Gene: NNMT

4837
-
nicotinamide N-methyltransferase
protein-coding
11q23.2
Ensembl:ENSG00000166741 MIM:600008 Vega:OTTHUMG00000168245 UniprotKB:P40261
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.783e-1 (AD)  8.479e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MEDAG0.711
LOX0.654
ITIH30.611
CNN10.603
ESM10.599
DKK20.566
FBLN50.565
PTGS20.562
COL8A10.553
PCSK70.547

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAMTSL5-0.302
TEX15-0.289
SALL3-0.282
C6orf99-0.27
C5orf64-0.267
PDE11A-0.266
ZFHX4-0.262
DIAPH3-0.26
FAM151A-0.257
NXNL1-0.254

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00627NiacinSmall Molecule59-67-6Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NNMT mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NNMT mRNA"20056577
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NNMT mRNA"21346803
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of NNMT mRNA25716159
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NNMT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NNMT mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NNMT mRNA21420995|2649742
D000082AcetaminophenAcetaminophen affects the expression of NNMT mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NNMT mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NNMT mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NNMT gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NNMT mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NNMT mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NNMT mRNA24449571
C547126AZM551248AZM551248 results in increased expression of NNMT mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of NNMT mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of NNMT mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NNMT mRNA19770486|2196490
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NNMT mRNA"20382639
D004958EstradiolEstradiol results in increased expression of NNMT mRNA18191855
D004958EstradiolEstradiol results in increased expression of NNMT protein18191855
C006780bisphenol Abisphenol A results in increased expression of NNMT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NNMT gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NNMT mRNA17484886
D002251Carbon TetrachloridePLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NNMT mRNA]16006527
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NNMT mRNA24763279
C026690cerous chloridecerous chloride affects the expression of NNMT mRNA23139204
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NNMT mRNA17585979
D002994ClofibrateClofibrate results in decreased activity of NNMT protein18442974
D002994ClofibrateClofibrate results in decreased expression of NNMT mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NNMT mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of NNMT mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NNMT mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of NNMT mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of NNMT mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of NNMT mRNA25562108
D000069439DasatinibDasatinib results in increased expression of NNMT mRNA20579391
D004008DiclofenacDiclofenac results in increased expression of NNMT mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NNMT mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of NNMT mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of NNMT mRNA18042831|2260994
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NNMT mRNA28085963
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NNMT mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of NNMT mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of NNMT mRNA28943392
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NNMT mRNA18253720
C024629dimethyl phthalatedimethyl phthalate results in increased expression of NNMT mRNA26924002
D004237DiuronDiuron metabolite results in decreased expression of NNMT mRNA24172598
D004237DiuronDiuron results in decreased expression of NNMT mRNA25152437
C118739entinostatentinostat results in increased expression of NNMT mRNA27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of NNMT mRNA20064776
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NNMT mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NNMT mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NNMT mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NNMT mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NNMT mRNA17108234
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NNMT mRNA18253720
D005485FlutamideFlutamide results in decreased expression of NNMT mRNA24136188
C056933fumonisin B1fumonisin B1 results in decreased expression of NNMT mRNA16221962
C039281furanfuran results in increased methylation of NNMT gene22079235
C056507gemcitabinegemcitabine results in increased expression of NNMT mRNA17039268
D005839GentamicinsGentamicins results in decreased expression of NNMT mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NNMT mRNA24763279
C010178heliotrineheliotrine results in decreased expression of NNMT mRNA26100227
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NNMT mRNA24796395|2675264
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NNMT mRNA27339419
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NNMT mRNA26378955
D008345ManganeseManganese results in increased activity of NNMT protein22249857
D015741MetriboloneMetribolone results in increased expression of NNMT mRNA17010675
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NNMT mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of NNMT mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NNMT mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NNMT mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of NNMT mRNA24136188
D009532NickelNickel results in increased expression of NNMT mRNA25583101
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of NNMT protein19716841
C570897NSC668394NSC668394 results in increased expression of NNMT mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NNMT mRNA20971185
D000069463Olive OilOlive Oil analog affects the expression of NNMT mRNA17349074
D000073878Palm OilPalm Oil results in decreased expression of NNMT mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of NNMT mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of NNMT mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NNMT mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of NNMT mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of NNMT mRNA19363144|1948288
D010634PhenobarbitalPhenobarbital results in increased activity of NNMT protein18442974
D010634PhenobarbitalPhenobarbital results in increased activity of NNMT protein18442974
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NNMT mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NNMT mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of NNMT mRNA16221962|2005976
C006253pirinixic acidpirinixic acid results in increased expression of NNMT mRNA18445702
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of NNMT mRNA]20059764
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NNMT mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NNMT mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NNMT mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of NNMT mRNA18332044
D017035PravastatinPravastatin results in increased expression of NNMT mRNA27225895
D017035PravastatinPravastatin results in decreased expression of NNMT mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NNMT mRNA28903501
D011441PropylthiouracilPropylthiouracil results in increased expression of NNMT mRNA24780913
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of NNMT mRNA26100227
C059514resveratrolresveratrol results in increased expression of NNMT mRNA25905778
C009237senecioninesenecionine results in decreased expression of NNMT mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of NNMT mRNA26100227
C078903seocalcitolseocalcitol results in decreased expression of NNMT mRNA12040012
D053260SootSoot results in increased expression of NNMT mRNA22461453
C075117squalestatin 1squalestatin 1 affects the expression of NNMT mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of NNMT mRNA27225895
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NNMT mRNA26378955
C013698tallowtallow affects the expression of NNMT mRNA19680557
D013629TamoxifenESR2 protein affects the reaction [Tamoxifen results in increased expression of NNMT mRNA]14699072
D013629TamoxifenTamoxifen affects the expression of NNMT mRNA14699072
D013629TamoxifenTamoxifen affects the expression of NNMT mRNA17555576|2093736
C004648testosterone enanthatetestosterone enanthate affects the expression of NNMT mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NNMT mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NNMT mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of NNMT mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NNMT gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NNMT mRNA19770486|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NNMT mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NNMT mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of NNMT mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of NNMT mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of NNMT mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NNMT mRNA28065790
D014112ToxapheneToxaphene results in decreased expression of NNMT mRNA23153324
C032910triadimefontriadimefon results in increased expression of NNMT mRNA19363144
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NNMT mRNA28973375
D014303TrinitrotolueneTrinitrotoluene affects the expression of NNMT mRNA21346803
C057693troglitazonetroglitazone results in increased expression of NNMT mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of NNMT mRNA25716160|2915479
D014635Valproic AcidValproic Acid results in increased expression of NNMT mRNA23179753|2718838
C029297vinylidene chloridevinylidene chloride results in increased expression of NNMT mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008112nicotinamide N-methyltransferase activity-IBA21873635  
GO:0008112nicotinamide N-methyltransferase activity-TAS-  
GO:0008170N-methyltransferase activity-IBA21873635  
GO:0030760pyridine N-methyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010243response to organonitrogen compound-IEA-  
GO:0031100animal organ regeneration-IEA-  
GO:0032259methylation-TAS-  
GO:0034356NAD biosynthesis via nicotinamide riboside salvage pathway-TAS-  
GO:0042493response to drug-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-196807Nicotinate metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-197264Nicotinamide salvagingTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-2408508Metabolism of ingested SeMet, Sec, MeSec into H2SeIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet