Gene info: ID 4821

Gene: NKX2-2

GENE ID: 4821

Synonyms: NKX2.2|NKX2B

Description: NK2 homeobox 2

Gene type: protein-coding

Location: 20p11.22

dbXrefs: Ensembl:ENSG00000125820 MIM:604612 Vega:OTTHUMG00000170524 UniprotKB:O95096

RefSeq: NG_042186.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.902e-1 (AD) 8.795e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DPF3	0.801
PLXNB1	0.794
CYP27A1	0.789
PHGDH	0.789
MPST	0.778
KIAA1755	0.778
FGFR2	0.77
LLGL1	0.768
DDR1	0.765
PHLPP1	0.763

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HS6ST3	-0.477
CDH7	-0.471
CCDC68	-0.468
CNTN5	-0.461
SERTM1	-0.461
PRSS12	-0.459
KCNH5	-0.458
OR1F1	-0.454
TPH2	-0.448
KLF8	-0.447

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NKX2-2 mRNA"	27291303
C015001	arsenite	arsenite results in increased methylation of NKX2-2 promoter	23974009
D001280	Atrazine	Atrazine results in decreased expression of NKX2-2 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NKX2-2 mRNA	27195522
C006780	bisphenol A	bisphenol A results in increased methylation of NKX2-2 gene	28505145
D002330	Carmustine	Carmustine results in decreased expression of NKX2-2 mRNA	15980968
D003042	Cocaine	Cocaine results in decreased expression of NKX2-2 mRNA	17898221
D003976	Diazinon	Diazinon results in increased methylation of NKX2-2 gene	22964155
D004041	Dietary Fats	[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 mRNA	23884882
D004041	Dietary Fats	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 mRNA]	23884882
D004041	Dietary Fats	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 protein]	23884882
D005947	Glucose	[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 mRNA	23884882
D005947	Glucose	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 mRNA]	23884882
D005947	Glucose	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 protein]	23884882
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NKX2-2 mRNA	24796395
C008261	lead acetate	lead acetate results in decreased expression of NKX2-2 mRNA	22613225
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of NKX2-2 mRNA	17506889
D008713	Methimazole	Methimazole results in increased expression of NKX2-2 mRNA	17399805
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NKX2-2 mRNA"	21673326
C494474	perchlorate	perchlorate results in increased expression of NKX2-2 mRNA	17399805
D011441	Propylthiouracil	Propylthiouracil results in increased expression of NKX2-2 mRNA	17399805
C059514	resveratrol	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 mRNA]	23884882
C059514	resveratrol	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX2-2 protein]	23884882
D012999	Soman	Soman results in increased expression of NKX2-2 mRNA	19281266
D014284	Triiodothyronine	Triiodothyronine results in increased expression of NKX2-2 mRNA	17403546
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NKX2-2 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NKX2-2 mRNA	16922920
D014212	Tretinoin	[Tretinoin co-treated with EGF protein] results in increased expression of NKX2-2 mRNA	17196394
D014212	Tretinoin	[Tretinoin co-treated with SHH protein] results in increased expression of NKX2-2 protein	15996115
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of NKX2-2 gene	25560391
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of NKX2-2 mRNA	17506889

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000987	proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0003682	chromatin binding	-	ISS	-
GO:0003713	transcription coactivator activity	-	ISS	-
GO:0008134	transcription factor binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003323	type B pancreatic cell development	-	IEA	-
GO:0003326	pancreatic A cell fate commitment	-	IEA	-
GO:0003327	type B pancreatic cell fate commitment	-	IEA	-
GO:0003329	pancreatic PP cell fate commitment	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007224	smoothened signaling pathway	-	IEA	-
GO:0007420	brain development	-	TAS	1346742
GO:0009749	response to glucose	-	IEA	-
GO:0014003	oligodendrocyte development	-	IEA	-
GO:0021522	spinal cord motor neuron differentiation	-	IEA	-
GO:0021530	spinal cord oligodendrocyte cell fate specification	-	IEA	-
GO:0021554	optic nerve development	-	IEA	-
GO:0031018	endocrine pancreas development	-	TAS	-
GO:0032570	response to progesterone	-	IEA	-
GO:0045665	negative regulation of neuron differentiation	-	IEA	-
GO:0045666	positive regulation of neuron differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0048565	digestive tract development	-	IEA	-
GO:0048665	neuron fate specification	-	IEA	-
GO:0048708	astrocyte differentiation	-	IEA	-
GO:0048714	positive regulation of oligodendrocyte differentiation	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	ISS	-
GO:0060580	ventral spinal cord interneuron fate determination	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-

KEGG ID	KEGG Term
hsa04950	Maturity onset diabetes of the young

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-186712	Regulation of beta-cell development	TAS
R-HSA-186712	Regulation of beta-cell development	IEA
R-HSA-210745	Regulation of gene expression in beta cells	IEA
R-HSA-210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17478053	Glial-restricted precursors: patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro. (2007 Jun 8)	Buch SK	Neuroscience
26373813	Differential Contributions of Alcohol and Nicotine-Derived Nitrosamine Ketone (NNK) to White Matter Pathology in the Adolescent Rat Brain. (2015 Nov)	Tong M	Alcohol Alcohol