Gene info: ID 4771

Gene: NF2

GENE ID: 4771

Synonyms: ACN|BANF|SCH

Description: neurofibromin 2

Gene type: protein-coding

Location: 22q12.2

dbXrefs: Ensembl:ENSG00000186575 MIM:607379 Vega:OTTHUMG00000030727 UniprotKB:P35240

RefSeq: NG_009057.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.386e-1 (AD) 8.104e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GIT1	0.914
PDXK	0.908
PPP1R9B	0.902
WIZ	0.901
BTBD2	0.901
BAP1	0.894
MAP3K10	0.893
FBRSL1	0.892
DVL1	0.892
GNA11	0.891

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.712
OR4F29	-0.667
TFPI2	-0.351
VRK2	-0.346
SH2D1A	-0.338
C9orf135	-0.326
CTNNA3	-0.325
CD48	-0.323
SGMS2	-0.321
SLC51B	-0.313

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of NF2 mRNA	12419474
D000082	Acetaminophen	Acetaminophen affects the expression of NF2 mRNA	17562736
D000638	Amiodarone	Amiodarone results in increased expression of NF2 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NF2 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of NF2 mRNA	11940349\|2525818
D001194	Asbestos	NF2 gene mutant form results in increased susceptibility to Asbestos	16319530
D017638	Asbestos, Crocidolite	"NF2 gene mutant form results in increased susceptibility to Asbestos, Crocidolite"	12802287\|1616628
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of NF2 mRNA	23117580
C006780	bisphenol A	bisphenol A affects the expression of NF2 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of NF2 mRNA	12419474
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of NF2 mRNA	19320972
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of NF2 mRNA	19549813
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of NF2 mRNA	23914054
D003976	Diazinon	Diazinon affects the expression of NF2 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of NF2 mRNA	21266533
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of NF2 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of NF2 mRNA	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of NF2 mRNA]	27392435
C000944	dicrotophos	dicrotophos results in increased expression of NF2 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of NF2 mRNA	18042831
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of NF2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of NF2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NF2 mRNA	17942748
C001277	geldanamycin	geldanamycin results in increased expression of NF2 mRNA	26705709
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of NF2 mRNA	12419474
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of NF2 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of NF2 mRNA]	27392435
C561695	(+)-JQ1 compound	NF2 protein results in decreased susceptibility to (+)-JQ1 compound	23430699
D008727	Methotrexate	Methotrexate results in decreased expression of NF2 mRNA	24449571
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NF2 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NF2 mRNA"	20188158
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of NF2 promoter"	26251327
C500085	muraglitazar	muraglitazar results in decreased expression of NF2 mRNA	21515302
D009532	Nickel	Nickel results in increased expression of NF2 mRNA	24768652
C022838	nickel chloride	nickel chloride affects the expression of NF2 mRNA	22546817
D000073878	Palm Oil	Palm Oil results in decreased expression of NF2 mRNA	18042831
D010938	Plant Oils	Plant Oils results in decreased expression of NF2 mRNA	23370395
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of NF2 mRNA	19244175
D012643	Selenium	Selenium results in increased expression of NF2 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of NF2 mRNA	25895662
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of NF2 mRNA	27862939
D012999	Soman	Soman results in increased expression of NF2 mRNA	19281266
D013629	Tamoxifen	Tamoxifen affects the expression of NF2 mRNA	17555576
C501413	tesaglitazar	tesaglitazar results in decreased expression of NF2 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NF2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NF2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NF2 mRNA	17942748
C402769	tipifarnib	tipifarnib results in increased expression of NF2 mRNA	16403772
C483909	torcetrapib	torcetrapib results in increased expression of NF2 mRNA	23228038
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of NF2 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NF2 mRNA"	26179874
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of NF2 mRNA	19244175
D014810	Vitamin E	Vitamin E results in increased expression of NF2 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of NF2 mRNA	20044591
D015032	Zinc	Zinc results in decreased expression of NF2 mRNA	16870260
C016837	zinc chloride	zinc chloride results in decreased expression of NF2 mRNA	16870260

