Gene: NFATC1

4772
NF-ATC|NF-ATc1.2|NFAT2|NFATc
nuclear factor of activated T cells 1
protein-coding
18q23
Ensembl:ENSG00000131196 MIM:600489 Vega:OTTHUMG00000132897 UniprotKB:O95644
NG_029226.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.554e-1 (AD)  6.690e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs177820chr18:79516964 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05302701chr18:77196320NFATC18.500e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRP100.893
PLEKHA70.881
TTC380.857
PIEZO10.855
CDC14A0.854
PHF21B0.845
ABHD40.844
TRAF3IP20.842
TRIP60.839
TULP30.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYOZ3-0.58
PPEF1-0.576
ABCC12-0.57
CALHM1-0.568
AGMAT-0.567
GPR61-0.566
EPHA5-0.565
CNTN6-0.562
PTPRR-0.562
GABRG3-0.561

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NFATC1 mRNA"27291303
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate affects the localization of NFATC1 protein26522449
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NFATC1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFATC1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of NFATC1 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFATC1 mRNA"27188386
C0908608-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate"8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate affects the localization of NFATC1 protein"16533816
C0162768-bromocyclic GMP8-bromocyclic GMP affects the localization of NFATC1 protein16533816
D000082AcetaminophenAcetaminophen affects the expression of NFATC1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of NFATC1 mRNA17585979
D000255Adenosine TriphosphateAdenosine Triphosphate affects the localization of NFATC1 protein26522449
D000255Adenosine Triphosphateazetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein]26522449
D000255Adenosine TriphosphateAdenosine Triphosphate affects the localization of NFATC1 protein21464294
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]19028555
D001151ArsenicArsenic affects the methylation of NFATC1 gene25304211
D001151ArsenicArsenic results in decreased methylation of NFATC1 gene27838757
D001374AzacitidineAzacitidine results in increased expression of NFATC1 mRNA20823114
C082735azetidineazetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein]26522449
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NFATC1 mRNA27858113
D001554BenzeneBenzene results in increased expression of NFATC1 mRNA19162166
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NFATC1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NFATC1 mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NFATC1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NFATC1 mRNA22228805
C006780bisphenol Abisphenol A affects the methylation of NFATC1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of NFATC1 mRNA23900028|2606340
C006780bisphenol Abisphenol A results in increased methylation of NFATC1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide affects the localization of NFATC1 protein21601586
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide affects the localization of NFATC1 protein22434021
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NFATC1 mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NFATC1 mRNA23741332
D000001CalcimycinNFATC1 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNFSF10 protein]21603612
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of NFATC1 protein24244623
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [Cyclosporine results in decreased expression of NFATC1 protein]24244623
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of NFATC1 protein24244623
D002746ChlorpromazineChlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]21869564
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NFATC1 gene20938992
C022990chromic chloride[cobaltous chloride co-treated with chromic chloride] results in increased expression of NFATC1 mRNA25966675
D002858Chromium AlloysChromium Alloys results in increased expression of NFATC1 mRNA25966675
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NFATC1 mRNA27858113
C018021cobaltous chloride[cobaltous chloride co-treated with chromic chloride] results in increased expression of NFATC1 mRNA25966675
C018021cobaltous chloridecobaltous chloride results in increased expression of NFATC1 mRNA25966675
D019327Copper SulfateCopper Sulfate results in increased expression of NFATC1 mRNA19549813
D065366Cryptoxanthins[Cryptoxanthins co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA18636177
D065366CryptoxanthinsCryptoxanthins promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of NFATC1 mRNA]18636177
C030973cupric oxidecupric oxide results in increased expression of NFATC1 mRNA22077320
C038459curdlancurdlan inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1]24821724
D016572CyclosporineCyclosporine affects the localization of and results in decreased activity of NFATC1 protein24244623
D016572Cyclosporine[Cyclosporine co-treated with NGF protein] affects the localization of NFATC1 protein24244623
D016572CyclosporineCyclosporine inhibits the reaction [Oxygen deficiency affects the localization of NFATC1 protein]19028555
D016572CyclosporineCyclosporine inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]19028555
D016572CyclosporineCyclosporine results in decreased expression of NFATC1 protein24244623
D016572Cyclosporine[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [Cyclosporine results in decreased expression of NFATC1 protein]24244623
D016572CyclosporineCyclosporine inhibits the reaction [Isoproterenol affects the localization of NFATC1 protein]11435416
D016572CyclosporineCyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]19349967
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NFATC1 mRNA23640034
C017180decamethrindecamethrin results in decreased expression of NFATC1 protein22634059
C014347decitabinedecitabine results in decreased expression of NFATC1 mRNA17785578
C007262deoxynivalenoldeoxynivalenol affects the localization of NFATC1 protein22846391
C007262deoxynivalenoldeoxynivalenol affects the localization of NFATC1 protein21074547
D002945CisplatinCisplatin results in decreased expression of NFATC1 mRNA27392435
C118739entinostatentinostat results in increased expression of NFATC1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFATC1 mRNA"27188386
D005459FluoridesFluorides results in decreased expression of NFATC1 mRNA22610969
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NFATC1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of NFATC1 mRNA17938736
D019833GenisteinGenistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA]17295206
C442759ginsenoside Rb1ginsenoside Rb1 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]22386813
D006247HarmineHarmine affects the localization of NFATC1 protein25751815
D017313FenretinideFenretinide results in decreased expression of NFATC1 mRNA16467112
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [Ionomycin results in decreased phosphorylation of NFATC1 protein]12203019
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased activity of NFATC1 protein12203019
D019271HypoxanthineHypoxanthine results in decreased activity of NFATC1 protein12203019
C540383INCB018424INCB018424 promotes the reaction [TNF protein affects the localization of NFATC1 protein]22941906
D015759IonomycinHydrogen Peroxide inhibits the reaction [Ionomycin results in decreased phosphorylation of NFATC1 protein]12203019
D015759IonomycinIonomycin results in decreased phosphorylation of NFATC1 protein12203019
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NFATC1 mRNA25613284
D007545IsoproterenolCyclosporine inhibits the reaction [Isoproterenol affects the localization of NFATC1 protein]11435416
D007545IsoproterenolIsoproterenol affects the localization of NFATC1 protein11435416
D007545IsoproterenolIsoproterenol promotes the reaction [NFATC1 protein binds to GATA4 protein]11435416
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to NFATC1 promoter]]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to NFATC1 promoter]]24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]24799421
D007854LeadLead results in increased expression of NFATC1 mRNA26518054
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NFATC1 mRNA22185406
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NFATC1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NFATC1 mRNA26011545
C523799MRK 003NFATC1 results in decreased susceptibility to MRK 00319903844
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of NFATC1 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NFATC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NFATC1 mRNA"25554681
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]26792726
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]26792726
C025589ochratoxin Aochratoxin A results in increased acetylation of NFATC1 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of NFATC1 promoter] which results in increased expression of NFATC1 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of NFATC1 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NFATC1 mRNA25729387
D010100OxygenCyclosporine inhibits the reaction [Oxygen deficiency affects the localization of NFATC1 protein]19028555
D010100OxygenOxygen deficiency affects the localization of NFATC1 protein19028555
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of NFATC1 mRNA18593933
D010575PesticidesPesticides results in decreased methylation of NFATC1 gene28396702
D010634PhenobarbitalPhenobarbital affects the expression of NFATC1 mRNA23091169
D010656PhenylephrineCyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]19349967
D010656PhenylephrineKCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]12403671
D010656PhenylephrinePhenylephrine results in increased localization of and results in increased activity of NFATC1 protein19349967
D010936Plant ExtractsPlant Extracts results in decreased expression of NFATC1 mRNA23557933
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NFATC1 mRNA27029645
D011794QuercetinQuercetin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]19495926
D011794QuercetinQuercetin results in decreased expression of NFATC1 mRNA22185406
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA19059307
C059514resveratrolresveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]16267019
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]19900598
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]19900598
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NFATC1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NFATC1 mRNA23806026
D012834SilverSilver results in increased expression of NFATC1 mRNA27131904
C091861spermine nitric oxide complexspermine nitric oxide complex affects the localization of NFATC1 protein16533816
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA19059307
D013629TamoxifenTamoxifen results in increased expression of NFATC1 mRNA19031437
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]19028555
D013749TetrachlorodibenzodioxinCyclosporine inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]19028555
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the localization of NFATC1 protein19028555
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFATC1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NFATC1 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NFATC1 mRNA20819909|2405805
D013755Tetradecanoylphorbol AcetateNFATC1 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNFSF10 protein]21603612
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of NFATC1 protein24244623
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [Cyclosporine results in decreased expression of NFATC1 protein]24244623
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of NFATC1 protein24244623
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NFATC1 mRNA25613284
D019284ThapsigarginThapsigargin promotes the reaction [PPP3CA protein results in decreased phosphorylation of NFATC1 protein]10898953
C479163tofacitinibtofacitinib promotes the reaction [TNF protein affects the localization of NFATC1 protein]22941906
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NFATC1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of NFATC1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of NFATC1 mRNA"19682533
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
D014212TretinoinTretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]17291456
C011559tributyltinRo 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]17291456
C011559tributyltintributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]17291456
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NFATC1 mRNA19042947
C030665triphenyltintriphenyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]17291456
C057693troglitazonetroglitazone results in decreased expression of NFATC1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of NFATC1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NFATC1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of NFATC1 gene28853863|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NFATC1 gene25560391
C017967W 7W 7 inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]21869564
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]23994090
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of NFATC1 mRNA18593933
D019287Zinc SulfateZinc Sulfate results in decreased expression of NFATC1 mRNA27504894
D019287Zinc Sulfate[Cryptoxanthins co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA18636177
D019287Zinc SulfateCryptoxanthins promotes the reaction [[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of NFATC1 mRNA]18636177
D019287Zinc Sulfate[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA17295206
D019287Zinc SulfateGenistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of NFATC1 mRNA]17295206
D019287Zinc Sulfate[Zinc Sulfate co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of NFATC1 mRNA18636177

