Gene info: ID 4852

Gene: NPY

GENE ID: 4852

Synonyms: PYY4

Description: neuropeptide Y

Gene type: protein-coding

Location: 7p15.3

dbXrefs: Ensembl:ENSG00000122585 MIM:162640 Vega:OTTHUMG00000022973 UniprotKB:P01303

RefSeq: NG_016148.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 97

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.335e-1 (AD) 9.881e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRHBP	0.766
CORT	0.765
SST	0.749
TMEFF2	0.72
RAB33A	0.704
ERP29	0.694
DPYSL5	0.691
HMOX2	0.686
KCNF1	0.685
TCEAL7	0.683

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZIC5	-0.426
CDC14A	-0.414
SLC2A4	-0.402
ARHGAP42	-0.392
PARD3B	-0.387
TGFBR3	-0.382
OR4F5	-0.381
TNFRSF11B	-0.381
MAML2	-0.379
FREM2	-0.378

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02952	Alpha-Aminoisobutyric Acid	Small Molecule		Experimental	Target
DB03380	L-Tyrosinamide	Small Molecule	4985-46-0	Experimental	Target

ID	Drug Name	Action	PubMed
C582212	1NMPP1 compound	[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of NPY mRNA	27417517
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NPY mRNA"	29112739
C511295	2,2',4,4'-tetrabromodiphenyl ether	"ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NPY mRNA]"	29112739
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of NPY mRNA"	21724226
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
D020909	Acarbose	Acarbose results in decreased expression of NPY protein	18290871
D000082	Acetaminophen	Acetaminophen results in decreased expression of NPY mRNA	17585979
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of NPY mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NPY mRNA]	17585979
D000255	Adenosine Triphosphate	NPY protein affects the susceptibility to Adenosine Triphosphate	15003356
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of NPY gene	27153756
D000535	Aluminum	NPY protein affects the metabolism of Aluminum	11709213
D000639	Amitriptyline	Amitriptyline results in increased expression of NPY mRNA	22341215
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NPY mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of NPY mRNA	19497417
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of NPY protein	19497417
D000661	Amphetamine	NPY protein results in decreased susceptibility to Amphetamine	12183048
D000661	Amphetamine	Amphetamine affects the expression of NPY protein	16896163
D000661	Amphetamine	Amphetamine results in decreased expression of NPY mRNA	15680483\|1608454
D000661	Amphetamine	Amphetamine results in decreased expression of NPY protein	12005258\|1568048
D000661	Amphetamine	Amphetamine results in increased expression of NPY mRNA	15183010
D000661	Amphetamine	FOS protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]	16084549
D000661	Amphetamine	Haloperidol promotes the reaction [Amphetamine results in decreased expression of NPY protein]	15985714
D000661	Amphetamine	JUN protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]	16084549
D000661	Amphetamine	NPY mutant form promotes the reaction [Amphetamine results in increased expression of CARTPT mRNA]	25825358
D000661	Amphetamine	NPY protein affects the susceptibility to Amphetamine	16101753
D000661	Amphetamine	NPY protein results in increased susceptibility to Amphetamine	12005258
D000661	Amphetamine	PRKCA protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]	16101753
D000661	Amphetamine	S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY mRNA]	25825358
D000661	Amphetamine	S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY protein]	25825358
D000997	Antivenins	Antivenins inhibits the reaction [Scorpion Venoms results in increased hydrolysis of NPY protein]	25239630
C006632	arsenic trioxide	arsenic trioxide results in increased expression of NPY mRNA	11027660
C015001	arsenite	arsenite results in increased methylation of NPY promoter	23974009
D001218	Aspartame	Aspartame results in decreased expression of NPY protein	11890951
D001280	Atrazine	Atrazine results in increased expression of NPY mRNA	27413107
C487081	belinostat	belinostat results in increased expression of NPY mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NPY mRNA	19770486
D004958	Estradiol	Estradiol results in decreased expression of NPY mRNA	27014939
C095105	bexarotene	bexarotene results in increased expression of NPY mRNA	17630414
D001629	Bezafibrate	Bezafibrate results in increased expression of NPY mRNA	18787029
C403256	BIIE 0246	[BIIE 0246 results in decreased activity of NPY2R protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
C074212	bis(maltolato)oxovanadium(IV)	bis(maltolato)oxovanadium(IV) results in increased expression of NPY mRNA	11398143
C006780	bisphenol A	bisphenol A affects the expression of NPY mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of NPY mRNA	18180321
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of NPY mRNA	18958704
D002079	Butter	Butter results in increased expression of NPY protein	23038630
D002104	Cadmium	Cadmium results in increased expression of NPY mRNA	21694771
D002211	Capsaicin	Capsaicin inhibits the reaction [NPY protein affects the susceptibility to Potassium]	18055875
D002217	Carbachol	NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein]	3329090
D002714	Chlorisondamine	Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]	1714554
