Gene: NFKBIL1

4795
IKBL|LST1|NFKBIL
NFKB inhibitor like 1
protein-coding
6p21.33
Ensembl:ENSG00000204498 MIM:601022 Vega:OTTHUMG00000031038 UniprotKB:Q9UBC1
NG_012344.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20248972chr6:31515526NFKBIL1Promoter2.320e-4Alcohol use disorders26763658
cg16806077chr6:31513198NFKBIL1Promoter5.552e-4Alcohol use disorders26763658
cg21587837chr6:31525894NFKBIL12.200e-9Smoking27651444
cg21053741chr6:31525861NFKBIL11.340e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRPF310.914
THAP30.91
ARFRP10.909
CUTA0.907
THAP40.906
VPS280.906
NAA100.906
MRPL380.905
GIPC10.905
AURKAIP10.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.694
OR4F29-0.664
MTRNR2L6-0.385
MTRNR2L9-0.379
PZP-0.359
MTRNR2L10-0.359
FER1L6-0.354
KRT73-0.35
CEACAM3-0.349
KLRB1-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of NFKBIL1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of NFKBIL1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NFKBIL1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NFKBIL1 mRNA27195522
C006780bisphenol Abisphenol A results in increased expression of NFKBIL1 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of NFKBIL1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of NFKBIL1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NFKBIL1 promoter22457795
D016572CyclosporineCyclosporine results in increased expression of NFKBIL1 mRNA25562108
D002945CisplatinCisplatin results in increased expression of NFKBIL1 mRNA27594783
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFKBIL1 mRNA17942748
C016517indole-3-carbinolindole-3-carbinol affects the expression of NFKBIL1 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NFKBIL1 mRNA25613284
C013592mangiferinmangiferin results in decreased expression of NFKBIL1 mRNA15135318
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NFKBIL1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NFKBIL1 mRNA"20188158
C005273naringeninnaringenin results in increased expression of NFKBIL1 mRNA27838343
C005273naringeninnaringenin results in increased expression of NFKBIL1 protein27838343
D011374ProgesteroneProgesterone results in increased expression of NFKBIL1 mRNA21549006
D013605T-2 ToxinT-2 Toxin results in increased expression of NFKBIL1 mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFKBIL1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFKBIL1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NFKBIL1 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NFKBIL1 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of NFKBIL1 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NFKBIL1 gene27618143
D014635Valproic AcidValproic Acid affects the expression of NFKBIL1 mRNA25979313
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NFKBIL1 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  20829348  
GO ID GO Term Qualifier Evidence PubMed
GO:0007249I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway-IDA20829348  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA20829348  
GO:0032720negative regulation of tumor necrosis factor production-IMP20829348  
GO:0034122negative regulation of toll-like receptor signaling pathway-IBA21873635  
GO:0034122negative regulation of toll-like receptor signaling pathway-IDA20829348  
GO:0042994cytoplasmic sequestering of transcription factor-TAS8081366  
GO:0071222cellular response to lipopolysaccharide-IDA20829348  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20829348  
GO:0005829cytosol-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29744169Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)Heikkinen AMClin Exp Dent Res