamideDimethylformamide affects the expression of NEFH mRNA22954530
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of NEFH mRNA22105179
C434247diphenylditelluridediphenylditelluride results in increased phosphorylation of NEFH protein22885153|2318294
D004178DiquatDiquat affects the expression of NEFH mRNA22954530
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of NEFH mRNA24690739
C118739entinostatentinostat results in increased expression of NEFH mRNA27188386
D004837EpinephrineEpinephrine affects the expression of NEFH mRNA22954530
D000431EthanolEthanol affects the expression of NEFH mRNA22954530
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NEFH mRNA22954530
D019855Ethylene GlycolEthylene Glycol affects the expression of NEFH mRNA22954530
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in decreased expression of NEFH protein]27364615
D019833GenisteinGenistein results in increased methylation of NEFH gene28505145
D005990GlycerolGlycerol affects the expression of NEFH mRNA22954530
D007854LeadLead affects the expression of NEFH mRNA28903495
C008261lead acetatelead acetate results in increased expression of NEFH protein20797405
C029891lead chloridelead chloride results in increased expression of NEFH mRNA19651682
C054097lithium sulfatelithium sulfate affects the expression of NEFH mRNA22954530
D008294MalathionMalathion affects the expression of NEFH mRNA22954530
D008294MalathionMalathion results in increased expression of NEFH mRNA28385489
C025340manganese chloridemanganese chloride results in decreased expression of NEFH mRNA15295902
D008550MelatoninMelatonin analog results in decreased phosphorylation of NEFH protein18231852
D008550MelatoninMelatonin results in decreased phosphorylation of NEFH protein18231852
C042720mercuric bromidemercuric bromide results in decreased expression of NEFH mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEFH mRNA"27188386
C014655methamidophosmethamidophos affects the expression of NEFH protein15938848
D000432MethanolMethanol affects the expression of NEFH mRNA22954530
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NEFH mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NEFH mRNA19651682
C004925methylmercuric chloridemethylmercuric chloride results in decreased phosphorylation of NEFH protein28821999
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of NEFH protein25545984|2696572
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NEFH protein"26068050
C005238mipafoxmipafox results in decreased expression of NEFH protein27939611
D008942MitoxantroneNEFH protein affects the susceptibility to Mitoxantrone16217747
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NEFH mRNA]"19615344
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of NEFH mRNA"19615344
D009020MorphineMorphine results in increased expression of NEFH mRNA15183518
C025589ochratoxin Aochratoxin A results in decreased expression of and results in decreased phosphorylation of NEFH protein24792326
C031492octanoic acidoctanoic acid affects the expression of NEFH mRNA22954530
C016627octyl gallateoctyl gallate affects the expression of NEFH mRNA22954530
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NEFH protein"21704052
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of NEFH mRNA24888373
D009966OrphenadrineOrphenadrine affects the expression of NEFH mRNA22954530
D010261ParaoxonParaoxon results in decreased expression of NEFH protein27939611
D010269ParaquatParaquat affects the expression of NEFH mRNA22954530
D010269ParaquatParaquat results in decreased expression of NEFH mRNA19146868|2452170
D010269ParaquatParaquat results in decreased expression of NEFH protein24521700
D010278ParathionParathion affects the expression of NEFH mRNA22954530
D010278ParathionParathion results in decreased expression of NEFH mRNA19146868
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NEFH mRNA"25510870
D010416PentachlorophenolPentachlorophenol affects the expression of NEFH mRNA22954530
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of NEFH mRNA23602845
D010634PhenobarbitalPhenobarbital affects the expression of NEFH mRNA22954530
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEFH mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NEFH mRNA26272509
D010664Phenylmethylsulfonyl FluoridePhenylmethylsulfonyl Fluoride inhibits the reaction [tri-o-cresyl phosphate results in increased degradation of NEFH protein]19573574
C003121phosphinothricinphosphinothricin affects the expression of NEFH mRNA22954530
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NEFH mRNA19710929
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of NEFH mRNA24888373
D019357Potassium CitratePotassium Citrate affects the expression of NEFH mRNA22954530
C031512potassium sulfatepotassium sulfate affects the expression of NEFH mRNA22954530
D011374ProgesteroneProgesterone results in decreased expression of NEFH mRNA18070364
D0198402-Propanol2-Propanol affects the expression of NEFH mRNA22954530
C005556propionaldehydepropionaldehyde results in increased expression of NEFH mRNA26079696
D011433PropranololPropranolol affects the expression of NEFH mRNA22954530
D011441PropylthiouracilPropylthiouracil results in decreased expression of NEFH mRNA24780913
C059514resveratrolresveratrol results in increased expression of NEFH protein23651583
D019782RiluzoleRiluzole results in decreased phosphorylation of NEFH protein19429076
D012524SarinSarin results in increased phosphorylation of NEFH protein21439362
D012601Scopolamine Hydrobromide"6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of NEFH protein]"22096544
D012601Scopolamine HydrobromideAshwagandha inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of NEFH protein]22096544
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of NEFH protein22096544
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NEFH mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NEFH mRNA23806026
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of NEFH mRNA]21095227
C017947sodium arsenite"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NEFH mRNA]"19615344
C017947sodium arsenitesodium arsenite results in decreased expression of NEFH mRNA19615344
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of NEFH protein18674524
D017693Sodium BicarbonateSodium Bicarbonate affects the expression of NEFH mRNA22954530
D012999SomanSoman results in increased phosphorylation of NEFH protein21439362
C049985staurosporine aglyconestaurosporine aglycone results in decreased expression of NEFH protein25545984
D013629TamoxifenTamoxifen affects the expression of NEFH mRNA14699072
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of NEFH mRNA22954530
D013752TetracyclineTetracycline affects the expression of NEFH mRNA22954530
D019284ThapsigarginThapsigargin results in decreased expression of NEFH mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of NEFH mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of NEFH mRNA23411599
D014212TretinoinTretinoin results in increased expression of NEFH mRNA21934132|2390381
C011559tributyltinAcetylcysteine inhibits the reaction [tributyltin results in decreased expression of NEFH protein]26079211
C011559tributyltintributyltin results in decreased expression of NEFH protein26079211
D014236TrichlorfonTrichlorfon results in decreased expression of NEFH protein27939611
C012589trichostatin Atrichostatin A results in increased expression of NEFH mRNA24935251
C040533trimethyltin chloridetrimethyltin chloride results in decreased expression of NEFH mRNA19651682
C040533trimethyltin chloridetrimethyltin chloride results in decreased expression of NEFH protein19651682
C025541tri-o-cresyl phosphatePhenylmethylsulfonyl Fluoride inhibits the reaction [tri-o-cresyl phosphate results in increased degradation of NEFH protein]19573574
C025541tri-o-cresyl phosphatetri-o-cresyl phosphate results in decreased expression of NEFH protein19428928
C025541tri-o-cresyl phosphatetri-o-cresyl phosphate results in increased degradation of NEFH protein19573574
C025541tri-o-cresyl phosphate3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFH protein]23743148
C025541tri-o-cresyl phosphatetri-o-cresyl phosphate results in decreased expression of NEFH protein23743148
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NEFH mRNA"24717766
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in decreased expression of NEFH mRNA24717766
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of NEFH protein24717766
C046243tryptanthrinetryptanthrine results in increased expression of NEFH protein23500671
D014415TunicamycinTunicamycin results in decreased expression of NEFH mRNA22378314
D014508UreaUrea affects the expression of NEFH mRNA22954530
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEFH mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NEFH mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NEFH gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NEFH mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of NEFH mRNA19651682
D014635Valproic AcidValproic Acid results in decreased expression of NEFH protein19651682
C111237vorinostatvorinostat results in increased expression of NEFH mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IMP7536898  
GO:0005200structural constituent of cytoskeleton-ISS-  
GO:0008017microtubule binding-TAS17498690  
GO:0019894kinesin binding-TAS17498690  
GO:0019901protein kinase binding-IPI9313898  24327345  
GO:0030674protein binding, bridging-ISS-  
GO:0070840dynein complex binding-TAS17498690  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IEA-  
GO:0007409axonogenesis-TAS17498690  
GO:0030031cell projection assembly-TAS17498690  
GO:0033693neurofilament bundle assembly-IMP7536898  
GO:0048936peripheral nervous system neuron axonogenesis-IEA-  
GO:0060052neurofilament cytoskeleton organization-IEA-  
GO:0061564axon development-IMP7536898  
GO:1902513regulation of organelle transport along microtubule-IMP7536898  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA27040688  
GO:0005737cytoplasm-ISS-  
GO:0005856cytoskeleton-IDA24327345  
GO:0005883neurofilament-NAS3138108  9313898  
GO:0014069postsynaptic density-IEA-  
GO:0030424axon-TAS14662745  
GO:0043209myelin sheath-IEA-  
GO:0097418neurofibrillary tangle-IDA21828286  
KEGG ID KEGG Term
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15236863Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. (2004 Aug)Iwamoto KNeurosci Res
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer