Gene: NF1

4763
NFNS|VRNF|WSS
neurofibromin 1
protein-coding
17q11.2
Ensembl:ENSG00000196712 MIM:613113 Vega:OTTHUMG00000132871 UniprotKB:P21359
NG_009018.1
PubMed
0   ANCO-SNPs
ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.326e-1 (AD)  1.779e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASH1L0.94
BOD1L10.939
RALGAPB0.937
KIAA11090.934
IPO90.933
ATRN0.931
UBE3A0.931
DNAJC180.931
TRAPPC80.929
HECTD10.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.555
OR4F29-0.51
CSAG1-0.435
PGF-0.387
RAB13-0.382
PDZK1IP1-0.372
ROM1-0.363
FLT3LG-0.355
PRRX2-0.353
TFPI2-0.352

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of NF1 mRNA"20406850
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of NF1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NF1 mRNA21420995|2776149
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NF1 mRNA25607892
D020106AcrylamideAcrylamide results in decreased expression of NF1 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of NF1 mRNA21298039
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NF1 mRNA25607892
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NF1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of NF1 mRNA24019935
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NF1 mRNA"17331233
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NF1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of NF1 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NF1 mRNA20106945
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NF1 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of NF1 mRNA19429434
C006780bisphenol Abisphenol A results in decreased expression of NF1 mRNA18007998
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NF1 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NF1 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of NF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of NF1 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of NF1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of NF1 mRNA26314263
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NF1 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NF1 mRNA25607892
C018475butyraldehydebutyraldehyde results in decreased expression of NF1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NF1 mRNA26472689
D002118CalciumNF1 protein results in decreased transport of Calcium21949590
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of NF1 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NF1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of NF1 mRNA26314263
D003042CocaineCocaine results in increased expression of NF1 mRNA16076954
D016572CyclosporineCyclosporine results in decreased expression of NF1 mRNA22147139
D016572CyclosporineCyclosporine results in increased methylation of NF1 promoter27989131
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
D004041Dietary FatsDietary Fats results in decreased expression of NF1 mRNA25016146
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
C118739entinostatentinostat results in decreased expression of NF1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NF1 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NF1 mRNA25607892
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of NF1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NF1 mRNA22079256
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NF1 mRNA29097150
D005473FluoxetineFluoxetine results in decreased expression of NF1 mRNA17105902
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NF1 gene20938992
C001277geldanamycingeldanamycin results in increased expression of NF1 mRNA26705709
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NF1 mRNA17183730
C544151jinfukangjinfukang results in decreased expression of NF1 mRNA27392435
C561695(+)-JQ1 compoundNF1 protein inhibits the reaction [SUZ12 gene mutant form results in increased susceptibility to (+)-JQ1 compound]25119042
C561695(+)-JQ1 compoundNF1 protein inhibits the reaction [SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901]]25119042
C410337K 7174K 7174 results in increased expression of NF1 mRNA24086573
C002385linsidominelinsidomine results in increased oxidation of NF1 protein28086193
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
C042720mercuric bromidemercuric bromide results in decreased expression of NF1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NF1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NF1 mRNA26272509|2800136
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C030957methylmercury IImethylmercury II results in increased expression of NF1 mRNA26314263
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NF1 mRNA"26251327
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of NF1 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA16357179
D009151Mustard GasMustard Gas results in increased expression of NF1 mRNA15674843
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of NF1 mRNA"29244179
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in decreased expression of NF1 mRNA21487212
D009532NickelNickel results in decreased expression of NF1 mRNA25583101
C025589ochratoxin Aochratoxin A metabolite results in increased expression of NF1 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of NF1 mRNA26314263
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NF1 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NF1 mRNA25607892
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NF1 mRNA]"21673326
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of NF1 mRNA26272509
D010269ParaquatParaquat affects the expression of NF1 mRNA15206577
C506614PD 0325901NF1 protein inhibits the reaction [SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901]]25119042
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NF1 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NF1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NF1 mRNA22079256
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of NF1 mRNA19429434
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NF1 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of NF1 mRNA25351596
C017947sodium arsenitesodium arsenite results in increased expression of NF1 mRNA20308225
C017947sodium arsenitesodium arsenite results in decreased methylation of NF1 gene24570342
D018038Sodium SeleniteSodium Selenite results in decreased expression of NF1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NF1 mRNA22298810
