Gene: NINJ2

4815
-
ninjurin 2
protein-coding
12p13.33
Ensembl:ENSG00000171840 MIM:607297 Vega:OTTHUMG00000090311 UniprotKB:Q9NZG7
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.997e-1 (AD)  7.351e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6489683chr12:627548 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOG0.923
MAG0.922
GJB10.922
EVI2A0.917
FOLH10.916
DMRT20.911
NKX6-20.908
TMEM1440.908
CLDN110.908
CYB5R20.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.47
NEUROD1-0.414
CHRNA2-0.401
WTIP-0.388
CNGB1-0.385
LTK-0.38
CCDC85C-0.38
PCDH8-0.378
GPR153-0.374
SP8-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NINJ2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NINJ2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NINJ2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NINJ2 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NINJ2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of NINJ2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of NINJ2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of NINJ2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NINJ2 mRNA21641981
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NINJ2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NINJ2 mRNA16483693
D001151ArsenicArsenic affects the methylation of NINJ2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of NINJ2 mRNA26705709
C006780bisphenol Abisphenol A affects the expression of NINJ2 mRNA25181051
D002509CephaloridineCephaloridine results in increased expression of NINJ2 mRNA18500788
D003471CuprizoneCuprizone results in decreased expression of NINJ2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of NINJ2 mRNA27989131
D019422Dietary SucroseDietary Sucrose results in decreased expression of NINJ2 mRNA26033743
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NINJ2 mRNA23649840
C082360fipronilfipronil results in decreased expression of NINJ2 mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of NINJ2 mRNA18035473
C069837fullerene C60fullerene C60 results in increased expression of NINJ2 mRNA19167457
C039281furanfuran results in increased expression of NINJ2 mRNA25539665|2619464
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of NINJ2 mRNA22467014
D007213IndomethacinIndomethacin results in increased expression of NINJ2 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NINJ2 mRNA23086925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NINJ2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NINJ2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NINJ2 mRNA"25554681
D009966OrphenadrineOrphenadrine affects the expression of NINJ2 mRNA23665939
C006253pirinixic acidpirinixic acid results in decreased expression of NINJ2 mRNA17950772|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of NINJ2 mRNA]17950772
D010936Plant ExtractsPlant Extracts results in decreased expression of NINJ2 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of NINJ2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of NINJ2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of NINJ2 mRNA21632981
D012969Sodium FluorideSodium Fluoride results in increased expression of NINJ2 mRNA27862939
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of NINJ2 mRNA22467014
D013739TestosteroneTestosterone results in increased expression of NINJ2 mRNA21475673
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NINJ2 mRNA21570461
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NINJ2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NINJ2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of NINJ2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of NINJ2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of NINJ2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of NINJ2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NINJ2 mRNA23665938
C088658zoledronic acidzoledronic acid results in decreased expression of NINJ2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007158neuron cell-cell adhesion-TAS10627596  
GO:0007399nervous system development-TAS10627596  
GO:0042246tissue regeneration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-TAS10627596  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21722921NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population. (2011 Sep 15)Wan XHJ Neurol Sci
24664524Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study. (2014 Nov)Zhu YJ Thromb Thrombolysis