Gene: NF2

4771
ACN|BANF|SCH
neurofibromin 2
protein-coding
22q12.2
Ensembl:ENSG00000186575 MIM:607379 Vega:OTTHUMG00000030727 UniprotKB:P35240
NG_009057.1
PubMed
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.386e-1 (AD)  8.104e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GIT10.914
PDXK0.908
PPP1R9B0.902
WIZ0.901
BTBD20.901
BAP10.894
MAP3K100.893
FBRSL10.892
DVL10.892
GNA110.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.712
OR4F29-0.667
TFPI2-0.351
VRK2-0.346
SH2D1A-0.338
C9orf135-0.326
CTNNA3-0.325
CD48-0.323
SGMS2-0.321
SLC51B-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of NF2 mRNA12419474
D000082AcetaminophenAcetaminophen affects the expression of NF2 mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of NF2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NF2 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of NF2 mRNA11940349|2525818
D001194AsbestosNF2 gene mutant form results in increased susceptibility to Asbestos16319530
D017638Asbestos, Crocidolite"NF2 gene mutant form results in increased susceptibility to Asbestos, Crocidolite"12802287|1616628
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of NF2 mRNA23117580
C006780bisphenol Abisphenol A affects the expression of NF2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NF2 mRNA12419474
C018021cobaltous chloridecobaltous chloride results in decreased expression of NF2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of NF2 mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NF2 mRNA23914054
D003976DiazinonDiazinon affects the expression of NF2 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NF2 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of NF2 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of NF2 mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of NF2 mRNA]27392435
C000944dicrotophosdicrotophos results in increased expression of NF2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of NF2 mRNA18042831
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NF2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NF2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NF2 mRNA17942748
C001277geldanamycingeldanamycin results in increased expression of NF2 mRNA26705709
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NF2 mRNA12419474
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of NF2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of NF2 mRNA]27392435
C561695(+)-JQ1 compoundNF2 protein results in decreased susceptibility to (+)-JQ1 compound23430699
D008727MethotrexateMethotrexate results in decreased expression of NF2 mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NF2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NF2 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of NF2 promoter"26251327
C500085muraglitazarmuraglitazar results in decreased expression of NF2 mRNA21515302
D009532NickelNickel results in increased expression of NF2 mRNA24768652
C022838nickel chloridenickel chloride affects the expression of NF2 mRNA22546817
D000073878Palm OilPalm Oil results in decreased expression of NF2 mRNA18042831
D010938Plant OilsPlant Oils results in decreased expression of NF2 mRNA23370395
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of NF2 mRNA19244175
D012643SeleniumSelenium results in increased expression of NF2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NF2 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of NF2 mRNA27862939
D012999SomanSoman results in increased expression of NF2 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of NF2 mRNA17555576
C501413tesaglitazartesaglitazar results in decreased expression of NF2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NF2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NF2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NF2 mRNA17942748
C402769tipifarnibtipifarnib results in increased expression of NF2 mRNA16403772
C483909torcetrapibtorcetrapib results in increased expression of NF2 mRNA23228038
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NF2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NF2 mRNA"26179874
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of NF2 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of NF2 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of NF2 mRNA20044591
D015032ZincZinc results in decreased expression of NF2 mRNA16870260
C016837zinc chloridezinc chloride results in decreased expression of NF2 mRNA16870260

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI9430655  9537418  10669747  10861283  15467741  16885985  
17210637  17242191  17509819  19144871  19615732  20178741  
20890305  21167305  21481793  23414517  24012335  24366813  
GO ID GO Term Qualifier Evidence PubMed
GO:0001707mesoderm formation-IEA-  
GO:0001953negative regulation of cell-matrix adhesion-TAS17210637  
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0007398ectoderm development-IEA-  
GO:0008285negative regulation of cell proliferation-IDA12444102  20178741  
GO:0008285negative regulation of cell proliferation-IMP17210637  
GO:0014010Schwann cell proliferation-IMP17353411  
GO:0014013regulation of gliogenesis-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0022408negative regulation of cell-cell adhesion-IDA17210637  
GO:0030036actin cytoskeleton organization-IMP9537418  
GO:0030336negative regulation of cell migration-TAS17210637  
GO:0031647regulation of protein stability-IEA-  
GO:0035330regulation of hippo signaling-IMP20159598  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0042532negative regulation of tyrosine phosphorylation of STAT protein-IDA12444102  
GO:0042981regulation of apoptotic process-IMP21167305  
GO:0043409negative regulation of MAPK cascade-IEA-  
GO:0045216cell-cell junction organization-IEA-  
GO:0045597positive regulation of cell differentiation-IEA-  
GO:0046426negative regulation of JAK-STAT cascade-IDA12444102  
GO:0051496positive regulation of stress fiber assembly-IMP9537418  
GO:0051726regulation of cell cycle-IMP21167305  
GO:0070306lens fiber cell differentiation-IEA-  
GO:0072091regulation of stem cell proliferation-IEA-  
GO:1900180regulation of protein localization to nucleus-IEA-  
GO:2000177regulation of neural precursor cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10401006  20178741  
GO:0005730nucleolus-IDA9537418  
GO:0005737cytoplasm-IDA9537418  
GO:0005769early endosome-IDA10861283  
GO:0005829cytosol-IDA-  
GO:0005856cytoskeleton-TAS8379998  
GO:0005886plasma membrane-IDA10401006  
GO:0005886plasma membrane-TAS-  
GO:0005912adherens junction-IEA-  
GO:0016020membrane-HDA19946888  
GO:0030027lamellipodium-IEA-  
GO:0030864cortical actin cytoskeleton-IEA-  
GO:0031527filopodium membrane-IEA-  
GO:0032154cleavage furrow-IEA-  
GO:0032587ruffle membrane-IEA-  
GO:0043005neuron projection-IEA-  
GO:0044297cell body-IEA-  
GO:0045177apical part of cell-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA17210637  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-5627123RHO GTPases activate PAKsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27628948The Emerging Role of the Hippo Pathway in Lung Cancers: Clinical Implications. (2017 Nov 30)Teoh SLCurr Drug Targets
26368609Oncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles. (2000 Jan)Kane ABInhal Toxicol
23435014Differential mutation profiles and similar intronic TP53 polymorphisms in asbestos-related lung cancer and pleural mesothelioma. (2013 May)Andujar PMutagenesis
23921927NF2 genetic alterations in sporadic vestibular schwannomas: clinical implications. (2013 Sep)Lassaletta LOtol Neurotol
19396864CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma -A miRNA microarray analysis. (2009 Jul)Guled MGenes Chromosomes Cancer