| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| RASSF8 | 0.719 |
| TGFB2 | 0.708 |
| SPPL2A | 0.701 |
| ITPR2 | 0.695 |
| SCML1 | 0.694 |
| SLC31A1 | 0.68 |
| ARHGAP42 | 0.679 |
| BEND7 | 0.678 |
| TMEM185B | 0.676 |
| FSTL1 | 0.675 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| S1PR5 | -0.402 |
| FAM178B | -0.396 |
| SLC5A11 | -0.379 |
| FXYD4 | -0.373 |
| GJC2 | -0.373 |
| BTBD16 | -0.371 |
| ARHGAP22 | -0.37 |
| FIBCD1 | -0.363 |
| E2F1 | -0.358 |
| FCHO1 | -0.354 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C051246 | 1-methylanthracene | [1-methylanthracene co-treated with fluoranthene] results in increased expression of NHS mRNA | 28329830 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NHS mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NHS mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NHS mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NHS mRNA" | 27188386 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of NHS mRNA | 29067470 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of NHS gene | 27153756 |
| D017638 | Asbestos, Crocidolite | "Asbestos, Crocidolite results in increased expression of NHS mRNA" | 18687144 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of NHS mRNA | 26001963 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased mutagenesis of NHS gene | 25435355 |
| D004958 | Estradiol | EGF protein inhibits the reaction [Estradiol results in decreased expression of NHS mRNA] | 24758408 |
| D004958 | Estradiol | Estradiol results in decreased expression of NHS mRNA | 24758408 |
| C006780 | bisphenol A | bisphenol A results in decreased methylation of NHS promoter | 27312807 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of NHS mRNA | 25181051 |
| C018475 | butyraldehyde | butyraldehyde results in increased expression of NHS mRNA | 26079696 |
| D020245 | p-Chloromercuribenzoic Acid | "[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NHS mRNA" | 27188386 |
| D020245 | p-Chloromercuribenzoic Acid | p-Chloromercuribenzoic Acid results in decreased expression of NHS mRNA | 26272509 |
| D002794 | Choline | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NHS gene | 20938992 |
| D002945 | Cisplatin | [Cisplatin co-treated with jinfukang] results in decreased expression of NHS mRNA | 27392435 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of NHS mRNA | 19561079|2739243 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of NHS mRNA | 25016146 |
| D002117 | Calcitriol | Calcitriol results in increased expression of NHS mRNA | 16002434 |
| D005020 | Ethyl Methanesulfonate | Ethyl Methanesulfonate results in increased expression of NHS mRNA | 23649840 |
| C007738 | fluoranthene | [1-methylanthracene co-treated with fluoranthene] results in increased expression of NHS mRNA | 28329830 |
| D005492 | Folic Acid | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NHS gene | 20938992 |
| D004397 | Fonofos | Fonofos results in increased methylation of NHS promoter | 22847954 |
| D005557 | Formaldehyde | Formaldehyde results in decreased expression of NHS mRNA | 20655997 |
| D005557 | Formaldehyde | Formaldehyde results in increased expression of NHS mRNA | 23649840 |
| D006830 | Hydralazine | [Hydralazine co-treated with Valproic Acid] results in increased expression of NHS mRNA | 17183730 |
| C544151 | jinfukang | [Cisplatin co-treated with jinfukang] results in decreased expression of NHS mRNA | 27392435 |
| C544151 | jinfukang | jinfukang results in decreased expression of NHS mRNA | 27392435 |
| D008558 | Melphalan | Melphalan results in decreased expression of NHS mRNA | 22363485 |
| C042720 | mercuric bromide | mercuric bromide results in decreased expression of NHS mRNA | 26272509 |
| C042720 | mercuric bromide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NHS mRNA" | 27188386 |
| D008715 | Methionine | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NHS gene | 20938992 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in decreased expression of NHS mRNA | 28001369 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of NHS mRNA | 26516004 |
| D010278 | Parathion | Parathion results in increased methylation of NHS promoter | 22847954 |
| C046012 | pentanal | pentanal results in increased expression of NHS mRNA | 26079696 |
| D010575 | Pesticides | Pesticides results in decreased expression of NHS mRNA | 27406225 |
