Gene: NFE2L1

4779
LCR-F1|NRF1|TCF11
nuclear factor, erythroid 2 like 1
protein-coding
17q21.32
Ensembl:ENSG00000082641 MIM:163260 Vega:OTTHUMG00000178706 UniprotKB:Q14494
NC_000017.11
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.062e-2 (AD)  4.029e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM168B0.949
DYNC1H10.947
RABGAP10.942
MFN20.941
SERINC30.939
EIF4H0.938
GOLGA20.936
AP2B10.936
APLP20.933
C6orf890.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.742
OR4F5-0.737
MTRNR2L6-0.368
MTRNR2L9-0.355
MTRNR2L10-0.347
MTRNR2L2-0.28
TTLL10-0.279
TTLL10-AS1-0.277
KLRB1-0.277
MTRNR2L3-0.274

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04147Lauryl Dimethylamine-N-OxideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NFE2L1 mRNA"25614096
C0059753,4-dihydroxyphenylethanol"3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of NFE2L1 mRNA]"20938484
C0059753,4-dihydroxyphenylethanol"3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of NFE2L1 protein]"20938484
C5809354-((4-hydroxyphenylimino)methyl)benzene-1,2-diol"4-((4-hydroxyphenylimino)methyl)benzene-1,2-diol results in increased expression of NFE2L1 mRNA"28960787
C5809354-((4-hydroxyphenylimino)methyl)benzene-1,2-diol"4-((4-hydroxyphenylimino)methyl)benzene-1,2-diol results in increased expression of NFE2L1 protein"28960787
C0006193364-(E)-((p-tolylimino)-methylbenzene-1,2-diol)"4-(E)-((p-tolylimino)-methylbenzene-1,2-diol) results in increased expression of NFE2L1 mRNA"28960787
C0006193364-(E)-((p-tolylimino)-methylbenzene-1,2-diol)"4-(E)-((p-tolylimino)-methylbenzene-1,2-diol) results in increased expression of NFE2L1 protein"28960787
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of NFE2L1 mRNA12419474
C0293704-toluidine4-toluidine results in increased expression of NFE2L1 mRNA27638505
D000082AcetaminophenAcetaminophen results in increased expression of NFE2L1 mRNA29067470
D000171Acrolein"3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of NFE2L1 mRNA]"20938484
D000171Acrolein"3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of NFE2L1 protein]"20938484
D000171AcroleinAcrolein results in decreased expression of NFE2L1 mRNA20938484
D000171AcroleinAcrolein results in decreased expression of NFE2L1 protein20938484
D001151ArsenicArsenic results in increased expression of NFE2L121235219
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in increased activity of NFE2L1 protein16487037
C015001arsenitearsenite results in decreased expression of NFE2L1 mRNA22476201
C015001arsenitearsenite results in increased expression of NFE2L1 protein22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in decreased expression of NFE2L1 mRNA]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L1 protein]22476201
C015001arseniteNFE2L1 protein affects the susceptibility to arsenite22476201
C015001arseniteNFE2L2 protein affects the reaction [arsenite affects the expression of NFE2L1 mRNA]22476201
C015001arseniteNFE2L2 protein affects the reaction [arsenite affects the expression of NFE2L1 protein]22476201
C015001arseniteNFE2L1 protein alternative form results in decreased methylation of arsenite28549828
C015001arsenite[NFE2L1 protein alternative form results in decreased methylation of arsenite] which results in decreased abundance of monomethylarsonic acid28549828
C011669ascorbate-2-phosphate[ascorbate-2-phosphate co-treated with GULO protein] affects the expression of and affects the localization of NFE2L1 protein17510056
C011669ascorbate-2-phosphateNFE2L1 protein affects the reaction [ascorbate-2-phosphate results in increased expression of SP7 mRNA]17510056
D001205Ascorbic AcidAscorbic Acid results in increased expression of NFE2L1 mRNA25130429
D001205Ascorbic AcidAscorbic Acid results in increased expression of NFE2L1 protein25130429
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NFE2L1 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of NFE2L1 protein alternative form28549828
D004958EstradiolEstradiol results in increased expression of NFE2L1 mRNA25130429|2896078
D004958EstradiolEstradiol results in increased expression of NFE2L1 protein25130429|2896078
C006780bisphenol Abisphenol A results in increased expression of NFE2L1 mRNA23360430|2927551
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NFE2L1 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of NFE2L1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of NFE2L1 mRNA25181051
D020126Brefeldin ABrefeldin A affects the reaction [sodium arsenite affects the localization of NFE2L1 protein]20805060
C584509C646 compoundC646 compound results in increased expression of NFE2L1 mRNA26191083
D002185CannabidiolCannabidiol results in increased expression of NFE2L1 mRNA21542829
D002220CarbamazepineCarbamazepine affects the expression of NFE2L1 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NFE2L1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NFE2L1 gene20938992
D002994ClofibrateClofibrate results in decreased expression of NFE2L1 mRNA17585979
C018021cobaltous chloride[cobaltous chloride co-treated with Oxygen deficiency] results in increased expression of NFE2L1 protein19278353
C018021cobaltous chloridecobaltous chloride results in increased expression of NFE2L1 protein19278353
D003042CocaineCocaine results in increased expression of NFE2L1 mRNA18000554
D003474CurcuminCurcumin results in increased expression of NFE2L1 protein23710286
D016572CyclosporineCyclosporine results in increased expression of NFE2L1 mRNA20106945|2798913
C014347decitabinedecitabine affects the methylation of NFE2L1 gene17630775
D013759DronabinolDronabinol results in increased expression of NFE2L1 mRNA21542829
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NFE2L1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of NFE2L1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of NFE2L1 mRNA]20032058
D002945CisplatinCisplatin promotes the reaction [Piroxicam results in decreased expression of NFE2L1 mRNA]21858171
D004317DoxorubicinDoxorubicin results in decreased expression of NFE2L1 protein26781513
D004317DoxorubicinDoxorubicin results in increased expression of NFE2L1 protein26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in decreased expression of NFE2L1 protein]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in increased expression of NFE2L1 protein]26781513
D004967EstrogensEstrogens results in increased expression of NFE2L1 protein15994367
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NFE2L1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFE2L1 mRNA17942748
D018120FinasterideFinasteride results in increased expression of NFE2L1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NFE2L1 gene20938992
D005839GentamicinsGentamicins results in decreased expression of NFE2L1 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of NFE2L1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of NFE2L1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NFE2L1 mRNA12419474
C056599icariinicariin results in increased expression of NFE2L1 mRNA17883938
C056599icariinicariin results in increased expression of NFE2L1 protein17883938
C492448ICG 001ICG 001 results in increased expression of NFE2L1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NFE2L1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NFE2L1 mRNA28628672
D048628KetolidesKetolides analog results in increased expression of NFE2L1 mRNA24967691
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NFE2L1 gene20938992
D008727MethotrexateNFE2L1 protein affects the susceptibility to Methotrexate16217747
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NFE2L1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of NFE2L1 promoter"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NFE2L1 mRNA"20188158
C020300monomethylarsonic acid[NFE2L1 protein alternative form results in decreased methylation of arsenite] which results in decreased abundance of monomethylarsonic acid28549828
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of NFE2L1 mRNA20024957
D009538NicotineNicotine results in increased splicing of NFE2L1 mRNA alternative form23825647
D010100Oxygen[cobaltous chloride co-treated with Oxygen deficiency] results in increased expression of NFE2L1 protein19278353
D010100OxygenOxygen deficiency results in increased expression of NFE2L1 protein19278353
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NFE2L1 mRNA19616056
C006253pirinixic acidpirinixic acid results in increased expression of NFE2L1 mRNA18301758|2081375
D010894PiroxicamCisplatin promotes the reaction [Piroxicam results in decreased expression of NFE2L1 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of NFE2L1 mRNA21858171
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of NFE2L1 mRNA16497877
C059514resveratrolresveratrol results in increased expression of NFE2L1 mRNA25130429|2896078
C059514resveratrolresveratrol results in increased expression of NFE2L1 protein25130429|2896078
C017947sodium arseniteBrefeldin A affects the reaction [sodium arsenite affects the localization of NFE2L1 protein]20805060
C017947sodium arseniteNFE2L1 protein affects the reaction [sodium arsenite results in increased expression of GCLC mRNA]20805060
C017947sodium arseniteNFE2L1 protein affects the reaction [sodium arsenite results in increased expression of GCLM mRNA]20805060
C017947sodium arseniteNFE2L1 protein affects the reaction [sodium arsenite results in increased expression of NQO1 mRNA]20805060
C017947sodium arsenitesodium arsenite affects the localization of NFE2L1 protein20805060
C017947sodium arsenitesodium arsenite promotes the reaction [NFE2L1 protein binds to NQO1 promoter]20805060
C017947sodium arsenitesodium arsenite results in decreased expression of NFE2L1 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased activity of NFE2L1 protein20805060
C017947sodium arsenitesodium arsenite results in increased expression of NFE2L1 mRNA20805060
C017947sodium arsenitesodium arsenite results in increased expression of NFE2L1 protein20805060
C017947sodium arseniteTunicamycin affects the reaction [sodium arsenite affects the localization of NFE2L1 protein]20805060
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]28549828
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]28549828
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of GSTM1 mRNA]28549828
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of GSTO1 mRNA]28549828
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]28549828
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]28549828
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of NQO1 mRNA]28549828
C017947sodium arseniteNFE2L1 protein alternative form results in decreased susceptibility to sodium arsenite28549828
C017947sodium arsenitesodium arsenite results in increased expression of NFE2L1 protein alternative form28549828
D018038Sodium SeleniteSodium Selenite results in increased expression of NFE2L1 mRNA24383545
D013467SulindacSulindac results in increased expression of NFE2L1 mRNA11906190
D013467SulindacSulindac results in increased expression of NFE2L1 mRNA24136188
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of NFE2L1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFE2L1 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFE2L1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NFE2L1 mRNA28213091
C012589trichostatin Atrichostatin A results in increased expression of NFE2L1 mRNA15901671
D014415TunicamycinTunicamycin affects the reaction [sodium arsenite affects the localization of NFE2L1 protein]20805060
D014520UrethaneUrethane results in increased expression of NFE2L1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NFE2L1 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of NFE2L1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of NFE2L1 mRNA15901671
C025643vinclozolinvinclozolin results in decreased expression of NFE2L1 mRNA23034163
D014750VincristineVincristine results in increased expression of NFE2L1 mRNA23649840
D014810Vitamin EVitamin E results in increased expression of NFE2L1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding-IEA-  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS8248256  
GO:0003712transcription coregulator activity-TAS9826775  
GO:0005515protein binding-IPI20102225  
GO:0008289lipid binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS9826775  
GO:0006783heme biosynthetic process-TAS9501099  
GO:0006954inflammatory response-TAS9826775  
GO:0008203cholesterol metabolic process-IEA-  
GO:0009653anatomical structure morphogenesis-TAS9501099  
GO:0030218erythrocyte differentiation-IEA-  
GO:0034599cellular response to oxidative stress-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal