Gene: NNAT

4826
Peg5
neuronatin
protein-coding
20q11.23
Ensembl:ENSG00000053438 MIM:603106 Vega:OTTHUMG00000032420 UniprotKB:Q16517
NG_009263.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.984e-1 (AD)  7.590e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NSG20.922
ACTR3B0.918
SEZ60.913
CGREF10.913
HPCA0.905
SLC1A60.899
LRRC730.892
CDK5R20.891
SUSD40.888
SYT50.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCGR3B-0.572
MAGEA12-0.562
CXCR2-0.557
NFE2-0.548
IL18RAP-0.542
TNFRSF10C-0.541
REST-0.539
CXCR1-0.535
LATS2-0.535
CST7-0.534

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NNAT mRNA"15215175
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of NNAT mRNA15135645
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NNAT mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in increased expression of NNAT mRNA15305145
C547126AZM551248AZM551248 results in decreased expression of NNAT mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of NNAT mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of NNAT mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NNAT mRNA22228805|2719552
D004958EstradiolEstradiol results in increased expression of NNAT mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of NNAT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NNAT gene28505145
D002220CarbamazepineCarbamazepine affects the expression of NNAT mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NNAT mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NNAT mRNA27339419
D003471CuprizoneCuprizone affects the expression of NNAT mRNA26577399
C014347decitabinedecitabine results in increased expression of NNAT mRNA17762496
C014347decitabine[decitabine affects the methylation of NNAT protein] which affects the expression of NNAT mRNA18381416|1838141
D003907DexamethasoneDexamethasone results in increased expression of NNAT mRNA25047013
D003976DiazinonDiazinon results in increased methylation of NNAT gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NNAT mRNA27392435
D002945CisplatinCisplatin results in increased expression of NNAT mRNA27392435
D004237DiuronDiuron results in decreased expression of NNAT mRNA25152437
D004610Ellagic AcidEllagic Acid results in increased expression of NNAT mRNA12002526
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NNAT mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NNAT mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NNAT mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NNAT mRNA15834898
D005419FlavonoidsFlavonoids results in increased expression of NNAT mRNA18035473
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in increased methylation of NNAT mRNA22959928
C039281furanfuran results in increased expression of NNAT mRNA27387713
C039281furanfuran results in increased methylation of NNAT gene22079235
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NNAT mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NNAT mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of NNAT promoter"26251327
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of NNAT mRNA16525678
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NNAT mRNA16026605
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NNAT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NNAT mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of NNAT mRNA18978301
D009550NigericinNNAT protein results in decreased susceptibility to Nigericin12101027
D005996NitroglycerinNitroglycerin results in increased expression of NNAT mRNA12102619
D010100OxygenOxygen deficiency results in increased expression of NNAT mRNA26516004
C006253pirinixic acidpirinixic acid results in increased expression of NNAT mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of NNAT mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of NNAT mRNA23018184
D011441PropylthiouracilPropylthiouracil results in increased expression of NNAT mRNA24780913
D012402RotenoneNNAT protein results in decreased susceptibility to Rotenone12101027
D012402RotenoneRotenone results in decreased expression of NNAT mRNA27900601
C009277sodium arsenatesodium arsenate results in decreased expression of NNAT mRNA21795629
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in increased methylation of NNAT mRNA22959928
D012999SomanSoman results in increased expression of NNAT mRNA19281266
D013629TamoxifenTamoxifen affects the expression of NNAT mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NNAT mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NNAT mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NNAT mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NNAT mRNA17942748|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NNAT mRNA26232522
D019284ThapsigarginThapsigargin results in decreased expression of NNAT mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NNAT mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NNAT mRNA20133372
D014212TretinoinTretinoin results in decreased expression of NNAT mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NNAT mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of NNAT mRNA22378314
D014634ValinomycinNNAT protein results in decreased susceptibility to Valinomycin12101027
D014635Valproic AcidValproic Acid results in increased expression of NNAT mRNA24849673

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007420brain development-IBA21873635  
GO:0009249protein lipoylation-TAS8813377  
GO:0030182neuron differentiation-IEA-  
GO:0032024positive regulation of insulin secretion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22677950Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)Liu YEpigenetics