Gene: NQO2

4835
DHQV|DIA6|NMOR2|QR2
N-ribosyldihydronicotinamide:quinone reductase 2
protein-coding
6p25.2
Ensembl:ENSG00000124588 MIM:160998 Vega:OTTHUMG00000014130 UniprotKB:P16083
NG_034013.1
PubMed
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.606e-2 (AD)  6.513e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMD30.918
PSMD80.913
AP2S10.912
RRAGA0.912
MDH20.912
IDH3B0.911
IMP30.911
MRPL370.91
APMAP0.91
DCTN30.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.654
OR4F29-0.605
MTRNR2L6-0.384
MTRNR2L9-0.368
RAI14-0.358
CTNNA3-0.35
MTRNR2L10-0.333
KCNJ15-0.329
REST-0.327
CXCR2-0.325

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00170MenadioneSmall Molecule58-27-5Approved|NutraceuticalTarget
DB01065MelatoninSmall Molecule73-31-4Approved|NutraceuticalTarget
DB01087PrimaquineSmall Molecule90-34-6ApprovedTarget
DB02709ResveratrolSmall Molecule501-36-0Approved|Experimental|InvestigationalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB0354110-Propargyl-5,8-Dideazafolic AcidSmall MoleculeExperimentalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB04253TretazicarSmall Molecule21919-05-1InvestigationalTarget
DB07339(3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dioneSmall MoleculeExperimentalTarget
DB08190N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamideSmall MoleculeExperimentalTarget
DB082285,8-dimethoxy-1,4-dimethylquinolin-2(1H)-oneSmall MoleculeExperimentalTarget
DB087446-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-oneSmall MoleculeExperimentalTarget
DB06695Dabigatran etexilateSmall Molecule211915-06-9ApprovedEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NQO2 mRNA"28903501
C4457011-benzyl-1,4-dihydronicotinamide"chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C4457011-benzyl-1,4-dihydronicotinamide"chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
C4457011-benzyl-1,4-dihydronicotinamide"Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C4457011-benzyl-1,4-dihydronicotinamide"Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
C4457011-benzyl-1,4-dihydronicotinamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C4457011-benzyl-1,4-dihydronicotinamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
C4457011-benzyl-1,4-dihydronicotinamide"NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide"20399199
C4457011-benzyl-1,4-dihydronicotinamide"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol"20399199
C4457011-benzyl-1,4-dihydronicotinamide"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1"20399199
C4457011-benzyl-1,4-dihydronicotinamide"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2"20399199
C4457011-benzyl-1,4-dihydronicotinamide"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3"20399199
C4457011-benzyl-1,4-dihydronicotinamide"resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C4457011-benzyl-1,4-dihydronicotinamide"resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NQO2 mRNA28329830
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NQO2 mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NQO2 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NQO2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NQO2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NQO2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NQO2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NQO2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NQO2 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of NQO2 mRNA28522335
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of NQO2 mRNA28713220
D034341Aristolochic AcidsAristolochic Acids results in decreased expression of NQO2 mRNA19717638
C006632arsenic trioxidearsenic trioxide results in increased expression of NQO2 mRNA21461292
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of NQO2 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NQO2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NQO2 mRNA20127859
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NQO2 mRNA21715664
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of NQO2 mRNA"28987381
D004958EstradiolEstradiol results in increased expression of NQO2 mRNA19167446
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NQO2 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of NQO2 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of NQO2 mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NQO2 mRNA15336504
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in increased expression of NQO2 protein]20359164
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NQO2 mRNA27339419
C007054chrysoeriol"chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C007054chrysoeriol"chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
C007054chrysoeriolchrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
C007054chrysoeriolchrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
D003024ClozapineNQO2 gene SNP affects the susceptibility to Clozapine14617031
D003042CocaineCocaine results in increased expression of NQO2 mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of NQO2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NQO2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of NQO2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of NQO2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of NQO2 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of NQO2 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of NQO2 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NQO2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of NQO2 mRNA21151649
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in increased expression of NQO2 protein]20359164
D004041Dietary FatsDietary Fats results in increased expression of NQO2 protein20359164
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NQO2 mRNA"28433925
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of NQO2 mRNA25380136
D004317DoxorubicinDoxorubicin results in decreased expression of NQO2 mRNA25896364
C118739entinostatentinostat results in increased expression of NQO2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C500988estradiol-3,4-quinone"estradiol-3,4-quinone binds to NQO2 protein"18996184
C500988estradiol-3,4-quinone"NQO2 protein results in increased reduction of estradiol-3,4-quinone"18996184
C500988estradiol-3,4-quinone"Quercetin inhibits the reaction [NQO2 protein results in increased reduction of estradiol-3,4-quinone]"18996184
