Gene: NID1

4811
NID
nidogen 1
protein-coding
1q42.3
Ensembl:ENSG00000116962 MIM:131390 Vega:OTTHUMG00000040071 UniprotKB:P14543
NG_033228.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.923e-1 (AD)  8.002e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IRAK30.846
ITGA10.828
LATS20.811
HEYL0.807
RBMS20.802
DOCK60.797
IL1R10.796
IL4R0.796
PEAR10.794
GPR40.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.605
MARCH4-0.584
SLC7A4-0.581
ABCC12-0.578
DLK2-0.572
HAS1-0.57
NEUROD6-0.561
RTP1-0.56
CRH-0.559
KCNB2-0.549

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00013UrokinaseBiotechDrug9039-53-6Approved|Investigational|WithdrawnTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NID1 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NID1 mRNA"19114083
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of NID1 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NID1 mRNA"25380136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of NID1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NID1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NID1 mRNA"27188386
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NID1 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NID1 mRNA23626723
C0293704-toluidine4-toluidine results in decreased expression of NID1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NID1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NID1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NID1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of NID1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of NID1 mRNA11264010
D020106AcrylamideAcrylamide results in decreased expression of NID1 mRNA28959563
C010531actinoninactinonin inhibits the reaction [Cisplatin results in increased cleavage of NID1 protein]25957482
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NID1 mRNA16483693
D001151ArsenicArsenic affects the expression of NID1 protein24675094
D001280AtrazineAtrazine results in increased expression of NID1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NID1 mRNA19770486
D001663BilirubinBilirubin results in decreased expression of NID1 mRNA20196124
C006780bisphenol Abisphenol A results in decreased expression of NID1 mRNA22687993
C006780bisphenol Abisphenol A results in decreased expression of NID1 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of NID1 mRNA24136188
D002220CarbamazepineCarbamazepine affects the expression of NID1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NID1 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NID1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NID1 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of NID1 mRNA26577399|2752363
D003520CyclophosphamideNID1 protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of NID1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of NID1 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NID1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NID1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NID1 mRNA27392435
D002945Cisplatinactinonin inhibits the reaction [Cisplatin results in increased cleavage of NID1 protein]25957482
D002945CisplatinCisplatin results in increased cleavage of NID1 protein25957482
D002945CisplatinMEP1B gene mutant form inhibits the reaction [Cisplatin results in increased cleavage of NID1 protein]25957482
D002945CisplatinCisplatin results in decreased expression of NID1 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of NID1 mRNA28302478
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of NID1 mRNA17490981
D004041Dietary FatsDietary Fats results in increased expression of NID1 mRNA19030233|2260994
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of NID1 mRNA]19030233
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NID1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NID1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NID1 mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of NID1 mRNA"21785161
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NID1 mRNA"19480007
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of NID1 mRNA25380136
D004237DiuronDiuron results in decreased expression of NID1 mRNA25152437
D004237DiuronDiuron results in increased expression of NID1 mRNA21551480
C118739entinostatentinostat results in increased expression of NID1 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NID1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NID1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of NID1 mRNA23649840
D017313FenretinideFenretinide results in decreased expression of NID1 mRNA28973697
C051890irinotecanirinotecan metabolite results in increased expression of NID1 mRNA15956246
C051890irinotecanirinotecan results in increased expression of NID1 mRNA15956246
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NID1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of NID1 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NID1 mRNA27339419
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NID1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of NID1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NID1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NID1 mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NID1 mRNA23876855
D009151Mustard GasMustard Gas results in decreased expression of NID1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of NID1 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NID1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NID1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of NID1 mRNA25380136
C029938nickel sulfatenickel sulfate results in decreased expression of NID1 mRNA16166746
C012655nimesulidenimesulide results in decreased expression of NID1 mRNA24136188
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NID1 mRNA19074003
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NID1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of NID1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of NID1 mRNA24205000
C046012pentanalpentanal results in increased expression of NID1 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NID1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NID1 protein26879310
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NID1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of NID1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of NID1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of NID1 mRNA19482888
D011374ProgesteroneProgesterone results in decreased expression of NID1 mRNA19693291
D011441PropylthiouracilPropylthiouracil results in increased expression of NID1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NID1 mRNA27029645
C009166retinol acetateretinol acetate results in increased expression of NID1 mRNA16772331
C089032rimonabantrimonabant affects the expression of NID1 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of NID1 mRNA]19030233
C089730rosiglitazonerosiglitazone affects the expression of NID1 protein19556978
C089730rosiglitazonerosiglitazone results in decreased expression of NID1 mRNA21515302
C089730rosiglitazonerosiglitazone results in increased expression of NID1 mRNA21172411
C010327salinomycinsalinomycin results in decreased expression of NID1 mRNA19682730
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NID1 mRNA22431001
C017947sodium arsenitesodium arsenite affects the expression of NID1 mRNA16507464
D012969Sodium FluorideSodium Fluoride results in decreased expression of NID1 protein28918527
D012999SomanSoman results in increased expression of NID1 mRNA19281266
C501413tesaglitazartesaglitazar results in increased expression of NID1 mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of NID1 mRNA19693291|2040306
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NID1 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NID1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NID1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NID1 mRNA19770486
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of NID1 mRNA28973375
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NID1 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NID1 mRNA28065790
D014050TolueneToluene results in increased expression of NID1 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NID1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of NID1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of NID1 mRNA17138961
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NID1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NID1 mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of NID1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NID1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NID1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NID1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased expression of NID1 mRNA24896083
D014638VanadatesVanadates results in decreased expression of NID1 mRNA22714537
D014640VancomycinVancomycin results in decreased expression of NID1 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of NID1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of NID1 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005518collagen binding-IDA22952693  
GO:0043236laminin binding-IDA22952693  
GO:0043237laminin-1 binding-IEA-  
GO:0043394proteoglycan binding-IPI22952693  
GO ID GO Term Qualifier Evidence PubMed
GO:0007160cell-matrix adhesion-IEA-  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0032836glomerular basement membrane development-IEA-  
GO:0071711basement membrane organization-TAS22952693  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IDA22952693  
GO:0005605basal lamina-IEA-  
GO:0031012extracellular matrix-HDA23658023  
GO:0062023collagen-containing extracellular matrix-HDA27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0071944cell periphery-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-3000157Laminin interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27459457Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies. (2016 Sep)Li WQAm J Public Health