Gene: CNOT2

4848
CDC36|HSPC131|NOT2|NOT2H
CCR4-NOT transcription complex subunit 2
protein-coding
12q15
Ensembl:ENSG00000111596 MIM:604909 Vega:OTTHUMG00000169481 UniprotKB:Q9NZN8
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.498e-1 (AD)  3.190e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11178177chr12:70297525 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TIAL10.922
PDS5A0.922
RPS6KB10.922
PRPF4B0.916
ZNF2070.913
DHX150.913
RIOK30.908
TBC1D230.907
MAP3K70.906
UHRF20.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.58
OR4F29-0.555
HES5-0.319
PLA2G5-0.275
NXNL1-0.243
BTBD17-0.236
REN-0.228
C16orf74-0.219
WNT7B-0.211
PPP1R3G-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CNOT2 mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of CNOT2 protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CNOT2 mRNA"18648102
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of CNOT2 mRNA14583596
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CNOT2 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of CNOT2 mRNA15761015
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CNOT2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CNOT2 mRNA"19150397|2038263
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CNOT2 mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of CNOT2 mRNA19167446
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of CNOT2 gene28505145
C006780bisphenol Abisphenol A results in increased expression of CNOT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CNOT2 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of CNOT2 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of CNOT2 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CNOT2 mRNA16934159
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CNOT2 mRNA23650126
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of CNOT2 mRNA19524605
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CNOT2 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of CNOT2 mRNA28302478
C024629dimethyl phthalatedimethyl phthalate affects the expression of CNOT2 mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CNOT2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CNOT2 mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of CNOT2 mRNA20655997
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of CNOT2 gene28505145
D005839GentamicinsGentamicins results in increased expression of CNOT2 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CNOT2 mRNA20044591
D008345ManganeseManganese results in decreased expression of CNOT2 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of CNOT2 mRNA17175027
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CNOT2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CNOT2 mRNA"26251327
C025589ochratoxin Aochratoxin A results in decreased acetylation of CNOT2 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of CNOT2 promoter] which results in decreased expression of CNOT2 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of CNOT2 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CNOT2 mRNA25729387
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CNOT2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CNOT2 mRNA22079256
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of CNOT2 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNOT2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNOT2 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CNOT2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CNOT2 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of CNOT2 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of CNOT2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of CNOT2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of CNOT2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CNOT2 mRNA22083351|2317975
D014635Valproic AcidValproic Acid results in decreased methylation of CNOT2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of CNOT2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CNOT2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001226RNA polymerase II transcription corepressor binding-IDA16712523  
GO:0003712transcription coregulator activity-TAS10637334  
GO:0004535poly(A)-specific ribonuclease activitycontributes_toIMP21299754  
GO:0005515protein binding-IPI10637334  16189514  16778766  17452450  21981923  21984185  
26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA14707134  16712523  
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening-TAS-  
GO:0001829trophectodermal cell differentiation-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-NAS10637334  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0010606positive regulation of cytoplasmic mRNA processing body assembly-IMP21299754  
GO:0017148negative regulation of translation-IBA21873635  
GO:0031047gene silencing by RNA-IEA-  
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway-IMP16778766  
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic-IEA-  
GO:2000036regulation of stem cell population maintenance-IBA21873635  
GO:2000036regulation of stem cell population maintenance-IMP22367759  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS10637334  
GO:0005737cytoplasm-IDA21299754  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016020membrane-HDA19946888  
GO:0030014CCR4-NOT complex-IDA19558367  
GO:0030015CCR4-NOT core complex-IBA21873635  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-429914Deadenylation-dependent mRNA decayTAS
R-HSA-429947Deadenylation of mRNATAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804115TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal