Gene: ATP1A2

477
FHM2|MHP2
ATPase Na+/K+ transporting subunit alpha 2
protein-coding
1q23.2
Ensembl:ENSG00000018625 MIM:182340 Vega:OTTHUMG00000024080 UniprotKB:P50993
NG_008014.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.192e-1 (AD)  1.280e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EZR0.904
GOLIM40.895
SLC1A20.895
AMOT0.894
ALDH9A10.885
NTRK20.884
GLUD10.884
MSI20.883
SLC1A30.877
ALDH6A10.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.631
OR4F29-0.622
ENPP6-0.247
CHRM5-0.247
LIPH-0.235
KLK8-0.23
PPP1R17-0.229
PRR15-0.229
CPXM2-0.226
NPFFR2-0.224

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01092OuabainSmall Molecule630-60-4ApprovedTarget
DB09479Rubidium chloride Rb-82Small Molecule132486-03-4Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ATP1A2 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ATP1A2 protein"21673325
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of ATP1A2 mRNA22193206
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of ATP1A2 mRNA"28940058
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of ATP1A2 mRNA"16192472
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP1A2 mRNA"27188386
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Ammonia results in increased expression of ATP1A2 mRNA]"20447429
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Ammonia results in increased expression of ATP1A2 protein]"20447429
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP1A2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ATP1A2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ATP1A2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ATP1A2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ATP1A2 gene27153756
C010845aluminum chloridealuminum chloride results in decreased activity of ATP1A2 protein16162844
D000638AmiodaroneAmiodarone results in decreased expression of ATP1A2 mRNA8071999
D000638AmiodaroneAmiodarone results in decreased expression of ATP1A2 protein12479229|7573397
D000641Ammonia"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Ammonia results in increased expression of ATP1A2 mRNA]"20447429
D000641Ammonia"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Ammonia results in increased expression of ATP1A2 protein]"20447429
D000641AmmoniaAmmonia results in increased expression of ATP1A2 mRNA20447429
D000641AmmoniaAmmonia results in increased expression of ATP1A2 protein20447429
D000641AmmoniaSRC protein affects the reaction [Ammonia results in increased expression of ATP1A2 mRNA]20447429
D000641AmmoniaSRC protein affects the reaction [Ammonia results in increased expression of ATP1A2 protein]20447429
D000641Ammoniatyrphostin AG 1478 inhibits the reaction [Ammonia results in increased expression of ATP1A2 mRNA]20447429
D000641Ammoniatyrphostin AG 1478 inhibits the reaction [Ammonia results in increased expression of ATP1A2 protein]20447429
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ATP1A2 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of ATP1A2 mRNA12558987
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATP1A2 mRNA20106945
D004958EstradiolEstradiol results in decreased expression of ATP1A2 mRNA26945725
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of ATP1A2 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of ATP1A2 mRNA20170705
C006780bisphenol Abisphenol A results in increased methylation of ATP1A2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ATP1A2 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of ATP1A2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ATP1A2 mRNA12832660
D002301Cardiac GlycosidesCardiac Glycosides binds to and results in decreased activity of ATP1A2 protein18487447
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP1A2 mRNA20938992
C480342clothianidinclothianidin results in decreased expression of ATP1A2 mRNA29044138
D060729Coal AshCoal Ash results in decreased expression of ATP1A2 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of ATP1A2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ATP1A2 mRNA19549813
D003630DaunorubicinDaunorubicin results in decreased expression of ATP1A2 mRNA26537877|2894005
C014347decitabinedecitabine affects the expression of ATP1A2 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ATP1A2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ATP1A2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ATP1A2 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ATP1A2 mRNA28962523
D002945CisplatinCisplatin affects the expression of ATP1A2 mRNA23300844
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ATP1A2 mRNA26924002
D004077DigoxinDigoxin results in decreased expression of ATP1A2 mRNA19687166
D004077Digoxin"N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA]"19687166
C034504digoxin-like factorsdigoxin-like factors results in decreased activity of ATP1A2 protein17980562
D002117CalcitriolCalcitriol results in increased expression of ATP1A2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ATP1A2 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of ATP1A2 mRNA26924002
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of ATP1A2 mRNA22193206
D004237DiuronDiuron results in decreased expression of ATP1A2 mRNA25152437
