Gene: NGFR

4804
CD271|Gp80-LNGFR|TNFRSF16|p75(NTR)|p75NTR
nerve growth factor receptor
protein-coding
17q21.33
Ensembl:ENSG00000064300 MIM:162010 Vega:OTTHUMG00000161495 UniprotKB:P08138
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.824e-1 (AD)  9.895e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17369032chr17:47590326NGFR3.880e-9Maternal smoking in pregnancy27040690
cg17369032chr17:47590326NGFR5.400e-14Maternal smoking in pregnancy27040690
cg17369032chr17:47590326NGFR1.570e-14Maternal smoking in pregnancy27040690
cg12561474chr17:47590237NGFR7.250e-9Maternal smoking in pregnancy27040690
cg06943627chr17:47590179NGFR5.520e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPSB10.807
GDNF0.769
FZD50.763
BIRC30.761
TNFRSF12A0.76
LMNA0.759
CLCF10.757
RRBP10.727
SNAI10.727
TNFAIP60.723

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN1-0.454
KCNQ4-0.441
KIT-0.44
VIP-0.427
CUX2-0.426
IGF1-0.422
ERBB4-0.414
DBH-0.411
SCRT1-0.409
LYPD6-0.407

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of NGFR mRNA"16269432
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of NGFR mRNA"19162173
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NGFR mRNA"23196670
C4824923,4,5,4'-tetramethoxystilbene"3,4,5,4'-tetramethoxystilbene results in increased expression of NGFR mRNA"22687606
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]18056468
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of NGFR mRNA]18056468
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NGFR mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of NGFR mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of NGFR mRNA17088403
D000082AcetaminophenAcetaminophen results in increased expression of NGFR protein17088403
D000082AcetaminophenN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Acetaminophen results in increased expression of NGFR mRNA]17088403
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NGFR mRNA21632981|2210060
D000447AldehydesAldehydes results in increased expression of NGFR mRNA25014914
D000452AldrinAldrin results in increased expression of NGFR mRNA18579281
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of NGFR mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NGFR mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NGFR protein16483693
D001241AspirinAspirin analog results in increased expression of NGFR protein17447067
D001280AtrazineAtrazine results in decreased expression of NGFR mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NGFR mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NGFR mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NGFR mRNA21964900
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NGFR mRNA21839799
D004958EstradiolEstradiol results in increased expression of NGFR mRNA20106945|2163298
D004958EstradiolEstradiol results in increased expression of NGFR mRNA25210133
C006780bisphenol Abisphenol A affects the expression of NGFR mRNA20170705
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NGFR mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of NGFR mRNA25181051
D001905Botulinum ToxinsBotulinum Toxins results in increased expression of NGFR protein8089707
C018475butyraldehydebutyraldehyde results in increased expression of NGFR mRNA26079696
D020148Butyric AcidButyric Acid results in increased expression of NGFR mRNA12800193
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NGFR protein21796402
D019256Cadmium ChlorideNGFR protein affects the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]21796402
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in increased expression of NGFR protein20836997
C055494caffeic acid phenethyl esterNGFR protein affects the susceptibility to caffeic acid phenethyl ester20836997
C055494caffeic acid phenethyl esterNGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in decreased activity of MMP2 protein]20836997
C055494caffeic acid phenethyl esterNGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in decreased activity of MMP9 protein]20836997
C055494caffeic acid phenethyl esterNGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of GFAP protein]20836997
C055494caffeic acid phenethyl esterNGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of RHOB protein]20836997
C055494caffeic acid phenethyl esterNGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of S100B protein]20836997
D000074262Canola OilCanola Oil metabolite results in increased expression of NGFR mRNA27363782
D002211CapsaicinCapsaicin results in decreased expression of NGFR mRNA8971780
D002211CapsaicinCapsaicin results in increased expression of NGFR protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of NGFR protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of NGFR protein]22150557
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NGFR mRNA17805973
D000068579CelecoxibCelecoxib results in increased expression of NGFR mRNA17447067
D000068579CelecoxibCelecoxib results in increased expression of NGFR protein17447067
D002509CephaloridineCephaloridine results in increased expression of NGFR mRNA18500788
D004390ChlorpyrifosChlorpyrifos results in increased expression of NGFR mRNA27163631
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NGFR gene20938992
C480342clothianidinclothianidin results in increased expression of NGFR mRNA29044138
D003024ClozapineClozapine results in decreased expression of NGFR protein14598305
D003024ClozapineClozapine results in decreased expression of NGFR protein alternative form14598305
D003024ClozapineClozapine results in decreased expression of NGFR mRNA12111809|1651314
D019327Copper SulfateCopper Sulfate results in increased expression of NGFR mRNA18579281