D002714	Chlorisondamine	Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]	1714554
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of NPY mRNA	20682304\|2677502
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of NPY protein	26775027
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPY mRNA	20938992
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of NPY mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NPY mRNA]	17585979
D003000	Clonidine	Clonidine results in decreased expression of NPY mRNA	1878751
D003000	Clonidine	Clonidine results in increased expression of NPY mRNA	1878751
D003000	Clonidine	Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]	1878751
D003000	Clonidine	Clonidine results in decreased secretion of NPY protein	2455193
D003000	Clonidine	Clonidine results in increased expression of NPY protein	2455193
D003024	Clozapine	Clozapine results in decreased expression of NPY mRNA	16516965
D003042	Cocaine	Cocaine affects the expression of NPY mRNA	17851536\|2018794
D003042	Cocaine	Cocaine results in decreased expression of NPY mRNA	16076954
D003345	Corticosterone	Corticosterone results in decreased expression of NPY mRNA	15755911
C009160	cyclonite	cyclonite results in increased expression of NPY mRNA	25559034
D003561	Cytarabine	Cytarabine results in decreased expression of NPY mRNA	21198554
D016047	Zalcitabine	"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNA"	18606552
D003847	Deoxyglucose	Deoxyglucose results in increased expression of NPY mRNA	10683841
D003891	Desipramine	Desipramine results in decreased secretion of NPY protein	2455193
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA]	20504635
D003907	Dexamethasone	Dexamethasone results in increased expression of NPY mRNA	1671012
D003976	Diazinon	Diazinon results in increased expression of NPY mRNA	20682304
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of NPY mRNA	23656968
D003994	Bucladesine	Bucladesine results in increased expression of NPY mRNA	19912776
D004026	Dieldrin	Dieldrin results in increased expression of NPY mRNA	20682304
D019422	Dietary Sucrose	Dietary Sucrose results in decreased expression of NPY mRNA	18627777
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of NPY mRNA	28871463
D004298	Dopamine	"[N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin results in decreased activity of SIGMAR1 protein] inhibits the reaction [NPY protein results in increased abundance of Dopamine]"	18005069
D004298	Dopamine	NPY protein results in increased abundance of Dopamine	18005069
D004298	Dopamine	SIGMAR1 protein promotes the reaction [NPY protein results in increased abundance of Dopamine]	18005069
C118739	entinostat	entinostat results in increased expression of NPY mRNA	27188386
D004791	Enzyme Inhibitors	Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]	24792324
D000431	Ethanol	Ethanol results in decreased expression of NPY mRNA	11095510
D004997	Ethinyl Estradiol	ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in decreased expression of NPY mRNA]	29112739
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NPY mRNA	29112739
D005411	Flame Retardants	ESR1 gene mutant form inhibits the reaction [Flame Retardants results in decreased expression of NPY mRNA]	29112739
D005411	Flame Retardants	Flame Retardants results in decreased expression of NPY mRNA	29112739
D005473	Fluoxetine	Fluoxetine affects the expression of NPY mRNA	19344674
D005473	Fluoxetine	Fluoxetine results in decreased expression of NPY mRNA	20692053
D005473	Fluoxetine	Fluoxetine results in increased expression of NPY mRNA	20816900
D005473	Fluoxetine	Fluoxetine affects the expression of NPY mRNA	9729278
D005473	Fluoxetine	Fluoxetine results in decreased expression of NPY mRNA	16042082
D005473	Fluoxetine	Fluoxetine results in decreased secretion of NPY mRNA	8737424
D005473	Fluoxetine	Fluoxetine results in decreased secretion of NPY protein	8737424
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPY mRNA	20938992
D005632	Fructose	Fructose results in decreased expression of NPY mRNA	18627777
C069837	fullerene C60	fullerene C60 results in increased expression of NPY mRNA	19167457
C039281	furan	furan results in decreased expression of NPY mRNA	26194646
D005839	Gentamicins	Gentamicins results in increased expression of NPY mRNA	22061828
D005947	Glucose	Glucose deficiency results in increased expression of NPY mRNA	11177238
D005947	Glucose	Glucose results in decreased expression of NPY mRNA	18627777
D005947	Glucose	Glucose results in decreased expression of NPY protein	16210367
C004312	glycidol	glycidol results in decreased expression of NPY mRNA	24915197
C514793	gp120 protein, Human immunodeficiency virus 1	"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNA"	18606552
D006145	Guanethidine	Guanethidine results in decreased secretion of NPY protein	15003356
D006145	Guanethidine	Guanethidine results in decreased expression of NPY protein	14527964\|9460767
D006145	Guanethidine	Guanethidine results in decreased secretion of NPY protein	2455193
D006220	Haloperidol	Haloperidol promotes the reaction [Amphetamine results in decreased expression of NPY protein]	15985714
D006220	Haloperidol	Haloperidol results in decreased expression of NPY mRNA	16516965
D006220	Haloperidol	Haloperidol results in increased expression of NPY protein	7644023
D018738	Hexamethonium	Hexamethonium inhibits the reaction [Nicotine results in increased expression of NPY mRNA]	2233698
D006854	Hydrocortisone	Hydrocortisone affects the expression of NPY protein	7955553
D007213	Indomethacin	Indomethacin inhibits the reaction [NPY protein affects the abundance of Potassium]	10737671
D007608	Kainic Acid	NPY protein results in decreased susceptibility to Kainic Acid	15451008
D007608	Kainic Acid	Kainic Acid results in increased expression of NPY mRNA	9427505
D007608	Kainic Acid	Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]	9427505
D007649	Ketamine	NPY protein results in increased susceptibility to Ketamine	11454027
C008281	limonene	limonene results in decreased expression of NPY protein	22757684
C008281	limonene	limonene results in decreased expression of NPY mRNA	22757684
C018584	linalool	linalool results in increased expression of NPY protein	22757684
C018584	linalool	linalool results in increased expression of NPY mRNA	22757684
D008094	Lithium	Lithium results in increased expression of NPY mRNA	17572454
D008094	Lithium	Lithium results in increased expression of NPY protein	17572454
D019808	Losartan	Losartan inhibits the reaction [NPY protein affects the abundance of Potassium]	10737671
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of NPY mRNA	21641980
D008383	Margarine	Margarine results in increased expression of NPY protein	23038630
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in increased expression of NPY mRNA	15930374
D008694	Methamphetamine	Methamphetamine results in decreased expression of NPY protein	17910739
D008694	Methamphetamine	NPY1R protein affects the reaction [NPY protein results in decreased susceptibility to Methamphetamine]	15930374
D008694	Methamphetamine	NPY2R protein affects the reaction [NPY protein results in decreased susceptibility to Methamphetamine]	15930374
D008694	Methamphetamine	NPY protein results in decreased susceptibility to Methamphetamine	15930374
D008713	Methimazole	Methimazole results in decreased expression of NPY mRNA	17403546
D008713	Methimazole	Methimazole results in increased expression of NPY mRNA	17403546
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPY mRNA	20938992
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NPY mRNA"	19285098
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NPY protein"	17910739
D009020	Morphine	Morphine results in increased expression of NPY mRNA	20144693\|2117881
C500085	muraglitazar	muraglitazar results in decreased expression of NPY mRNA	21515302
D015544	Inositol 1,4,5-Trisphosphate	"[Norepinephrine co-treated with NPY protein] results in increased abundance of Inositol 1,4,5-Trisphosphate"	7742479
D015544	Inositol 1,4,5-Trisphosphate	"neuropeptide Y (18-36) inhibits the reaction [NPY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"	7742479
D015544	Inositol 1,4,5-Trisphosphate	"NPY protein results in increased abundance of Inositol 1,4,5-Trisphosphate"	7742479
D015544	Inositol 1,4,5-Trisphosphate	"PYX 2 inhibits the reaction [NPY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"	7742479
C097963	N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin	"[N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin results in decreased activity of SIGMAR1 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]"	18005069
C097963	N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin	"[N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin results in decreased activity of SIGMAR1 protein] inhibits the reaction [NPY protein results in increased abundance of Dopamine]"	18005069
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of NPY mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of NPY mRNA"	25554681
C059889	neuropeptide Y (18-36)	"neuropeptide Y (18-36) inhibits the reaction [NPY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"	7742479
D009532	Nickel	Nickel results in decreased expression of NPY mRNA	20682304
C028007	nickel monoxide	nickel monoxide affects the expression of NPY mRNA	19167457
D009538	Nicotine	Nicotine results in increased secretion of NPY protein	2784250
D009538	Nicotine	Hexamethonium inhibits the reaction [Nicotine results in increased expression of NPY mRNA]	2233698
D009538	Nicotine	Nicotine results in increased expression of NPY mRNA	2233698
D009538	Nicotine	Nicotine results in increased expression of NPY protein	1907749\|23623838
D005996	Nitroglycerin	Nitroglycerin results in increased expression of NPY protein	10426492
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of NPY mRNA	27935865
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NPY mRNA	27935865
D009638	Norepinephrine	NPY protein affects the susceptibility to Norepinephrine	15003356
D009638	Norepinephrine	"[Norepinephrine co-treated with NPY protein] results in increased abundance of Inositol 1,4,5-Trisphosphate"	7742479
D009638	Norepinephrine	NPY protein results in decreased secretion of Norepinephrine	2455193
D016627	Oxidopamine	Oxidopamine results in decreased expression of NPY protein	3805164\|9460767
D016627	Oxidopamine	Oxidopamine results in increased expression of NPY mRNA	15303306
C076029	olanzapine	olanzapine results in decreased expression of NPY mRNA	16516965
C076029	olanzapine	olanzapine results in increased expression of NPY protein	21695181
C055122	orlistat	orlistat results in increased expression of NPY protein	15962606
D009966	Orphenadrine	Orphenadrine affects the expression of NPY mRNA	23665939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of NPY mRNA	25729387
D010095	Oxotremorine	Oxotremorine results in increased expression of NPY protein	1907749
D010126	Ozone	Ozone results in increased expression of NPY mRNA	16716893
D017239	Paclitaxel	Paclitaxel results in increased expression of NPY protein	17686523
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of NPY mRNA	26272509
C084656	paricalcitol	paricalcitol results in increased expression of NPY mRNA	25037058
C076213	PD 142893	PD 142893 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]	12234805
D010424	Pentobarbital	NPY1R protein affects the reaction [NPY protein results in increased susceptibility to Pentobarbital]	11454027
D010424	Pentobarbital	NPY protein results in increased susceptibility to Pentobarbital	11454027
C494474	perchlorate	perchlorate results in decreased expression of NPY mRNA	17403546
C494474	perchlorate	perchlorate results in increased expression of NPY mRNA	17403546
D010615	Phenacetin	Phenacetin results in increased expression of NPY mRNA	17082564
D010656	Phenylephrine	NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]	10660688
D010656	Phenylephrine	NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]	10660688
D010656	Phenylephrine	NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]	10660688
D010656	Phenylephrine	NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]	10660688
D010656	Phenylephrine	[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein	11499749
D010656	Phenylephrine	Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]	10660688
D010656	Phenylephrine	Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]	10660688
C030299	phenylhydrazine	phenylhydrazine results in increased expression of NPY mRNA	17082564
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of NPY mRNA	26272509
D010665	Phenylpropanolamine	Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]	24792324
D010665	Phenylpropanolamine	NPY1R protein affects the reaction [Phenylpropanolamine results in decreased expression of NPY protein]	23052195
D010665	Phenylpropanolamine	Phenylpropanolamine results in decreased expression of NPY mRNA	17684035\|2198978
D010665	Phenylpropanolamine	Phenylpropanolamine results in decreased expression of NPY protein	17684035\|2198978
D010665	Phenylpropanolamine	[Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]	21989786
D010665	Phenylpropanolamine	S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]	24792324
D010665	Phenylpropanolamine	STAT3 mRNA promotes the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]	24792324
D010862	Pilocarpine	NPY protein results in decreased susceptibility to Pilocarpine	15451008
D010862	Pilocarpine	Pilocarpine results in increased expression of NPY protein	12821374
D010862	Pilocarpine	Pilocarpine results in increased expression of NPY protein	12231234
D010862	Pilocarpine	[BIIE 0246 results in decreased activity of NPY2R protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
D010862	Pilocarpine	DRD2 protein promotes the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
D010862	Pilocarpine	"[N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin results in decreased activity of SIGMAR1 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]"	18005069
D010862	Pilocarpine	NPY results in decreased susceptibility to Pilocarpine	18005069
D010862	Pilocarpine	[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of NPY mRNA	27935865
C006253	pirinixic acid	pirinixic acid results in decreased expression of NPY mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in decreased expression of NPY mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in decreased expression of NPY mRNA	23557933
D011188	Potassium	NPY protein inhibits the reaction [CALCA protein affects the susceptibility to Potassium]	18055875
D011188	Potassium	Capsaicin inhibits the reaction [NPY protein affects the susceptibility to Potassium]	18055875
D011188	Potassium	NPY protein inhibits the reaction [CALCA protein affects the susceptibility to Potassium]	18055875
D011188	Potassium	NPY protein results in increased susceptibility to Potassium	18055875
D011188	Potassium	Potassium results in increased secretion of NPY protein	29320738
D011188	Potassium	Propofol inhibits the reaction [Potassium results in increased secretion of NPY protein]	29320738
D011188	Potassium	AGT protein alternative form affects the reaction [NPY protein affects the abundance of Potassium]	10737671
D011188	Potassium	Indomethacin inhibits the reaction [NPY protein affects the abundance of Potassium]	10737671
D011188	Potassium	Losartan inhibits the reaction [NPY protein affects the abundance of Potassium]	10737671
D011188	Potassium	NPY1R protein affects the reaction [NPY protein affects the abundance of Potassium]	10737671
D011188	Potassium	NPY protein affects the abundance of Potassium	10737671
D011188	Potassium	ramiprilat inhibits the reaction [NPY protein affects the abundance of Potassium]	10737671
D011189	Potassium Chloride	Potassium Chloride results in increased expression of NPY mRNA	2233698
