Gene: NEUROD1

4760
BETA2|BHF-1|MODY6|NEUROD|bHLHa3
neuronal differentiation 1
protein-coding
2q31.3
Ensembl:ENSG00000162992 MIM:601724 Vega:OTTHUMG00000132583 UniprotKB:Q13562
NG_011820.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.041e-1 (AD)  2.485e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX20.749
GPR830.743
TRERF10.727
ZNF1840.727
CDC60.725
GRB140.718
SHROOM30.718
ASB20.708
PCDH80.707
HPCAL10.691

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLCO1A2-0.521
CTNNA3-0.513
MOBP-0.492
C5orf64-0.488
SH2D1A-0.487
PPP1R14A-0.472
TMCC3-0.469
S1PR5-0.468
ZFP57-0.462
FXYD4-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NEUROD1 mRNA"19114083
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of NEUROD1 mRNA]18191635
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of NEUROD1 protein]18191635
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEUROD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEUROD1 mRNA"27188386
C496492abrineabrine results in increased expression of NEUROD1 mRNA22595364
D019342Acetic AcidAcetic Acid results in increased expression of NEUROD1 protein21296659
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NEUROD1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NEUROD1 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NEUROD1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NEUROD1 mRNA24449571
D001151ArsenicArsenic affects the expression of NEUROD1 protein24675094
C015001arsenitearsenite results in increased methylation of NEUROD1 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEUROD1 mRNA21839799
C006780bisphenol Abisphenol A affects the methylation of NEUROD1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of NEUROD1 mRNA28774890
C006780bisphenol Abisphenol A results in decreased expression of NEUROD1 mRNA25381574|2596372
C006780bisphenol Abisphenol A results in increased methylation of NEUROD1 gene28505145
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROD1 mRNA]25963729
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of NEUROD1 protein21296659
D002220CarbamazepineCarbamazepine affects the expression of NEUROD1 mRNA25979313
D002235CarbofuranCarbofuran results in decreased expression of NEUROD1 mRNA22240977|2898298
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NEUROD1 mRNA20691718
D019327Copper SulfateCopper Sulfate results in decreased expression of NEUROD1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of NEUROD1 mRNA19789285
D003471CuprizoneCuprizone results in decreased expression of NEUROD1 mRNA25704630
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROD1 mRNA]25963729
D003474CurcuminCurcumin results in increased expression of NEUROD1 mRNA25963729
D003976DiazinonDiazinon results in increased expression of NEUROD1 mRNA29108742
C016366dibenzothiophenedibenzothiophene results in decreased expression of NEUROD1 mRNA23656968
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NEUROD1 mRNA26924002
C472511dimethylarsinous aciddimethylarsinous acid affects the localization of NEUROD1 protein26024302
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of NEUROD1 protein26024302
C024629dimethyl phthalatedimethyl phthalate affects the expression of NEUROD1 mRNA26924002
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of NEUROD1 mRNA19272428
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NEUROD1 mRNA15212814
D005013EthosuximideEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]26420483
D005013EthosuximideEthosuximide results in increased expression of NEUROD1 mRNA26420483
D005472FluorouracilFluorouracil affects the expression of NEUROD1 mRNA16584549
D005472FluorouracilFluorouracil results in decreased expression of NEUROD1 protein21296659
D007529IsoflavonesIsoflavones affects the expression of NEUROD1 mRNA18522411
C008261lead acetatelead acetate results in decreased expression of NEUROD1 mRNA24260418
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of NEUROD1 mRNA23017109
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NEUROD1 mRNA23179753|2320347
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NEUROD1 mRNA28001369
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEUROD1 mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of NEUROD1 mRNA19150642
C059539midostaurinmidostaurin results in increased expression of NEUROD1 mRNA20980353
C406082monomethylarsonous acidmonomethylarsonous acid affects the localization of NEUROD1 protein26024302
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of NEUROD1 mRNA26024302
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of NEUROD1 protein26024302
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NEUROD1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of NEUROD1 mRNA15674843
C025589ochratoxin Aochratoxin A results in decreased expression of NEUROD1 mRNA21703336
C474055octylphenoloctylphenol inhibits the reaction [Streptozocin results in decreased expression of NEUROD1 mRNA]24781736
C474055octylphenoloctylphenol results in increased expression of NEUROD1 mRNA24781736
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of NEUROD1 mRNA23017109
D010634PhenobarbitalPhenobarbital results in increased expression of NEUROD1 mRNA12832660
D010695PhlorhizinPhlorhizin results in increased expression of NEUROD1 mRNA16123366
D028321Plant PreparationsPlant Preparations affects the expression of NEUROD1 mRNA18522411
D020959PolyethylenePolyethylene results in decreased expression of NEUROD1 mRNA23203475
D011441PropylthiouracilPropylthiouracil results in increased expression of NEUROD1 mRNA24780913
C089730rosiglitazone2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of NEUROD1 mRNA]18191635
C089730rosiglitazone2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of NEUROD1 protein]18191635
C089730rosiglitazonerosiglitazone results in increased expression of NEUROD1 mRNA18191635
C089730rosiglitazonerosiglitazone results in increased expression of NEUROD1 protein18191635
D020123SirolimusSirolimus results in decreased expression of NEUROD1 mRNA20622751
C017947sodium arsenitesodium arsenite affects the localization of NEUROD1 protein26024302
C017947sodium arsenitesodium arsenite results in decreased expression of NEUROD1 mRNA22641621|2602430
C017947sodium arsenitesodium arsenite results in decreased expression of NEUROD1 protein26024302|2912135
D013311Streptozocinoctylphenol inhibits the reaction [Streptozocin results in decreased expression of NEUROD1 mRNA]24781736
D013311StreptozocinStreptozocin results in decreased expression of NEUROD1 mRNA24781736
D013619TacrineTacrine results in increased expression of NEUROD1 mRNA12832660
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEUROD1 mRNA24058054
D014212TretinoinTretinoin results in increased expression of NEUROD1 mRNA18599177
D014212TretinoinTretinoin affects the expression of NEUROD1 mRNA16211290
C012589trichostatin Atrichostatin A results in decreased expression of NEUROD1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of NEUROD1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of NEUROD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NEUROD1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NEUROD1 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of NEUROD1 mRNA25423262
C102817voglibosevoglibose results in increased expression of NEUROD1 mRNA19208898
D015032ZincZinc results in decreased expression of NEUROD1 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001102RNA polymerase II activating transcription factor binding-IPI19619559  
GO:0003682chromatin binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IDA10545951  
GO:0003713transcription coactivator activity-IDA14752053  19619559  
GO:0005515protein binding-IPI14752053  
GO:0008134transcription factor binding-IPI10545951  16321656  
GO:0043565sequence-specific DNA bindingcontributes_toIDA10545951  
GO:0046982protein heterodimerization activity-IDA14752053  
GO:0046982protein heterodimerization activity-IPI10545951  
GO:0070888E-box binding-IDA14752053  
GO ID GO Term Qualifier Evidence PubMed
GO:0003326pancreatic A cell fate commitment-IEA-  
GO:0003329pancreatic PP cell fate commitment-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006913nucleocytoplasmic transport-IEA-  
GO:0007263nitric oxide mediated signal transduction-IDA17941991  
GO:0009749response to glucose-IMP10545951  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0021542dentate gyrus development-ISS-  
GO:0021549cerebellum development-ISS-  
GO:0022008neurogenesis-TAS8786144  
GO:0023019signal transduction involved in regulation of gene expression-IEA-  
GO:0030073insulin secretion-IDA17941991  
GO:0031018endocrine pancreas development-ISS9308961  
GO:0031018endocrine pancreas development-TAS-  
GO:0035881amacrine cell differentiation-ISS-  
GO:0035883enteroendocrine cell differentiation-ISS-  
GO:0042493response to drug-IEA-  
GO:0042593glucose homeostasis-ISS9308961  
GO:0043065positive regulation of apoptotic process-ISS-  
GO:0045597positive regulation of cell differentiation-ISS-  
GO:0045666positive regulation of neuron differentiation-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10545951  
GO:0046426negative regulation of JAK-STAT cascade-IEA-  
GO:0048562embryonic organ morphogenesis-ISS9308961  
GO:0048666neuron development-IEA-  
GO:0048839inner ear development-ISS-  
GO:0050796regulation of insulin secretion-IC10545951  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA14752053  
GO:0060730regulation of intestinal epithelial structure maintenance-ISS-  
GO:0071156regulation of cell cycle arrest-ISS-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:2000675negative regulation of type B pancreatic cell apoptotic process-ISS9308961  
GO:2000679positive regulation of transcription regulatory region DNA binding-IDA19619559  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC10545951  
GO:0005634nucleus-IDA14752053  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0090575RNA polymerase II transcription factor complex-IDA10545951  
KEGG ID KEGG Term
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-186712Regulation of beta-cell developmentTAS
R-HSA-210745Regulation of gene expression in beta cellsIEA
R-HSA-210746Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cellsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24719457NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas. (2014 Jun)Osborne JKMol Biol Cell