Gene: NOTCH4

4855
INT3
notch 4
protein-coding
6p21.32
Ensembl:ENSG00000204301 MIM:164951 Vega:OTTHUMG00000031044 UniprotKB:Q99466
NG_028190.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11868595chr6:32191226NOTCH44.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLT40.843
PKN30.828
ESAM0.819
MYO1C0.816
ACVRL10.802
DOCK60.801
CXorf360.793
ITPR30.791
MMRN20.789
TIE10.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.376
OR4F29-0.35
MARCH4-0.333
ST6GAL2-0.33
PPEF1-0.327
OR4F5-0.323
NEUROD6-0.317
KIT-0.312
CPLX3-0.311
ABCD2-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NOTCH4 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of NOTCH4 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of NOTCH4 mRNA17562736
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NOTCH4 mRNA25607892
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NOTCH4 mRNA25607892
D001151ArsenicArsenic affects the methylation of NOTCH4 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NOTCH4 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of NOTCH4 mRNA22378314
D001285AtropineAtropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]17390078
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NOTCH4 mRNA22610609
C006780bisphenol Abisphenol A affects the expression of NOTCH4 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NOTCH4 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NOTCH4 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NOTCH4 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NOTCH4 mRNA25607892
C018475butyraldehydebutyraldehyde results in decreased expression of NOTCH4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased cleavage of NOTCH4 protein25118938
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NOTCH4 promoter22457795
D003033Coal TarCoal Tar results in increased expression of NOTCH4 mRNA27858113
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NOTCH4 mRNA23914054
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
D002945CisplatinFolic Acid affects the reaction [Cisplatin affects the expression of NOTCH4 mRNA]16898872
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NOTCH4 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NOTCH4 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
D005492Folic AcidFolic Acid affects the reaction [Cisplatin affects the expression of NOTCH4 mRNA]16898872
D017313FenretinideFenretinide results in increased expression of NOTCH4 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of NOTCH4 mRNA20003209
C008261lead acetatelead acetate results in increased expression of NOTCH4 mRNA22609695
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
D008345ManganeseManganese results in decreased expression of NOTCH4 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of NOTCH4 mRNA17175027
D015735MifepristoneMifepristone results in decreased expression of NOTCH4 mRNA25972201
C523799MRK 003NOTCH4 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NOTCH4 mRNA"25554681
D009532NickelNickel results in decreased expression of NOTCH4 mRNA25583101
D009538NicotineNicotine results in decreased expression of NOTCH4 protein20722969
D009538Nicotine[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein20722969
D009538Nicotine[Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein20722969
D009538NicotineVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]20722969
D009538NicotineVitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]20722969
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NOTCH4 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NOTCH4 mRNA25607892
D010100OxygenOxygen deficiency results in increased expression of NOTCH4 mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of NOTCH4 mRNA]26476374
D010126OzoneNOTCH4 gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 mRNA]25658374
D010126OzoneNOTCH4 protein results in decreased susceptibility to Ozone25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of ATP6V0D2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of AVPR1A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of BCL2L15 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of CCL17 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of CCL7 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of CD200R4 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of CXCL3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of DDC mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of DEPDC1A mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of ECM2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of EREG mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of HAS2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of HPX mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of LILR4B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of LILRB4 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of MFSD2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of SERPINA3M mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of SLC26A4 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of SOCS3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of SPC25 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of TEF mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of TFPI2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of THBS3 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of TRIP13 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] results in decreased expression of LRG1 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] results in decreased expression of MT2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] results in increased activity of RELA protein25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] results in increased expression of CLEC3B mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] results in increased expression of TNF mRNA25658374
D010278ParathionAtropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]17390078
D010278ParathionParathion results in increased expression of NOTCH4 protein17390078
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
D015237DinoprostDinoprost results in decreased cleavage of NOTCH4 protein21209419
D015237DinoprostDinoprost results in decreased expression of NOTCH4 mRNA21209419
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of NOTCH4 mRNA]26476374
D019438RitonavirRitonavir results in decreased expression of NOTCH4 protein20722969
D019438Ritonavir[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein20722969
D019438RitonavirVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]20722969
D019258Saquinavir[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein20722969
D019258Saquinavir[Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein20722969
D019258SaquinavirSaquinavir results in decreased expression of NOTCH4 protein20722969
D019258SaquinavirVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]20722969
D019258SaquinavirVitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]20722969
D019821SimvastatinSimvastatin results in increased expression of NOTCH4 mRNA19109527
D053260SootSoot affects the expression of NOTCH4 mRNA26551751
D013752TetracyclineTetracycline results in decreased expression of NOTCH4 mRNA28882639
C009495titanium dioxidetitanium dioxide affects the expression of NOTCH4 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of NOTCH4 mRNA27760801
D014212TretinoinTretinoin results in decreased expression of NOTCH4 mRNA16604517
D014520UrethaneUrethane results in decreased expression of NOTCH4 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NOTCH4 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA25607892
D014810Vitamin EVitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]20722969
D014810Vitamin EVitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]20722969

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-TAS11823422  
GO:0005515protein binding-IPI7671825  11101851  
GO:0038023signaling receptor activity-TAS11823422  
GO:0046982protein heterodimerization activity-TAS8681805  
GO ID GO Term Qualifier Evidence PubMed
GO:0001569branching involved in blood vessel morphogenesis-ISS-  
GO:0001709cell fate determination-TAS11823422  
GO:0001763morphogenesis of a branching structure-ISS-  
GO:0001886endothelial cell morphogenesis-IEA-  
GO:0001944vasculature development-ISS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-TAS18663143  
GO:0030097hemopoiesis-TAS11532344  
GO:0030154cell differentiation-NAS11823422  
GO:0030879mammary gland development-IDA9576833  
GO:0042060wound healing-IEA-  
GO:0045596negative regulation of cell differentiation-NAS11823422  
GO:0045602negative regulation of endothelial cell differentiation-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-TAS11823422  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-TAS8681805  
GO:0005654nucleoplasm-TAS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS11823422  
GO:0009986cell surface-IDA11823422  
KEGG ID KEGG Term
hsa04320Dorso-ventral axis formation
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1912399Pre-NOTCH Processing in the Endoplasmic ReticulumIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-1980150Signaling by NOTCH4TAS
R-HSA-1980150Signaling by NOTCH4IEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-350054Notch-HLH transcription pathwayTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-5083630Defective LFNG causes SCDO3TAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23395714Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia. (2013 Aug)Sinkus MLBrain Behav Immun
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One
29577422NOTCH4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case-control study. (2018 Mar 26)Shi XJ Clin Lab Anal
28061457Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer. (2017 Feb 21)Xiong JOncotarget