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001085RNA polymerase II transcription factor binding-ISS-  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-ISS-  
GO:0001225RNA polymerase II transcription coactivator binding-IEA-  
GO:0003682chromatin binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS9506523  10821850  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-ISS-  
GO:0005515protein binding-IPI17882263  18218901  21880741  23468591  24954618  25609649  
GO:0005528FK506 binding-TAS8702849  
GO:0008134transcription factor binding-IBA21873635  
GO:0048273mitogen-activated protein kinase p38 binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001816cytokine production-IBA21873635  
GO:0006366transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS8702849  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0030178negative regulation of Wnt signaling pathway-ISS-  
GO:0033173calcineurin-NFAT signaling cascade-IBA21873635  
GO:0033173calcineurin-NFAT signaling cascade-IDA14979875  
GO:0035556intracellular signal transduction-IDA14749367  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA14749367  14979875  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14979875  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI14979875  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:1905064negative regulation of vascular smooth muscle cell differentiation-IDA23853098  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA15304486  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12370307  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0016604nuclear body-IDA-  
GO:0044798nuclear transcription factor complex-IBA21873635  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)IEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-2025928Calcineurin activates NFATTAS
R-HSA-2025928Calcineurin activates NFATIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-5607763CLEC7A (Dectin-1) induces NFAT activationTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28791728Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study. (2017 Nov)Barrow TMJ Pathol