Gene info: ID 4825

Gene: NKX6-1

GENE ID: 4825

Synonyms: NKX6.1|NKX6A

Description: NK6 homeobox 1

Gene type: protein-coding

Location: 4q21.23

dbXrefs: Ensembl:ENSG00000163623 MIM:602563 Vega:OTTHUMG00000130426 UniprotKB:P78426

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.885e-1 (AD) 8.384e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PGF	0.663
CNN2	0.6
FOXL2	0.593
KANK2	0.589
AJUBA	0.584
TBX2	0.584
CCDC102A	0.575
SIX2	0.575
TES	0.574
RUNX3	0.572

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNQ5	-0.473
SV2B	-0.468
IPCEF1	-0.468
ZNF365	-0.464
RYR2	-0.463
NOS1AP	-0.46
NAV3	-0.458
KCNV1	-0.458
TBR1	-0.455
VSTM5	-0.455

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NKX6-1 mRNA"	19114083
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [LEPR gene mutant form results in decreased expression of NKX6-1 mRNA]	23274897
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	"[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of NKX6-1 mRNA"	22968147
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of NKX6-1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of NKX6-1 gene	28458013
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NKX6-1 mRNA	16483693
C015001	arsenite	arsenite results in increased methylation of NKX6-1 promoter	23974009
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NKX6-1 mRNA	22228805
C006780	bisphenol A	bisphenol A affects the methylation of NKX6-1 promoter	27334623
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NKX6-1 gene	20938992
D003471	Cuprizone	Cuprizone results in increased expression of NKX6-1 mRNA	27523638
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of NKX6-1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of NKX6-1 mRNA	27392435
D004041	Dietary Fats	[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 mRNA	23884882
D004041	Dietary Fats	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 mRNA]	23884882
D004041	Dietary Fats	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 protein]	23884882
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of NKX6-1 mRNA	26033743
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NKX6-1 mRNA	23550701
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NKX6-1 gene	20938992
D005947	Glucose	NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein]	18347054
D005947	Glucose	[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 mRNA	23884882
D005947	Glucose	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 mRNA]	23884882
D005947	Glucose	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 protein]	23884882
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of NKX6-1 mRNA	27392435
C011890	kojic acid	kojic acid results in decreased expression of NKX6-1 mRNA	16595896
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NKX6-1 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of NKX6-1 mRNA	20864626
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of NKX6-1 mRNA	23602845
D010695	Phlorhizin	Phlorhizin results in increased expression of NKX6-1 mRNA	16123366
D010936	Plant Extracts	Plant Extracts results in decreased expression of NKX6-1 mRNA	23557933
C059514	resveratrol	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 mRNA]	23884882
C059514	resveratrol	resveratrol inhibits the reaction [[Dietary Fats co-treated with Glucose] results in decreased expression of NKX6-1 protein]	23884882
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of NKX6-1 mRNA	27862939
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NKX6-1 mRNA	24058054
D014635	Valproic Acid	Valproic Acid results in decreased methylation of NKX6-1 gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0003682	chromatin binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001764	neuron migration	-	IEA	-
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007224	smoothened signaling pathway	-	IEA	-
GO:0009887	animal organ morphogenesis	-	TAS	10567713
GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification	-	IEA	-
GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification	-	IEA	-
GO:0030516	regulation of axon extension	-	IEA	-
GO:0031016	pancreas development	-	ISS	-
GO:0032024	positive regulation of insulin secretion	-	IEA	-
GO:0035094	response to nicotine	-	IEA	-
GO:0044342	type B pancreatic cell proliferation	-	ISS	-
GO:0045666	positive regulation of neuron differentiation	-	IEA	-
GO:0045686	negative regulation of glial cell differentiation	-	IEA	-
GO:0045687	positive regulation of glial cell differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0048709	oligodendrocyte differentiation	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	ISS	-
GO:0051594	detection of glucose	-	ISS	-
GO:0071345	cellular response to cytokine stimulus	-	IEA	-
GO:0071375	cellular response to peptide hormone stimulus	-	IEA	-
GO:0072560	type B pancreatic cell maturation	-	ISS	-
GO:2000078	positive regulation of type B pancreatic cell development	-	ISS	-
GO:2001222	regulation of neuron migration	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa04950	Maturity onset diabetes of the young

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-186712	Regulation of beta-cell development	IEA
R-HSA-210745	Regulation of gene expression in beta cells	IEA
R-HSA-210747	Regulation of gene expression in early pancreatic precursor cells	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27865370	Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer. (2016 Nov)	Cheng SJ	Oral Oncol
18687784	Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life. (2008 Dec)	Somm E	Endocrinology