Gene info: ID 4800

Gene: NFYA

GENE ID: 4800

Synonyms: CBF-A|CBF-B|HAP2|NF-YA

Description: nuclear transcription factor Y subunit alpha

Gene type: protein-coding

Location: 6p21.1

dbXrefs: Ensembl:ENSG00000001167 MIM:189903 Vega:OTTHUMG00000014669 UniprotKB:P23511

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.018e-1 (AD) 3.942e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATXN1L	0.892
PHF10	0.86
ZNF621	0.852
PTPN11	0.849
ANKIB1	0.844
KIF16B	0.844
ZFP91	0.841
FRS2	0.822
SYNJ2BP	0.817
DYNC1LI2	0.816

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.546
OR4F5	-0.488
NPW	-0.28
KCNG2	-0.236
MUC12	-0.215
PRSS56	-0.214
GSG1	-0.212
LRRC26	-0.209
TGFBR3L	-0.207
OR2T35	-0.205

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"	25510870
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of NFYA mRNA"	18648102
D000082	Acetaminophen	Acetaminophen results in increased expression of NFYA mRNA	21420995
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of NFYA gene	27153756
D001151	Arsenic	Arsenic affects the methylation of NFYA gene	25304211
D001205	Ascorbic Acid	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of NFYA mRNA	16443354
D001554	Benzene	Benzene results in decreased expression of NFYA mRNA	21382456
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NFYA mRNA	20064835\|2623829
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of NFYA mRNA"	26238291
C006780	bisphenol A	bisphenol A affects the expression of NFYA mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of NFYA mRNA	25181051
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of NFYA mRNA]	20360939
D002994	Clofibrate	Clofibrate results in decreased expression of NFYA mRNA	16081524
D003033	Coal Tar	Coal Tar results in decreased expression of NFYA mRNA	27858113
D019327	Copper Sulfate	Copper Sulfate results in increased expression of NFYA mRNA	19549813
D003474	Curcumin	Curcumin results in decreased expression of NFYA mRNA	15713895
D016572	Cyclosporine	Cyclosporine results in increased expression of NFYA mRNA	25562108
D003703	Demecolcine	Demecolcine results in increased expression of NFYA mRNA	23649840
D003976	Diazinon	Diazinon results in increased methylation of NFYA gene	22964155
D002945	Cisplatin	Cisplatin promotes the reaction [NFYA protein binds to TP63 protein]	20959455
D002945	Cisplatin	Cisplatin results in increased expression of NFYA protein	20959455
D002945	Cisplatin	TP63 protein alternative form promotes the reaction [Cisplatin results in increased expression of NFYA protein]	20959455
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of NFYA mRNA	26924002
D004052	Diethylnitrosamine	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of NFYA mRNA]	20360939
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of NFYA mRNA	20360939
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of NFYA mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of NFYA mRNA	20463971
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NFYA protein	23301498
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NFYA mRNA	22079256
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of NFYA mRNA	23649840
D005038	Ethylnitrosourea	Ethylnitrosourea promotes the reaction [NFYA protein binds to KRAS exon]	16271038
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased activity of NFYA protein	16271038
D005472	Fluorouracil	Fluorouracil inhibits the reaction [NFYA protein binds to UBE2C promoter]	27129209
D005472	Fluorouracil	Fluorouracil promotes the reaction [NFYA protein binds to UBE2C promoter]	27129209
D005472	Fluorouracil	TP53 protein mutant form affects the reaction [Fluorouracil promotes the reaction [NFYA protein binds to UBE2C promoter]]	27129209
D005557	Formaldehyde	Formaldehyde results in decreased expression of NFYA mRNA	20655997
C008261	lead acetate	lead acetate results in increased expression of NFYA mRNA	21829687
C045463	leflunomide	leflunomide results in decreased expression of NFYA mRNA	28988120
D008727	Methotrexate	Methotrexate affects the expression of NFYA mRNA	18502557
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon]	16271038
D008748	Methylcholanthrene	Methylcholanthrene results in increased activity of NFYA protein	16271038
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of NFYA mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of NFYA mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NFYA mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NFYA mRNA"	20188158
D016685	Mitomycin	Mitomycin results in increased expression of NFYA mRNA	12760830
D016685	Mitomycin	NFYA protein affects the susceptibility to Mitomycin	16217747
C022838	nickel chloride	nickel chloride results in increased expression of NFYA mRNA	17547211
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"	25510870
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of NFYA mRNA	24642059
D019800	Phenol	Phenol results in increased expression of NFYA mRNA	17547211
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NFYA mRNA	19710929
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NFYA mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of NFYA mRNA	22079256
D011441	Propylthiouracil	Propylthiouracil results in increased expression of NFYA mRNA	24780913
D011794	Quercetin	Quercetin inhibits the reaction [NFYA protein binds to CCNB1 promoter]	19009557
D012293	Rifampin	Rifampin results in decreased expression of NFYA mRNA	24552687
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of NFYA mRNA	27862939
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NFYA mRNA	21570461\|2405805
C099150	trabectedin	trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein]	15961672
D014212	Tretinoin	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of NFYA mRNA	16443354
D014212	Tretinoin	Tretinoin results in increased expression of NFYA mRNA	23724009
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NFYA mRNA"	26179874
D014520	Urethane	Urethane results in increased expression of NFYA mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of NFYA mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of NFYA mRNA	28001369
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of NFYA gene	25560391
C111237	vorinostat	vorinostat results in increased expression of NFYA mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	contributes_to	IDA	11256944
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0003677	DNA binding	-	IDA	15243141
GO:0003700	DNA-binding transcription factor activity	-	TAS	1774067 2000400
GO:0005515	protein binding	-	IPI	10571058 12659632 12741956 15243141 16189514 16959611 19060904 20936779 23332751 25416956
GO:0044212	transcription regulatory region DNA binding	contributes_to	IDA	11256944

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006355	regulation of transcription, DNA-templated	-	IDA	15243141
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	TAS	2000400
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0048511	rhythmic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	15243141 15964792
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0016602	CCAAT-binding factor complex	-	IDA	15243141
GO:0032993	protein-DNA complex	-	IDA	11256944
GO:0090575	RNA polymerase II transcription factor complex	-	IDA	11256944

KEGG ID	KEGG Term
hsa04612	Antigen processing and presentation

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	TAS
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	IEA
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	IEA
R-HSA-380994	ATF4 activates genes	TAS
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	TAS
R-HSA-381042	PERK regulates gene expression	TAS
R-HSA-381119	Unfolded Protein Response (UPR)	TAS
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-8957322	Metabolism of steroids	TAS
R-HSA-8957322	Metabolism of steroids	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25177835	A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. (2014 Oct)	Faisal M	Comput Biol Med