Gene: NEUROG1

4762
AKA|Math4C|NEUROD3|bHLHa6|ngn1
neurogenin 1
protein-coding
5q31.1
Ensembl:ENSG00000181965 MIM:601726 Vega:OTTHUMG00000129138 UniprotKB:Q92886
NC_000005.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.878e-1 (AD)  8.657e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD1B0.687
C10orf1130.684
DMRTC20.681
OR2J20.667
OR4K30.656
ZAN0.655
OR4D10.651
APOBEC40.648
NPHS20.642
TAS2R410.64

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCF2-0.325
SPAG8-0.318
PARG-0.311
HENMT1-0.308
CEP72-0.307
FAM174B-0.305
TMEFF2-0.302
C17orf100-0.301
PTH2R-0.3
HDDC3-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of NEUROG1 mRNA"16580782
D000082AcetaminophenAcetaminophen results in decreased expression of NEUROG1 mRNA22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NEUROG1 mRNA16483693
D001151ArsenicArsenic affects the methylation of NEUROG1 gene25304211
C015001arsenitearsenite results in increased methylation of NEUROG1 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NEUROG1 promoter]19654925
C006780bisphenol Abisphenol A affects the expression of NEUROG1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of NEUROG1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of NEUROG1 mRNA25181051|2596372
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROG1 mRNA]25963729
D019256Cadmium ChlorideCadmium Chloride affects the expression of NEUROG1 mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NEUROG1 promoter22457795
D002220CarbamazepineCarbamazepine results in decreased expression of NEUROG125524013
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROG1 mRNA]25963729
D003474CurcuminCurcumin results in increased expression of NEUROG1 mRNA25963729
D016572CyclosporineCyclosporine results in decreased methylation of NEUROG1 promoter27989131
D003907Dexamethasone[Dexamethasone co-treated with Genistein] results in decreased expression of NEUROG1 mRNA25136773
D003907DexamethasoneDexamethasone results in decreased expression of NEUROG1 mRNA25136773
C121718dicyclanildicyclanil results in increased expression of NEUROG1 mRNA15664270
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of NEUROG1 mRNA19272428
D000431EthanolEthanol results in increased expression of NEUROG1 mRNA19460430
D019833Genistein[Dexamethasone co-treated with Genistein] results in decreased expression of NEUROG1 mRNA25136773
D007854LeadLead affects the expression of NEUROG1 mRNA28903495
D007854LeadLead affects the methylation of NEUROG1 gene24519525
C008261lead acetatelead acetate results in increased expression of NEUROG1 mRNA24260418
D010269ParaquatParaquat results in decreased expression of NEUROG1 mRNA25314302
D010936Plant ExtractsPlant Extracts results in decreased expression of NEUROG1 mRNA23557933
D012834SilverSilver results in increased expression of NEUROG1 mRNA25976698
C017947sodium arsenitesodium arsenite results in decreased expression of NEUROG1 mRNA22641621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEUROG1 mRNA14600291
D014212TretinoinTretinoin results in increased expression of NEUROG1 mRNA18599177
C012589trichostatin Atrichostatin A results in decreased expression of NEUROG1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of NEUROG1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of NEUROG1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NEUROG125524013
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NEUROG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000989transcription factor activity, transcription factor binding-ISS-  
GO:0003677DNA binding-ISS-  
GO:0003682chromatin binding-ISS-  
GO:0003700DNA-binding transcription factor activity-TAS8816493  
GO:0005515protein binding-IPI25416956  
GO:0042803protein homodimerization activity-IDA20102160  
GO:0070888E-box binding-IDA20102160  
GO:0070888E-box binding-ISS-  
GO:1990837sequence-specific double-stranded DNA binding-IDA20102160  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS8816493  
GO:0007356thorax and anterior abdomen determination-IGI23419067  
GO:0007399nervous system development-TAS8816493  
GO:0021559trigeminal nerve development-IGI23419067  
GO:0021650vestibulocochlear nerve formation-IGI23419067  
GO:0030182neuron differentiation-IEA-  
GO:0030432peristalsis-IGI23419067  
GO:0031223auditory behavior-IGI23419067  
GO:0031536positive regulation of exit from mitosis-IEA-  
GO:0035112genitalia morphogenesis-IGI23419067  
GO:0042472inner ear morphogenesis-IGI23419067  
GO:0045165cell fate commitment-IEA-  
GO:0045666positive regulation of neuron differentiation-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048634regulation of muscle organ development-IGI23419067  
GO:0048806genitalia development-IGI23419067  
GO:0048839inner ear development-IGI23419067  
GO:0050885neuromuscular process controlling balance-IGI23419067  
GO:0051091positive regulation of DNA-binding transcription factor activity-ISS-  
GO:0071626mastication-IGI23419067  
GO:0090102cochlea development-IGI23419067  
GO:0090103cochlea morphogenesis-IGI23419067  
GO:0097094craniofacial suture morphogenesis-IGI23419067  
GO:0098583learned vocalization behavior-IGI23419067  
GO:1901078negative regulation of relaxation of muscle-IGI23419067  
GO:1905747negative regulation of saliva secretion-IGI23419067  
GO:1905748hard palate morphogenesis-IGI23419067  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25862628DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. (2015 Aug)Kupers LKInt J Epidemiol
23539450Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. (2013 May 1)Burnett-Hartman ANCancer Res