Gene: NMT1

4836
NMT
N-myristoyltransferase 1
protein-coding
17q21.31
Ensembl:ENSG00000136448 MIM:160993 Vega:OTTHUMG00000180003 UniprotKB:P30419
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.100e-1 (AD)  6.784e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2301597chr17:45095905 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IP6K10.966
TM9SF40.955
DNAJA30.948
RXRB0.948
ATG9A0.948
FBXO310.946
ZFYVE10.945
URGCP0.944
PPP2R5D0.944
SMG70.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.665
OR4F29-0.612
TFPI2-0.392
KLRB1-0.389
KLRF1-0.361
FZD10-0.353
ASB4-0.336
RAI14-0.334
TBX21-0.333
CD2-0.331

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02180Myristoyl-CoaSmall Molecule3130-72-1ExperimentalTarget
DB02477[Cyclohexylethyl]-[[[[4-[2-Methyl-1-Imidazolyl-Butyl]Phenyl]Acetyl]-Seryl]-Lysinyl]-AmineSmall MoleculeExperimentalTarget
DB03062(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-MethanoneSmall MoleculeExperimentalTarget
DB03062(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-MethanoneSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of NMT1 mRNA"20206263
D000082AcetaminophenAcetaminophen results in decreased expression of NMT1 mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of NMT1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NMT1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of NMT1 mRNA20458559
D001280AtrazineAtrazine results in increased expression of NMT1 mRNA26518232
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NMT1 mRNA21715664
D004958EstradiolEstradiol results in decreased expression of NMT1 mRNA16705744
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of NMT1 mRNA17404688
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NMT1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of NMT1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NMT1 mRNA15336504
C028031cadmium acetatecadmium acetate results in decreased expression of NMT1 mRNA18155341
C054133casticincasticin results in decreased expression of NMT1 mRNA28444820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NMT1 mRNA23650126
D003300Copper[Copper binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased activity of NMT1 protein16600465
D003375CoumestrolCoumestrol results in increased expression of NMT1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of NMT1 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of NMT1 mRNA24921660
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NMT1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NMT1 mRNA21266533
D004026DieldrinDieldrin results in increased expression of NMT1 mRNA28385952
D004237DiuronDiuron results in increased expression of NMT1 mRNA21551480
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of NMT1 mRNA25198161
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NMT1 protein23301498
D018120FinasterideFinasteride results in increased expression of NMT1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NMT1 mRNA24136188
D019833GenisteinGenistein results in decreased expression of NMT1 mRNA16705744
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NMT1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NMT1 mRNA28628672
C410337K 7174K 7174 results in decreased expression of NMT1 mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of NMT1 mRNA24967691
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NMT1 mRNA"24972896
D008345Manganese[Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased activity of NMT1 protein16600465
D008777MethyltestosteroneMethyltestosterone results in decreased expression of NMT1 mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NMT1 mRNA20886546
C516322N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide[Copper binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased activity of NMT1 protein16600465
C516322N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide[Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in decreased activity of NMT1 protein16600465
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NMT1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NMT1 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of NMT1 mRNA24136188
D009532NickelNickel results in increased expression of NMT1 mRNA25583101
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NMT1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of NMT1 mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of NMT1 mRNA23811191
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of NMT1 mRNA17404688
C045950propiconazolepropiconazole results in increased expression of NMT1 mRNA21278054
D012822Silicon DioxideSilicon Dioxide results in increased expression of NMT1 mRNA25351596
C017947sodium arsenitesodium arsenite results in increased expression of NMT1 mRNA20886546
D013749TetrachlorodibenzodioxinSRC protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of NMT1 mRNA]14708085
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NMT1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NMT1 mRNA14708085
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NMT1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NMT1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of NMT1 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of NMT1 mRNA17292431
D014638VanadatesVanadates results in decreased expression of NMT1 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of NMT1 mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of NMT1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004379glycylpeptide N-tetradecanoyltransferase activity-IBA21873635  
GO:0004379glycylpeptide N-tetradecanoyltransferase activity-IDA25255805  
GO:0004379glycylpeptide N-tetradecanoyltransferase activity-TAS-  
GO:0019107myristoyltransferase activity-IDA22865860  
GO:0019107myristoyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0006499N-terminal protein myristoylation-TAS-  
GO:0018008N-terminal peptidyl-glycine N-myristoylation-IBA21873635  
GO:0018008N-terminal peptidyl-glycine N-myristoylation-IDA25255805  
GO:0022400regulation of rhodopsin mediated signaling pathway-TAS-  
GO:0042180cellular ketone metabolic process-IDA22865860  
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9353336  9506952  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0019898extrinsic component of membrane-IDA9506952  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-2514856The phototransduction cascadeTAS
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-75108Activation, myristolyation of BID and translocation to mitochondriaTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal