Gene: NEUROD2

4761
NDRF|bHLHa1
neuronal differentiation 2
protein-coding
17q12
Ensembl:ENSG00000171532 MIM:601725 Vega:OTTHUMG00000133211 UniprotKB:Q15784
NC_000017.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.122e-1 (AD)  5.402e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMX10.909
GALNT90.905
SLC6A70.901
SLC17A70.898
MPPED10.89
ADAM110.889
GABBR20.887
RTN4RL20.877
IGSF210.875
GFRA20.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAP1-0.602
EVA1A-0.571
C1orf87-0.564
ARHGEF5-0.555
WWTR1-0.544
LRAT-0.541
SLC51B-0.535
TFPI2-0.532
EGFLAM-0.529
ATP11C-0.529

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000447AldehydesAldehydes results in increased expression of NEUROD2 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NEUROD2 mRNA16483693
C095105bexarotenebexarotene results in increased expression of NEUROD2 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of NEUROD2 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of NEUROD2 promoter27334623
C018475butyraldehydebutyraldehyde results in increased expression of NEUROD2 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NEUROD2 mRNA23650126
D002922CiguatoxinsCiguatoxins affects the expression of NEUROD2 mRNA18353800
D003033Coal TarCoal Tar results in decreased expression of NEUROD2 mRNA27858113
D003471CuprizoneCuprizone results in decreased expression of NEUROD2 mRNA26577399
D013759DronabinolDronabinol results in decreased expression of NEUROD2 mRNA17578508
D004041Dietary FatsDietary Fats results in increased expression of NEUROD2 mRNA25016146
C118739entinostatentinostat results in decreased expression of NEUROD2 mRNA27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEUROD2 mRNA17942748
D005473FluoxetineFluoxetine results in decreased expression of NEUROD2 mRNA17033635
D004397FonofosFonofos results in increased methylation of NEUROD2 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of NEUROD2 mRNA19167457
D007854LeadLead affects the expression of NEUROD2 mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NEUROD2 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NEUROD2 mRNA24810058
C028007nickel monoxidenickel monoxide results in decreased expression of NEUROD2 mRNA19167457
D010269ParaquatParaquat results in decreased expression of NEUROD2 mRNA22563483
D010278ParathionParathion results in increased methylation of NEUROD2 promoter22847954
C046012pentanalpentanal results in increased expression of NEUROD2 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of NEUROD2 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of NEUROD2 mRNA26079696
C012568terbufosterbufos results in increased methylation of NEUROD2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEUROD2 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEUROD2 mRNA17942748
C009495titanium dioxidetitanium dioxide results in decreased expression of NEUROD2 mRNA23557971
D014212TretinoinNEUROD2 protein affects the reaction [Tretinoin results in increased expression of FABP7 mRNA]16083855
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NEUROD2 gene25560391
C025643vinclozolinvinclozolin affects the expression of NEUROD2 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS8816493  
GO:0003714transcription corepressor activity-ISS-  
GO:0046982protein heterodimerization activity-ISS-  
GO:0070888E-box binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001662behavioral fear response-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS8816493  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007399nervous system development-TAS8816493  
GO:0008306associative learning-IEA-  
GO:0016567protein ubiquitination-ISS-  
GO:0021695cerebellar cortex development-ISS-  
GO:0031915positive regulation of synaptic plasticity-ISS-  
GO:0045666positive regulation of neuron differentiation-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048666neuron development-IEA-  
GO:0050850positive regulation of calcium-mediated signaling-ISS-  
GO:0051091positive regulation of DNA-binding transcription factor activity-ISS-  
GO:0071257cellular response to electrical stimulus-ISS-  
GO:0071277cellular response to calcium ion-ISS-  
GO:0090129positive regulation of synapse maturation-ISS-  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO:2000297negative regulation of synapse maturation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20880594Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample. (2011 May 15)Zill PPsychiatry Res