Gene info: ID 4793

Gene: NFKBIB

GENE ID: 4793

Synonyms: IKBB|TRIP9

Description: NFKB inhibitor beta

Gene type: protein-coding

Location: 19q13.2

dbXrefs: Ensembl:ENSG00000104825 MIM:604495 Vega:OTTHUMG00000177631 UniprotKB:Q15653

RefSeq: NG_029624.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.541e-1 (AD) 4.119e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EEF1D	0.894
RPLP2	0.869
RPS15	0.852
FBL	0.852
RPS9	0.842
FAU	0.842
PTMA	0.841
RPL28	0.84
NENF	0.84
CHMP4A	0.838

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.668
OR4F5	-0.613
HS6ST3	-0.263
HSD3B1	-0.256
ACTA2-AS1	-0.25
GPR52	-0.243
NCR3LG1	-0.239
C4orf45	-0.234
ZIM2	-0.228
PP2D1	-0.227

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C569107	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one	"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased expression of NFKBIB mRNA"	23826121
C569107	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one	"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased expression of NFKBIB protein"	23826121
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of NFKBIB mRNA"	19114083
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of NFKBIB mRNA"	23829299
C003898	2-anisidine	2-anisidine affects the expression of NFKBIB mRNA	28089782
C521391	3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester	"3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester affects the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of NFKBIB protein]"	26790578
C583074	4,4'-hexafluorisopropylidene diphenol	"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NFKBIB protein modified form]"	28751236
D000079	Acetaldehyde	Acetaldehyde results in increased expression of NFKBIB protein	14722113
D000082	Acetaminophen	Acetaminophen results in decreased expression of NFKBIB mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of NFKBIB mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of NFKBIB mRNA	17522070
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]	10381628
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased degradation of NFKBIB protein]	10661865
D020106	Acrylamide	Acrylamide results in increased expression of NFKBIB mRNA	28959563
C000188	alachlor	alachlor inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	15907790
D006710	Homocysteine	Homocysteine results in increased degradation of NFKBIB protein	17586618
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NFKBIB mRNA	16483693
C023650	aniline	aniline results in decreased expression of NFKBIB protein	18420242
D047310	Apigenin	Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]	15322261
C526219	apple polyphenol extract	apple polyphenol extract results in increased expression of NFKBIB mRNA	18351577
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of NFKBIB mRNA	20471514
C006632	arsenic trioxide	arsenic trioxide results in increased expression of NFKBIB mRNA	19769630
D001241	Aspirin	Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIB protein]	14753751
D001241	Aspirin	Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein]	15036249
C052064	astragaloside A	astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]	25604657
C052064	astragaloside A	astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein]	25604657
D001310	Auranofin	Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	10820281
C006680	baicalein	baicalein results in decreased phosphorylation of NFKBIB protein	21803068
D001554	Benzene	Benzene results in increased expression of NFKBIB mRNA	19162166
D001554	Benzene	Benzene metabolite results in decreased degradation of NFKBIB protein	15894107
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NFKBIB mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NFKBIB mRNA	27195522
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NFKBIB mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	11543732
D004958	Estradiol	Estradiol results in increased expression of NFKBIB mRNA	17522070
C006780	bisphenol A	[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NFKBIB protein modified form]	28751236
C006780	bisphenol A	bisphenol A results in increased expression of NFKBIB mRNA	19371625
C006780	bisphenol A	bisphenol A results in increased expression of NFKBIB mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NFKBIB mRNA	28628672
D000069286	Bortezomib	Bortezomib results in increased expression of NFKBIB mRNA	20977926\|2591341
D000069286	Bortezomib	Bortezomib results in increased stability of NFKBIB protein	15543232
C584509	C646 compound	C646 compound results in decreased expression of NFKBIB mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of NFKBIB protein	23948867
D002185	Cannabidiol	Cannabidiol results in increased expression of NFKBIB mRNA	21542829
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of NFKBIB mRNA	17522070
D002258	Carbonyl Cyanide m-Chlorophenyl Hydrazone	Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of NFKBIB protein	15978749
C054133	casticin	casticin results in decreased expression of NFKBIB mRNA	27862857
D012844	Sincalide	[Palmitic Acid co-treated with Sincalide] results in increased degradation of NFKBIB protein	26873426
D012844	Sincalide	Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased degradation of NFKBIB protein]	26873426
C026690	cerous chloride	cerous chloride results in decreased expression of NFKBIB mRNA	21656643
C026690	cerous chloride	cerous chloride results in decreased expression of NFKBIB protein	21656643
D002725	Chloroform	Chloroform results in increased expression of NFKBIB mRNA	17522070
D002726	Chlorogenic Acid	Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]	20026373
D002784	Cholesterol	Cholesterol inhibits the reaction [irbesartan results in increased phosphorylation of NFKBIB protein]	19028402
D002784	Cholesterol	Cholesterol results in increased phosphorylation of NFKBIB protein	19028402
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein	24690739
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein	24690739
D003474	Curcumin	Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16934299
D016572	Cyclosporine	Cyclosporine results in increased expression of NFKBIB mRNA	25562108
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of NFKBIB mRNA	24921660
D017373	Cyproterone Acetate	[Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NFKBIB protein modified form]	28751236
D003545	Cysteine	Cysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]	10381628
D013759	Dronabinol	Dronabinol results in increased expression of NFKBIB mRNA	21542829
C007262	deoxynivalenol	deoxynivalenol results in increased expression of NFKBIB mRNA	22846391
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NFKBIB mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NFKBIB mRNA	28628672
D004041	Dietary Fats	Dietary Fats results in increased expression of NFKBIB mRNA	25016146
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NFKBIB mRNA	18253720
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein	24690739
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein	24690739
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased phosphorylation of NFKBIB protein"	25721693
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of NFKBIB mRNA"	23811387
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NFKBIB mRNA	22079256
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of NFKBIB mRNA	17522070
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NFKBIB mRNA	18253720
D018120	Finasteride	Finasteride results in increased expression of NFKBIB mRNA	24136188
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein	11020383
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased degradation of NFKBIB protein	11020383
D005485	Flutamide	Flutamide results in increased expression of NFKBIB mRNA	24136188
D062610	Fungal Polysaccharides	Fungal Polysaccharides affects the expression of NFKBIB protein	22687552
D005707	Gallic Acid	Gallic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]	21420233
D005897	Glafenine	Glafenine results in increased expression of NFKBIB mRNA	24136188
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of NFKBIB mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of NFKBIB mRNA	17109745
D005944	Glucosamine	IL1B affects the reaction [Glucosamine results in increased expression of NFKBIB mRNA]	17109745
D006861	Hydrogen Peroxide	Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIB protein]	14753751
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIB protein	14753751
D047348	Hydrolyzable Tannins	Hydrolyzable Tannins inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]	20026373
C031927	hydroquinone	hydroquinone results in decreased degradation of NFKBIB protein	15894107
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NFKBIB mRNA	28628672
D007213	Indomethacin	Indomethacin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]	18799549
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NFKBIB mRNA	25613284
C081309	irbesartan	Cholesterol inhibits the reaction [irbesartan results in increased phosphorylation of NFKBIB protein]	19028402
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NFKBIB mRNA	28628672
C570295	labdanolic acid methyl ester	"labdanolic acid methyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIB protein]"	22036724
C570295	labdanolic acid methyl ester	labdanolic acid methyl ester results in decreased degradation of NFKBIB protein	22036724
D007854	Lead	Lead results in decreased expression of NFKBIB mRNA	19921347
C017461	lead nitrate	lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]	11891201
C482199	lipopolysaccharide, E coli O55-B5	"3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester affects the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of NFKBIB protein]"	26790578
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased degradation of NFKBIB protein"	26790578
C440499	lipopolysaccharide, Escherichia coli O111 B4	"labdanolic acid methyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIB protein]"	22036724
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIB protein"	22036724
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased degradation of NFKBIB protein	16890772
D008070	Lipopolysaccharides	Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16890772
D008070	Lipopolysaccharides	sulforafan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16890772
D008070	Lipopolysaccharides	Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16890772
D008070	Lipopolysaccharides	alachlor inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	15907790
D008070	Lipopolysaccharides	Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	10820281
D008070	Lipopolysaccharides	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	11543732
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of NFKBIB protein	12878042
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased degradation of NFKBIB protein	10820281\|1154373
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NFKBIB mRNA	10975854\|2658214
D008070	Lipopolysaccharides	MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	21586572
D008070	Lipopolysaccharides	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	17855475
D008070	Lipopolysaccharides	sodium arsenite inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	23106696
D008070	Lipopolysaccharides	Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16934299
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased degradation of NFKBIB protein	16934299
D047311	Luteolin	Luteolin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]	15322261
C501277	Mangifera indica extract	Mangifera indica extract inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]	21420233
C013592	mangiferin	mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]	21420233
C013592	mangiferin	mangiferin results in decreased expression of NFKBIB mRNA	15135318
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of NFKBIB mRNA	23649840
D015741	Metribolone	[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NFKBIB protein modified form]	28751236
C080418	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	17855475
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of NFKBIB mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of NFKBIB mRNA"	25554681\|2562005
D009285	Naphthoquinones	Naphthoquinones results in increased expression of NFKBIB mRNA	23811387
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of NFKBIB mRNA	17522070
C051752	nefazodone	nefazodone results in increased expression of NFKBIB mRNA	24136188
D009532	Nickel	Nickel results in increased expression of NFKBIB mRNA	25583101
D009538	Nicotine	NFKBIB protein affects the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D019308	Palmitic Acid	[Palmitic Acid co-treated with Sincalide] results in increased degradation of NFKBIB protein	26873426
D019308	Palmitic Acid	Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased degradation of NFKBIB protein]	26873426
D052638	Particulate Matter	Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16890772
C410127	PCB 180	PCB 180 results in increased expression of NFKBIB mRNA	23829299
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of NFKBIB mRNA	19095052
C060836	pioglitazone	pioglitazone inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIB protein]	17055343
D010936	Plant Extracts	Plant Extracts results in increased expression of NFKBIB mRNA	18351577
D028321	Plant Preparations	Plant Preparations results in increased degradation of NFKBIB protein	25019244
D011134	Polysaccharides	Polysaccharides results in increased degradation of NFKBIB protein	25019244
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NFKBIB mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of NFKBIB mRNA	22079256\|2271453
C009091	protocatechuic acid	protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]	20026373
C020972	pyrrolidine dithiocarbamic acid	Acetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased degradation of NFKBIB protein]	10661865
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in decreased degradation of NFKBIB protein	10661865
D011794	Quercetin	Quercetin results in increased expression of NFKBIB mRNA	25862958
D011794	Quercetin	Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased degradation of NFKBIB protein]	26873426
D017382	Reactive Oxygen Species	[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein	11020383
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIB protein]	17055343
C059514	resveratrol	resveratrol affects the reaction [TNF protein results in decreased expression of NFKBIB protein]	16178859
D012643	Selenium	Selenium results in increased expression of NFKBIB mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of NFKBIB mRNA	23221170
C009277	sodium arsenate	sodium arsenate results in decreased expression of NFKBIB mRNA	23922661
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in decreased expression of NFKBIB protein]	24570342
C017947	sodium arsenite	sodium arsenite results in decreased expression of NFKBIB protein	24570342
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of and results in increased degradation of NFKBIB protein	11835400
C017947	sodium arsenite	sodium arsenite inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	23106696
D053260	Soot	Soot results in increased expression of NFKBIB mRNA	26551751
C016766	sulforafan	sulforafan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16890772
D016559	Tacrolimus	Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NFKBIB protein]	18172213\|1817288
D013629	Tamoxifen	Tamoxifen inhibits the reaction [ESR1 protein binds to NFKBIB protein]	23665804
D013656	Taurocholic Acid	astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]	25604657
D013656	Taurocholic Acid	astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein]	25604657
D013656	Taurocholic Acid	Taurocholic Acid results in decreased expression of NFKBIB mRNA	25604657
D013656	Taurocholic Acid	Taurocholic Acid results in decreased expression of NFKBIB protein	25604657
D013739	Testosterone	Testosterone results in decreased expression of NFKBIB mRNA	20403060
D013749	Tetrachlorodibenzodioxin	Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NFKBIB protein]	18172213\|1817288
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NFKBIB mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NFKBIB promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NFKBIB mRNA	21354282
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NFKBIB protein	18172213\|1817288
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NFKBIB mRNA	21215274
D013752	Tetracycline	Tetracycline results in increased expression of NFKBIB mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]	20026373
D013755	Tetradecanoylphorbol Acetate	Hydrolyzable Tannins inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]	20026373
D013755	Tetradecanoylphorbol Acetate	protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]	20026373
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein	20026373
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NFKBIB mRNA	25613284
D019284	Thapsigargin	Thapsigargin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]	18799549
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of NFKBIB mRNA	28065790
C024746	tobacco tar	tobacco tar results in decreased degradation of NFKBIB protein	15894107
D014108	Tosylphenylalanyl Chloromethyl Ketone	Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]	10381628
D014108	Tosylphenylalanyl Chloromethyl Ketone	Cysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]	10381628
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein	10381628
D014118	Toxins, Biological	"Toxins, Biological affects the expression of NFKBIB mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased degradation of NFKBIB protein	18280257
D014241	Trichloroethylene	Trichloroethylene results in increased expression of NFKBIB mRNA	19448997
D014638	Vanadates	Vanadates results in decreased expression of NFKBIB mRNA	22714537
C034028	vanadyl sulfate	vanadyl sulfate results in increased degradation of NFKBIB protein	10521501
D001335	Vehicle Emissions	Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]	16890772
D014810	Vitamin E	Vitamin E results in increased expression of NFKBIB mRNA	19244175
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of NFKBIB mRNA	12756304
D015054	Zymosan	Zymosan results in increased degradation of NFKBIB protein	18694995

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003713	transcription coactivator activity	-	TAS	7776974
GO:0005515	protein binding	-	IPI	10498867 14685242 14743216 15601829 21988832 24973451 25241761 25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006351	transcription, DNA-templated	-	TAS	7776974
GO:0007165	signal transduction	-	TAS	7776974
GO:0071222	cellular response to lipopolysaccharide	-	IEA	-
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05131	Shigellosis
hsa05140	Leishmaniasis
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24498427	Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. (2014)	Ryan DM	PLoS One