Gene: NODAL

4838
HTX5
nodal growth differentiation factor
protein-coding
10q22.1
Ensembl:ENSG00000156574 MIM:601265 Vega:OTTHUMG00000018408 UniprotKB:Q96S42
NG_012448.2
PubMed
CD|ND|AD
125   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.091e-1 (AD)  3.205e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES50.415
SSX20.408
IGF20.383
SLC6A10.371
DIO20.37
MYLK20.364
PIPOX0.36
INS-IGF20.354
MUSTN10.347
CLEC3B0.344

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSD11B2-0.371
KIF19-0.37
FKBP5-0.331
AZGP1-0.319
RASEF-0.313
PTGER1-0.312
CRYAA-0.302
CLEC4E-0.291
SFTPC-0.284
TMEM31-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of NODAL mRNA"18648102
D000079AcetaldehydeAcetaldehyde affects the expression of NODAL mRNA22634333
D000082AcetaminophenAcetaminophen affects the expression of NODAL mRNA17562736
D019342Acetic AcidAcetic Acid affects the expression of NODAL protein21296659
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of NODAL mRNA21298039
D001280AtrazineAtrazine results in increased expression of NODAL mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NODAL promoter]19654925
C006780bisphenol Abisphenol A results in increased expression of NODAL mRNA18007998
C006780bisphenol Abisphenol A results in decreased expression of NODAL mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid affects the expression of NODAL protein21296659
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NODAL gene20938992
C014347decitabinedecitabine results in increased expression of NODAL mRNA27915011
D016190CarboplatinNODAL results in increased susceptibility to Carboplatin21224400
D002945CisplatinCisplatin results in increased expression of NODAL mRNA21224400
D002945CisplatinNODAL results in increased susceptibility to Cisplatin21224400
D005472FluorouracilFluorouracil results in decreased expression of NODAL protein21296659
C061365flusilazoleflusilazole affects the expression of NODAL mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NODAL gene20938992
D018021Lithium ChlorideLithium Chloride results in increased expression of NODAL mRNA17506889
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NODAL gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NODAL mRNA22555245|2390381
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NODAL mRNA22555245
C091888monoisoamyl-2,3-dimercaptosuccinate"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of NODAL mRNA"19615344
C511794N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide"N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide affects the localization of NODAL"21337468
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NODAL mRNA"25620056
C022838nickel chloridenickel chloride affects the localization of NODAL21337468
D010656PhenylephrinePhenylephrine affects the expression of NODAL mRNA11029149
D010656PhenylephrinePhenylephrine affects the expression of NODAL protein11029149
D010936Plant ExtractsPlant Extracts results in decreased expression of NODAL mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of NODAL mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of NODAL mRNA21770760
C017947sodium arsenite"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of NODAL mRNA"19615344
C017947sodium arsenitesodium arsenite results in decreased expression of NODAL mRNA19615344
D013739TestosteroneTestosterone results in decreased expression of NODAL mRNA22138414
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NODAL mRNA21354282
C009495titanium dioxidetitanium dioxide results in increased expression of NODAL mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of NODAL mRNA"19682533
C011559tributyltintributyltin results in increased expression of NODAL mRNA27614199
D014635Valproic AcidValproic Acid affects the expression of NODAL mRNA25979313|2607246
D014635Valproic AcidValproic Acid affects the expression of NODAL mRNA26072468
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NODAL gene25560391
C016837zinc chloridezinc chloride affects the localization of NODAL21337468
D019287Zinc SulfateZinc Sulfate results in increased expression of NODAL mRNA17506889

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0008083growth factor activity-IEA-  
GO:0016015morphogen activity-NAS21159651  
GO:0070698type I activin receptor binding-IBA21873635  
GO:0070698type I activin receptor binding-IMP21356369  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001831trophectodermal cellular morphogenesis-IEA-  
GO:0001842neural fold formation-IEA-  
GO:0001889liver development-IEA-  
GO:0001890placenta development-IMP21356369  
GO:0001892embryonic placenta development-IEA-  
GO:0001893maternal placenta development-IEA-  
GO:0001944vasculature development-IEA-  
GO:0001947heart looping-IEA-  
GO:0002085inhibition of neuroepithelial cell differentiation-IEA-  
GO:0007420brain development-IEA-  
GO:0009880embryonic pattern specification-IEA-  
GO:0010085polarity specification of proximal/distal axis-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010470regulation of gastrulation-IEA-  
GO:0010575positive regulation of vascular endothelial growth factor production-IMP21116837  
GO:0010721negative regulation of cell development-IEA-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IMP21741376  
GO:0019827stem cell population maintenance-IEA-  
GO:0022409positive regulation of cell-cell adhesion-IMP21116837  
GO:0030509BMP signaling pathway-IBA21873635  
GO:0032927positive regulation of activin receptor signaling pathway-IGI15150278  
GO:0033505floor plate morphogenesis-IEA-  
GO:0035987endodermal cell differentiation-IMP21741376  
GO:0042074cell migration involved in gastrulation-IEA-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA15150278  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0045766positive regulation of angiogenesis-IMP21116837  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048327axial mesodermal cell fate specification-IEA-  
GO:0048382mesendoderm development-IMP21741376  
GO:0048468cell development-IBA21873635  
GO:0048546digestive tract morphogenesis-IEA-  
GO:0048701embryonic cranial skeleton morphogenesis-IEA-  
GO:0048859formation of anatomical boundary-IEA-  
GO:0050679positive regulation of epithelial cell proliferation-IDA21656830  
GO:0051091positive regulation of DNA-binding transcription factor activity-IMP21116837  
GO:0060136embryonic process involved in female pregnancy-IEA-  
GO:0060137maternal process involved in parturition-IEA-  
GO:0060391positive regulation of SMAD protein signal transduction-IMP21741376  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO:0060460left lung morphogenesis-IEA-  
GO:0060766negative regulation of androgen receptor signaling pathway-IDA21656830  
GO:0060802epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP21116837  
GO:0090010transforming growth factor beta receptor signaling pathway involved in primitive streak formation-IEA-  
GO:1900164nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry-IEA-  
GO:1900224positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry-ISS-  
GO:1901164negative regulation of trophoblast cell migration-IDA21356369  
GO:1901383negative regulation of chorionic trophoblast cell proliferation-IDA15150278  
GO:2000036regulation of stem cell population maintenance-TAS21630377  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA21656830  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1181150Signaling by NODALIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1433617Regulation of signaling by NODALIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19141402Loss of heterozygosity for Rb locus and pRb immunostaining in laryngeal cancer: a clinicopathologic, molecular and immunohistochemical study. (2008)Pietruszewska WFolia Histochem Cytobiol
24560569Oncologic outcomes of patients undergoing videoscopic inguinal lymphadenectomy for metastatic melanoma. (2014 Apr)Martin BMJ Am Coll Surg
27002481Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma. (2016 Sep)Dixon PRHead Neck
7836799Expression of GST-mu transferase in breast cancer patients and healthy controls. (1994 Oct-Dec)Paradiso AInt J Biol Markers
29483073The Combined Association of Modifiable Risk Factors with Breast Cancer Risk in the Women's Health Initiative. (2018 Feb 26)Arthur RCancer Prev Res (Phila)
26572255Outcomes After Surgery in High-Risk Patients With Early Stage Lung Cancer. (2016 Mar)Sancheti MSAnn Thorac Surg
24706381Combined P16 and human papillomavirus testing predicts head and neck cancer survival. (2014 Nov 15)Salazar CRInt J Cancer
20593958NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and colorectal cancer predisposition in the ethnic Kashmiri population. (2010)Sameer ASAsian Pac J Cancer Prev
28860576PD-L1 expression in lung cancer and its correlation with driver mutations: a meta-analysis. (2017 Aug 31)Zhang MSci Rep
24987916Smokers with cervix cancer have more uterine corpus invasive disease and an increased risk of recurrence after treatment with chemoradiation. (2014 Sep)Mileshkin LInt J Gynecol Cancer
27750372Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma. (2017 Mar)Pattle SBGenes Chromosomes Cancer
8617082p53 mutations in non-small cell lung carcinomas in Hong Kong. (1996 Mar)Lung MLChest
29544748The prognostic value of high LncRNA AFAP1-AS1 expression in various cancers: A systematic review and meta-analysis containing 21 studies. (2018 Jun)Zhou YClin Chim Acta
10945633hMLH1 and hMSH2 expression correlates with allelic imbalance on chromosome 3p in non-small cell lung carcinomas. (2000 Aug 1)Xinarianos GCancer Res
7977955Increased expression of basic fibroblast growth factor in squamous carcinogenesis of the head and neck is less prevalent following smoking cessation. (1994 Nov)Hughes CJAm J Surg
15635575Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma. (2005 Jan-Feb)Puri SKAm J Otolaryngol
25415160Morbid obesity as an independent risk factor for disease-specific mortality in women with cervical cancer. (2014 Dec)Frumovitz MObstet Gynecol
16549820Association of the PDCD5 locus with lung cancer risk and prognosis in smokers. (2006 Apr 10)Spinola MJ Clin Oncol
29356189Effect of time to simulation and treatment for patients with oropharyngeal cancer receiving definitive radiotherapy in the era of risk stratification using smoking and human papillomavirus status. (2018 Apr)Amsbaugh MJHead Neck
24565983Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. (2014 May)Vainshtein JMOral Oncol
23749933Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma. (2013 Jun)Wang YCAnticancer Res
14654716Tumor markers (CEA, CA 125, CYFRA 21-1, SCC and NSE) in patients with non-small cell lung cancer as an aid in histological diagnosis and prognosis. Comparison with the main clinical and pathological prognostic factors. (2003 Aug-Sep)Molina RTumour Biol
27042224Clinical analysis of sixty-four patients with T1aN2M0 stage non-small cell lung cancer who had undergone resection. (2016 Mar)Xiong JThorac Cancer
24179496Differences in EGFR and KRAS mutation spectra in lung adenocarcinoma of never and heavy smokers. (2013 Nov)Takamochi KOncol Lett
25545260Trends in human papillomavirus-related oropharyngeal cancer in Israel. (2016 Apr)Amit MHead Neck
10504637Bronchoalveolar carcinoma: clinical, radiologic, and pathologic factors and survival. (1999 Oct)Okubo KJ Thorac Cardiovasc Surg
25801358Detailed Analysis of Clinicopathologic Factors Demonstrate Distinct Difference in Outcome and Prognostic Factors Between Surgically Treated HPV-Positive and Negative Oropharyngeal Cancer. (2015 Dec)Iyer NGAnn Surg Oncol
22743286Tumor cell anaplasia and multinucleation are predictors of disease recurrence in oropharyngeal squamous cell carcinoma, including among just the human papillomavirus-related cancers. (2012 Jul)Lewis JS JrAm J Surg Pathol
9511435[Molecular biological and biochemical features of breast cancer]. (1998)Khanson KPVestn Ross Akad Med Nauk
23086268Association of glutathione S-transferase omega gene polymorphisms with progression of head and neck cancer. (2012 Dec)Sanguansin SMol Biol Rep
14581353Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. (2003 Oct 15)Miller CTClin Cancer Res
26573952Clinical significance of preoperative C-reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma. (2016 Aug)Li ZSBJU Int
17621627KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma. (2007 Nov 1)Teixeira MSInt J Cancer
20940365Interaction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes. (2011 Jan)Supic GJ Dent Res
17663890[Spanish medical center collaboration on smoking research from 1999 through 2003 according to the Science Citation Index]. (2007 Jul)Villanueva Serrano SJArch Bronconeumol
28789387Urinary levels of prostaglandin E2 are positively correlated with intratumoral infiltration of Foxp3(+) regulatory T cells in non-small cell lung cancer. (2017 Aug)Shimizu KOncol Lett
24099733Prognostic factors in a multicentre study of 247 atypical pulmonary carcinoids. (2014 Apr)Daddi NEur J Cardiothorac Surg
22399565Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. (2012 Apr 15)Malkoski SPClin Cancer Res
23803060Serum level of mast cell tryptase in patients with oral squamous cell carcinoma: lack of correlation with clinicopathologic factors. (2013)Jaafari-Ashkavandi ZAsian Pac J Cancer Prev
26251219Does active smoking induce hematogenous metastatic spread in colon cancer? (2015 Nov)Amri RAm J Surg
18760943Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients. (2008 Nov)Oliveira LROral Surg Oral Med Oral Pathol Oral Radiol Endod
24086446Mortality and recurrence risk in relation to the use of lipid-lowering drugs in a prospective breast cancer patient cohort. (2013)Nickels SPLoS One
14710013Epidermal growth factor receptor in undifferentiated carcinoma of the nasopharynx. (2004 Jan)Leong JLLaryngoscope
29299663Prognostic factors in patients with penile cancer after surgical management. (2018 Mar)Wen SWorld J Urol
15329320Comparison of cytokeratin 20 RNA and angiogenin in voided urine samples as diagnostic tools for bladder carcinoma. (2004 Sep)Eissa SClin Biochem
8776417SSCP pattern indicative for p53 mutation is related to advanced stage and high-grade of tongue cancer. (1996 Jul)Atula SEur J Cancer B Oral Oncol
1330149Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck. (1992 Jul)Field JKEur J Cancer B Oral Oncol
21778309Prognostic significance of angiogenic factors in uterine cervical cancer. (2011 Aug)Landt SAnticancer Res
24171785Prognostic molecular markers in head and neck squamous cell carcinoma in a New Zealand population: matrix metalloproteinase-2 and sialyl Lewis x antigen. (2015 Nov)Gunawardena IANZ J Surg
23434054Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. (2013 Jun)Young RJOral Oncol
12948402[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]. (2003 Jun)Zhu LQAi Zheng
26514270Clinical parameters predicting development of pulmonary malignancies in patients treated for head and neck squamous cell carcinoma. (2016 Apr)Madana JHead Neck
25973117Pulmonary Langerhans cell histiocytosis with cervical lymph node involvement, and coexistence with pulmonary tuberculosis and right pneumothorax: a case report and review of literature. (2015)Gao LInt J Clin Exp Pathol
8640667High neuron specific enolase levels in bronchoalveolar lavage fluid of patients with lung carcinoma: diagnostic value, relation to serum neuron specific enolase, and staging. (1996 May 15)Dowlati ACancer
22115925Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study. (2012 Jul)Granata RAnn Oncol
27732623Obstructive Sleep Apnea and Pathological Characteristics of Resected Pancreatic Ductal Adenocarcinoma. (2016)Dal Molin MPLoS One
10665750Smoking and survival from lung cancer. (1999)Holli KActa Oncol
26681652Promoter methylation of APC and RAR-beta genes as prognostic markers in non-small cell lung cancer (NSCLC). (2016 Feb)Feng HExp Mol Pathol
20646498[Clinical and prognostic analysis of skip N2 metastases in stage IIIA-N2 non-small cell lung cancer]. (2010 May 15)Zhang LMZhonghua Wai Ke Za Zhi
19216085Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer. (2009 Apr)Kanauchi NEur J Cardiothorac Surg
24535381Risk factors for mediastinal lymph node metastasis in non-small-cell lung cancer by PET/CT. (2014 May)Xu ZQNucl Med Commun
16631234Endometrial cancer in Kentucky: the impact of age, smoking status, and rural residence. (2006 Oct)Modesitt SCGynecol Oncol
26728104Prognostic value of radiographic extracapsular extension in locally advanced head and neck squamous cell cancers. (2016 Jan)Liu JTOral Oncol
8730127Gouty arthritis in nodal osteoarthritis. (1996 Apr)Fam AGJ Rheumatol
18814932Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients. (2009 Apr)Choi CMLung Cancer
19434873[Pancreatic tumors]. (2008 Oct)Iglesias-Garcia JGastroenterol Hepatol
24953865Interactions between clinical factors, p16, and cyclin-D1 expression and survival outcomes in oropharyngeal and hypopharyngeal squamous cell carcinoma. (2015 Nov)Ang SHHead Neck
28075104Esophageal Cancer. (2017 Jan 1)Short MWAm Fam Physician
7952630Exon 8 mutation of p53 gene associated with nodal metastasis in non-small-cell lung cancer. (1994 Dec)Lee LNAm J Respir Crit Care Med
25621262Prognostic and predictive factors in gingivo buccal complex squamous cell carcinoma: role of tumor budding and pattern of invasion. (2015 Mar)Manjula BVIndian J Otolaryngol Head Neck Surg
11759373[Severe accidental hypothermia in an elderly woman]. (2001 Nov)Knobel BHarefuah
27523454Defining risk groups of patients with cancer of unknown primary site and cervical nodal metastases by F-18 fluorodeoxyglucose positron emission tomography and computed tomography imaging. (2016 Aug)Su YYKaohsiung J Med Sci
27209503High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma. (2016 Jul 15)Khwaja SSInt J Radiat Oncol Biol Phys
27225345Expression of PD-L1 Identifies a Subgroup of More Aggressive Non-Small Cell Carcinomas of the Lung. (2016)Sterlacci WPathobiology
26904215Clinicopathologic correlates of postoperative N1 or N2 nodal upstaging in non-small cell lung cancer. (2016 Jan)Moon YJ Thorac Dis
28874120The association between smoking and breast cancer characteristics and outcome. (2017 Sep 6)Goldvaser HBMC Cancer
26310237A different entity: a population based study of characteristics and recurrence patterns in oropharyngeal squamous cell carcinomas. (2015 Aug 28)Murray SJ Otolaryngol Head Neck Surg
28554757Clinicopathological significance and prognostic role of EZH2 expression in non-small cell lung cancer. (2017 Jul)Kim NYPathol Res Pract
23676560Biostatistics primer: what a clinician ought to know--prognostic and predictive factors. (2013 Jun)Simms LJ Thorac Oncol
26509127The Significance of Serum Carcinoembryonic Antigen in Lung Adenocarcinoma. (2015 Oct)Kim JJKorean J Thorac Cardiovasc Surg
21547471Prognostic factors for upper urinary tract urothelial carcinomas: stage, grade, and smoking status. (2011 Dec)Simsir AInt Urol Nephrol
27835577A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population. (2016 Dec 6)Zhang YOncotarget
9767968[Adenocarcinoma of the pancreas. General characteristics]. (1998 Mar 21)Andre TPresse Med
23561806Does bilobectomy offer satisfactory long-term survival outcome for non-small cell lung cancer? (2013 May)Icard PAnn Thorac Surg
10914730Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis. (2000 Jul)Tae KClin Cancer Res
1498077Factors influencing complete response and survival in patients with head and neck cancer treated with platinum-based induction chemotherapy. A Hellenic Co-operative Oncology Group Study. (1992 Jul)Fountzilas GAnn Oncol
14616566Anterior tongue cancer: age is not a predictor of outcome and should not alter treatment. (2003 Nov)Veness MJANZ J Surg
10652400Head and neck squamous cell carcinoma: better to be young. (2000 Feb)Lacy PDOtolaryngol Head Neck Surg
18474878EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. (2008 Jul 1)Kumar BJ Clin Oncol
28699269Determinants of short and long term outcomes in patients undergoing immediate breast reconstruction following neoadjuvant chemotherapy. (2017 Dec)Wengler CAJ Surg Oncol
27027313Predicting EGFR mutation status in lung cancer:Proposal for a scoring model using imaging and demographic characteristics. (2016 Nov)Sabri AEur Radiol
28461789Is immunohistochemical evaluation of p16 in oropharyngeal cancer enough to predict the HPV positivity? (2017 May-Jun)Golusinski PRep Pract Oncol Radiother
16299236Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer. (2005 Nov 15)Gure AOClin Cancer Res
24626127Oropharyngeal squamous cell carcinoma treatment: current standards and future directions. (2014 May)Marur SCurr Opin Oncol
2807652Dietary exposures and other factors of possible prognostic significance in relation to tumour size and nodal involvement in early-stage breast cancer. (1989 Sep)Hebert JRInt J Epidemiol
22387125Prognostic features, human papillomavirus status, and epidermal growth factor receptor expression in oral squamous cell carcinoma in young adults. (2012 Nov-Dec)Thomas LAm J Otolaryngol
