Gene: NOV

4856
CCN3|IBP-9|IGFBP-9|IGFBP9|NOVh
nephroblastoma overexpressed
protein-coding
8q24.12
Ensembl:ENSG00000136999 MIM:164958 Vega:OTTHUMG00000164984 UniprotKB:P48745
NG_009779.1
PubMed
0   ANCO-SNPs
CD|ND|AD
19   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.530e-1 (AD)  6.318e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLCL20.896
MYCBP20.889
PGM2L10.883
RAB27B0.883
FAM102B0.883
DCAF60.881
PARM10.881
BHLHB90.881
DGKE0.879
AKT30.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OLAH-0.531
STON2-0.519
MYL3-0.515
ROM1-0.513
MYOM1-0.51
HVCN1-0.509
ASB4-0.504
FXYD3-0.502
RAB13-0.499
S100A1-0.498

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00030Insulin HumanBiotechDrug11061-68-0Approved|InvestigationalTarget
DB00071Insulin PorkBiotechDrug12584-58-6ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NOV mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of NOV mRNA"20406850
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of NOV mRNA16460773
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NOV mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NOV mRNA"27188386
D000447AldehydesAldehydes results in increased expression of NOV mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NOV mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NOV mRNA16483693
D001151ArsenicArsenic affects the expression of NOV protein24675094
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NOV mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NOV mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NOV mRNA"20382639
D004958Estradiol[Cycloheximide co-treated with Estradiol] results in decreased expression of NOV mRNA15072547
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of NOV mRNA20660070
D004958EstradiolEstradiol results in decreased expression of NOV mRNA15072547|1898477
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NOV mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of NOV mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NOV mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of NOV mRNA25270620
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NOV mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NOV mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of NOV mRNA22079614
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of NOV mRNA16460773
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NOV mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of NOV mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NOV mRNA17484886
D003042CocaineCocaine results in increased expression of NOV mRNA17898221
D003345CorticosteroneCorticosterone results in increased expression of NOV mRNA15755911
D003513Cycloheximide[Cycloheximide co-treated with Estradiol] results in decreased expression of NOV mRNA15072547
D003513CycloheximideCycloheximide results in increased expression of NOV mRNA15072547
D016572CyclosporineCyclosporine results in decreased expression of NOV mRNA27989131
D016572CyclosporineCyclosporine results in decreased methylation of NOV promoter27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NOV mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of NOV mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NOV mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of NOV mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NOV mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of NOV mRNA21658437
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of NOV mRNA"19480007
D004237DiuronDiuron results in decreased expression of NOV mRNA21551480|2515243
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NOV mRNA23550701
C082360fipronilfipronil results in decreased expression of NOV mRNA23962444
D005419FlavonoidsFlavonoids results in increased expression of NOV mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of NOV mRNA16510598
D005473FluoxetineFluoxetine results in decreased expression of NOV mRNA17033635
C070081fulvestrantfulvestrant results in increased expression of NOV mRNA15072547|1898477
C070081fulvestrantfulvestrant results in increased expression of NOV protein18984771
D017313FenretinideFenretinide results in decreased expression of NOV mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NOV mRNA20044591
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of NOV mRNA15072547
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NOV mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of NOV mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NOV mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of NOV mRNA28628672
D007529IsoflavonesIsoflavones affects the expression of NOV mRNA16365062
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NOV mRNA27392435
C544151jinfukangjinfukang results in increased expression of NOV mRNA27392435
D008154LucanthoneLucanthone results in increased expression of NOV mRNA21148553
D008353MannitolMannitol results in decreased expression of NOV mRNA25270620
D008748MethylcholanthreneMethylcholanthrene results in increased expression of NOV mRNA20713471
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of NOV mRNA25270620
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NOV mRNA19074003
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of NOV mRNA24888373
D000073878Palm OilPalm Oil results in increased expression of NOV mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NOV mRNA"27188386
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of NOV mRNA26705709
C046012pentanalpentanal results in increased expression of NOV mRNA26079696
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of NOV mRNA22790973
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of NOV mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NOV mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NOV mRNA17560707
D010795Phthalic AcidsPhthalic Acids results in increased expression of NOV mRNA21061450
D010938Plant OilsPlant Oils results in increased expression of NOV mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of NOV mRNA21334430
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of NOV mRNA24888373