D011224	Prazosin	[Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]	21989786
D011374	Progesterone	Progesterone results in increased expression of NPY mRNA	18070364
D011374	Progesterone	Progesterone results in decreased expression of NPY mRNA	22238285
D011374	Progesterone	NPY protein results in increased secretion of Progesterone	20150881
D011372	Progestins	Progestins results in increased expression of NPY mRNA	19609016
D015742	Propofol	Propofol inhibits the reaction [Potassium results in increased secretion of NPY protein]	29320738
D011441	Propylthiouracil	Propylthiouracil affects the expression of NPY mRNA	24780913
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of NPY mRNA	17403546
D011441	Propylthiouracil	Propylthiouracil results in increased expression of NPY mRNA	17403546
C079216	PYX 2	"PYX 2 inhibits the reaction [NPY protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"	7742479
D019257	Quinpirole	"NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]"	12183048
C052549	ramiprilat	ramiprilat inhibits the reaction [NPY protein affects the abundance of Potassium]	10737671
D017330	Remoxipride	[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
C087120	RES 701-1	RES 701-1 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]	12234805
D012110	Reserpine	Reserpine results in increased expression of NPY mRNA	8955796
D012110	Reserpine	Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]	1714554
D012110	Reserpine	Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]	1714554
D012110	Reserpine	Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA]	20504635
D012110	Reserpine	Reserpine results in decreased expression of NPY mRNA	2233698\|7911764
D012110	Reserpine	Reserpine results in decreased expression of NPY protein	3805164
D012110	Reserpine	Reserpine results in increased expression of NPY mRNA	1671012\|1676830\|
D012110	Reserpine	Reserpine results in increased expression of NPY protein	1907749\|3215285\|
D012110	Reserpine	Reserpine results in decreased expression of NPY protein	2455193
D012110	Reserpine	Reserpine results in increased secretion of NPY protein	2455193
C089730	rosiglitazone	rosiglitazone results in increased expression of NPY mRNA	25788674
C089730	rosiglitazone	rosiglitazone results in decreased expression of NPY mRNA	21515302
D012402	Rotenone	Rotenone results in increased expression of NPY mRNA	27900601
C534628	SCH 23390	[Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]	21989786
C534628	SCH 23390	SCH 23390 results in increased expression of NPY protein	7644023
D012604	Scorpion Venoms	Antivenins inhibits the reaction [Scorpion Venoms results in increased hydrolysis of NPY protein]	25239630
D012604	Scorpion Venoms	Scorpion Venoms results in increased hydrolysis of NPY protein	25239630
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY mRNA]	25825358
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY protein]	25825358
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]	24792324
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of NPY mRNA	25895662
D012999	Soman	Soman results in increased expression of NPY mRNA	19281266
D053260	Soot	Soot results in increased expression of NPY mRNA	26551751
D013311	Streptozocin	INS protein inhibits the reaction [Streptozocin results in increased expression of NPY mRNA]	20219977
D013311	Streptozocin	Streptozocin results in increased expression of NPY mRNA	20219977
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of NPY mRNA	21641980
D013549	Sweetening Agents	Sweetening Agents results in decreased expression of NPY mRNA	18627777
D013726	Terbutaline	NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein]	3329090
C501413	tesaglitazar	tesaglitazar results in decreased expression of NPY mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NPY mRNA	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NPY mRNA	19465110
D013749	Tetrachlorodibenzodioxin	AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPY mRNA]	23871856
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NPY mRNA	15977195\|2229881
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of NPY mRNA	15977195
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NPY mRNA	15093705\|2387185
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]	10660688
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]	10660688
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of NPY protein	19912776
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]"	12183048
D013779	Tetrodotoxin	Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of NPY mRNA]	2233698
D013874	Thiopental	Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]	9427505
C009495	titanium dioxide	titanium dioxide results in decreased expression of NPY mRNA	23409001
C009495	titanium dioxide	titanium dioxide results in increased expression of NPY mRNA	19464567
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of NPY mRNA	20133372
C052342	topiramate	topiramate results in increased expression of NPY protein	17572454
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of NPY mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of NPY mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of NPY mRNA	23724009
C062527	tribromoethanol	NPY protein results in increased susceptibility to tribromoethanol	11454027
