Gene: NOTCH3

4854
CADASIL|CADASIL1|CASIL|IMF2|LMNS
notch 3
protein-coding
19p13.12
Ensembl:ENSG00000074181 MIM:600276 Vega:OTTHUMG00000183217 UniprotKB:Q9UM47
NG_009819.1
PubMed
0   ANCO-SNPs
ND
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.973e-1 (AD)  5.592e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPER10.822
PDGFRB0.769
FOXF20.749
PEAR10.748
TBX20.736
NDUFA4L20.736
KANK20.729
SLC12A70.724
IGF20.71
EBF10.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC175-0.384
SMIM18-0.351
PRDM12-0.344
KCTD4-0.343
IL13RA2-0.342
ROPN1L-0.336
KLHL35-0.33
BCL2L10-0.325
MAD2L1-0.325
ZNF165-0.323

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of NOTCH3 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of NOTCH3 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NOTCH3 mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of NOTCH3 mRNA16788091
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of NOTCH3 mRNA"27567155
C0114215-chloro-2-methyl-4-isothiazolin-3-one5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of NOTCH3 mRNA20713136
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of NOTCH3 mRNA"28073004
D000082AcetaminophenAcetaminophen affects the expression of NOTCH3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NOTCH3 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NOTCH3 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of NOTCH3 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NOTCH3 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NOTCH3 mRNA26001963
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of NOTCH3 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NOTCH3 mRNA19770486
C006780bisphenol Abisphenol A affects the expression of NOTCH3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NOTCH3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NOTCH3 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of NOTCH3 mRNA20147733
C018475butyraldehydebutyraldehyde results in decreased expression of NOTCH3 mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased expression of NOTCH3 mRNA17720352
C005563captaxcaptax results in decreased expression of NOTCH3 mRNA20713136
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of NOTCH3 mRNA20713136
D003375CoumestrolCoumestrol results in decreased expression of NOTCH3 mRNA19167446
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NOTCH3 mRNA17379624
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NOTCH3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NOTCH3 mRNA27392435
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
D004041Dietary FatsDietary Fats results in increased expression of NOTCH3 mRNA18042831
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of NOTCH3 mRNA20713136
D004147DioxinsDioxins affects the expression of NOTCH3 mRNA20463971
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
D000431EthanolEthanol results in increased expression of NOTCH3 mRNA20713136
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NOTCH3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NOTCH3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH3 mRNA17942748
C540355fenamidonefenamidone results in increased expression of NOTCH3 mRNA27029645
C004312glycidolglycidol results in decreased expression of NOTCH3 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of NOTCH3 mRNA16467112
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA15477007
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NOTCH3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NOTCH3 mRNA26752646
D007657Ketone BodiesKetone Bodies results in decreased expression of NOTCH3 mRNA16807920
C008259lauryl gallatelauryl gallate results in increased expression of NOTCH3 mRNA20713136
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NOTCH3 mRNA12057914
D008727MethotrexateMethotrexate affects the expression of NOTCH3 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NOTCH3 mRNA26011545
C523799MRK 003NOTCH3 protein modified form results in decreased susceptibility to MRK 00321994468
C523799MRK 003NOTCH3 results in increased susceptibility to MRK 00317804716
D009151Mustard GasMustard Gas results in decreased expression of NOTCH3 mRNA28402575
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of NOTCH3 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NOTCH3 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of NOTCH3 mRNA26516004
D010126OzoneNOTCH3 protein results in decreased susceptibility to Ozone25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of ADAMTS4 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of ALDH1A3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of ASF1B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of ASPM mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of AURKB mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of BCL3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of BRCA1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of BUB1B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CCL22 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CCL2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CCL7 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CCNB1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CDC20 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CDC6 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CDCA3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CDKN3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CENPF mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CHRNA7 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CLEC5A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of D1ERTD564E mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of D5ERTD255E mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of DEPDC1A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of DLGAP5 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of E2F7 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of ECT2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of HDDC3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of HMMR mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of IL33 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of IL6 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of IQGAP3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of KIF22 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of KIF23 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of KIFC1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of KIFC5B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of KNTC1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of LNCPINT mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of MALAT1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of MCM6 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of MS4A6D mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of MTHFD2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of NEK2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of NUF2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of PLK1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of POLE mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of PRC1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of PRSS22 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of RACGAP1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of RETNLB mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SAA1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SAA3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SDF2L1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SELE mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SERPINA3N mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SGO1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SGO2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SHCBP1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SOCS3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SPRR1A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of SPRR2A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of STIL mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TCF19 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TFPI2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of THBS1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TNC mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TNFRSF12A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TRIM12A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TRIM30D mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TRIM34 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TTK mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in decreased expression of ARXES1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in decreased expression of ARXES2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in decreased expression of DDC mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in decreased expression of MEX3B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of ANLN mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of AREG mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of