28144684Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis. (2017 Apr)Yildirim MStrahlenther Onkol
29210145Squamous cell carcinoma of unknown primary of the head and neck: Favorable prognostic factors comparable to those in oropharyngeal cancer. (2018 May)Zhou MJHead Neck
21584560Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis. (1992 Sep)Papadakis EInt J Oncol
15364129Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer. (2004 Oct)Oyanagi HLung Cancer
25736461A contemporary review of management and prognostic factors of upper tract urothelial carcinoma. (2015 Apr)Leow JJCancer Treat Rev
26424708Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer. (2015 Sep 30)Shimizu KWorld J Surg Oncol
15482324Elevated serum levels of a c-erbB-2 oncogene product in oral squamous cell carcinoma patients. (2004 Nov)Chen CHJ Oral Pathol Med
24716958Analysis on the characteristics and prognosis of pulmonary neuroendocrine tumors. (2014)Wu BSAsian Pac J Cancer Prev
29380447Differential impact of CX3CL1 on lung cancer prognosis in smokers and non-smokers. (2018 May)Su YCMol Carcinog
14692803Bronchial epithelial-myoepithelial carcinoma. (2004 Jan)Ru KArch Pathol Lab Med
28290074Abnormal brain white matter network in young smokers: a graph theory analysis study. (2018 Apr)Zhang YBrain Imaging Behav
21115604Outcome of patients with metastatic renal cell carcinoma treated with targeted therapy without cytoreductive nephrectomy. (2011 May)Richey SLAnn Oncol
15754996Intratumoral oxygenation of invasive squamous cell carcimoma of the vulva is not correlated with regional lymph node metastasis. (2005)Stone JEEur J Gynaecol Oncol
23846787Differential expression of cytochrome P450 omega-hydroxylase isoforms and their association with clinicopathological features in pancreatic ductal adenocarcinoma. (2013 Dec)Gandhi AVAnn Surg Oncol
21945224Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer. (2011 Nov)Shersher DDAnn Thorac Surg
22966403Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma. (2010 Sep)Zhang POncol Lett
22572237Prognostic impact of nestin expression in resected large cell neuroendocrine carcinoma of the lung. (2012 Aug)Ryuge SLung Cancer
20338307Prognostic heterogeneity in multilevel N2 non-small cell lung cancer patients: importance of lymphadenopathy and occult intrapulmonary metastases. (2010 Apr)Sakao YAnn Thorac Surg
25608155Metabolic phenotype of stage IV lung adenocarcinoma: relationship with epidermal growth factor receptor mutation. (2015 Mar)Lee EYClin Nucl Med
19967414Increased H2O2 level in exhaled breath condensate in primary breast cancer patients. (2010 Jun)Stolarek RAJ Cancer Res Clin Oncol
23726808Interleukin 1B rs16944 G>A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. (2013 Oct)Zheng LClin Biochem
10813511A study of smoking, p53 tumor suppressor gene alterations and non-small cell lung cancer. (2000 Apr)Tammemagi MCAnn Epidemiol
29496043Induction chemotherapy followed by concurrent chemoradiation versus concurrent chemoradiation alone in the definitive management of p16-positive oropharyngeal squamous cell carcinoma with low-neck or N3 disease. (2018 Mar)Bhattasali OOral Oncol
23167377Serum level of MMP-3 in patients with oral squamous cell carcinoma--lack of association with clinico-pathological features. (2012)Tadbir AAAsian Pac J Cancer Prev
19467945Detection and screening of oral cancer and pre-cancerous lesions. (2009 May)Kao SYJ Chin Med Assoc
10607923Clinical importance of correlations between p53 immunoreactivity and clinicopathological parameters in lung carcinoma. (1999)Dursun BAPathol Oncol Res
27142401Contemporary Hospitalization Rate Among Adults With Complex Congenital Heart Disease. (2016 May)Cedars AWorld J Pediatr Congenit Heart Surg
25729497Characteristics of Expression of Matrix Metalloproteinases (MMP-2 and MMP-9) in Glottic Squamous Cell Carcinoma and Benign Vocal Fold Lesions. (2015 Mar)Uloza VClin Exp Otorhinolaryngol
25771076High metastatic node number, not extracapsular spread or N-classification is a node-related prognosticator in transorally-resected, neck-dissected p16-positive oropharynx cancer. (2015 May)Sinha POral Oncol