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of NPY mRNA	24935251\|2627250
C005445	triphenyl phosphate	"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NPY mRNA]"	29112739
C005445	triphenyl phosphate	"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NPY mRNA"	29112739
C016805	tris(1,3-dichloro-2-propyl)phosphate	"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NPY mRNA]"	29112739
C016805	tris(1,3-dichloro-2-propyl)phosphate	"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NPY mRNA"	29112739
D014317	Tritolyl Phosphates	"ESR1 gene mutant form inhibits the reaction [[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NPY mRNA]"	29112739
D014317	Tritolyl Phosphates	"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in decreased expression of NPY mRNA"	29112739
C057693	troglitazone	troglitazone results in decreased expression of NPY mRNA	21515302
C022884	undecane	undecane results in increased expression of NPY protein	17337753
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of NPY mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of NPY mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of NPY mRNA	24896083
D014639	Vanadium	Vanadium results in increased expression of NPY mRNA	19000753
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of NPY mRNA	11294500
D014640	Vancomycin	Vancomycin results in increased expression of NPY mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of NPY gene	25560391
D014701	Veratridine	Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of NPY mRNA]	2233698
D014701	Veratridine	Veratridine results in increased expression of NPY mRNA	2233698
D020888	Vigabatrin	Vigabatrin results in increased expression of NPY mRNA	16194568
D020888	Vigabatrin	Vigabatrin results in increased expression of NPY protein	16194568
D014747	Vinblastine	Vinblastine results in decreased expression of NPY mRNA	1671012
C025643	vinclozolin	vinclozolin results in increased expression of NPY mRNA	23034163
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of NPY mRNA	26272509
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NPY mRNA	27935865
D015016	Yohimbine	Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]	1878751
D015032	Zinc	Zinc deficiency results in decreased expression of NPY mRNA	12672911\|1641375
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of NPY mRNA	27215404
C022189	zonisamide	zonisamide results in increased expression of NPY protein	16194568

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001664	G-protein coupled receptor binding	-	IBA	21873635
GO:0004930	G-protein coupled receptor activity	-	TAS	1321422
GO:0005102	signaling receptor binding	-	TAS	8132547 10698177
GO:0005179	hormone activity	-	IBA	21873635
GO:0005184	neuropeptide hormone activity	-	IBA	21873635
GO:0005184	neuropeptide hormone activity	-	TAS	2427515
GO:0005246	calcium channel regulator activity	-	TAS	8132547
GO:0031841	neuropeptide Y receptor binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006816	calcium ion transport	-	TAS	8132547
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	8132547
GO:0007218	neuropeptide signaling pathway	-	IBA	21873635
GO:0007267	cell-cell signaling	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	TAS	10557353
GO:0007631	feeding behavior	-	IBA	21873635
GO:0007631	feeding behavior	-	TAS	10698177
GO:0008217	regulation of blood pressure	-	IEA	-
GO:0008283	cell proliferation	-	TAS	10488139
GO:0008343	adult feeding behavior	-	ISS	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0021954	central nervous system neuron development	-	IEP	20846339
GO:0021987	cerebral cortex development	-	IEP	9067840
GO:0031175	neuron projection development	-	IEP	20846339
GO:0032100	positive regulation of appetite	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	ISS	-
GO:0005623	cell	-	TAS	2444979
GO:0005794	Golgi apparatus	-	IDA	-

KEGG ID	KEGG Term
hsa04920	Adipocytokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
7494448	Nicotine elicits changes in expression of adrenal catecholamine biosynthetic enzymes, neuropeptide Y and immediate early genes by injection but not continuous administration. (1995 Aug)	Hiremagalur B	Brain Res Mol Brain Res
16377459	The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. (2005 Jul)	Schroeder JP	Alcohol
21822476	Modulation of tyrosine hydroxylase, neuropeptide y, glutamate, and substance p in Ganglia and brain areas involved in cardiovascular control after chronic exposure to nicotine. (2011)	Ferrari MF	Int J Hypertens
9865811	Depression and stimulant dependence: neurobiology and pharmacotherapy. (1998 Dec)	Kosten TR	J Nerv Ment Dis
22848202	Cigarette smoking and brain regulation of energy homeostasis. (2012)	Chen H	Front Pharmacol
23085848	The central amygdala and alcohol: role of gamma-aminobutyric acid, glutamate, and neuropeptides. (2012 Dec 1)	Roberto M	Cold Spring Harb Perspect Med
12215082	A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. (2002 Sep)	Lappalainen J	Arch Gen Psychiatry
18619427	Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake. (2008 Sep 4)	Chen H	Brain Res
11701716	Chronic maternal nicotine exposure alters neuronal systems in the arcuate nucleus that regulate feeding behavior in the newborn rhesus macaque. (2001 Nov)	Grove KL	J Clin Endocrinol Metab