D004317DoxorubicinDoxorubicin results in decreased expression of ATP1A2 mRNA26537877|2894005
D004656EnalaprilEnalapril results in increased expression of ATP1A2 mRNA18418421
D004656EnalaprilEnalapril results in increased expression of ATP1A2 protein18418421
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ATP1A2 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ATP1A2 mRNA15834898|1735126
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP1A2 mRNA20938992
D019833GenisteinGenistein results in decreased expression of ATP1A2 mRNA26865667
D017313FenretinideFenretinide results in decreased expression of ATP1A2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ATP1A2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ATP1A2 mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of ATP1A2 protein17337753
D007649KetamineKetamine results in increased expression of ATP1A2 mRNA20080153
D007657Ketone BodiesKetone Bodies results in increased expression of ATP1A2 mRNA16807920
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ATP1A2 protein21114982
D008094LithiumLithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]19995221
D019808LosartanLosartan results in increased expression of ATP1A2 mRNA18418421
D019808LosartanLosartan results in increased expression of ATP1A2 protein18418421
D008466MechlorethamineMechlorethamine results in decreased expression of ATP1A2 mRNA17107856
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP1A2 mRNA20938992
D008731MethoxychlorMethoxychlor results in decreased expression of ATP1A2 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATP1A2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ATP1A2 mRNA"20188158
D008942MitoxantroneMitoxantrone results in decreased expression of ATP1A2 mRNA26537877|2894005
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ATP1A2 mRNA26924002
C481648N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine"N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA]"19687166
C481648N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine"N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]"19687166
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ATP1A2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ATP1A2 mRNA"25554681
D009532NickelNickel results in decreased expression of ATP1A2 mRNA24768652|2558310
D009532NickelNickel results in decreased expression of ATP1A2 mRNA24084258
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ATP1A2 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ATP1A2 mRNA27935865
C024713n-tetradecanen-tetradecane results in decreased expression of ATP1A2 protein17337753
D010269ParaquatParaquat results in decreased expression of ATP1A2 mRNA21371552
D010269ParaquatParaquat results in increased expression of ATP1A2 mRNA21371552
D010269ParaquatParaquat affects the expression of ATP1A2 mRNA16854511
D010269ParaquatParaquat results in decreased expression of ATP1A2 mRNA17077588
D010269ParaquatParaquat results in increased expression of ATP1A2 mRNA18198484
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of ATP1A2 mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ATP1A2 mRNA16221955
D010634PhenobarbitalPhenobarbital affects the expression of ATP1A2 mRNA19159669
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ATP1A2 mRNA27935865
C045950propiconazolepropiconazole results in increased expression of ATP1A2 mRNA28970091
C005556propionaldehydepropionaldehyde results in increased expression of ATP1A2 mRNA26079696
D012402RotenoneRotenone results in decreased expression of ATP1A2 mRNA27900601
D012834SilverSilver analog results in increased expression of ATP1A2 mRNA22727896
D012835Silver NitrateSilver Nitrate results in decreased expression of ATP1A2 mRNA22727896
D053260SootSoot results in decreased expression of ATP1A2 mRNA26551751
D010042OuabainLithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]19995221
D010042OuabainOuabain binds to ATP1A2 protein12479229
D010042OuabainOuabain results in increased expression of ATP1A2 mRNA19995221
D010042OuabainATP1A2 protein affects the susceptibility to Ouabain15458945|1616616
D010042OuabainOuabain binds to and results in decreased activity of ATP1A2 protein18487447
D010042OuabainOuabain results in decreased activity of ATP1A2 protein16166162
D010042Ouabain"N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]"19687166
D010042OuabainOuabain affects the expression of ATP1A2 protein11834625
D010042OuabainOuabain results in decreased expression of ATP1A2 mRNA19687166
D010042OuabainOuabain results in increased expression of ATP1A2 protein16716361|1989770
C087114tebuconazoletebuconazole results in increased expression of ATP1A2 mRNA28970091
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ATP1A2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ATP1A2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATP1A2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATP1A2 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of ATP1A2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ATP1A2 mRNA20133372
D024505TocopherolsTocopherols results in increased expression of ATP1A2 mRNA17654050
D014212TretinoinTretinoin results in decreased expression of ATP1A2 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP1A2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ATP1A2 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ATP1A2 mRNA19042947