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NQO2 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of NQO2 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of NQO2 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NQO2 protein18951874
C492448ICG 001ICG 001 results in increased expression of NQO2 mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate results in decreased activity of NQO2 protein21859103
D007545IsoproterenolIsoproterenol results in decreased expression of NQO2 mRNA21335049
C544151jinfukangjinfukang results in increased expression of NQO2 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of NQO2 mRNA22641619
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of NQO2 mRNA"28987381
D008550MelatoninMelatonin affects the activity of NQO2 protein22289031
D008550Melatonin"Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
D008550Melatonin"Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
D008550MelatoninMelatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
D008550MelatoninMelatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
D008550MelatoninMelatonin binds to NQO2 protein17762829
D008550MelatoninMelatonin results in decreased activity of NQO2 protein21859103
D008748MethylcholanthreneMethylcholanthrene results in increased expression of NQO2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NQO2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NQO2 mRNA20061341
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NQO2 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NQO2 protein24625837
C550454N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C550454N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
C550454N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]"20399199
C550454N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]"20399199
C550454N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [Paraquat results in increased activity of NQO2 protein]"22289031
C550454N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide results in decreased activity of NQO2 protein"22289031
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NQO2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NQO2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NQO2 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of NQO2 mRNA24136188
C029938nickel sulfatenickel sulfate results in increased expression of NQO2 mRNA22714537
C018613nicotinamide-beta-ribosidechrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
C018613nicotinamide-beta-ribosidechrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
C018613nicotinamide-beta-ribosideMelatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
C018613nicotinamide-beta-ribosideMelatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
C018613nicotinamide-beta-riboside"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]"20399199
C018613nicotinamide-beta-riboside"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]"20399199
C018613nicotinamide-beta-ribosideNQO2 protein results in increased oxidation of nicotinamide-beta-riboside20399199
C018613nicotinamide-beta-riboside"[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol"20399199
C018613nicotinamide-beta-riboside[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q120399199
C018613nicotinamide-beta-riboside[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q220399199
C018613nicotinamide-beta-riboside[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 320399199
C018613nicotinamide-beta-ribosideresveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
C018613nicotinamide-beta-ribosideresveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
C025589ochratoxin Aochratoxin A results in decreased expression of NQO2 mRNA19717638
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NQO2 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of NQO2 mRNA26272509
D010269Paraquat"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [Paraquat results in increased activity of NQO2 protein]"22289031
D010269ParaquatNQO2 protein results in increased susceptibility to Paraquat22289031
D010269ParaquatParaquat results in increased activity of NQO2 protein22289031
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of NQO2 mRNA18593933
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of NQO2 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NQO2 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of NQO2 mRNA18445702
D011441PropylthiouracilPropylthiouracil results in decreased expression of NQO2 mRNA24780913
C107773pterostilbenepterostilbene results in increased expression of NQO2 mRNA24936659
C107773pterostilbenepterostilbene results in increased expression of NQO2 protein24936659
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NQO2 mRNA27029645
D011794QuercetinQuercetin binds to NQO2 protein15350128
D011794Quercetin"Quercetin inhibits the reaction [NQO2 protein results in increased reduction of estradiol-3,4-quinone]"18996184
D011794QuercetinQuercetin results in decreased expression of NQO2 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of NQO2 mRNA19167446
C059514resveratrolNQO2 protein inhibits the reaction [resveratrol results in decreased expression of AKT1 protein]24968355
C059514resveratrolNQO2 protein promotes the reaction [resveratrol results in decreased expression of BCL2 protein]19661309
C059514resveratrolNQO2 protein promotes the reaction [resveratrol results in decreased expression of RELA protein]19661309
C059514resveratrolresveratrol analog results in decreased activity of NQO2 protein23953689
C059514resveratrolresveratrol binds to and results in decreased activity of NQO2 protein15350128|2395368
C059514resveratrolresveratrol binds to NQO2 protein24968355
C059514resveratrol[resveratrol binds to NQO2 protein] inhibits the reaction [NQO2 protein binds to AKT1 protein]24968355
C059514resveratrolresveratrol inhibits the reaction [AKT1 protein binds to NQO2 protein]24968355
C059514resveratrol"resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C059514resveratrol"resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
C059514resveratrolresveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
C059514resveratrolresveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
C059514resveratrolresveratrol results in increased expression of and affects the localization of NQO2 protein16759640
C059514resveratrolresveratrol results in increased expression of NQO2 protein15993843
C059514resveratrolresveratrol binds to NQO2 protein modified form23953689
C059514resveratrolresveratrol results in decreased activity of NQO2 protein17762829|2185910
D015474IsotretinoinIsotretinoin results in decreased expression of NQO2 mRNA20436886
D012524SarinSarin results in decreased expression of NQO2 mRNA19522546
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of NQO2 mRNA20861374
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NQO2 mRNA23221170
C017947sodium arsenitesodium arsenite results in increased expression of NQO2 mRNA22714537|2451658
D0150862,6-Dichloroindophenol"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol"20399199
D0150862,6-Dichloroindophenol"[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol"20399199
D012969Sodium FluorideSodium Fluoride results in increased expression of NQO2 protein28918527
C016766sulforafansulforafan results in increased expression of NQO2 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NQO2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NQO2 protein11154737
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NQO2 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NQO2 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NQO2 promoter]21889950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NQO2 mRNA21889950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NQO2 mRNA18796159|2121527
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NQO2 mRNA16979875
D013792ThalidomideThalidomide results in decreased expression of NQO2 mRNA26217789
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NQO2 protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NQO2 mRNA22363418
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NQO2 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NQO2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of NQO2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of NQO2 mRNA20488242
C012589trichostatin Atrichostatin A affects the expression of NQO2 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of NQO2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of NQO2 mRNA28973697
C025203Ubiquinone Q1"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q1"20399199
C025203Ubiquinone Q1[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q120399199
C025204Ubiquinone Q2"chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C025204Ubiquinone Q2chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
C025204Ubiquinone Q2"Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C025204Ubiquinone Q2Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
C025204Ubiquinone Q2"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C025204Ubiquinone Q2"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]"20399199
C025204Ubiquinone Q2"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2"20399199
C025204Ubiquinone Q2[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q220399199
C025204Ubiquinone Q2"resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]"20399199
C025204Ubiquinone Q2resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]20399199
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NQO2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NQO2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NQO2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of NQO2 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of NQO2 mRNA22615374
D024483Vitamin K 3"chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
D024483Vitamin K 3chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
D024483Vitamin K 3"Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
D024483Vitamin K 3Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
D024483Vitamin K 3"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
D024483Vitamin K 3"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]"20399199
D024483Vitamin K 3"[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3"20399199
D024483Vitamin K 3[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 320399199
D024483Vitamin K 3"resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]"20399199
D024483Vitamin K 3resveratrol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]20399199
D024483Vitamin K 3NQO2 affects the susceptibility to Vitamin K 312351651
D024483Vitamin K 3NQO2 gene mutant form results in decreased susceptibility to Vitamin K 321859103
D024483Vitamin K 3NQO2 protein results in increased activity of Vitamin K 317762829
C111237vorinostatvorinostat results in increased expression of NQO2 protein17593366
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of NQO2 mRNA18593933
D015032ZincZinc affects the expression of NQO2 mRNA16979875
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NQO2 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001512dihydronicotinamide riboside quinone reductase activity-IDA18254726  
GO:0001512dihydronicotinamide riboside quinone reductase activity-TAS-  
GO:0003955NAD(P)H dehydrogenase (quinone) activity-IBA21873635  
GO:0005515protein binding-IPI16189514  24606901  25416956  
GO:0008270zinc ion binding-IDA18254726  
GO:0009055electron transfer activity-IBA21873635  
GO:0009055electron transfer activity-IDA10945627  18254726  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0016491oxidoreductase activity-IDA10945627  
GO:0016661oxidoreductase activity, acting on other nitrogenous compounds as donors-IDA10945627  
GO:0031404chloride ion binding-IDA18254726  
GO:0042803protein homodimerization activity-IPI18254726  
GO:0071949FAD binding-IDA18254726  
GO:1904408melatonin binding-IDA18254726  
GO:1905594resveratrol binding-IDA18254726  
GO ID GO Term Qualifier Evidence PubMed
GO:0006805xenobiotic metabolic process-TAS-  
GO:0022900electron transport chain-IEA-  
GO:0055114oxidation-reduction process-IDA18254726  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA10945627  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19350405Population study of genetic polymorphisms and superficial bladder cancer risk in Han-Chinese smokers in Shanghai. (2009 Dec)Wen HInt Urol Nephrol
12960511Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms. (2003 Aug)Okubo TAlcohol Clin Exp Res
20966810Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk. (2011 Jan)Mohelnikova-Duchonova BPancreas