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NOV mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of NOV mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of NOV mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of NOV mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of NOV mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of NOV mRNA27029645
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of NOV mRNA19059307
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NOV mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of NOV mRNA12016162
D012999SomanSoman results in decreased expression of NOV mRNA19281266
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in decreased expression of NOV mRNA19059307
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NOV mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of NOV mRNA19074003
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NOV mRNA28111298
C032910triadimefontriadimefon results in decreased expression of NOV mRNA26705709
C012589trichostatin Atrichostatin A results in increased expression of NOV mRNA24935251
D014635Valproic AcidValproic Acid results in decreased methylation of NOV gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NOV mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of NOV mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of NOV mRNA23034163
D014800VitalliumVitallium analog results in decreased expression of NOV mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-IPI12050162  
GO:0005178integrin binding-IBA21873635  
GO:0005178integrin binding-IPI12695522  15611078  
GO:0005515protein binding-IPI9927660  15181016  15213231  
GO:0005520insulin-like growth factor binding-IEA-  
GO:0008083growth factor activity-IEA-  
GO:0008201heparin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IDA12695522  
GO:0002062chondrocyte differentiation-IMP21871891  
GO:0007155cell adhesion-IBA21873635  
GO:0007165signal transduction-IBA21873635  
GO:0010468regulation of gene expression-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010761fibroblast migration-IDA15611078  
GO:0010832negative regulation of myotube differentiation-IDA12050162  
GO:0014909smooth muscle cell migration-IDA20139355  
GO:0030308negative regulation of cell growth-IMP15181016  
GO:0033627cell adhesion mediated by integrin-IDA12695522  15611078  
GO:0035767endothelial cell chemotaxis-IDA12695522  
GO:0044342type B pancreatic cell proliferation-ISS-  
GO:0045747positive regulation of Notch signaling pathway-IDA12050162  20139355  
GO:0046676negative regulation of insulin secretion-ISS-  
GO:0048659smooth muscle cell proliferation-IDA20139355  
GO:0050728negative regulation of inflammatory response-ISS-  
GO:0060326cell chemotaxis-IDA15611078  
GO:0060392negative regulation of SMAD protein signal transduction-ISS-  
GO:0060548negative regulation of cell death-IBA21873635  
GO:0061484hematopoietic stem cell homeostasis-IMP17463287  
GO:0071603endothelial cell-cell adhesion-IDA12695522  
GO:0090027negative regulation of monocyte chemotaxis-IMP21063504  
GO:1901223negative regulation of NIK/NF-kappaB signaling-IMP21063504  
GO:1902731negative regulation of chondrocyte proliferation-IMP21871891  
GO:1904057negative regulation of sensory perception of pain-ISS-  
GO:1990523bone regeneration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-ISS-  
GO:0005737cytoplasm-IMP15181016  
GO:0005737cytoplasm-ISS-  
GO:0005921gap junction-IMP15181016  
GO:0005921gap junction-ISS-  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
GO:0031012extracellular matrix-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17574092Hazardous alcohol drinking and premature mortality in Russia: a population based case-control study. (2007 Jun 16)Leon DALancet
25701171Necitumumab plus pemetrexed and cisplatin as first-line therapy in patients with stage IV non-squamous non-small-cell lung cancer (INSPIRE): an open-label, randomised, controlled phase 3 study. (2015 Mar)Paz-Ares LLancet Oncol
29800768Short-term effects of airport-associated ultrafine particle exposure on lung function and inflammation in adults with asthma. (2018 May 22)Habre REnviron Int
23262251Factors associated with wound complications in women with obstetric anal sphincter injuries (OASIS). (2013 Apr)Stock LAm J Obstet Gynecol
19841052Smoking of crack cocaine as a risk factor for HIV infection among people who use injection drugs. (2009 Oct 27)DeBeck KCMAJ
17579708Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer. (2007 Jun 20)Chen PPPLoS One
27787372Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies. (2016 Oct)Zhuo XMedicine (Baltimore)
25684501Screening for patients with non-small cell lung cancer who could survive long term chemotherapy. (2015)Wu XYAsian Pac J Cancer Prev
21995436Cigarette smoke-induced early growth response-1 regulates the expression of the cysteine-rich 61 in human skin dermal fibroblasts. (2011 Dec)Kim JNExp Dermatol
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med
27803869Alcohol consumption and dry eye syndrome: a Meta-analysis. (2016)You YSInt J Ophthalmol
29045961[Effects of recent upper respiratory-tract infections on incidence of the perioperative respiratory adverse events in children: a prospective cohort study]. (2017 Oct 18)Li CQBeijing Da Xue Xue Bao Yi Xue Ban
24396098Rates and determinants of seasonal influenza vaccination in pregnancy and association with neonatal outcomes. (2014 Mar 4)Legge ACMAJ
16999015[New features in the recommendations of the Second Hungarian Therapeutic Consensus Conference]. (2006 Jul 16)Pados GOrv Hetil
29096949Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial. (2018 Dec 23)Colombel JFLancet
29146301Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. (2017 Dec)Hastie ATLancet Respir Med
7853601Preferred strategies for secondary infrainguinal bypass: lessons learned from 300 consecutive reoperations. (1995 Feb)Belkin MJ Vasc Surg
28426731Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma susceptibility. (2017)Lau HKPLoS One
24866166Passive smoking exposure from partners as a risk factor for ER+/PR+ double positive breast cancer in never-smoking Chinese urban women: a hospital-based matched case control study. (2014)Tong JHPLoS One