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Ammonia results in increased expression of ATP1A2 mRNA]20447429
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Ammonia results in increased expression of ATP1A2 protein]20447429
C022884undecaneundecane results in increased expression of ATP1A2 protein17337753
D014635Valproic AcidValproic Acid results in decreased expression of ATP1A2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of ATP1A2 mRNA24935251
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ATP1A2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ATP1A2 mRNA23034163
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ATP1A2 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005391sodium:potassium-exchanging ATPase activity-IBA21873635  
GO:0005391sodium:potassium-exchanging ATPase activity-IDA10636900  
GO:0005391sodium:potassium-exchanging ATPase activity-IMP12539047  
GO:0005391sodium:potassium-exchanging ATPase activitycontributes_toIMP23954377  
GO:0005515protein binding-IPI23954377  
GO:0005524ATP bindingcontributes_toIMP23954377  
GO:0008144drug bindingcontributes_toIPI23954377  
GO:0016887ATPase activitycontributes_toIMP23954377  
GO:0030955potassium ion bindingcontributes_toIMP23954377  
GO:0031402sodium ion bindingcontributes_toIMP23954377  
GO:0051087chaperone binding-IPI10636900  
GO:1990239steroid hormone binding-IDA14742675  
GO ID GO Term Qualifier Evidence PubMed
GO:0001504neurotransmitter uptake-IEA-  
GO:0002026regulation of the force of heart contraction-IEA-  
GO:0002087regulation of respiratory gaseous exchange by neurological system process-IEA-  
GO:0006813potassium ion transport-NAS10642400  
GO:0006814sodium ion transport-NAS10642400  
GO:0006883cellular sodium ion homeostasis-IBA21873635  
GO:0006883cellular sodium ion homeostasis-IDA10636900  
GO:0006940regulation of smooth muscle contraction-IEA-  
GO:0006942regulation of striated muscle contraction-NAS10642400  
GO:0008217regulation of blood pressure-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0008542visual learning-IEA-  
GO:0010107potassium ion import-IBA21873635  
GO:0010107potassium ion import-IDA10636900  
GO:0010248establishment or maintenance of transmembrane electrochemical gradient-IEA-  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-TAS23608603  
GO:0015991ATP hydrolysis coupled proton transport-IBA21873635  
GO:0015991ATP hydrolysis coupled proton transport-IEA-  
GO:0019229regulation of vasoconstriction-IEA-  
GO:0030007cellular potassium ion homeostasis-IBA21873635  
GO:0030007cellular potassium ion homeostasis-IC23954377  
GO:0030007cellular potassium ion homeostasis-IDA10636900  
GO:0035094response to nicotine-IEA-  
GO:0036376sodium ion export across plasma membrane-IBA21873635  
GO:0036376sodium ion export across plasma membrane-IDA10636900  
GO:0040011locomotion-IEA-  
GO:0045822negative regulation of heart contraction-IEA-  
GO:0045988negative regulation of striated muscle contraction-IEA-  
GO:0046034ATP metabolic process-IMP23954377  
GO:0051481negative regulation of cytosolic calcium ion concentration-IEA-  
GO:0051946regulation of glutamate uptake involved in transmission of nerve impulse-NAS23954377  
GO:0051966regulation of synaptic transmission, glutamatergic-NAS23954377  
GO:0055119relaxation of cardiac muscle-TAS23224879  
GO:0060048cardiac muscle contraction-TAS23224879  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0071383cellular response to steroid hormone stimulus-IDA14742675  
GO:0086004regulation of cardiac muscle cell contraction-IEA-  
GO:0086009membrane repolarization-TAS23954377  
GO:0086012membrane depolarization during cardiac muscle cell action potential-TAS23608603  
GO:0086064cell communication by electrical coupling involved in cardiac conduction-TAS19683723  
GO:1903170negative regulation of calcium ion transmembrane transport-ISS-  
GO:1903280negative regulation of calcium:sodium antiporter activity-ISS-  
GO:1903416response to glycoside-IC14742675  
GO:1903416response to glycoside-ISS-  
GO:1990573potassium ion import across plasma membrane-IC23954377  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA12539047  
GO:0005768endosome-IEA-  
GO:0005886plasma membrane-IDA12539047  
GO:0005886plasma membrane-TAS-  
GO:0005890sodium:potassium-exchanging ATPase complex-IC12539047  
GO:0005890sodium:potassium-exchanging ATPase complex-IDA10636900  23954377  
GO:0005901caveola-IEA-  
GO:0014704intercalated disc-IEA-  
GO:0016020membrane-IDA23954377  
GO:0030315T-tubule-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043209myelin sheath-IEA-  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa04260Cardiac muscle contraction
hsa04960Aldosterone-regulated sodium reabsorption
hsa04964Proximal tubule bicarbonate reclamation
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04973Carbohydrate digestion and absorption
hsa04974Protein digestion and absorption
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27814792Atp1a2 contributes modestly to alcohol-related behaviors. (2016 Nov)Gritz SMAlcohol
23459313Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study. (2013 Dec)Harriott AMSpringerplus