Gene: NFYA

4800
CBF-A|CBF-B|HAP2|NF-YA
nuclear transcription factor Y subunit alpha
protein-coding
6p21.1
Ensembl:ENSG00000001167 MIM:189903 Vega:OTTHUMG00000014669 UniprotKB:P23511
NC_000006.12
PubMed
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.018e-1 (AD)  3.942e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATXN1L0.892
PHF100.86
ZNF6210.852
PTPN110.849
ANKIB10.844
KIF16B0.844
ZFP910.841
FRS20.822
SYNJ2BP0.817
DYNC1LI20.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.546
OR4F5-0.488
NPW-0.28
KCNG2-0.236
MUC12-0.215
PRSS56-0.214
GSG1-0.212
LRRC26-0.209
TGFBR3L-0.207
OR2T35-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NFYA mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of NFYA mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NFYA gene27153756
D001151ArsenicArsenic affects the methylation of NFYA gene25304211
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of NFYA mRNA16443354
D001554BenzeneBenzene results in decreased expression of NFYA mRNA21382456
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NFYA mRNA20064835|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of NFYA mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of NFYA mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NFYA mRNA25181051
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of NFYA mRNA]20360939
D002994ClofibrateClofibrate results in decreased expression of NFYA mRNA16081524
D003033Coal TarCoal Tar results in decreased expression of NFYA mRNA27858113
D019327Copper SulfateCopper Sulfate results in increased expression of NFYA mRNA19549813
D003474CurcuminCurcumin results in decreased expression of NFYA mRNA15713895
D016572CyclosporineCyclosporine results in increased expression of NFYA mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of NFYA mRNA23649840
D003976DiazinonDiazinon results in increased methylation of NFYA gene22964155
D002945CisplatinCisplatin promotes the reaction [NFYA protein binds to TP63 protein]20959455
D002945CisplatinCisplatin results in increased expression of NFYA protein20959455
D002945CisplatinTP63 protein alternative form promotes the reaction [Cisplatin results in increased expression of NFYA protein]20959455
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NFYA mRNA26924002
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of NFYA mRNA]20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NFYA mRNA20360939
C024629dimethyl phthalatedimethyl phthalate affects the expression of NFYA mRNA26924002
D004147DioxinsDioxins affects the expression of NFYA mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NFYA protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NFYA mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NFYA mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea promotes the reaction [NFYA protein binds to KRAS exon]16271038
D005038EthylnitrosoureaEthylnitrosourea results in increased activity of NFYA protein16271038
D005472FluorouracilFluorouracil inhibits the reaction [NFYA protein binds to UBE2C promoter]27129209
D005472FluorouracilFluorouracil promotes the reaction [NFYA protein binds to UBE2C promoter]27129209
D005472FluorouracilTP53 protein mutant form affects the reaction [Fluorouracil promotes the reaction [NFYA protein binds to UBE2C promoter]]27129209
D005557FormaldehydeFormaldehyde results in decreased expression of NFYA mRNA20655997
C008261lead acetatelead acetate results in increased expression of NFYA mRNA21829687
C045463leflunomideleflunomide results in decreased expression of NFYA mRNA28988120
D008727MethotrexateMethotrexate affects the expression of NFYA mRNA18502557
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon]16271038
D008748MethylcholanthreneMethylcholanthrene results in increased activity of NFYA protein16271038
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NFYA mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NFYA mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NFYA mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NFYA mRNA"20188158
D016685MitomycinMitomycin results in increased expression of NFYA mRNA12760830
D016685MitomycinNFYA protein affects the susceptibility to Mitomycin16217747
C022838nickel chloridenickel chloride results in increased expression of NFYA mRNA17547211
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NFYA mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of NFYA mRNA24642059
D019800PhenolPhenol results in increased expression of NFYA mRNA17547211
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NFYA mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of NFYA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NFYA mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of NFYA mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [NFYA protein binds to CCNB1 promoter]19009557
D012293RifampinRifampin results in decreased expression of NFYA mRNA24552687
D012969Sodium FluorideSodium Fluoride results in decreased expression of NFYA mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFYA mRNA21570461|2405805
C099150trabectedintrabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein]15961672
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of NFYA mRNA16443354
D014212TretinoinTretinoin results in increased expression of NFYA mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NFYA mRNA"26179874
D014520UrethaneUrethane results in increased expression of NFYA mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NFYA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NFYA mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NFYA gene25560391
C111237vorinostatvorinostat results in increased expression of NFYA mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toIDA11256944  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IDA15243141  
GO:0003700DNA-binding transcription factor activity-TAS1774067  2000400  
GO:0005515protein binding-IPI10571058  12659632  12741956  15243141  16189514  16959611  
19060904  20936779  23332751  25416956  
GO:0044212transcription regulatory region DNA bindingcontributes_toIDA11256944  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IDA15243141  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-TAS2000400  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0048511rhythmic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15243141  15964792  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0016602CCAAT-binding factor complex-IDA15243141  
GO:0032993protein-DNA complex-IDA11256944  
GO:0090575RNA polymerase II transcription factor complex-IDA11256944  
KEGG ID KEGG Term
hsa04612Antigen processing and presentation
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)IEA
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)IEA
R-HSA-380994ATF4 activates genesTAS
R-HSA-381033ATF6 (ATF6-alpha) activates chaperonesTAS
R-HSA-381042PERK regulates gene expressionTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-381183ATF6 (ATF6-alpha) activates chaperone genesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8957322Metabolism of steroidsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25177835A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. (2014 Oct)Faisal MComput Biol Med