Gene info: ID 4794

Gene: NFKBIE

GENE ID: 4794

Synonyms: IKBE

Description: NFKB inhibitor epsilon

Gene type: protein-coding

Location: 6p21.1

dbXrefs: Ensembl:ENSG00000146232 MIM:604548 Vega:OTTHUMG00000014762 UniprotKB:O00221

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.301e-1 (AD) 8.059e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg00668559	chr6:44230977	NFKBIE		4.300e-17	Smoking	27651444
cg15787744	chr6:44234175	NFKBIE		1.500e-10	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IER5	0.775
NTMT1	0.766
UBE2S	0.762
UBE2F	0.749
HMGA1	0.749
ZFAND2A	0.744
ZNF513	0.744
VOPP1	0.741
FNDC4	0.737
HM13	0.736

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.495
OR4F29	-0.436
P2RY14	-0.362
CTNNA3	-0.35
CYP4B1	-0.327
OMD	-0.323
ADH1B	-0.316
VNN2	-0.312
TRPV5	-0.311
OCLN	-0.31

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of NFKBIE mRNA	28329830
C003898	2-anisidine	2-anisidine affects the expression of NFKBIE mRNA	28089782
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of NFKBIE mRNA"	25380136
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of NFKBIE mRNA	19191707
D000082	Acetaminophen	Acetaminophen affects the expression of NFKBIE mRNA	25458485
D000082	Acetaminophen	Acetaminophen affects the expression of NFKBIE mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of NFKBIE mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of NFKBIE protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of NFKBIE mRNA	19770486
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of NFKBIE mRNA	18247414
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of NFKBIE mRNA	17696278
D001151	Arsenic	NFKBIE mRNA results in decreased susceptibility to Arsenic	17976673
C006632	arsenic trioxide	arsenic trioxide results in decreased degradation of and results in increased stability of NFKBIE protein	12560223
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of NFKBIE mRNA	20471514
C006632	arsenic trioxide	Bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of NFKBIE mRNA]	20471514
C015001	arsenite	arsenite results in decreased expression of NFKBIE mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of NFKBIE mRNA]	18929588
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of NFKBIE mRNA"	18687144\|2535159
D001280	Atrazine	Atrazine results in increased expression of NFKBIE mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NFKBIE mRNA	18247414
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NFKBIE mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NFKBIE mRNA	19770486
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIE protein]	12185005
C006780	bisphenol A	bisphenol A results in decreased expression of NFKBIE mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of NFKBIE mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of NFKBIE mRNA	25181051
D000069286	Bortezomib	Bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of NFKBIE mRNA]	20471514
D000069286	Bortezomib	Bortezomib results in increased stability of NFKBIE protein	15543232
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of NFKBIE mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in increased expression of NFKBIE mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of NFKBIE promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of NFKBIE protein	17544377
C054133	casticin	casticin results in decreased expression of NFKBIE mRNA	27862857
D002737	Chloroprene	Chloroprene results in decreased expression of NFKBIE mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NFKBIE gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of NFKBIE mRNA	28472532
D002922	Ciguatoxins	Ciguatoxins affects the expression of NFKBIE mRNA	18353800
D016572	Cyclosporine	Cyclosporine results in increased expression of NFKBIE mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of NFKBIE mRNA	23958496
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of NFKBIE mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of NFKBIE mRNA	21266533
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NFKBIE protein	23301498
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of NFKBIE mRNA	28329830
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NFKBIE gene	20938992
C002469	fusarenon-X	fusarenon-X results in increased expression of NFKBIE mRNA	24983900
C056507	gemcitabine	gemcitabine affects the expression of NFKBIE mRNA	17039268
D017313	Fenretinide	Fenretinide results in increased expression of NFKBIE mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of NFKBIE mRNA	20044591
C492448	ICG 001	ICG 001 results in increased expression of NFKBIE mRNA	26191083
D007213	Indomethacin	Indomethacin results in increased expression of NFKBIE mRNA	28201806
C011890	kojic acid	kojic acid results in increased expression of NFKBIE mRNA	16595896
C045463	leflunomide	leflunomide results in decreased expression of NFKBIE mRNA	19751817
D008070	Lipopolysaccharides	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIE protein]	12185005
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of NFKBIE protein	12185005
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased degradation of NFKBIE protein	17855110
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NFKBIE mRNA	25890327\|2658214
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of NFKBIE mRNA	21641980
C013592	mangiferin	mangiferin results in decreased expression of NFKBIE mRNA	15135318
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NFKBIE gene	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of NFKBIE mRNA	17696278
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of NFKBIE mRNA	25234470
D009151	Mustard Gas	Mustard Gas results in increased expression of NFKBIE mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of NFKBIE mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of NFKBIE mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of NFKBIE mRNA	25380136
D009532	Nickel	Nickel results in increased expression of NFKBIE mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of NFKBIE mRNA	19167457
D009538	Nicotine	Nicotine results in decreased expression of NFKBIE mRNA	18247414
C507134	ON 01910	ON 01910 affects the expression of NFKBIE mRNA	22351695
C016030	pantogab	pantogab results in decreased expression of NFKBIE mRNA	17379144
D052638	Particulate Matter	[NFKBIE gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of NFKBIE mRNA	21222557\|2122255
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of NFKBIE mRNA	18593933
C046012	pentanal	pentanal results in increased expression of NFKBIE mRNA	26079696
D010634	Phenobarbital	Phenobarbital affects the expression of NFKBIE mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of NFKBIE mRNA	23091169
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NFKBIE mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of NFKBIE mRNA	20059764
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of NFKBIE mRNA]	20059764
D011441	Propylthiouracil	Propylthiouracil results in increased expression of NFKBIE mRNA	24780913
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA	19059307
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of NFKBIE mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of NFKBIE mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of NFKBIE mRNA	19073995
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of NFKBIE mRNA	23221170
D053260	Soot	Soot results in increased expression of NFKBIE mRNA	26551751
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of NFKBIE mRNA	21641980
D016559	Tacrolimus	Tacrolimus results in increased expression of NFKBIE mRNA	23958496
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA	19059307
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NFKBIE mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NFKBIE mRNA	19770486
C009495	titanium dioxide	titanium dioxide results in increased expression of NFKBIE mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of NFKBIE mRNA	20133372
D014520	Urethane	Urethane results in increased expression of NFKBIE mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of NFKBIE mRNA	22083351
D014635	Valproic Acid	Valproic Acid affects the expression of NFKBIE mRNA	17292431
D014640	Vancomycin	Vancomycin results in decreased expression of NFKBIE mRNA	18930951
D001335	Vehicle Emissions	[NFKBIE gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of NFKBIE mRNA	21222557\|2122255
C025643	vinclozolin	vinclozolin results in increased methylation of NFKBIE promoter	22570695
C029297	vinylidene chloride	vinylidene chloride results in increased expression of NFKBIE mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of NFKBIE mRNA	20044591
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of NFKBIE mRNA	18593933
D015054	Zymosan	Zymosan results in increased degradation of NFKBIE protein	18694995

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	14743216 16769727 21988832

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0042942	D-serine transport	-	IEA	-
GO:0042994	cytoplasmic sequestering of transcription factor	-	TAS	9135156

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001650	fibrillar center	-	IDA	-
GO:0005634	nucleus	-	IDA	-
GO:0005737	cytoplasm	-	TAS	9135156
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0048471	perinuclear region of cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23577190	PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)	Suzuki T	PLoS One
28542447	Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women. (2017)	Wang X	PLoS One
29574730	Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression. (2018 Mar 25)	White PC	J Periodontal Res