Gene: NFATC3

4775
NFAT4|NFATX
nuclear factor of activated T cells 3
protein-coding
16q22.1
Ensembl:ENSG00000072736 MIM:602698 Vega:OTTHUMG00000137555 UniprotKB:Q12968
NG_029147.1
PubMed
0   ANCO-SNPs
ND
2   
3.822e-1 (AD)  1.349e-1 (ND)   (Frontal_Cortex)
2.666e-1 (AD)  3.137e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDM5A0.873
KAT6A0.778
ZNF810.777
ZNF2340.77
RNF1690.769
TRIM560.766
NFKB10.76
CHD10.759
RBMS20.75
LAMC10.747

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.472
CRH-0.428
SPEF1-0.415
MYCNOS-0.409
CRYBA2-0.398
SPDEF-0.393
NT5M-0.389
BHLHA9-0.388
PNMT-0.369
HBQ1-0.367

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]"15799720
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide affects the localization of NFATC3 protein]"15799720
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NFATC3 mRNA"21346803
D000255Adenosine TriphosphateAdenosine Triphosphate affects the localization of NFATC3 protein21464294
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NFATC3 gene27153756
D001151ArsenicArsenic affects the expression of NFATC3 mRNA18414638
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NFATC3 mRNA20064835
C006780bisphenol Abisphenol A affects the methylation of NFATC3 promoter27334623
C006780bisphenol Abisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]12709020
C006780bisphenol Abisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]12709020
C006780bisphenol ATacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]12709020
C006780bisphenol Abisphenol A affects the expression of NFATC3 mRNA25181051
C086539BQ 788[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased localization of NFATC3 protein]20369390
D000001CalcimycinNFATC3 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNFSF10 protein]21603612
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NFATC3 mRNA16934159
D019327Copper SulfateCopper Sulfate results in decreased expression of NFATC3 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of NFATC3 mRNA21041162
D016572CyclosporineCyclosporine inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased localization of NFATC3 protein]20369390
D003907DexamethasoneDexamethasone results in decreased expression of NFATC3 mRNA21041162
D003976DiazinonDiazinon results in increased methylation of NFATC3 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NFATC3 mRNA21266533
D002945CisplatinCisplatin results in increased expression of NFATC3 mRNA27392435
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of NFATC3 mRNA21858171
D004041Dietary FatsDietary Fats results in increased expression of NFATC3 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of NFATC3 mRNA]19030233
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of NFATC3 mRNA21041162
C007517diphenyleneiodonium[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
D004317Doxorubicin"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]"15799720
D004317DoxorubicinCyclosporine inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
D004317Doxorubicin[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
D004317DoxorubicinDoxorubicin affects the localization of NFATC3 protein15799720
D004317Doxorubicin[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of NFATC3 mRNA27181935
D004317DoxorubicinGPX1 protein inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
D004317DoxorubicinSOD2 protein inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
D000431EthanolEthanol promotes the reaction [sodium arsenite results in increased expression of NFATC3 mRNA]26220687
D000431EthanolEthanol results in increased expression of NFATC3 mRNA26220687
D000431Ethanol[sodium arsenite co-treated with Ethanol] affects the localization of NFATC3 protein26220687
D000431Ethanol[sodium arsenite co-treated with Ethanol] results in increased expression of NFATC3 protein26220687
D000431Ethanolsodium arsenite promotes the reaction [Ethanol results in increased expression of NFATC3 mRNA]26220687
D000431Ethanol[sodium arsenite co-treated with Ethanol] results in increased expression of NFATC3 protein26220687
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFATC3 mRNA17942748
C004912ethylbenzeneethylbenzene results in decreased expression of NFATC3 mRNA20955722
D062610Fungal Polysaccharides[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of NFATC3 mRNA27181935
D005839GentamicinsGentamicins results in increased expression of NFATC3 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of NFATC3 mRNA24136188
D006247HarmineHarmine affects the localization of NFATC3 protein25751815
D006493Heparin"Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein]"16259952
D017313FenretinideFenretinide results in decreased expression of NFATC3 mRNA28973697
C072551HS 142-1[HS 142-1 results in decreased activity of NPR1 protein] which results in increased localization of NFATC3 protein15939815
D006861Hydrogen Peroxide"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide affects the localization of NFATC3 protein]"15799720
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of NFATC3 protein15799720
D006861Hydrogen Peroxide[mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide affects the localization of NFATC3 protein]15799720
D015759Ionomycinbisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]12709020
D015759Ionomycinnonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]12709020
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]12709020
D015759Ionomycin[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA12709020
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NFATC3 mRNA25613284
D015759IonomycinIonomycin affects the localization of NFATC3 protein15799720
D018021Lithium ChlorideLithium Chloride results in increased activity of NFATC3 protein20694829
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NFATC3 mRNA21641980
D008694MethamphetamineMethamphetamine affects the localization of NFATC3 protein15644446
D008694MethamphetamineMethamphetamine results in increased expression of NFATC3 mRNA19564919
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine affects the localization of NFATC3 protein]15644446
D008727MethotrexateMethotrexate results in increased expression of NFATC3 mRNA17400583
D008752Methylene ChlorideMethylene Chloride results in decreased expression of NFATC3 mRNA20955722