| C012568 | terbufos | terbufos results in increased methylation of NHS promoter | 22847954 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of NHS mRNA | 22574217 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of NHS mRNA | 23724009 |
| C012589 | trichostatin A | trichostatin A results in increased expression of NHS mRNA | 24935251 |
| D014635 | Valproic Acid | [Hydralazine co-treated with Valproic Acid] results in increased expression of NHS mRNA | 17183730 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of NHS mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of NHS mRNA | 24935251 |
| D019287 | Zinc Sulfate | Zinc Sulfate results in decreased expression of NHS mRNA | 27215404 |
| C088658 | zoledronic acid | zoledronic acid results in decreased expression of NHS mRNA | 24714768 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0002088 | lens development in camera-type eye | - | IBA | 21873635 |
| GO:0030154 | cell differentiation | - | IBA | 21873635 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005794 | Golgi apparatus | - | IDA | - |
| GO:0005923 | bicellular tight junction | - | IEA | - |
| GO:0005925 | focal adhesion | - | IEA | - |
| GO:0016324 | apical plasma membrane | - | IEA | - |
| GO:0016604 | nuclear body | - | IDA | - |
| GO:0030027 | lamellipodium | - | IEA | - |
| GO:0030054 | cell junction | - | IDA | - |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 15924351 | Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study. (2005 Sep) | Tranah GJ | Mol Carcinog |
| 26388349 | Is grand-parental smoking associated with adolescent obesity? A three-generational study. (2016 Mar) | Dougan MM | Int J Obes (Lond) |
| 16544653 | Clean break. (2006 Mar 8-14) | Davis C | Nurs Stand |
| 28497755 | Autologous stem-cell transplantation in treatment-refractory Crohn's disease: an analysis of pooled data from the ASTIC trial. (2017 Jun) | Lindsay JO | Lancet Gastroenterol Hepatol |
| 28060453 | Model-based economic evaluations in smoking cessation and their transferability to new contexts: a systematic review. (2017 Jun) | Berg ML | Addiction |
| 28255437 | Effects of a smoking ban on clozapine plasma concentrations in a nonsecure psychiatric unit. (2017 Feb) | Gee SH | Ther Adv Psychopharmacol |
| 19248103 | Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. (2009 Mar) | Karlson EW | Arthritis Rheum |
| 18462498 | Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. (2008) | Costenbader KH | Arthritis Res Ther |
| 23495093 | Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis. (2013 Jul) | Karlson EW | Arthritis Care Res (Hoboken) |
| 25872852 | Chronic obstructive pulmonary disease part 1: smoking cessation. (2015 Apr 15) | Jones D | Nurs Stand |
| 21611123 | Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London. (2011) | Chang CK | PLoS One |
| 16257992 | Improvements in quality of clinical care in English general practice 1998-2003: longitudinal observational study. (2005 Nov 12) | Campbell SM | BMJ |
| 18378981 | Specialised alcohol treatment services are a luxury the NHS cannot afford. (2008 Apr) | Luty J | Br J Psychiatry |
| 24831822 | What is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation. (2014 May) | Leaviss J | Health Technol Assess |
| 14988221 | Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study. (2004 Jul) | Tranah GJ | Carcinogenesis |
| 20441712 | Early referral strategies for management of people with markers of renal disease: a systematic review of the evidence of clinical effectiveness, cost-effectiveness and economic analysis. (2010 Apr) | Black C | Health Technol Assess |
| 22961230 | The cost-effectiveness of smoking cessation support delivered by mobile phone text messaging: Txt2stop. (2013 Oct) | Guerriero C | Eur J Health Econ |
| 27406646 | Geographic variation in the treatment of non-ST-segment myocardial infarction in the English National Health Service: a cohort study. (2016 Jul 12) | Dondo TB | BMJ Open |
| 26932138 | Cohort profile of the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Case Register: current status and recent enhancement of an Electronic Mental Health Record-derived data resource. (2016 Mar 1) | Perera G | BMJ Open |
| 20185811 | Lipoprotein-associated phospholipase A2 activity and incident coronary heart disease among men and women with type 2 diabetes. (2010 May) | Hatoum IJ | Diabetes |
| 10168390 | Implementation of non-smoking policies in hospitals--Tom Hurst Memorial Lecture. (1996) | Ashcroft S | World Hosp Health Serv |
| 19247474 | Genome-wide and candidate gene association study of cigarette smoking behaviors. (2009) | Caporaso N | PLoS One |
| 29247083 | Study protocol for a randomised controlled trial of Allen Carr's Easyway programme versus Lambeth and Southwark NHS for smoking cessation. (2017 Dec 14) | Wood KV | BMJ Open |
| 27459457 | Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies. (2016 Sep) | Li WQ | Am J Public Health |
| 26370095 | Are financial incentives cost-effective to support smoking cessation during pregnancy? (2016 Feb) | Boyd KA | Addiction |
| 17551456 | Caring for patients with COPD and their families in the community. (2007 May) | McHugh G | Br J Community Nurs |
| 27664209 | Novel circulating placental markers prokineticin-1, soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor and association with late miscarriage. (2016 Dec) | Jayasena CN | Hum Reprod |
| 14670879 | Incidence of cancer among UK Gulf war veterans: cohort study. (2003 Dec 13) | Macfarlane GJ | BMJ |
| 16901700 | The pathophysiology of emphysema: considerations for critical care nursing practice. (2006 Dec) | Mattison S | Intensive Crit Care Nurs |
| 25294559 | Particulate matter and risk of Parkinson disease in a large prospective study of women. (2014 Oct 7) | Palacios N | Environ Health |
| 29102992 | Association of psychological distress, quality of life and costs with carpal tunnel syndrome severity: a cross-sectional analysis of the PALMS cohort. (2017 Nov 3) | Jerosch-Herold C | BMJ Open |
| 14612848 | Influence of the hormonal changes during the normal menstrual cycle in healthy young women on soluble adhesion molecules, plasma homocysteine, free radical markers and lipoprotein fractions. (2003 Sep) | Elhadd TA | Int Angiol |
| 19149829 | Cost-effectiveness of pharmacy and group behavioural support smoking cessation services in Glasgow. (2009 Feb) | Boyd KA | Addiction |
| 24847019 | In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. (2014 Jul) | Fowler PA | Hum Reprod |
| 24685909 | Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history. (2015 Aug) | Sparks JA | Ann Rheum Dis |
| 29669708 | Evaluation of Two Mobile Health Apps in the Context of Smoking Cessation: Qualitative Study of Cognitive Behavioral Therapy (CBT) Versus Non-CBT-Based Digital Solutions. (2018 Apr 18) | Tudor-Sfetea C | JMIR Mhealth Uhealth |
| 24293491 | [Volumes of services supplied by Italian Stop-Smoking Services and their characteristics predictive of abstinence]. (2013 Jul-Oct) | Gorini G | Epidemiol Prev |
| 21062464 | Trial Protocol: Using genotype to tailor prescribing of nicotine replacement therapy: a randomised controlled trial assessing impact of communication upon adherence. (2010 Nov 9) | Marteau TM | BMC Public Health |
| 20051749 | Anti-TNF-alpha agents are less effective for the treatment of rheumatoid arthritis in current smokers. (2010 Jan) | Abhishek A | J Clin Rheumatol |
| 18063597 | Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. (2008 Jan) | Jensen MK | Eur Heart J |
| 17004407 | Best practice in smoking cessation services for pregnant women: results of a survey of three services reporting the highest national returns, and three beacon services. (2006 Sep) | Lee M | J R Soc Promot Health |
| 27703782 | Ketamine: stimulating antidepressant treatment? (2016 May) | Malhi GS | BJPsych Open |
| 25403204 | Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus. (2015 Jan 1) | Yuan C | J Clin Oncol |
| 26098791 | Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis. (2015 Oct) | Kim K | Arthritis Rheumatol |
| 24474868 | Acamprosate in the treatment of alcoholism: a budget impact analysis for the National Health Service in Italy. (2012) | Colombo GL | Subst Abuse Rehabil |
| 27417619 | StopApp: Using the Behaviour Change Wheel to Develop an App to Increase Uptake and Attendance at NHS Stop Smoking Services. (2016 Jun 8) | Fulton EA | Healthcare (Basel) |
| 25409898 | An evaluation of a multi-site community pharmacy-based chronic obstructive pulmonary disease support service. (2015 Feb) | Wright D | Int J Pharm Pract |
| 19194882 | Genetic determinants of hair color and Parkinson's disease risk. (2009 Jan) | Gao X | Ann Neurol |