D013849ThimerosalThimerosal affects the expression of NF1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NF1 mRNA20133372
D014212TretinoinTretinoin results in increased expression of NF1 mRNA23724009
C011559tributyltintributyltin results in increased expression of NF1 mRNA26314263
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NF1 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of NF1 mRNA24935251
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NF1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NF1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of NF1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of NF1 gene29154799
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA25607892
C111237vorinostatvorinostat results in decreased expression of NF1 mRNA27188386
D015032ZincZinc results in decreased expression of NF1 mRNA19071009
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of NF1 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IDA1568247  1570015  2121371  
GO:0005515protein binding-IPI11356864  16374483  23027611  
GO:0008429phosphatidylethanolamine binding-IDA17187824  
GO:0031210phosphatidylcholine binding-IDA17187824  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-ISS-  
GO:0000165MAPK cascade-TAS-  
GO:0001649osteoblast differentiation-ISS-  
GO:0001656metanephros development-ISS-  
GO:0001666response to hypoxia-ISS-  
GO:0001889liver development-ISS-  
GO:0001937negative regulation of endothelial cell proliferation-IMP16648142  17404841  
GO:0001938positive regulation of endothelial cell proliferation-IEA-  
GO:0001952regulation of cell-matrix adhesion-ISS-  
GO:0001953negative regulation of cell-matrix adhesion-IEA-  
GO:0006469negative regulation of protein kinase activity-ISS-  
GO:0007154cell communication-ISS-  
GO:0007265Ras protein signal transduction-ISS-  
GO:0007406negative regulation of neuroblast proliferation-ISS-  
GO:0007420brain development-ISS-  
GO:0007422peripheral nervous system development-ISS-  
GO:0007507heart development-ISS-  
GO:0007519skeletal muscle tissue development-IEA-  
GO:0008542visual learning-ISS-  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:0010468regulation of gene expression-IEA-  
GO:0014044Schwann cell development-ISS-  
GO:0014065phosphatidylinositol 3-kinase signaling-ISS-  
GO:0016525negative regulation of angiogenesis-IEA-  
GO:0021510spinal cord development-ISS-  
GO:0021764amygdala development-IEA-  
GO:0021897forebrain astrocyte development-ISS-  
GO:0021915neural tube development-IEA-  
GO:0021987cerebral cortex development-ISS-  
GO:0022011myelination in peripheral nervous system-ISS-  
GO:0030036actin cytoskeleton organization-ISS-  
GO:0030198extracellular matrix organization-ISS-  
GO:0030199collagen fibril organization-ISS-  
GO:0030325adrenal gland development-ISS-  
GO:0030336negative regulation of cell migration-IMP16648142  
GO:0032228regulation of synaptic transmission, GABAergic-IEA-  
GO:0034605cellular response to heat-IEA-  
GO:0035021negative regulation of Rac protein signal transduction-IEA-  
GO:0042060wound healing-ISS-  
GO:0042308negative regulation of protein import into nucleus-IEA-  
GO:0043065positive regulation of apoptotic process-ISS-  
GO:0043087regulation of GTPase activity-IMP1570015  
GO:0043407negative regulation of MAP kinase activity-ISS-  
GO:0043409negative regulation of MAPK cascade-IMP16648142  
GO:0043409negative regulation of MAPK cascade-ISS-  
GO:0043473pigmentation-ISS-  
GO:0043525positive regulation of neuron apoptotic process-ISS-  
GO:0043535regulation of blood vessel endothelial cell migration-IMP17404841  
GO:0043547positive regulation of GTPase activity-IDA2121371  
GO:0043547positive regulation of GTPase activity-IMP16648142  
GO:0043547positive regulation of GTPase activity-ISS-  
GO:0045124regulation of bone resorption-ISS-  
GO:0045671negative regulation of osteoclast differentiation-IEA-  
GO:0045685regulation of glial cell differentiation-ISS-  
GO:0045762positive regulation of adenylate cyclase activity-ISS-  
GO:0045765regulation of angiogenesis-IMP17404841  
GO:0046929negative regulation of neurotransmitter secretion-IEA-  
GO:0048147negative regulation of fibroblast proliferation-ISS-  
GO:0048169regulation of long-term neuronal synaptic plasticity-IEA-  
GO:0048485sympathetic nervous system development-ISS-  
GO:0048593camera-type eye morphogenesis-ISS-  
GO:0048712negative regulation of astrocyte differentiation-IEA-  
GO:0048715negative regulation of oligodendrocyte differentiation-ISS-  
GO:0048745smooth muscle tissue development-ISS-  
GO:0048820hair follicle maturation-IEA-  
GO:0048844artery morphogenesis-ISS-  
GO:0048853forebrain morphogenesis-ISS-  
GO:0050890cognition-IMP17299016  
GO:0061534gamma-aminobutyric acid secretion, neurotransmission-IEA-  
GO:0061535glutamate secretion, neurotransmission-IEA-  
GO:0098597observational learning-IEA-  
GO:1900271regulation of long-term synaptic potentiation-IEA-  
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS1550670  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-ISS1550670  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030424axon-IDA1550670  
GO:0030425dendrite-IDA1550670  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802953RAS signaling downstream of NF1 loss-of-function variantsTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27027665Gene aberrations for precision medicine against lung adenocarcinoma. (2016 Jun)Saito MCancer Sci
28256572Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities. (2017 Jun)Yoshida AMod Pathol
27018750Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1. (2016 Jun)Johnson KJCancer Epidemiol
27113098CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer. (2017 Feb)Wu YYJ Formos Med Assoc
29127119RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition. (2018 Mar 15)Hayashi TClin Cancer Res
18948947Somatic mutations affect key pathways in lung adenocarcinoma. (2008 Oct 23)Ding LNature
25483400Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans. (2015 May 15)Repunte-Canonigo VBiol Psychiatry
23108390Neurofibromatosis 1-related osteopenia often progresses to osteoporosis in 12 years. (2013 Jan)Heerva ECalcif Tissue Int
21550781Voice-related quality of life in adults with neurofibromatosis type 1. (2012 Mar)Cosyns MJ Voice