Gene info: ID 4784

Gene: NFIX

GENE ID: 4784

Description: nuclear factor I X

Gene type: protein-coding

Location: 19p13.13

dbXrefs: Ensembl:ENSG00000008441 MIM:164005 Vega:OTTHUMG00000180726 UniprotKB:Q14938

RefSeq: NG_032925.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.058e-1 (AD) 2.468e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg05356319	chr19:13122449	NFIX		9.080e-8	Alcohol consumption der day	27843151
cg24135793	chr19:13122567	NFIX		1.740e-8	Alcohol consumption der day	27843151
cg17344906	chr19:13202507	NFIX		8.540e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDC42BPB	0.919
ZBTB4	0.906
CACNG7	0.903
SMARCC2	0.887
TOM1L2	0.884
ELAVL3	0.882
GNAO1	0.88
EVI5L	0.878
FAM219A	0.875
ZC3H7B	0.875

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.722
OR4F29	-0.721
C1orf87	-0.402
ARHGEF35	-0.397
IL24	-0.391
SLAMF6	-0.364
TFPI2	-0.363
TPRG1	-0.363
CLEC4D	-0.362
C9orf135	-0.361

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of NFIX mRNA"	18281256
C541131	2,2',3,3',4,4',5-heptachlorobiphenyl	"2,2',3,3',4,4',5-heptachlorobiphenyl affects the expression of NFIX mRNA"	24050789
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of NFIX mRNA"	21703328
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NFIX mRNA"	20056577
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of NFIX mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl affects the expression of NFIX mRNA"	21703328
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NFIX mRNA]"	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the expression of NFIX mRNA"	21703328
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFIX mRNA"	20959002
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of NFIX mRNA"	18648102
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of NFIX mRNA	12419474
C029370	4-toluidine	4-toluidine results in increased expression of NFIX mRNA	27638505
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of NFIX mRNA"	28073004
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of NFIX gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of NFIX mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of NFIX gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of NFIX mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of NFIX mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NFIX mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NFIX mRNA	22300585
D004958	Estradiol	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of NFIX mRNA]	16977382
C006780	bisphenol A	bisphenol A affects the methylation of NFIX promoter	27334623
C006780	bisphenol A	bisphenol A affects the expression of NFIX mRNA	25181051
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of NFIX mRNA]	19228888
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of NFIX mRNA	12419474
C584509	C646 compound	C646 compound results in decreased expression of NFIX mRNA	26191083
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNA	12634122
D002330	Carmustine	NFIX mRNA affects the susceptibility to Carmustine	16365179
D002737	Chloroprene	Chloroprene results in increased expression of NFIX mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of NFIX mRNA	20691718
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NFIX mRNA	20938992
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNA	12634122
D003042	Cocaine	Cocaine affects the expression of NFIX protein	11299316
D003042	Cocaine	Cocaine results in increased expression of NFIX mRNA	11299316
C029892	cupric chloride	cupric chloride results in decreased expression of NFIX mRNA	17211630
D003471	Cuprizone	Cuprizone results in decreased expression of NFIX mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of NFIX mRNA	25562108
C014347	decitabine	decitabine results in decreased expression of NFIX mRNA	19363521
C014347	decitabine	TP53 protein affects the reaction [decitabine results in decreased expression of NFIX mRNA]	19363521
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of NFIX mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of NFIX mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of NFIX mRNA	27392435\|2759478
C000944	dicrotophos	dicrotophos results in increased expression of NFIX mRNA	28302478
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NFIX mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of NFIX mRNA	19467301\|2501614
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFIX mRNA"	22485181
D004237	Diuron	Diuron results in decreased expression of NFIX mRNA	25152437
D004317	Doxorubicin	Doxorubicin affects the methylation of NFIX gene	28962528
D000431	Ethanol	Ethanol results in decreased expression of NFIX mRNA	15353170
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NFIX mRNA	17557909
D005038	Ethylnitrosourea	Ethylnitrosourea results in decreased expression of NFIX mRNA	15954086
C082360	fipronil	fipronil results in decreased expression of NFIX mRNA	23962444
D005485	Flutamide	Flutamide results in decreased expression of NFIX mRNA	24793618
D005492	Folic Acid	Folic Acid results in increased expression of NFIX mRNA	25006883
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NFIX mRNA	20938992
C069837	fullerene C60	fullerene C60 results in increased expression of NFIX mRNA	19167457