20813242	Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. (2010)	Bjork K	Int Rev Neurobiol
28138095	Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. (2017 Mar 1)	Ladron de Guevara-Miranda D	Dis Model Mech
20554694	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (2010 Jul-Aug)	Kovanen L	Alcohol Alcohol
17207894	Regulation of hypothalamic NPY by diet and smoking. (2007 Feb)	Chen H	Peptides
15337374	Interactions between NPY and CRF in the amygdala to regulate emotionality. (2004 Aug)	Sajdyk TJ	Neuropeptides
16531608	Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss. (2006 Jun 1)	Chen H	Am J Respir Crit Care Med
15182714	Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. (2004 Jun 10)	Davies AG	Neuron
15056272	Neuropeptides: implications for alcoholism. (2004 Apr)	Cowen MS	J Neurochem
18468678	Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. (2008 Jun)	Rylkova D	Neuropeptides
12359508	Diverse functions of neuropeptide Y revealed using genetically modified animals. (2002 Apr-Jun)	Thorsell A	Neuropeptides
21790673	Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. (2012 Jan)	Sakharkar AJ	Alcohol Clin Exp Res
27918953	Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis. (2017 Feb)	Pendharkar SA	Cytokine
16611091	Neuropeptide y: role in emotion and alcohol dependence. (2006 Apr)	Carvajal C	CNS Neurol Disord Drug Targets
18828811	Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (2008 Dec)	Wetherill L	Alcohol Clin Exp Res
9454808	Neuropeptide Y attenuates naloxone-precipitated morphine withdrawal via Y5-like receptors. (1998 Feb)	Woldbye DP	J Pharmacol Exp Ther
12818715	Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. (2003 Jun)	Leibowitz SF	Physiol Behav
22387704	Plasma neuropeptide Y levels relate cigarette smoking and smoking cessation to body weight regulation. (2012 Jun 10)	Hussain T	Regul Pept
17979774	Relevance of neuropeptide Y (NPY) in psychiatry. (2007)	Eaton K	Curr Top Med Chem
25161819	Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. (2014 Jul)	Archer NP	Brain Behav
22938859	Neuropeptide Y (NPY) in the extended amygdala is recruited during the transition to alcohol dependence. (2012 Dec)	Gilpin NW	Neuropeptides
25324788	Effect of Acetaldehyde Intoxication and Withdrawal on NPY Expression: Focus on Endocannabinoidergic System Involvement. (2014)	Plescia F	Front Psychiatry
17572454	Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role? (2007 Sep 10)	Mathe AA	Physiol Behav
17940214	Detrimental metabolic effects of combining long-term cigarette smoke exposure and high-fat diet in mice. (2007 Dec)	Chen H	Am J Physiol Endocrinol Metab
15520048	Increased fasting plasma ghrelin levels during alcohol abstinence. (2005 Jan-Feb)	Kim DJ	Alcohol Alcohol
19102068	[Morphometric characteristics of neuropeptide Y immunoreactive neurons of human cortical amygdaloid nucleus]. (2008 May-Jun)	Malis M	Med Pregl
24528596	Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. (2014 Aug)	Sakharkar AJ	Int J Neuropsychopharmacol
18241322	Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. (2008 Mar)	Zill P	Alcohol Clin Exp Res
15048644	Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. (2004 Apr 1)	Sullivan PF	Am J Med Genet B Neuropsychiatr Genet
1391883	[Effects of neuropeptide Y on rat body temperature in normal conditions and after ethanol administration]. (1992 Apr)	Timofeeva LV	Biull Eksp Biol Med
10397286	Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. (1999 Jun)	Hwang BH	Alcohol Clin Exp Res
12605064	Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence. (2003 Feb)	Pandey SC	Alcohol Clin Exp Res
24290310	Operant alcohol self-administration in dependent rats: focus on the vapor model. (2014 May)	Vendruscolo LF	Alcohol
27389447	The role of neuropeptide Y in the pathophysiology of atherosclerotic cardiovascular disease. (2016 Oct 1)	Zhu P	Int J Cardiol
9209958	Degeneration of intrapancreatic nerve fibers after chronic alcohol administration in mice. (1997 Apr)	Berger Z	Int J Pancreatol
20028368	Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. (2010 Mar 1)	Zhang H	Alcohol Clin Exp Res
22101113	Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. (2012 Feb)	Gilpin NW	Neurosci Biobehav Rev
28477725	Epigenetic mechanisms of alcoholism and stress-related disorders. (2017 May)	Palmisano M	Alcohol
12544000	NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. (2003 Jan)	Zhu G	Alcohol Clin Exp Res
11330489	Motilin- and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia. (2000 Oct-Dec)	Jonsson BH	Integr Physiol Behav Sci
24189487	The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. (2014 Mar)	Witkin JM	Pharmacol Ther
23652361	Association between neuropeptide Y gene polymorphisms and alcohol dependence: a case-control study in two independent populations. (2013)	Bhaskar LV	Eur Addict Res
16545872	Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. (2006 Sep)	Heilig M	Pharmacol Ther
15749341	Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. (2005)	Spence JP	Neuroscience
18501411	Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. (2008 Sep)	Gilpin NW	Pharmacol Biochem Behav
19630743	From QTL to candidate gene: a genetic approach to alcoholism research. (2009 May)	Spence JP	Curr Drug Abuse Rev
