Gene: NFATC2

4773
NFAT1|NFATP
nuclear factor of activated T cells 2
protein-coding
20q13.2
Ensembl:ENSG00000101096 MIM:600490 Vega:OTTHUMG00000032747 UniprotKB:Q13469
NC_000020.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.339e-1 (AD)  6.462e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18740175chr20:50110833NFATC23.500e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF1B0.849
GPSM30.843
CMTM70.843
ARHGAP300.835
ADPRH0.834
PIK3R50.833
CARD60.832
TBXAS10.832
ADAP20.83
MYO1F0.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.557
HAS1-0.55
KCNB2-0.549
SLC7A4-0.534
PPEF1-0.531
ATOH7-0.53
LRFN2-0.526
LRTM2-0.52
CALHM1-0.52
MAGIX-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4763084-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide"4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide inhibits the reaction [[Muscarine co-treated with Calcium] affects the localization of NFATC2 protein]"24990931
C4763084-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide"4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide inhibits the reaction [[Thapsigargin co-treated with Calcium] affects the localization of NFATC2 protein]"24990931
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NFATC2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NFATC2 mRNA]17585979
D019342Acetic AcidAcetic Acid inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein]17615583
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NFATC2 mRNA21298039
D001151ArsenicArsenic affects the methylation of NFATC2 gene25304211
C015001arsenitearsenite results in increased methylation of NFATC2 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NFATC2 mRNA"24160326
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of NFATC2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NFATC2 promoter]19654925
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of NFATC2 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of NFATC2 mRNA24758408
C472777bisperoxovanadiumbisperoxovanadium affects the localization of NFATC2 protein12493747
C472777bisperoxovanadiumbisperoxovanadium promotes the reaction [NFATC2 protein binds to PTGS2 promoter]12493747
C472777bisperoxovanadiumNFATC2 protein affects the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]12493747
D001761BleomycinMIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of NFATC2 mRNA]28726637
D001761BleomycinBleomycin results in increased expression of NFATC2 mRNA28726637
D000001CalcimycinCalcimycin results in increased activity of NFATC2 protein12789233
D000001CalcimycinCyclosporine inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein]12789233
D000001Calcimycinfisetin inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein]12789233
D000001CalcimycinNFATC2 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNFSF10 protein]21603612
D000001Calcimycin"Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein]"23941771
D000001CalcimycinPlant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein]23941771
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein23941771
D002118Calcium"4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide inhibits the reaction [[Muscarine co-treated with Calcium] affects the localization of NFATC2 protein]"24990931
D002118Calcium"4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide inhibits the reaction [[Thapsigargin co-treated with Calcium] affects the localization of NFATC2 protein]"24990931
D002118Calcium[Muscarine co-treated with Calcium] affects the localization of NFATC2 protein24990931
D002118Calcium[Thapsigargin co-treated with Calcium] affects the localization of NFATC2 protein24990931
D002118CalciumCalcium affects the localization of NFATC2 protein11592964
D002118CalciumCalcium results in decreased phosphorylation of NFATC2 protein11592964
D002118CalciumPyrazoles analog inhibits the reaction [Calcium affects the localization of NFATC2 protein]11592964
D002118CalciumPyrazoles analog inhibits the reaction [Calcium results in decreased phosphorylation of NFATC2 protein]11592964
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NFATC2 gene20938992
D007464Clioquinol[Clioquinol binds to Copper] which results in decreased expression of NFATC2 protein18346929
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NFATC2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NFATC2 mRNA]17585979
D003300Copper[Clioquinol binds to Copper] which results in decreased expression of NFATC2 protein18346929
D003300CopperCopper deficiency results in increased expression of NFATC2 mRNA26033743
D016572CyclosporineCyclosporine inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein]12789233
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NFATC2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NFATC2 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of NFATC2 mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of NFATC2 mRNA26033743
D002117CalcitriolCalcitriol results in decreased expression of NFATC2 mRNA16002434
C118739entinostatentinostat results in increased expression of NFATC2 mRNA27188386
C017875fisetinfisetin inhibits the reaction [Calcimycin results in increased activity of NFATC2 protein]12789233
C017875fisetinfisetin results in decreased activity of NFATC2 protein16343431
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NFATC2 gene20938992
D006247HarmineHarmine affects the localization of NFATC2 protein25751815
D017313FenretinideFenretinide results in decreased expression of NFATC2 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NFATC2 mRNA17183730
D015759IonomycinAcetic Acid inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein]17615583
D015759Ionomycin[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein17615583
D015759Ionomycin[Ionomycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [NFATC2 protein binds to KPNB1 protein]17615583
D015759Ionomycin[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein17615583
D015759IonomycinSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein]17615583
D015759IonomycinSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [NFATC2 protein binds to KPNB1 protein]]17615583
D015759IonomycinSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein]17615583
D015759Ionomycin[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of and results in decreased phosphorylation of NFATC2 protein17615583
D015759IonomycinSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein]17615583
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NFATC2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NFATC2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NFATC2 mRNA26387944
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NFATC2 mRNA"24972896
D000432MethanolMethanol affects the localization of and results in increased activity of NFATC2 protein20616203
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NFATC2 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NFATC2 mRNA"20188158|2625132
C523799MRK 003NFATC2 results in increased susceptibility to MRK 00319903844
D009116Muscarine"4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide inhibits the reaction [[Muscarine co-treated with Calcium] affects the localization of NFATC2 protein]"24990931
D009116Muscarine[Muscarine co-treated with Calcium] affects the localization of NFATC2 protein24990931
C107594N-(4-hydroxyphenyl)arachidonylamideN-(4-hydroxyphenyl)arachidonylamide results in decreased activity of NFATC2 protein17196940
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NFATC2 mRNA"25554681
D009538NicotineNicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]15231866
C007350nitrofennitrofen results in increased expression of NFATC2 mRNA27522126
C007350nitrofennitrofen results in increased expression of NFATC2 protein27522126
D009822Oils, Volatile"Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein]"23941771
D010100OxygenOxygen deficiency results in increased expression of NFATC2 mRNA26516004
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of NFATC2 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of NFATC2 mRNA20813756
D010938Plant OilsPlant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein]23941771
D011720PyrazolesPyrazoles analog inhibits the reaction [Calcium affects the localization of NFATC2 protein]11592964
D011720PyrazolesPyrazoles analog inhibits the reaction [Calcium results in decreased phosphorylation of NFATC2 protein]11592964
C089730rosiglitazoneNFATC2 gene polymorphism affects the susceptibility to rosiglitazone20628086
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of NFATC2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NFATC2 mRNA23806026
D019346Sodium AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein]17615583
D019346Sodium AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [NFATC2 protein binds to KPNB1 protein]]17615583
D019346Sodium AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein]17615583
D019346Sodium AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein]17615583
C017947sodium arsenitesodium arsenite affects the methylation of NFATC2 gene28589171
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of NFATC2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFATC2 mRNA24058054
D013755Tetradecanoylphorbol AcetateAcetic Acid inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein]17615583
D013755Tetradecanoylphorbol Acetate[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein17615583
D013755Tetradecanoylphorbol Acetate[Ionomycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [NFATC2 protein binds to KPNB1 protein]17615583
D013755Tetradecanoylphorbol Acetate[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein17615583
D013755Tetradecanoylphorbol AcetateNFATC2 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNFSF10 protein]21603612
D013755Tetradecanoylphorbol Acetate"Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein]"23941771
D013755Tetradecanoylphorbol AcetatePlant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein]23941771
D013755Tetradecanoylphorbol AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein]17615583
D013755Tetradecanoylphorbol AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [NFATC2 protein binds to KPNB1 protein]]17615583
D013755Tetradecanoylphorbol AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein]17615583
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in decreased phosphorylation of NFATC2 protein23941771
D013755Tetradecanoylphorbol Acetate[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of and results in decreased phosphorylation of NFATC2 protein17615583
D013755Tetradecanoylphorbol AcetateSodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein]17615583
D019284Thapsigargin"4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide inhibits the reaction [[Thapsigargin co-treated with Calcium] affects the localization of NFATC2 protein]"24990931
D019284Thapsigargin[Thapsigargin co-treated with Calcium] affects the localization of NFATC2 protein24990931
D014118Toxins, Biological"Toxins, Biological affects the expression of NFATC2 mRNA"19682533
D014520UrethaneUrethane results in decreased expression of NFATC2 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NFATC2 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of NFATC2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of NFATC2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NFATC2 gene25560391
D014750VincristineNFATC2 gene SNP results in increased susceptibility to Vincristine21245421

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-TAS8668213  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS8668213  
GO:0005515protein binding-IPI16873067  17377532  18218901  19505873  21458306  21983832  
23105117  24561192  24954618  25609649  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IEA-  
GO:0019902phosphatase binding-IPI26248042  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001816cytokine production-IBA21873635  
GO:0001816cytokine production-IEA-  
GO:0006355regulation of transcription, DNA-templated-TAS8668213  
GO:0006366transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006974cellular response to DNA damage stimulus-IMP17875758  
GO:0014904myotube cell development-IEA-  
GO:0016477cell migration-IDA21871017  
GO:0030890positive regulation of B cell proliferation-IMP17875758  
GO:0033173calcineurin-NFAT signaling cascade-IBA21873635  
GO:0033173calcineurin-NFAT signaling cascade-IEA-  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0042493response to drug-IMP17875758  
GO:0045589regulation of regulatory T cell differentiation-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA15790681  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0050853B cell receptor signaling pathway-IMP17875758  
GO:1901741positive regulation of myoblast fusion-IEA-  
GO:1905064negative regulation of vascular smooth muscle cell differentiation-IDA23853098  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12370307  12656674  
GO:0005634nucleus-TAS8668213  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005737cytoplasm-IDA12656674  
GO:0005737cytoplasm-TAS8668213  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0044798nuclear transcription factor complex-IBA21873635  
GO:0044798nuclear transcription factor complex-IEA-  
GO:1990904ribonucleoprotein complex-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)IEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-2025928Calcineurin activates NFATTAS
R-HSA-2025928Calcineurin activates NFATIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-5607763CLEC7A (Dectin-1) induces NFAT activationTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26642056In Utero Cigarette Smoke Affects Allergic Airway Disease But Does Not Alter the Lung Methylome. (2015)Eyring KRPLoS One
26333835Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. (2015 Dec)Scheinfeldt LBAm J Med Genet B Neuropsychiatr Genet