D005897	Glafenine	Glafenine results in decreased expression of NFIX mRNA	24136188
D017313	Fenretinide	Fenretinide results in decreased expression of NFIX mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of NFIX mRNA	12419474
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of NFIX mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NFIX mRNA	24796395
D007854	Lead	Lead affects the expression of NFIX mRNA	28903495
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNA	12634122
D001556	Lindane	Lindane results in increased expression of NFIX mRNA	17785943
D008070	Lipopolysaccharides	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of NFIX mRNA]	16977382
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NFIX mRNA	16977382
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NFIX mRNA	21641980
D008345	Manganese	Manganese results in decreased expression of NFIX mRNA	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of NFIX mRNA	17175027
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of NFIX mRNA	20938992
D008727	Methotrexate	Methotrexate results in increased expression of NFIX mRNA	24449571
D008731	Methoxychlor	Methoxychlor affects the expression of NFIX mRNA	20829426
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NFIX mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of NFIX promoter"	26251327
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of NFIX mRNA"	25620056
D009532	Nickel	Nickel results in decreased expression of NFIX mRNA	24768652\|2558310
D009532	Nickel	Nickel results in decreased expression of NFIX mRNA	12540486
C028007	nickel monoxide	nickel monoxide results in increased expression of NFIX mRNA	19167457
C016030	pantogab	pantogab results in decreased expression of NFIX mRNA	17379144
C410127	PCB 180	PCB 180 affects the expression of NFIX mRNA	24050789
C410127	PCB 180	PCB 180 affects the expression of NFIX mRNA	21703328
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of NFIX mRNA	23892564
D010634	Phenobarbital	Phenobarbital results in decreased expression of NFIX mRNA	23091169
D010705	Phosgene	Phosgene affects the expression of NFIX mRNA	16300373
C006253	pirinixic acid	pirinixic acid results in decreased expression of NFIX mRNA	20059764\|2381119
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of NFIX mRNA]	20059764
D011205	Povidone	[Silver analog co-treated with Povidone] results in increased expression of NFIX mRNA	25194297
C035988	procymidone	procymidone results in increased expression of NFIX mRNA	15686871
D011374	Progesterone	Progesterone affects the expression of NFIX mRNA	17251523
C045950	propiconazole	propiconazole results in decreased expression of NFIX mRNA	21278054
C059514	resveratrol	resveratrol results in increased expression of NFIX mRNA	12002526
C059514	resveratrol	resveratrol results in decreased expression of NFIX protein	25505154
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of NFIX mRNA	23806026
D012834	Silver	[Silver analog co-treated with Povidone] results in increased expression of NFIX mRNA	25194297
C009277	sodium arsenate	sodium arsenate results in increased expression of NFIX mRNA	21795629
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNA	12634122
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NFIX mRNA	21641980
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of NFIX mRNA]	19228888
D014284	Triiodothyronine	Triiodothyronine results in increased expression of NFIX mRNA	19228888
D013629	Tamoxifen	Tamoxifen results in decreased expression of NFIX mRNA	15849065
C047246	temozolomide	NFIX mRNA affects the susceptibility to temozolomide	16365179
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NFIX mRNA	24058054
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NFIX mRNA	16054898\|2121527
D013853	Thioacetamide	Thioacetamide results in decreased expression of NFIX mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of NFIX mRNA	23557971
D014241	Trichloroethylene	Trichloroethylene results in increased expression of NFIX mRNA	19448997
D014241	Trichloroethylene	Trichloroethylene results in increased expression of NFIX mRNA	19448997
C057693	troglitazone	troglitazone results in decreased expression of NFIX mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in increased methylation of NFIX gene	29154799
C025643	vinclozolin	vinclozolin affects the expression of NFIX mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of NFIX mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of NFIX mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0003677	DNA binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	TAS	7590749 8340106
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	TAS	7937100
GO:0005515	protein binding	-	IPI	25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	19706729
GO:0006260	DNA replication	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	TAS	7937100
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	19706729

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-73980	RNA Polymerase III Transcription Termination	IEA
R-HSA-74158	RNA Polymerase III Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27602958	Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms. (2016 Oct 25)	Freeman JR	Oncotarget