Gene info: ID 4851

Gene: NOTCH1

GENE ID: 4851

Synonyms: AOS5|AOVD1|TAN1|hN1

Description: notch 1

Gene type: protein-coding

Location: 9q34.3

dbXrefs: Ensembl:ENSG00000148400 MIM:190198 Vega:OTTHUMG00000020935 UniprotKB:P46531

RefSeq: NG_007458.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.069e-1 (AD) 1.293e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg12076931	chr9:139427171	NOTCH1	Gene body	2.958e-4	Alcohol use disorders	26763658
cg05784201	chr9:139407609	NOTCH1	Gene body	3.583e-4	Alcohol use disorders	26763658
cg13951862	chr9:139425582	NOTCH1	Gene body	4.350e-4	Alcohol use disorders	26763658
cg05019807	chr9:139410393	NOTCH1	Gene body	6.938e-4	Alcohol use disorders	26763658
cg14120703	chr9:139416102	NOTCH1		7.000e-15	Smoking	27651444
cg13876222	chr9:139399348	NOTCH1		1.640e-12	Alcohol consumption per day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TLN1	0.848
KANK1	0.841
ARHGEF40	0.828
SLC4A2	0.823
CASKIN2	0.82
SLC12A4	0.809
TRIOBP	0.807
PIEZO1	0.803
TCF3	0.796
LAMB2	0.796

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SMIM18	-0.484
CDH8	-0.438
FSTL5	-0.437
PTPRR	-0.426
CBLN1	-0.424
PPEF1	-0.424
KCNB2	-0.423
PCSK1	-0.418
MYOZ3	-0.412
SLC17A6	-0.411

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C105351	1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene	"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NOTCH1 protein"	23284745
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased activity of NOTCH1 protein modified form"	19382889
C576532	2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide	"[2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide co-treated with cyclopamine] results in decreased expression of and results in decreased cleavage of NOTCH1 protein"	21498710
C576532	2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide	"[2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide co-treated with Quercetin] results in decreased expression of and results in decreased cleavage of NOTCH1 protein"	21498710
C576532	2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide	"2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide results in decreased cleavage of NOTCH1 protein"	21498710
C576532	2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide	"[cyclopamine co-treated with 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide] results in decreased cleavage of NOTCH1 protein"	21498710
C576532	2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide	"[Quercetin co-treated with 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide] results in decreased cleavage of NOTCH1 protein"	21498710
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of NOTCH1 mRNA"	18343893
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in increased expression of NOTCH1 mRNA"	20702594
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of NOTCH1 protein"	21908764
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein]	17513037
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]	17513037
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein	20348013
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of ACTA2 protein	20348013
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of CDH1 protein	20348013
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of MMP2 protein	20348013
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of MMP9 protein	20348013
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of SNAI1 protein	20348013
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]	27989784
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased expression of NOTCH1 protein	27989784
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NOTCH1 mRNA"	18042819\|2070259
C585745	4-amino-2-trifluoromethyl-phenyl retinate	4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of NOTCH1 protein	28130038
C585745	4-amino-2-trifluoromethyl-phenyl retinate	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of NOTCH1 protein]"	28130038
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of NOTCH1 mRNA	19191707
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of NOTCH1 mRNA"	28073004
D000082	Acetaminophen	Acetaminophen results in increased expression of NOTCH1 mRNA	22230336\|2906747
D016604	Aflatoxin B1	[Zearalenone co-treated with Aflatoxin B1] results in increased expression of NOTCH1 mRNA	28965971
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of NOTCH1 mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NOTCH1 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [PROM1 protein results in increased activity of NOTCH1 protein]	23832679
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of NOTCH1 protein	23542114
C006632	arsenic trioxide	[arsenic trioxide results in decreased activity of NOTCH1 protein] which results in decreased phosphorylation of and results in decreased activity of STAT3 protein	23542114
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of NOTCH1	25088040
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of NOTCH1 mRNA	22949821\|2297810
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of NOTCH1 protein	22949821\|2297810
C006632	arsenic trioxide	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide results in decreased expression of NOTCH1 protein]	24801890
C006632	arsenic trioxide	NOTCH1 protein results in decreased susceptibility to arsenic trioxide	22949821
C015001	arsenite	arsenite results in decreased expression of NOTCH1 protein modified form	18633435
C015001	arsenite	arsenite results in increased expression of NOTCH1 protein	22011395
C015001	arsenite	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form]	18633435
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of NOTCH1 mRNA"	23917077
C006680	baicalein	baicalein results in increased activity of NOTCH1 protein	19160421
C006680	baicalein	baicalein results in increased expression of NOTCH1 mRNA	19160421
C038044	baicalin	baicalin results in increased activity of NOTCH1 protein	19160421
C038044	baicalin	baicalin results in increased expression of NOTCH1 mRNA	19160421
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA	27858113
D001554	Benzene	Benzene results in increased expression of NOTCH1 mRNA	24993241
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA	27858113
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of NOTCH1 mRNA	23994337
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NOTCH1 mRNA	19770486\|2222880
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide results in decreased expression of NOTCH1 protein]	24801890
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOTCH1 mRNA	24497960
D004958	Estradiol	Estradiol promotes the reaction [NOTCH1 protein binds to CCND1 promoter]	19838210
D004958	Estradiol	Estradiol affects the expression of NOTCH1 mRNA	15598610
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of NOTCH1 mRNA	19693291
C006780	bisphenol A	bisphenol A results in decreased expression of NOTCH1 mRNA	26363213
C006780	bisphenol A	bisphenol A affects the methylation of NOTCH1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of NOTCH1 mRNA	21932408
C006780	bisphenol A	bisphenol A affects the expression of NOTCH1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of NOTCH1 gene	28505145
C006780	bisphenol A	NOTCH1 protein modified form results in decreased susceptibility to bisphenol A	19218331
C000606543	BMS-906024	BMS-906024 results in decreased expression of NOTCH1 mutant form	27148573
D019274	Botulinum Toxins, Type A	"NOTCH1 results in decreased susceptibility to Botulinum Toxins, Type A"	23884415
C584509	C646 compound	C646 compound results in increased expression of NOTCH1 mRNA	26191083
D002101	Cacodylic Acid	Cacodylic Acid affects the expression of NOTCH1 mRNA	17720352
D019256	Cadmium Chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
D019256	Cadmium Chloride	Cadmium Chloride results in increased cleavage of and affects the localization of NOTCH1 protein	25118938
D019256	Cadmium Chloride	JAG1 mutant form inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
D019256	Cadmium Chloride	JAG2 mutant form inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
D019256	Cadmium Chloride	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]"	25118938
D019256	Cadmium Chloride	NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	25118938
D019256	Cadmium Chloride	NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]	25118938
D019256	Cadmium Chloride	NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]	25118938
D019256	Cadmium Chloride	NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]	25118938
D019256	Cadmium Chloride	NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]	25118938
D019256	Cadmium Chloride	picropodophyllin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
D019256	Cadmium Chloride	pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
D019256	Cadmium Chloride	tyrphostin AG 1478 inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of NOTCH1 promoter	22457795
D002392	Catechin	Catechin results in increased expression of NOTCH1 mRNA	15465739
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of NOTCH1 mRNA	18668222
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of NOTCH1 mRNA	19654923
C074702	chromium hexavalent ion	MAP2K7 protein promotes the reaction [chromium hexavalent ion results in increased expression of NOTCH1 mRNA]	19654923
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NOTCH1 mRNA	27858113
C031180	chrysene	chrysene results in decreased expression of NOTCH1 mRNA	26377693
C018021	cobaltous chloride	cobaltous chloride results in increased expression of NOTCH1 mRNA	22941251
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of NOTCH1 mRNA	24386269
D003300	Copper	Copper affects the expression of NOTCH1 mRNA	18522721
D003474	Curcumin	[Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein	18640131
D003474	Curcumin	Curcumin results in decreased expression of NOTCH1 mRNA	17927689
D003474	Curcumin	Curcumin results in decreased expression of NOTCH1 protein	18640131
D003474	Curcumin	Curcumin results in decreased expression of NOTCH1	18462866
C000541	cyclopamine	"[2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide co-treated with cyclopamine] results in decreased expression of and results in decreased cleavage of NOTCH1 protein"	21498710
C000541	cyclopamine	"[cyclopamine co-treated with 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide] results in decreased cleavage of NOTCH1 protein"	21498710
C000541	cyclopamine	cyclopamine results in decreased cleavage of NOTCH1 protein	21498710
C000541	cyclopamine	cyclopamine results in decreased expression of and results in decreased cleavage of NOTCH1 protein	21498710
D016047	Zalcitabine	Zalcitabine results in increased mutagenesis of NOTCH1 gene	18798262
D003634	DDT	DDT results in increased activity of NOTCH1 protein	18791200
D003634	DDT	MAP2K6 protein promotes the reaction [DDT results in increased activity of NOTCH1 protein]	18791200
C014347	decitabine	[decitabine co-treated with trichostatin A] results in decreased expression of NOTCH1 mRNA	17185465
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 mRNA]	18449946
D003907	Dexamethasone	Dexamethasone results in decreased expression of NOTCH1 mRNA	14618091
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of NOTCH1 mRNA	23430952
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of NOTCH1 protein	23430952
C042577	diallyl trisulfide	NOTCH1 mutant form promotes the reaction [diallyl trisulfide results in decreased activity of MMP2 protein]	23430952
C042577	diallyl trisulfide	NOTCH1 mutant form promotes the reaction [diallyl trisulfide results in decreased activity of MMP9 protein]	23430952
C042577	diallyl trisulfide	NOTCH1 mutant form promotes the reaction [diallyl trisulfide results in decreased secretion of VEGFA protein]	23430952
D002945	Cisplatin	Cisplatin results in decreased expression of NOTCH1 mRNA	27594783
C000944	dicrotophos	dicrotophos results in increased expression of NOTCH1 mRNA	28302478
D004026	Dieldrin	Dieldrin affects the expression of NOTCH1 mRNA	22546817
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of NOTCH1 mRNA	17854601\|2160768
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of NOTCH1 mRNA]	17854601
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of NOTCH1 mRNA	21041162
D004642	Emodin	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]	27989784
D004642	Emodin	Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]	27989784
D004642	Emodin	Emodin results in decreased expression of NOTCH1 protein	27989784
D004642	Emodin	NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]	27989784
D004642	Emodin	NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]	27989784
D004642	Emodin	NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]	27989784
D004642	Emodin	NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]	27989784
D004642	Emodin	NOTCH1 protein results in decreased susceptibility to Emodin	27989784
D000431	Ethanol	Ethanol results in decreased activity of NOTCH1 protein	16770775
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NOTCH1 mRNA	17557909
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of NOTCH1 mRNA	23649840
D015025	Zearalenone	[Zearalenone co-treated with Aflatoxin B1] results in increased expression of NOTCH1 mRNA	28965971
C540355	fenamidone	fenamidone results in increased expression of NOTCH1 mRNA	27029645
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA	21607683
D005473	Fluoxetine	Fluoxetine results in increased expression of NOTCH1 mRNA	19801843
D005473	Fluoxetine	Fluoxetine results in increased expression of NOTCH1 protein	19801843
D005557	Formaldehyde	Formaldehyde results in increased expression of NOTCH1 mRNA	23649840
C039281	furan	furan results in decreased expression of NOTCH1 mRNA	25539665
C056507	gemcitabine	gemcitabine results in increased expression of NOTCH1 protein	20940707
C056507	gemcitabine	sulforafan inhibits the reaction [gemcitabine results in increased expression of NOTCH1 protein]	20940707
D005839	Gentamicins	Gentamicins results in increased expression of NOTCH1 mRNA	22061828
C027492	Huang Qi	Huang Qi results in decreased expression of NOTCH1 mRNA	23258323
D006861	Hydrogen Peroxide	HIF1A protein affects the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]	25108166
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased cleavage of NOTCH1 protein	25108166
D006861	Hydrogen Peroxide	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]"	25108166
D006861	Hydrogen Peroxide	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]	25108166
C492448	ICG 001	ICG 001 results in increased expression of NOTCH1 mRNA	26191083
C492448	ICG 001	ICG 001 results in decreased activity of NOTCH1 protein modified form	19382889
D007529	Isoflavones	[Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein	18640131
D007529	Isoflavones	Isoflavones results in decreased expression of NOTCH1 protein	18640131
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NOTCH1 mRNA	25948186
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of NOTCH1 mRNA	25961927
C561695	(+)-JQ1 compound	NOTCH1 protein results in increased susceptibility to (+)-JQ1 compound	23430699
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of NOTCH1 mRNA"	24972896
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOTCH1 mRNA"	21843347
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NOTCH1 protein	18449946
D008070	Lipopolysaccharides	NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of CSF1 mRNA]	18449946
D008070	Lipopolysaccharides	NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]	18449946
D008070	Lipopolysaccharides	NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]	18449946
D008070	Lipopolysaccharides	NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	18449946
D008070	Lipopolysaccharides	NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]	18449946
D008070	Lipopolysaccharides	NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]	18449946
D008070	Lipopolysaccharides	NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]	18449946
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 mRNA]	18449946
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NOTCH1 mRNA	18449946
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NOTCH1 protein	18449946
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of NOTCH1 mRNA	23527032
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of NOTCH1 mRNA	20864626
C020771	methylmercury hydroxide	methylmercury hydroxide results in decreased expression of NOTCH1 protein	21908764
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of NOTCH1 mRNA	23649840
C523799	MRK 003	MRK 003 inhibits the reaction [resveratrol results in increased activity of NOTCH1]	21743969
C523799	MRK 003	MRK 003 results in decreased cleavage of NOTCH1 protein	17646409\|2116925
C523799	MRK 003	NOTCH1 protein modified form inhibits the reaction [MRK 003 results in decreased phosphorylation of and results in increased activity of RB1 protein]	19318552
C523799	MRK 003	MRK 003 results in decreased expression of NOTCH1 protein	19246562
D009151	Mustard Gas	Mustard Gas results in decreased expression of NOTCH1 mRNA	28402575
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of NOTCH1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of NOTCH1 mRNA"	25554681
C000621033	napabucasin	napabucasin results in decreased expression of NOTCH1 mRNA	25605917
D009525	Niacin	Niacin results in increased expression of NOTCH1 protein	19223914
C022838	nickel chloride	nickel chloride results in increased expression of NOTCH1 protein	26962057
C022838	nickel chloride	nickel chloride affects the expression of NOTCH1 mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in decreased expression of NOTCH1 mRNA	19167457
D009534	Niclosamide	Niclosamide results in decreased activity of NOTCH1 protein	19160421
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of NOTCH1 protein]"	28130038
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]"	25118938
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]"	25108166
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein]"	22039516
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH1 protein"	22039516
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein modified form"	18633435
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of NOTCH1 protein modified form]"	24223152
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased cleavage of NOTCH1 protein]"	22115781
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Oxygen deficiency results in increased expression of NOTCH1 protein]"	24223152
C025589	ochratoxin A	ochratoxin A results in increased acetylation of NOTCH1 promoter	29098329
C016340	o,p'-DDT	"MAPK14 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]"	18791200
C016340	o,p'-DDT	"MAPK1 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]"	18791200
C016340	o,p'-DDT	"o,p'-DDT results in increased phosphorylation of and results in increased activity of NOTCH1 protein"	18791200
C016340	o,p'-DDT	"SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]"	18791200
C016340	o,p'-DDT	"U 0126 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]"	18791200
D008939	Mitotane	Mitotane results in increased activity of NOTCH1 protein	18791200
C030110	oxaliplatin	NOTCH1 protein affects the susceptibility to oxaliplatin	19147571
C030110	oxaliplatin	oxaliplatin results in increased expression of NOTCH1 protein modified form	19147571
C030110	oxaliplatin	Sulfonamides inhibits the reaction [oxaliplatin results in increased expression of NOTCH1 protein modified form]	19147571
D010100	Oxygen	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of NOTCH1 protein modified form]"	24223152
D010100	Oxygen	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Oxygen deficiency results in increased expression of NOTCH1 protein]"	24223152
D010100	Oxygen	Oxygen deficiency affects the localization of NOTCH1 protein modified form	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of NOTCH1 mRNA	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of NOTCH1 protein	24223152
D010100	Oxygen	Oxygen deficiency affects the localization of NOTCH1 protein modified form	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of NOTCH1 mRNA	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of NOTCH1 protein	24223152
D010269	Paraquat	Paraquat affects the expression of NOTCH1 mRNA	24053911
C410127	PCB 180	PCB 180 results in increased expression of NOTCH1 protein	21908764
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of NOTCH1 mRNA	23892564
C031181	phenanthrene	phenanthrene results in decreased expression of NOTCH1 mRNA	19457238
C058305	phenethyl isothiocyanate	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein]"	22039516
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein	22039516
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of NOTCH1 mRNA	22039516
D010654	Phenylbutyrates	"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NOTCH1 protein"	23284745
C522973	PI103	PI103 results in increased activity of NOTCH1 protein modified form	19382889
C415032	picropodophyllin	picropodophyllin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
C121565	pifithrin	pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
C006253	pirinixic acid	pirinixic acid results in increased expression of NOTCH1 mRNA	18301758\|2381119
D020959	Polyethylene	Polyethylene results in decreased expression of NOTCH1 mRNA	23203475
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of NOTCH1 mRNA	22714537
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of NOTCH1 mRNA	19693291
C045950	propiconazole	propiconazole results in decreased expression of NOTCH1 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of NOTCH1 mRNA	24780913
D015237	Dinoprost	Dinoprost results in decreased cleavage of NOTCH1 protein	21209419
D015237	Dinoprost	Dinoprost results in decreased expression of NOTCH1 mRNA	21209419
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of NOTCH1 mRNA	27029645
D011794	Quercetin	"[2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide co-treated with Quercetin] results in decreased expression of and results in decreased cleavage of NOTCH1 protein"	21498710
D011794	Quercetin	"[Quercetin co-treated with 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide] results in decreased cleavage of NOTCH1 protein"	21498710
D011794	Quercetin	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]	25108166
D011794	Quercetin	Quercetin results in decreased expression of and affects the cleavage of NOTCH1 protein	21498710
D011794	Quercetin	Quercetin results in decreased expression of and results in decreased cleavage of NOTCH1 protein	20032413
C059514	resveratrol	MRK 003 inhibits the reaction [resveratrol results in increased activity of NOTCH1]	21743969
C059514	resveratrol	NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of NKX2-1 mRNA]	23594881
C059514	resveratrol	NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of PAX8 mRNA]	23594881
C059514	resveratrol	NOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of SLC5A5 mRNA]	23594881
C059514	resveratrol	resveratrol affects the expression of NOTCH1 mRNA	25896424
C059514	resveratrol	resveratrol affects the expression of NOTCH1 protein	25896424
C059514	resveratrol	resveratrol results in decreased expression of NOTCH1 mRNA	25061499
C059514	resveratrol	resveratrol results in decreased expression of NOTCH1 protein	17868649\|2506149
C059514	resveratrol	resveratrol results in increased activity of NOTCH1	21743969
C059514	resveratrol	resveratrol results in increased expression of NOTCH1 mRNA	23594881
C059514	resveratrol	resveratrol results in increased expression of NOTCH1 protein	23594881
C009166	retinol acetate	retinol acetate results in increased expression of NOTCH1 mRNA	16772331
C009172	rhodioloside	rhodioloside results in decreased expression of NOTCH1 mRNA	24929042
C093642	SB 203580	"SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]"	18791200
D019821	Simvastatin	Simvastatin results in increased cleavage of NOTCH1 protein	19109527
D019821	Simvastatin	Simvastatin results in increased expression of NOTCH1 mRNA	19109527
D012906	Smoke	Smoke results in decreased expression of NOTCH1 mRNA	21095227
C017947	sodium arsenite	sodium arsenite affects the expression of NOTCH1 mRNA	20056578
C017947	sodium arsenite	sodium arsenite inhibits the reaction [BMP6 protein results in increased activity of NOTCH1 protein]	23566955
C017947	sodium arsenite	sodium arsenite inhibits the reaction [U 0126 results in increased activity of NOTCH1 protein]	23566955
C017947	sodium arsenite	sodium arsenite results in increased expression of NOTCH1 mRNA	17879257
C016104	sodium bichromate	FBP1 protein inhibits the reaction [sodium bichromate results in increased expression of NOTCH1 protein]	28624442
C016104	sodium bichromate	sodium bichromate results in increased expression of NOTCH1 protein	28624442
D013449	Sulfonamides	Sulfonamides inhibits the reaction [oxaliplatin results in increased expression of NOTCH1 protein modified form]	19147571
C016766	sulforafan	sulforafan inhibits the reaction [gemcitabine results in increased expression of NOTCH1 protein]	20940707
D013605	T-2 Toxin	T-2 Toxin results in increased expression of NOTCH1 mRNA	26141394
D013629	Tamoxifen	Tamoxifen results in decreased expression of NOTCH1 protein	17343880
D013629	Tamoxifen	[Tamoxifen results in increased expression of MIR34A mRNA] which results in decreased expression of NOTCH1 protein	17343880
C112765	tanespimycin	tanespimycin results in increased activity of NOTCH1 protein modified form	19382889
D013739	Testosterone	Testosterone results in decreased expression of NOTCH1 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the activity of NOTCH1 protein	25585350
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NOTCH1 mRNA	18343893\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of NOTCH1 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of NOTCH1 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of NOTCH1 mRNA]	15667827
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NOTCH1 mRNA	17586704
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NOTCH1 mRNA	10886394\|1532836
C009495	titanium dioxide	titanium dioxide affects the expression of NOTCH1 mRNA	17656681
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of NOTCH1 mRNA	27404394
D014212	Tretinoin	"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of NOTCH1 protein"	23284745
D014212	Tretinoin	Tretinoin results in decreased expression of NOTCH1 mRNA	21934132\|2290670
D014212	Tretinoin	Tretinoin results in increased expression of NOTCH1 protein	28130038
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in decreased expression of NOTCH1 mRNA	17185465
C023764	triciribine	triciribine results in increased activity of NOTCH1 protein modified form	19382889
C030665	triphenyltin	triphenyltin results in decreased expression of NOTCH1 mRNA	12788061
D014415	Tunicamycin	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased cleavage of NOTCH1 protein]"	22115781
D014415	Tunicamycin	Tunicamycin results in increased cleavage of NOTCH1 protein	22115781
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form]	18633435
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]	25118938
C101044	tyrphostin AG 1478	tyrphostin AG 1478 results in increased expression of NOTCH1 protein modified form	18633435
C113580	U 0126	sodium arsenite inhibits the reaction [U 0126 results in increased activity of NOTCH1 protein]	23566955
C113580	U 0126	"U 0126 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]"	18791200
C113580	U 0126	U 0126 results in increased activity of NOTCH1 protein	23566955
D014501	Uranium	Uranium results in decreased expression of NOTCH1 mRNA	27639536
D014520	Urethane	Urethane results in increased expression of NOTCH1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of NOTCH1 mRNA	23179753\|2352703
D014635	Valproic Acid	Valproic Acid results in increased methylation of NOTCH1 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of NOTCH1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of NOTCH1 mRNA	19015723
D002762	Cholecalciferol	Cholecalciferol results in increased expression of NOTCH1 mRNA	17170073
C111237	vorinostat	vorinostat results in increased activity of NOTCH1 protein modified form	19382889
C009687	wortmannin	wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]	17513037
C009687	wortmannin	wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]	17513037
D015032	Zinc	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein]	17513037
D015032	Zinc	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]	17513037
D015032	Zinc	wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]	17513037
D015032	Zinc	wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]	17513037
D015032	Zinc	Zinc affects the localization of NOTCH1 protein	17513037
D015032	Zinc	Zinc results in decreased activity of NOTCH1 protein	17513037
D015032	Zinc	Zinc inhibits the reaction [NOTCH1 protein binds to RBPJ protein]	17513037

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	-	ISS	-
GO:0003700	DNA-binding transcription factor activity	-	IEA	-
GO:0004857	enzyme inhibitor activity	-	ISS	-
GO:0004888	transmembrane signaling receptor activity	-	IEA	-
GO:0005112	Notch binding	-	IEA	-
GO:0005509	calcium ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	10713164 11006133 11101851 11390662 16319921 16510869 16530044 17284587 17318174 17909182 18427106 18660822 19151708 19907488 20823234 20972443 21475249 22325781 23022380 23086448 25038227 25344755 25609649 25714926 25895060 26496610
GO:0019899	enzyme binding	-	ISS	-
GO:0031490	chromatin DNA binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001708	cell fate specification	-	IEA	-
GO:0001837	epithelial to mesenchymal transition	-	ISS	-
GO:0001889	liver development	-	IEA	-
GO:0001947	heart looping	-	ISS	-
GO:0002040	sprouting angiogenesis	-	IEA	-
GO:0002052	positive regulation of neuroblast proliferation	-	IEA	-
GO:0002437	inflammatory response to antigenic stimulus	-	IEA	-
GO:0003151	outflow tract morphogenesis	-	IMP	18593716
GO:0003157	endocardium development	-	ISS	-
GO:0003160	endocardium morphogenesis	-	ISS	-
GO:0003162	atrioventricular node development	-	IEA	-
GO:0003169	coronary vein morphogenesis	-	ISS	-
GO:0003180	aortic valve morphogenesis	-	IMP	16025100 17662764 18593716
GO:0003180	aortic valve morphogenesis	-	ISS	-
GO:0003180	aortic valve morphogenesis	-	TAS	20951801
GO:0003181	atrioventricular valve morphogenesis	-	ISS	-
GO:0003182	coronary sinus valve morphogenesis	-	IEA	-
GO:0003184	pulmonary valve morphogenesis	-	IMP	16025100
GO:0003184	pulmonary valve morphogenesis	-	ISS	-
GO:0003192	mitral valve formation	-	IMP	16025100
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	-	ISS	-
GO:0003203	endocardial cushion morphogenesis	-	ISS	-
GO:0003207	cardiac chamber formation	-	ISS	-
GO:0003208	cardiac ventricle morphogenesis	-	ISS	-
GO:0003209	cardiac atrium morphogenesis	-	ISS	-
GO:0003213	cardiac right atrium morphogenesis	-	ISS	-
GO:0003214	cardiac left ventricle morphogenesis	-	ISS	-
GO:0003219	cardiac right ventricle formation	-	IEA	-
GO:0003222	ventricular trabecula myocardium morphogenesis	-	ISS	-
GO:0003241	growth involved in heart morphogenesis	-	ISS	-
GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	-	ISS	-
GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	-	ISS	-
GO:0003270	Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation	-	IEA	-
GO:0003273	cell migration involved in endocardial cushion formation	-	ISS	-
GO:0003332	negative regulation of extracellular matrix constituent secretion	-	ISS	-
GO:0003344	pericardium morphogenesis	-	ISS	-
GO:0006355	regulation of transcription, DNA-templated	-	TAS	10713164
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006955	immune response	-	NAS	1831692
GO:0006959	humoral immune response	-	IEA	-
GO:0007050	cell cycle arrest	-	IDA	11306509
GO:0007219	Notch signaling pathway	-	IDA	11306509
GO:0007219	Notch signaling pathway	-	IMP	19682396
GO:0007219	Notch signaling pathway	-	TAS	10713164
GO:0007221	positive regulation of transcription of Notch receptor target	-	ISS	-
GO:0007221	positive regulation of transcription of Notch receptor target	-	TAS	-
GO:0007283	spermatogenesis	-	IEA	-
GO:0007368	determination of left/right symmetry	-	ISS	-
GO:0007386	compartment pattern specification	-	IEA	-
GO:0007409	axonogenesis	-	IEA	-
GO:0007440	foregut morphogenesis	-	IEA	-
GO:0007492	endoderm development	-	IEA	-
GO:0007507	heart development	-	IMP	21457232
GO:0008284	positive regulation of cell proliferation	-	IDA	17849174
GO:0008284	positive regulation of cell proliferation	-	IMP	20613903
GO:0008285	negative regulation of cell proliferation	-	IDA	11306509 20616313
GO:0009912	auditory receptor cell fate commitment	-	IEA	-
GO:0010614	negative regulation of cardiac muscle hypertrophy	-	ISS	-
GO:0010628	positive regulation of gene expression	-	ISS	-
GO:0010629	negative regulation of gene expression	-	IDA	11306509
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	IMP	17984306
GO:0010812	negative regulation of cell-substrate adhesion	-	IDA	16501043
GO:0010832	negative regulation of myotube differentiation	-	ISS	-
GO:0014031	mesenchymal cell development	-	ISS	-
GO:0014807	regulation of somitogenesis	-	IEA	-
GO:0021515	cell differentiation in spinal cord	-	IEA	-
GO:0021915	neural tube development	-	IEA	-
GO:0030216	keratinocyte differentiation	-	IEA	-
GO:0030279	negative regulation of ossification	-	ISS	-
GO:0030324	lung development	-	IEA	-
GO:0030335	positive regulation of cell migration	-	ISS	-
GO:0030513	positive regulation of BMP signaling pathway	-	ISS	-
GO:0030514	negative regulation of BMP signaling pathway	-	ISS	-
GO:0030900	forebrain development	-	IEA	-
GO:0031069	hair follicle morphogenesis	-	IEA	-
GO:0031100	animal organ regeneration	-	IEA	-
GO:0031960	response to corticosteroid	-	IEA	-
GO:0032495	response to muramyl dipeptide	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0035116	embryonic hindlimb morphogenesis	-	IEA	-
GO:0035148	tube formation	-	IMP	20616313
GO:0035914	skeletal muscle cell differentiation	-	IEA	-
GO:0035924	cellular response to vascular endothelial growth factor stimulus	-	IDA	20616313
GO:0042246	tissue regeneration	-	IEA	-
GO:0043086	negative regulation of catalytic activity	-	ISS	-
GO:0045070	positive regulation of viral genome replication	-	IEA	-
GO:0045603	positive regulation of endothelial cell differentiation	-	IEA	-
GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	-	IEA	-
GO:0045618	positive regulation of keratinocyte differentiation	-	IEA	-
GO:0045662	negative regulation of myoblast differentiation	-	IMP	10713164
GO:0045668	negative regulation of osteoblast differentiation	-	ISS	-
GO:0045747	positive regulation of Notch signaling pathway	-	TAS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	20616313
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0045955	negative regulation of calcium ion-dependent exocytosis	-	IEA	-
GO:0045967	negative regulation of growth rate	-	IDA	11306509
GO:0046427	positive regulation of JAK-STAT cascade	-	ISS	-
GO:0046533	negative regulation of photoreceptor cell differentiation	-	IEA	-
GO:0046579	positive regulation of Ras protein signal transduction	-	IDA	11306509
GO:0048103	somatic stem cell division	-	IEA	-
GO:0048708	astrocyte differentiation	-	IEA	-
GO:0048709	oligodendrocyte differentiation	-	IEA	-
GO:0048711	positive regulation of astrocyte differentiation	-	ISS	-
GO:0048715	negative regulation of oligodendrocyte differentiation	-	ISS	-
GO:0048754	branching morphogenesis of an epithelial tube	-	IEA	-
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	-
GO:0050679	positive regulation of epithelial cell proliferation	-	IEA	-
GO:0050768	negative regulation of neurogenesis	-	ISS	-
GO:0055008	cardiac muscle tissue morphogenesis	-	ISS	-
GO:0060038	cardiac muscle cell proliferation	-	IEA	-
GO:0060045	positive regulation of cardiac muscle cell proliferation	-	ISS	-
GO:0060253	negative regulation of glial cell proliferation	-	ISS	-
GO:0060271	cilium assembly	-	ISS	-
GO:0060317	cardiac epithelial to mesenchymal transition	-	ISS	-
GO:0060411	cardiac septum morphogenesis	-	ISS	-
GO:0060412	ventricular septum morphogenesis	-	IMP	16025100
GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	-	IEA	-
GO:0060740	prostate gland epithelium morphogenesis	-	IEA	-
GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	-	IEA	-
GO:0060842	arterial endothelial cell differentiation	-	ISS	-
GO:0060843	venous endothelial cell differentiation	-	ISS	-
GO:0060948	cardiac vascular smooth muscle cell development	-	ISS	-
GO:0060956	endocardial cell differentiation	-	ISS	-
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	-	ISS	-
GO:0060982	coronary artery morphogenesis	-	ISS	-
GO:0061314	Notch signaling involved in heart development	-	IMP	16025100 17662764
GO:0061384	heart trabecula morphogenesis	-	ISS	-
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	ISS	-
GO:0070168	negative regulation of biomineral tissue development	-	ISS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IDA	11306509
GO:0070986	left/right axis specification	-	IEA	-
GO:0071372	cellular response to follicle-stimulating hormone stimulus	-	IDA	20613903
GO:0072017	distal tubule development	-	IEA	-
GO:0072044	collecting duct development	-	IEA	-
GO:0072144	glomerular mesangial cell development	-	IEA	-
GO:0072602	interleukin-4 secretion	-	IEA	-
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	-	IDA	20616313
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IEA	-
GO:0097150	neuronal stem cell population maintenance	-	IEP	19682396
GO:1901201	regulation of extracellular matrix assembly	-	ISS	-
GO:1902263	apoptotic process involved in embryonic digit morphogenesis	-	IEA	-
GO:1902339	positive regulation of apoptotic process involved in morphogenesis	-	ISS	-
GO:1903849	positive regulation of aorta morphogenesis	-	IEA	-
GO:2000737	negative regulation of stem cell differentiation	-	IMP	19682396
GO:2000811	negative regulation of anoikis	-	IMP	17984306
GO:2000974	negative regulation of pro-B cell differentiation	-	ISS	-
GO:2001027	negative regulation of endothelial cell chemotaxis	-	IDA	20616313

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	TAS	-
GO:0001669	acrosomal vesicle	-	IEA	-
GO:0002193	MAML1-RBP-Jkappa- ICN1 complex	-	IDA	16510869
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	ISS	-
GO:0005634	nucleus	-	TAS	10713164
GO:0005654	nucleoplasm	-	TAS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005912	adherens junction	-	ISS	-
GO:0009986	cell surface	-	IEA	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0016324	apical plasma membrane	-	ISS	-
GO:0043235	receptor complex	-	IDA	23382219

KEGG ID	KEGG Term
hsa04320	Dorso-ventral axis formation
hsa04330	Notch signaling pathway
hsa05020	Prion diseases

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-157118	Signaling by NOTCH	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-186712	Regulation of beta-cell development	IEA
R-HSA-1912399	Pre-NOTCH Processing in the Endoplasmic Reticulum	IEA
R-HSA-1912408	Pre-NOTCH Transcription and Translation	IEA
R-HSA-1912408	Pre-NOTCH Transcription and Translation	TAS
R-HSA-1912420	Pre-NOTCH Processing in Golgi	TAS
R-HSA-1912420	Pre-NOTCH Processing in Golgi	IEA
R-HSA-1912422	Pre-NOTCH Expression and Processing	IEA
R-HSA-1912422	Pre-NOTCH Expression and Processing	TAS
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-1980143	Signaling by NOTCH1	TAS
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	TAS
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	IEA
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	TAS
R-HSA-2644603	Signaling by NOTCH1 in Cancer	TAS
R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	TAS
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	TAS
R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	TAS
R-HSA-2660825	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	TAS
R-HSA-2660826	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	TAS
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	TAS
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	TAS
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	TAS
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	TAS
R-HSA-350054	Notch-HLH transcription pathway	TAS
R-HSA-3781865	Diseases of glycosylation	TAS
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	TAS
R-HSA-5083630	Defective LFNG causes SCDO3	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	IEA
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8941856	RUNX3 regulates NOTCH signaling	IEA
R-HSA-8941856	RUNX3 regulates NOTCH signaling	TAS
R-HSA-9012852	Signaling by NOTCH3	TAS
R-HSA-9012852	Signaling by NOTCH3	IEA
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	TAS
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29383147	Cigarette smoke enhances initiation and progression of lung cancer by mutating Notch1/2 and dysregulating downstream signaling molecules. (2017 Dec 29)	Li W	Oncotarget
27565922	Hot spot mutations in Finnish non-small cell lung cancers. (2016 Sep)	Maki-Nevala S	Lung Cancer
28061457	Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer. (2017 Feb 21)	Xiong J	Oncotarget
26676959	Shear stress, arterial identity and atherosclerosis. (2016 Mar)	Lehoux S	Thromb Haemost
26873401	Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)	Sawada G	Gastroenterology
25631445	Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)	-	Nature
28415716	Single nucleotide polymorphism rs3124599 in Notch1 is associated with the risk of lung cancer in northeast Chinese non-smoking females. (2017 May 9)	Quan X	Oncotarget
25962154	Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)	Fragkiadaki P	PLoS One
26622547	Cigarette smoke induces the expression of Notch3, not Notch1, protein in lung adenocarcinoma. (2015 Aug)	Cheng Z	Oncol Lett
26900290	Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. (2016 Feb 21)	Sasaki Y	World J Gastroenterol
21609394	mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. (2012 Mar)	Ge W	J Cell Mol Med