C029892cupric chloridecupric chloride results in increased expression of NGFR mRNA24650576
D003520CyclophosphamideCyclophosphamide results in increased expression of NGFR mRNA18189308
D003520CyclophosphamideCyclophosphamide results in increased expression of NGFR protein18189308|1884282
D016572Cyclosporine[Cyclosporine co-treated with NGF protein] results in increased expression of NGFR mRNA24244623
D016572CyclosporineCyclosporine results in increased expression of NGFR mRNA20106945
D016572CyclosporineNGFR protein affects the reaction [[Cyclosporine co-treated with NGF protein] results in increased activity of CASP9 protein]24244623
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NGFR mRNA23640034
C014347decitabinedecitabine results in increased expression of NGFR mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NGFR mRNA28628672
D003976DiazinonDiazinon affects the expression of NGFR mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NGFR mRNA21266533
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of NGFR mRNA]27392435
D002945CisplatinCisplatin results in increased expression of NGFR mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of NGFR mRNA]27392435
D002117CalcitriolCalcitriol results in increased expression of NGFR mRNA26485663
D002117CalcitriolCalcitriol affects the activity of NGFR promoter8883959
D002117CalcitriolCalcitriol results in decreased expression of NGFR mRNA8883959
D002117CalcitriolCalcitriol results in increased expression of NGFR mRNA8883959
D002117CalcitriolCalcitriol results in increased expression of NGFR protein8883959
C521792DMU-212DMU-212 results in increased expression of NGFR mRNA22687606
D000431EthanolEthanol results in increased expression of NGFR mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NGFR mRNA17351261|2017070
C044894ethylcholine aziridiniumethylcholine aziridinium results in increased expression of NGFR protein15680337
C044894ethylcholine aziridiniumGlycosaminoglycans inhibits the reaction [ethylcholine aziridinium results in increased expression of NGFR protein]15680337
C033789fenarimolfenarimol results in increased expression of NGFR mRNA28970091
D005279FenoprofenFenoprofen results in increased expression of NGFR protein17409433
D005473FluoxetineNGFR protein results in increased susceptibility to Fluoxetine19621217
D005480Flurbiprofen4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Flurbiprofen results in increased expression of NGFR mRNA]18056468
D005480FlurbiprofenELAVL1 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]18056468
D005480FlurbiprofenFlurbiprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]18056468
D005480FlurbiprofenFlurbiprofen results in increased expression of NGFR mRNA17447067
D005480FlurbiprofenFlurbiprofen results in increased expression of NGFR protein17409433|1744706
D005480FlurbiprofenFlurbiprofen results in increased stability of and results in increased expression of NGFR mRNA18056468
D005480FlurbiprofenMAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]18056468
D005480FlurbiprofenMAPK14 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]18056468
D005480FlurbiprofenMAPKAPK2 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]18056468
D005480FlurbiprofenMAPKAPK3 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]18056468
D005480FlurbiprofenNGFR protein promotes the reaction [Flurbiprofen results in increased expression of GDF15 protein]21097678
C061365flusilazoleflusilazole results in increased expression of NGFR mRNA28263823
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NGFR gene20938992
D004397FonofosFonofos results in increased methylation of NGFR promoter22847954
D005632FructoseFructose results in decreased expression of NGFR mRNA18585860
C069837fullerene C60fullerene C60 results in increased expression of NGFR mRNA19167457
C002469fusarenon-Xfusarenon-X results in decreased expression of NGFR mRNA24983900
D019833GenisteinGenistein results in increased expression of NGFR mRNA26865667
C049863ginsenoside Rdginsenoside Rd results in increased expression of NGFR mRNA24599032
C049863ginsenoside Rdginsenoside Rd results in increased expression of NGFR protein24599032
C049864ginsenoside Reginsenoside Re results in increased expression of NGFR mRNA24599032
C049864ginsenoside Reginsenoside Re results in increased expression of NGFR protein24599032
C017343glyceollinglyceollin results in increased expression of NGFR mRNA19797619
D006025GlycosaminoglycansGlycosaminoglycans inhibits the reaction [ethylcholine aziridinium results in increased expression of NGFR protein]15680337
D006220HaloperidolHaloperidol results in decreased expression of NGFR mRNA16513140
D007052Ibuprofen4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of NGFR mRNA]18056468
D007052IbuprofenELAVL1 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]18056468
D007052IbuprofenIbuprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]18056468
D007052IbuprofenIbuprofen results in increased expression of NGFR mRNA17447067
D007052IbuprofenIbuprofen results in increased expression of NGFR protein17409433|1744706
D007052IbuprofenIbuprofen results in increased stability of and results in increased expression of NGFR mRNA18056468
D007052IbuprofenMAPK11 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]18056468
D007052IbuprofenMAPK14 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]18056468
D007052IbuprofenMAPKAPK2 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]18056468
D007052IbuprofenMAPKAPK3 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]18056468
D007052IbuprofenNGFR protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]21097678
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NGFR mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NGFR mRNA28628672
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of NGFR mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of NGFR mRNA]27392435
D007654KetoconazoleKetoconazole results in increased expression of NGFR mRNA28263823
D007660KetoprofenKetoprofen results in increased expression of NGFR protein17409433
D007854LeadLead results in decreased expression of [NTRK2 protein binds to NGFR protein]22345308
D007854LeadLead results in increased expression of NGFR protein22345308
C575077LM11A-31LM11A-31 binds to NGFR protein25277379
C025340manganese chloridemanganese chloride results in increased methylation of NGFR gene27913844
D009637MasoprocolMasoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
D009637MasoprocolMasoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
D008628MercuryMercury results in decreased expression of NGFR mRNA7781173
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NGFR gene20938992
D008727MethotrexateMethotrexate results in decreased expression of NGFR mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NGFR mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NGFR mRNA24810058
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Acetaminophen results in increased expression of NGFR mRNA]17088403
C488176N-acetyl-S-(alpha-methyl-4-(2-methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl esterN-acetyl-S-(alpha-methyl-4-(2-methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester results in increased expression of NGFR mRNA17447067
C488176N-acetyl-S-(alpha-methyl-4-(2-methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl esterN-acetyl-S-(alpha-methyl-4-(2-methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester results in increased expression of NGFR protein17447067
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of NGFR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NGFR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NGFR mRNA"25554681
D009288NaproxenNaproxen results in increased expression of NGFR protein17409433
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of NGFR protein]22150557
C008729oxaprozinoxaprozin results in increased expression of NGFR protein17409433
D010100OxygenNGFR protein results in increased susceptibility to Oxygen11463606
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of NGFR mRNA26272509
D010269ParaquatParaquat affects the expression of NGFR mRNA15206577
D010278ParathionParathion results in increased methylation of NGFR promoter22847954
C096822PD 90780PD 90780 inhibits the reaction [NGF protein binds to NGFR protein]18842820
C074968pentaacetyl geniposide2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C074968pentaacetyl geniposide2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C074968pentaacetyl geniposideMasoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C074968pentaacetyl geniposideMasoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C074968pentaacetyl geniposidepentaacetyl geniposide results in increased expression of NGFR mRNA17651887
C074968pentaacetyl geniposidepentaacetyl geniposide results in increased expression of NGFR protein17651887
C074968pentaacetyl geniposidepyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C074968pentaacetyl geniposidepyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C074968pentaacetyl geniposidepyrrolidine dithiocarbamic acid inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C074968pentaacetyl geniposidepyrrolidine dithiocarbamic acid inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C074968pentaacetyl geniposideSB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C074968pentaacetyl geniposideSB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C046012pentanalpentanal results in increased expression of NGFR mRNA26079696
D010575PesticidesPesticides results in decreased methylation of NGFR gene28396702
D010634PhenobarbitalPhenobarbital affects the expression of NGFR mRNA19136022|2309116
D010862PilocarpinePilocarpine results in increased expression of NGFR protein18815271
D010862PilocarpineNGFR protein results in increased susceptibility to Pilocarpine12097334
D010862PilocarpinePilocarpine results in increased expression of NGFR mRNA10436046
D010862PilocarpinePilocarpine results in increased expression of NGFR protein10436046|1209733
D010862PilocarpinePTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]21084616
D010862PilocarpinePilocarpine results in increased activity of NGFR protein21084616
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of NGFR mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of NGFR mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of NGFR mRNA17950772
D059808PolyphenolsPolyphenols results in decreased expression of NGFR mRNA16293270
C045950propiconazolepropiconazole results in decreased expression of NGFR mRNA21278054
C045950propiconazolepropiconazole results in increased expression of NGFR mRNA28970091
C005556propionaldehydepropionaldehyde results in increased expression of NGFR mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of NGFR mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
D000069348Quetiapine FumarateQuetiapine Fumarate results in decreased expression of NGFR mRNA12111809|1651314
C059514resveratrolMIR137 mRNA affects the reaction [resveratrol results in increased expression of NGFR mRNA]25505154
C059514resveratrolresveratrol results in increased expression of NGFR mRNA25505154