C429015mitoquinol[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
C429015mitoquinol[mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide affects the localization of NFATC3 protein]15799720
C429014mitoquinone[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein]15799720
C429014mitoquinone[mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide affects the localization of NFATC3 protein]15799720
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NFATC3 mRNA20886546
D015544Inositol 1,4,5-Trisphosphate"Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein]"16259952
D015544Inositol 1,4,5-Trisphosphate"Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein"16259952
C025256nonylphenolnonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]12709020
C025256nonylphenolnonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]12709020
C025256nonylphenolTacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]12709020
D010656Phenylephrine[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]15939815
D010656PhenylephrinePhenylephrine results in increased localization of NFATC3 protein15939815
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of NFATC3 mRNA21858171
D011374ProgesteroneProgesterone results in decreased expression of NFATC3 mRNA23018184
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of NFATC3 mRNA]19030233
C534628SCH 23390SCH 23390 affects the expression of NFATC3 mRNA19564919
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine affects the localization of NFATC3 protein]15644446
D019821SimvastatinSimvastatin promotes the reaction [NFATC3 protein binds to BCL2 promoter]20369390
D019821SimvastatinSimvastatin results in decreased localization of NFATC3 protein alternative form20369390
D019821SimvastatinSimvastatin results in increased localization of NFATC3 protein20369390
C017947sodium arseniteEthanol promotes the reaction [sodium arsenite results in increased expression of NFATC3 mRNA]26220687
C017947sodium arsenite[sodium arsenite co-treated with Ethanol] affects the localization of NFATC3 protein26220687
C017947sodium arsenite[sodium arsenite co-treated with Ethanol] results in increased expression of NFATC3 protein26220687
C017947sodium arsenitesodium arsenite promotes the reaction [Ethanol results in increased expression of NFATC3 mRNA]26220687
C017947sodium arsenitesodium arsenite results in increased expression of NFATC3 mRNA26220687
C017947sodium arsenite[sodium arsenite co-treated with Ethanol] results in increased expression of NFATC3 protein26220687
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NFATC3 mRNA21641980
D016559TacrolimusTacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]12709020
D016559TacrolimusTacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]12709020
D016559TacrolimusTacrolimus inhibits the reaction [Thapsigargin affects the localization of and results in increased activity of NFATC3 protein]10339586
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFATC3 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFATC3 mRNA17942748
D013755Tetradecanoylphorbol AcetateNFATC3 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNFSF10 protein]21603612
D013755Tetradecanoylphorbol Acetatebisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]12709020
D013755Tetradecanoylphorbol Acetatenonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]12709020
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]12709020
D013755Tetradecanoylphorbol Acetate[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA12709020
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NFATC3 mRNA25613284
D019284ThapsigarginTacrolimus inhibits the reaction [Thapsigargin affects the localization of and results in increased activity of NFATC3 protein]10339586
D019284ThapsigarginThapsigargin affects the localization of and results in increased activity of NFATC3 protein10339586
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NFATC3 mRNA20955722
C057693troglitazonetroglitazone results in decreased expression of NFATC3 mRNA28973697
D014520UrethaneUrethane results in increased expression of NFATC3 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of NFATC3 gene29154799
C025643vinclozolinvinclozolin results in increased expression of NFATC3 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of NFATC3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15173172  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15173172  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP15173172  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IGI23543060  
GO:0003682chromatin binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI24330068  
GO:0008134transcription factor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001816cytokine production-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS7749981  
GO:0006366transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS7739550  
GO:0006954inflammatory response-TAS7739550  
GO:0033173calcineurin-NFAT signaling cascade-IBA21873635  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18815128  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP15173172  
GO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II-IGI23543060  
GO:1905064negative regulation of vascular smooth muscle cell differentiation-IDA23853098  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12370307  18815128  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005737cytoplasm-IDA18815128  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0044798nuclear transcription factor complex-IBA21873635  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)IEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-2025928Calcineurin activates NFATTAS
R-HSA-2025928Calcineurin activates NFATIEA
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-5607763CLEC7A (Dectin-1) induces NFAT activationTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26522359[Qibaipingfei Capsule down-regulate the levels of calcineurin and nuclear factor of activated T-cells isoform c3 (NFATc3) in chronic obstructive pulmonary disease]. (2015 Nov)Zhu JXi Bao Yu Fen Zi Mian Yi Xue Za Zhi
28724635Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking. (2017 Sep 8)Kotla SJ Biol Chem