ARHGAP11A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of AURKA mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CCL17 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CCNA2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CCNB2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CD14 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CDCA5 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CDCA8 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CDT1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CENPE mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CENPH mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CEP55 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CH25H mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CHL1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CKAP2L mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CKAP2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CKS1B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CLEC4N mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CLSPN mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CTSK mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CXCL10 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CXCL2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CXCL3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CYP7B1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of D17H6S56E-5 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of DSCC1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of DTL mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of EREG mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of ESCO2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of FBXO15 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GAS2L3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GATM mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GCLC mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GINS1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GJB3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GLRX mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of HELLS mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of HOMER2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of HPX mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of KIF11 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of KIF20A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of KIF20B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of KRT19 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of LCN2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of LIG1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of LONRF3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of MAL mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of MCM5 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of MKI67 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of MMS22L mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of MT2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of NCAPG2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of NCAPG mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of NOP58 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of OIP5 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of PBK mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of PPP1R14D mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RAD51AP1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RAD51 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RETNLA mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RGS16 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RRM2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of S100A14 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SERPINA3M mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SFN mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SLC26A4 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SLC5A1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SLCO1A5 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SPAG5 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SPC24 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SPC25 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SPDL1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TGM1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of THBS1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TIMP1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TLR2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TMEM173 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TNF mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TNFSF9 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TOP2A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TRIP13 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TSHB mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of TYMS mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of UHRF1 mRNA25658374
D010126OzoneOzone results in increased expression of NOTCH3 mRNA25658374
D000073878Palm OilPalm Oil results in increased expression of NOTCH3 mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of NOTCH3 mRNA19095052
D011192Potassium DichromatePotassium Dichromate results in increased expression of NOTCH3 mRNA23608068
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NOTCH3 mRNA27029645
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of NOTCH3 mRNA"21152443
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA]15477007
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of NOTCH3 mRNA14699072
C010327salinomycinsalinomycin results in decreased expression of NOTCH3 mRNA19682730
D012643SeleniumSelenium results in increased expression of NOTCH3 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NOTCH3 mRNA23806026
D012906SmokeSmoke results in decreased expression of NOTCH3 mRNA21095227
D013629TamoxifenTamoxifen affects the expression of NOTCH3 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOTCH3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NOTCH3 mRNA16962184
C036919tetrachloroplatinatetetrachloroplatinate results in increased expression of NOTCH3 mRNA20713136
D013752TetracyclineTetracycline results in decreased expression of NOTCH3 mRNA28882639
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NOTCH3 mRNA15477007
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NOTCH3 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of NOTCH3 mRNA17569031
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA25607892
C088658zoledronic acidzoledronic acid results in decreased expression of NOTCH3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI11006133  11101851  17292860  
GO:0019899enzyme binding-IEA-  
GO:0038023signaling receptor activity-IMP15350543  
GO:0042802identical protein binding-IPI26051713  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0030900forebrain development-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045746negative regulation of Notch signaling pathway-TAS-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0048663neuron fate commitment-IEA-  
GO:0048844artery morphogenesis-IEA-  
GO:0072104glomerular capillary formation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-TAS-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA15350543  
GO:0005886plasma membrane-TAS-  
GO:0015629actin cytoskeleton-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04320Dorso-ventral axis formation
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1912399Pre-NOTCH Processing in the Endoplasmic ReticulumIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-350054Notch-HLH transcription pathwayTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-5083630Defective LFNG causes SCDO3TAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusIEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9017802Noncanonical activation of NOTCH3TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28281108Recognizing CADASIL: a Secondary Cause of Migraine with Aura. (2017 Apr)Burkett JGCurr Pain Headache Rep
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology
20167921Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals. (2010 Apr)Adib-Samii PStroke
28061457Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer. (2017 Feb 21)Xiong JOncotarget
20301673CADASIL (1993)Rutten J-
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One
26578659Predictors of Clinical Worsening in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: Prospective Cohort Study. (2016 Jan)Chabriat HStroke
23832984[Pathomechanisms and treatment of CADASIL]. (2013 Jul)Mizuno TBrain Nerve
22688109[Diagnosis, pathomechanism and treatment of CADASIL]. (2012)Mizuno TRinsho Shinkeigaku
26622547Cigarette smoke induces the expression of Notch3, not Notch1, protein in lung adenocarcinoma. (2015 Aug)Cheng ZOncol Lett
19859875[Periodontal disease as an early clinical sign of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)]. (2009 Nov 16-30)Luna-Maldonado ERev Neurol
19372454Different clinical phenotypes in monozygotic CADASIL twins with a novel NOTCH3 mutation. (2009 Jun)Mykkanen KStroke