C059514resveratrolMIR137 mRNA affects the reaction [resveratrol results in increased expression of NGFR mRNA]25505154
C059514resveratrolresveratrol results in increased expression of NGFR mRNA25505154
D018967RisperidoneRisperidone results in decreased expression of NGFR mRNA12111809|1651314
C093642SB 203580SB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]17651887
C093642SB 203580SB 203580 inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]17651887
C009250sevofluranesevoflurane affects the expression of NGFR mRNA15967596
D012906SmokeSmoke affects the expression of NGFR mRNA23693141
C025463sulindac sulfonesulindac sulfone results in increased expression of NGFR mRNA17447067
C025463sulindac sulfonesulindac sulfone results in increased expression of NGFR protein17447067
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of NGFR protein]22150557
C087114tebuconazoletebuconazole results in increased expression of NGFR mRNA28970091
C012568terbufosterbufos results in increased methylation of NGFR promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NGFR mRNA20106945|2163298
C009495titanium dioxidetitanium dioxide affects the expression of NGFR mRNA23557971
D014050TolueneToluene results in decreased expression of NGFR mRNA17481687
D014212TretinoinTretinoin results in increased expression of NGFR protein24190996
D014212TretinoinTretinoin results in increased expression of NGFR mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NGFR mRNA24935251|2627250
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NGFR mRNA29024780
D014520UrethaneUrethane results in increased expression of NGFR mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NGFR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NGFR mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of NGFR mRNA10689198|2489608
C025643vinclozolinvinclozolin results in increased expression of NGFR mRNA20566332
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NGFR mRNA"27188386
C111237vorinostatvorinostat results in increased expression of NGFR mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS1846035  
GO:0005035death receptor activity-IGI11927634  
GO:0005515protein binding-IPI11756426  14593116  14985763  19131967  19225519  21982860  
GO:0005516calmodulin binding-IDA24914971  
GO:0015026coreceptor activity-IDA16712417  
GO:0017137Rab GTPase binding-ISS-  
GO:0031625ubiquitin protein ligase binding-IPI11279055  
GO:0038023signaling receptor activity-TAS3022937  
GO:0043121neurotrophin binding-ISS-  
GO:0048406nerve growth factor binding-IBA21873635  
GO:0048406nerve growth factor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-ISS-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IMP26268439  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-TAS-  
GO:0007266Rho protein signal transduction-IDA16712417  
GO:0007411axon guidance-IBA21873635  
GO:0010977negative regulation of neuron projection development-IBA21873635  
GO:0031293membrane protein intracellular domain proteolysis-TAS-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0033209tumor necrosis factor-mediated signaling pathway-IEA-  
GO:0042593glucose homeostasis-ISS-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0043066negative regulation of apoptotic process-TAS-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-TAS-  
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process-TAS-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0048011neurotrophin TRK receptor signaling pathway-TAS-  
GO:0050771negative regulation of axonogenesis-TAS-  
GO:0050772positive regulation of axonogenesis-TAS-  
GO:0051402neuron apoptotic process-IGI11927634  
GO:1900182positive regulation of protein localization to nucleus-IDA26268439  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-IDA26268439  
GO:1903588negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IGI26268439  
GO:1904646cellular response to amyloid-beta-IDA11927634  
GO:2001273regulation of glucose import in response to insulin stimulus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005768endosome-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA16712417  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS3022937  
GO:0009986cell surface-ISS-  
GO:0016021integral component of membrane-NAS11927634  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04722Neurotrophin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-193634Axonal growth inhibition (RHOA activation)TAS
R-HSA-193639p75NTR signals via NF-kBTAS
R-HSA-193639p75NTR signals via NF-kBIEA
R-HSA-193648NRAGE signals death through JNKIEA
R-HSA-193670p75NTR negatively regulates cell cycle via SC1IEA
R-HSA-193681Ceramide signallingIEA
R-HSA-193692Regulated proteolysis of p75NTRTAS
R-HSA-193697p75NTR regulates axonogenesisTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-193704p75 NTR receptor-mediated signallingIEA
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADEIEA
R-HSA-205017NFG and proNGF binds to p75NTRTAS
R-HSA-205025NADE modulates death signallingTAS
R-HSA-205043NRIF signals cell death from the nucleusTAS
R-HSA-205043NRIF signals cell death from the nucleusIEA
R-HSA-209543p75NTR recruits signalling complexesTAS
R-HSA-209543p75NTR recruits signalling complexesIEA
R-HSA-209560NF-kB is activated and signals survivalTAS
R-HSA-209563Axonal growth stimulationTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-73887Death Receptor SignallingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29161446Microglia Activation and Gene Expression Alteration of Neurotrophins in the Hippocampus Following Early-Life Exposure to E-Cigarette Aerosols in a Murine Model. (2018 Mar 1)Zelikoff JTToxicol Sci