24179100	Effects of smoking cessation on beta-cell function, insulin sensitivity, body weight, and appetite. (2014 Feb)	Stadler M	Eur J Endocrinol
20811389	Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. (2010 Nov)	Sato N	J Hum Genet
8923446	Neuropathology of human sympathetic autonomic ganglia. (1996 Oct 1)	Schmidt RE	Microsc Res Tech
10837809	Nicotine administration enhances NPY expression in the rat hypothalamus. (2000 Jun 9)	Li MD	Brain Res
12122484	Nicotine and its withdrawal alter feeding induced by paraventricular hypothalamic injections of neuropeptide Y in Sprague-Dawley rats. (2002 Jul)	Bishop C	Psychopharmacology (Berl)
19913192	Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. (2009 Nov)	Ciccocioppo R	Alcohol
16383007	NPY in alcoholism and psychiatric disorders. (2006)	Thorsell A	EXS
28302012	Targeting NPY, CRF/UCNs and NPS Neuropeptide Systems to Treat Alcohol Use Disorder (AUD). (2017)	Rodriguez FD	Curr Med Chem
12454738	Severity of alcohol withdrawal symptoms and the T1128C polymorphism of the neuropeptide Y gene. (2002 Nov)	Koehnke MD	J Neural Transm (Vienna)
21524263	Current and promising pharmacotherapies, and novel research target areas in the treatment of alcohol dependence: a review. (2011)	Edwards S	Curr Pharm Des
16200210	Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. (2005 Oct)	Pandey SC	J Clin Invest
18385331	Brain chromatin remodeling: a novel mechanism of alcoholism. (2008 Apr 2)	Pandey SC	J Neurosci
2006146	Cocaine-induced reduction of brain neuropeptide Y synthesis dependent on medial prefrontal cortex. (1991 Mar 15)	Wahlestedt C	Proc Natl Acad Sci U S A
15052257	A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism. (2004)	Arlinde C	Pharmacogenomics J
21653710	Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. (2011 Sep)	Huang H	J Neurophysiol
15670655	Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. (2005 Feb 28)	Rimondini R	Neurosci Lett
21459365	Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. (2011 Jun 1)	Gilpin NW	Biol Psychiatry
22367168	Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. (2012 Aug)	Sorensen G	Psychopharmacology (Berl)
22544368	Mice lacking neuropeptide Y show increased sensitivity to cocaine. (2012 Sep)	Sorensen G	Synapse
24893293	Chronic alcohol consumption leads to neurochemical changes in the nucleus accumbens that are not fully reversed by withdrawal. (2014 Jul-Aug)	Pereira PA	Neurotoxicol Teratol
23459936	Exploring the genetic basis of chronic periodontitis: a genome-wide association study. (2013 Jun 1)	Divaris K	Hum Mol Genet
20368518	Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques. (2010 Apr)	Lindell SG	Arch Gen Psychiatry
12013027	Brain neuropeptide Y (NPY) in stress and alcohol dependence. (2002)	Heilig M	Rev Neurosci
16200206	The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism. (2005 Oct)	Wand G	J Clin Invest
21058960	Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin. (2011 Feb)	Leggio L	Alcohol Clin Exp Res
15897713	A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. (2005 May)	Mottagui-Tabar S	Alcohol Clin Exp Res
21995655	Central functions of neuropeptide Y in mood and anxiety disorders. (2011 Nov)	Wu G	Expert Opin Ther Targets
22560367	Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): effects on inhibitory transmission in central amygdala, and anxiety- & alcohol-related behaviors. (2012 Jun)	Gilpin NW	Alcohol
20482506	Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence. (2010)	Leggio L	Curr Pharm Des
21433370	Probe Report for NPY-Y2 Receptor Antagonists (2010)	Saldanha SA	-
11696660	Association of neuropeptide y polymorphism with the occurrence of type 1 and type 2 alcoholism. (2001 Oct)	Ilveskoski E	Alcohol Clin Exp Res
15201542	Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population. (2004 Jul)	Wallerstedt SM	J Hypertens
15582675	Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. (2004 Dec)	Valdez GR	Pharmacol Biochem Behav
25197167	Smoking is associated with reduced leptin and neuropeptide Y levels and higher pain experience in patients with fibromyalgia. (2014)	Bokarewa MI	Mediators Inflamm
17443794	Nicotine regulates mRNA expression of feeding peptides in the arcuate nucleus in neonatal rat pups. (2007 Feb 15)	Huang LZ	Dev Neurobiol
14691378	Neuropeptide-Y Y5 receptors modulate the onset and maintenance of operant ethanol self-administration. (2003 Dec)	Schroeder JP	Alcohol Clin Exp Res
24548628	Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal. (2014 Feb 18)	Gaio V	Diabetol Metab Syndr
23454535	Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference. (2013 Apr)	Sorensen G	Pharmacol Biochem Behav
17239487	Neuropeptide Y (NPY) in alcohol intake and dependence. (2007 Feb)	Thorsell A	Peptides
28811392	Role of sympathetic cotransmitter galanin on autonomic balance in heart failure: an active player or a bystander? (2017 Oct)	Ozkaramanli Gur D	Anatol J Cardiol
7511981	Innervation of normal human sural and optic nerves by noradrenaline- and peptide-containing nervi vasorum and nervorum: effect of diabetes and alcoholism. (1993 Dec 31)	Lincoln J	Brain Res
29056151	The Role of Neuropeptide Y (NPY) in Alcohol and Drug Abuse Disorders. (2017)	Robinson SL	Int Rev Neurobiol
15508020	Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice. (2005 Apr)	Chen H	Neuropsychopharmacology