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003779	actin binding	-	IEA	-
GO:0005515	protein binding	-	IPI	9430655 9537418 10669747 10861283 15467741 16885985 17210637 17242191 17509819 19144871 19615732 20178741 20890305 21167305 21481793 23414517 24012335 24366813

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001707	mesoderm formation	-	IEA	-
GO:0001953	negative regulation of cell-matrix adhesion	-	TAS	17210637
GO:0006469	negative regulation of protein kinase activity	-	IEA	-
GO:0007398	ectoderm development	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IDA	12444102 20178741
GO:0008285	negative regulation of cell proliferation	-	IMP	17210637
GO:0014010	Schwann cell proliferation	-	IMP	17353411
GO:0014013	regulation of gliogenesis	-	IEA	-
GO:0021766	hippocampus development	-	IEA	-
GO:0022408	negative regulation of cell-cell adhesion	-	IDA	17210637
GO:0030036	actin cytoskeleton organization	-	IMP	9537418
GO:0030336	negative regulation of cell migration	-	TAS	17210637
GO:0031647	regulation of protein stability	-	IEA	-
GO:0035330	regulation of hippo signaling	-	IMP	20159598
GO:0042475	odontogenesis of dentin-containing tooth	-	IEA	-
GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	-	IDA	12444102
GO:0042981	regulation of apoptotic process	-	IMP	21167305
GO:0043409	negative regulation of MAPK cascade	-	IEA	-
GO:0045216	cell-cell junction organization	-	IEA	-
GO:0045597	positive regulation of cell differentiation	-	IEA	-
GO:0046426	negative regulation of JAK-STAT cascade	-	IDA	12444102
GO:0051496	positive regulation of stress fiber assembly	-	IMP	9537418
GO:0051726	regulation of cell cycle	-	IMP	21167305
GO:0070306	lens fiber cell differentiation	-	IEA	-
GO:0072091	regulation of stem cell proliferation	-	IEA	-
GO:1900180	regulation of protein localization to nucleus	-	IEA	-
GO:2000177	regulation of neural precursor cell proliferation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	10401006 20178741
GO:0005730	nucleolus	-	IDA	9537418
GO:0005737	cytoplasm	-	IDA	9537418
GO:0005769	early endosome	-	IDA	10861283
GO:0005829	cytosol	-	IDA	-
GO:0005856	cytoskeleton	-	TAS	8379998
GO:0005886	plasma membrane	-	IDA	10401006
GO:0005886	plasma membrane	-	TAS	-
GO:0005912	adherens junction	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0030027	lamellipodium	-	IEA	-
GO:0030864	cortical actin cytoskeleton	-	IEA	-
GO:0031527	filopodium membrane	-	IEA	-
GO:0032154	cleavage furrow	-	IEA	-
GO:0032587	ruffle membrane	-	IEA	-
GO:0043005	neuron projection	-	IEA	-
GO:0044297	cell body	-	IEA	-
GO:0045177	apical part of cell	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	17210637

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-5627123	RHO GTPases activate PAKs	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27628948	The Emerging Role of the Hippo Pathway in Lung Cancers: Clinical Implications. (2017 Nov 30)	Teoh SL	Curr Drug Targets
26368609	Oncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles. (2000 Jan)	Kane AB	Inhal Toxicol
23435014	Differential mutation profiles and similar intronic TP53 polymorphisms in asbestos-related lung cancer and pleural mesothelioma. (2013 May)	Andujar P	Mutagenesis
23921927	NF2 genetic alterations in sporadic vestibular schwannomas: clinical implications. (2013 Sep)	Lassaletta L	Otol Neurotol
19396864	CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma -A miRNA microarray analysis. (2009 Jul)	Guled M	Genes Chromosomes Cancer