Gene: PNP

4860
NP|PRO1837|PUNP
purine nucleoside phosphorylase
protein-coding
14q11.2
Ensembl:ENSG00000198805 MIM:164050 Vega:OTTHUMG00000029546 UniprotKB:P00491
NG_009631.1
PubMed
0   ANCO-SNPs
OD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.942e-1 (AD)  4.232e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFKB20.898
HMOX10.879
PLAUR0.875
RAB200.87
YBX30.863
CLIC10.863
VASP0.86
SBNO20.857
EMP10.856
TUBB60.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALHM1-0.484
SLC7A4-0.484
NEUROD6-0.484
PPEF1-0.471
ABCC12-0.466
XKR4-0.461
MARCH4-0.46
LHX6-0.46
CASC15-0.457
KCNB2-0.453

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00242CladribineSmall Molecule4291-63-8Approved|InvestigationalTarget
DB00900DidanosineSmall Molecule69655-05-6ApprovedTarget
DB016678-azaguanineSmall Molecule134-58-7ExperimentalTarget
DB022222,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]PurineSmall MoleculeExperimentalTarget
DB02230Immucillin-GSmall MoleculeExperimentalTarget
DB02377GuanineSmall Molecule73-40-5ExperimentalTarget
DB023912-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-OneSmall MoleculeExperimentalTarget
DB02568PeldesineSmall Molecule-Experimental|InvestigationalTarget
DB027969-DeazainosineSmall Molecule89458-19-5ExperimentalTarget
DB02857GuanosineSmall Molecule118-00-3Experimental|InvestigationalTarget
DB03101Ribose-1-PhosphateSmall Molecule-ExperimentalTarget
DB03551(3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidiniumSmall MoleculeExperimentalTarget
DB036093-DeoxyguanosineSmall MoleculeExperimentalTarget
DB03881MT-Immucillin-HSmall MoleculeExperimentalTarget
DB04076HypoxanthineSmall Molecule68-94-0ExperimentalTarget
DB042609-(5,5-Difluoro-5-Phosphonopentyl)GuanineSmall MoleculeExperimentalTarget
DB04335InosineSmall Molecule58-63-9Approved|InvestigationalTarget
DB047539-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATESmall MoleculeExperimentalTarget
DB04754GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATESmall MoleculeExperimentalTarget
DB04757GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATESmall MoleculeExperimentalTarget
DB06185ForodesineSmall Molecule209799-67-7InvestigationalTarget
ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PNP mRNA"19167446
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of PNP mRNA"24821986
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNP mRNA"27188386
C0767789-deaza-9-(3-thienylmethyl)guanine9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C0767789-deaza-9-(3-thienylmethyl)guanine9-deaza-9-(3-thienylmethyl)guanine results in decreased activity of PNP protein8273599
C0767789-deaza-9-(3-thienylmethyl)guanine9-deaza-9-(3-thienylmethyl)guanine results in decreased activity of PNP protein7660883
C0767789-deaza-9-(3-thienylmethyl)guanine9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
C0767789-deaza-9-(3-thienylmethyl)guanine9-deaza-9-(3-thienylmethyl)guanine results in decreased activity of PNP protein1530667|7660882|
D000082AcetaminophenAcetaminophen results in increased expression of PNP mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of PNP protein22939915
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PNP mRNA17585979
D000082Acetaminophendioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein]22939915
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PNP mRNA]17585979
D000082AcetaminophenAcetaminophen affects the expression of PNP protein16099942
D000212AcyclovirAcyclovir inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of PNP mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PNP protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PNP gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PNP mRNA22100608|2715375
C096920AGN 193109AGN 193109 results in increased expression of PNP mRNA24821986
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PNP mRNA24449571
D001149Arsenates9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
D001149Arsenatesforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
D001149Arsenates[PNP protein co-treated with dihydrolipoic acid co-treated with Inosine] results in increased reduction of Arsenates12730608
D001149Arsenates[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates12730608
D001151ArsenicAS3MT gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]21605854
D001151ArsenicGSTO1 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]21605854
D001151ArsenicGSTO2 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]21605854
D001151ArsenicPNP gene polymorphism affects the susceptibility to Arsenic21605854
D001151ArsenicPNP gene polymorphism results in increased susceptibility to Arsenic18414634
D001151ArsenicPNP protein results in increased reduction of Arsenic18414634
C025657arsenic acid9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acidAcyclovir inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acidforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acidGuanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acidHypoxanthine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acidMersalyl inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acidp-Chloromercuribenzoic Acid inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acidPhosphates inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C025657arsenic acid[PNP protein co-treated with Dimercaprol co-treated with Inosine] results in increased reduction of arsenic acid12388830
C025657arsenic acid[PNP protein co-treated with Dithiothreitol co-treated with Guanosine] results in increased reduction of arsenic acid12388830
C025657arsenic acid[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid12388830
C025657arsenic acid[PNP protein co-treated with Mercaptoethanol co-treated with Inosine] results in increased reduction of arsenic acid12388830
C025657arsenic acid[PNP protein co-treated with Unithiol co-treated with Inosine] results in increased reduction of arsenic acid12388830
C025657arsenic acidPNP protein results in increased metabolism of arsenic acid12928150
C025657arsenic acid[PNP protein results in increased metabolism of arsenic acid] which results in increased chemical synthesis of arsenite12928150
C025657arsenic acidPNP protein results in increased reduction of arsenic acid15929903
C025657arsenic acidPNP protein results in increased reduction of arsenic acid19248796
C006632arsenic trioxidearsenic trioxide results in decreased expression of PNP mRNA19128835
C006632arsenic trioxidearsenic trioxide results in decreased expression of PNP protein25419056
C015001arsenitePNP protein results in increased chemical synthesis of arsenite12928150
C015001arsenite[PNP protein results in increased metabolism of arsenic acid] which results in increased chemical synthesis of arsenite12928150
C015001arsenitePNP protein results in increased chemical synthesis of arsenite19248796
D018053Arsenites[PNP protein co-treated with Dithiothreitol co-treated with Guanosine] results in increased chemical synthesis of Arsenites12388830
D018053Arsenites[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased chemical synthesis of Arsenites12388830
D018053Arsenites[PNP protein co-treated with dihydrolipoic acid co-treated with Inosine] results in increased chemical synthesis of Arsenites12730608
D018053Arsenites[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased chemical synthesis of Arsenites12730608
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PNP mRNA"25351596
D001205Ascorbic AcidAscorbic Acid affects the expression of PNP protein19224539
D001280AtrazineAtrazine affects the expression of PNP mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PNP mRNA26238291
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of PNP mRNA]24758408
D004958EstradiolEstradiol affects the expression of PNP mRNA14699072
D004958EstradiolEstradiol results in increased expression of PNP mRNA24758408
D004958EstradiolEstradiol results in increased expression of PNP mRNA14664709|1948475
C006780bisphenol Abisphenol A results in decreased expression of PNP mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PNP mRNA25181051
D001761BleomycinBleomycin results in decreased expression of PNP protein25933445
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PNP mRNA15336504
D002104CadmiumCadmium results in increased expression of PNP mRNA23256528
D002104CadmiumCadmium results in decreased expression of PNP mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PNP mRNA19031917
D019256Cadmium ChlorideCadmium Chloride affects the expression of PNP mRNA18804290
D002110CaffeineCaffeine results in increased expression of PNP protein6149265
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C070377CI 972CI 972 results in decreased activity of PNP protein8273599
C070377CI 972CI 972 results in decreased activity of PNP protein1530667|8128192|
D002922CiguatoxinsCiguatoxins affects the expression of PNP mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PNP mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of PNP mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PNP mRNA]17585979
D002994ClofibrateClofibrate results in increased expression of PNP protein16470657
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PNP mRNA17602206
D019327Copper SulfateCopper Sulfate results in increased expression of PNP mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PNP mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of PNP mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of PNP mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of PNP mRNA25562108
D013759DronabinolDronabinol affects the expression of PNP mRNA18454173
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PNP mRNA21266533
D002945CisplatinCisplatin results in increased expression of PNP mRNA27392435
D002945CisplatinCisplatin results in increased expression of PNP mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of PNP mRNA28302478
D004026DieldrinDieldrin results in increased expression of PNP mRNA28385952
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PNP mRNA17602206
C015144dihydrolipoic acid[PNP protein co-treated with dihydrolipoic acid co-treated with Inosine] results in increased chemical synthesis of Arsenites12730608
C015144dihydrolipoic acid[PNP protein co-treated with dihydrolipoic acid co-treated with Inosine] results in increased reduction of Arsenates12730608
D004112Dimercaprol[PNP protein co-treated with Dimercaprol co-treated with Inosine] results in increased reduction of arsenic acid12388830
C019357dioscindioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein]22939915
D004229Dithiothreitol9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229DithiothreitolAcyclovir inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229Dithiothreitolforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229DithiothreitolGuanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229DithiothreitolHypoxanthine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229DithiothreitolMersalyl inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229Dithiothreitolp-Chloromercuribenzoic Acid inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229DithiothreitolPhosphates inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D004229Dithiothreitol[PNP protein co-treated with Dithiothreitol co-treated with Guanosine] results in increased chemical synthesis of Arsenites12388830
D004229Dithiothreitol[PNP protein co-treated with Dithiothreitol co-treated with Guanosine] results in increased reduction of arsenic acid12388830
D004229Dithiothreitol[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased chemical synthesis of Arsenites12388830
D004229Dithiothreitol[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid12388830
D004229Dithiothreitol[PNP protein co-treated with Dithiothreitol] results in increased reduction of sodium arsenate analog19474219
D004229Dithiothreitol9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
D004229Dithiothreitolforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
D004229Dithiothreitol[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased chemical synthesis of Arsenites12730608
D004229Dithiothreitol[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates12730608
C108024emamectin benzoateemamectin benzoate results in increased expression of PNP mRNA18786259
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PNP mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of PNP mRNA]21233418
D004967EstrogensEstrogens results in increased expression of PNP mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PNP mRNA17557909
D005472FluorouracilPNP protein affects the susceptibility to Fluorouracil15548681
C113101forodesineforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C113101forodesineforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
C113101forodesineforodesine results in decreased activity of PNP protein15788719
D005839GentamicinsGentamicins results in increased expression of PNP mRNA22061828
D005839GentamicinsGentamicins results in increased expression of PNP protein22061828
D006147GuanineGuanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D006147GuaninePNP protein results in increased chemical synthesis of Guanine12730608
D006151Guanosine[PNP protein co-treated with Dithiothreitol co-treated with Guanosine] results in increased chemical synthesis of Arsenites12388830
D006151Guanosine[PNP protein co-treated with Dithiothreitol co-treated with Guanosine] results in increased reduction of arsenic acid12388830
D006151GuanosinePNP protein results in increased cleavage of Guanosine12730608
D019271HypoxanthineHypoxanthine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D019271HypoxanthinePNP protein results in increased chemical synthesis of Hypoxanthine12730608
D007288Inosine9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288InosineAcyclovir inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288Inosineforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288InosineGuanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288InosineHypoxanthine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288InosineMersalyl inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288Inosinep-Chloromercuribenzoic Acid inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288InosinePhosphates inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
D007288Inosine[PNP protein co-treated with Dimercaprol co-treated with Inosine] results in increased reduction of arsenic acid12388830
D007288Inosine[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased chemical synthesis of Arsenites12388830
D007288Inosine[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid12388830
D007288Inosine[PNP protein co-treated with Mercaptoethanol co-treated with Inosine] results in increased reduction of arsenic acid12388830
D007288Inosine[PNP protein co-treated with Unithiol co-treated with Inosine] results in increased reduction of arsenic acid12388830
D007288Inosine9-deaza-9-(3-thienylmethyl)guanine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
D007288Inosineforodesine inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates]12730608
D007288Inosine[PNP protein co-treated with dihydrolipoic acid co-treated with Inosine] results in increased chemical synthesis of Arsenites12730608
D007288Inosine[PNP protein co-treated with dihydrolipoic acid co-treated with Inosine] results in increased reduction of Arsenates12730608
D007288Inosine[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased chemical synthesis of Arsenites12730608
D007288Inosine[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of Arsenates12730608
D007288InosinePNP protein results in increased cleavage of Inosine12730608
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PNP mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of PNP mRNA20003209|2133504
D007649KetamineKetamine results in decreased expression of PNP mRNA20080153
D008623Mercaptoethanol[PNP protein co-treated with Mercaptoethanol co-treated with Inosine] results in increased reduction of arsenic acid12388830
D008634MersalylMersalyl inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PNP mRNA23103053
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of PNP mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PNP mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PNP protein26558463
C063855microcystin RRmicrocystin RR results in decreased expression of PNP protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PNP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PNP mRNA"25554681|2562005
D009532NickelNickel results in increased expression of PNP mRNA25583101
C025256nonylphenolnonylphenol results in increased expression of PNP mRNA22982499
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNP mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PNP mRNA26272509
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PNP mRNA18804290
D010578PetroleumPetroleum affects the expression of PNP mRNA25208076
D010710PhosphatesPhosphates inhibits the reaction [[PNP protein co-treated with Dithiothreitol co-treated with Inosine] results in increased reduction of arsenic acid]12388830
C006253pirinixic acidpirinixic acid results in decreased expression of PNP mRNA17426115|1844570
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PNP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PNP mRNA22079256
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PNP mRNA27029645
D011794QuercetinQuercetin results in increased expression of PNP mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of PNP mRNA19167446
D012822Silicon DioxideSilicon Dioxide results in increased expression of PNP mRNA25351596
D012834SilverSilver results in decreased expression of PNP mRNA27131904
C009277sodium arsenate[PNP protein co-treated with Dithiothreitol] results in increased reduction of sodium arsenate analog19474219
C017947sodium arsenitesodium arsenite results in increased expression of PNP mRNA28595984
D018038Sodium SeleniteSodium Selenite results in increased expression of PNP mRNA18175754
D013629TamoxifenTamoxifen affects the expression of PNP mRNA14699072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PNP mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PNP protein27189315
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PNP mRNA28065790
D014212TretinoinTretinoin results in decreased expression of PNP mRNA16054129
D014494Unithiol[PNP protein co-treated with Unithiol co-treated with Inosine] results in increased reduction of arsenic acid12388830
D014520UrethaneUrethane results in increased expression of PNP mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNP mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PNP mRNA19101580|2317975
D014810Vitamin EVitamin E results in decreased expression of PNP mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of PNP mRNA20044591
C111237vorinostatvorinostat results in increased expression of PNP mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of PNP mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001882nucleoside binding-IDA9305962  
GO:0002060purine nucleobase binding-IDA9305962  
GO:0004731purine-nucleoside phosphorylase activity-EXP2104852  6771276  
GO:0004731purine-nucleoside phosphorylase activity-IBA21873635  
GO:0004731purine-nucleoside phosphorylase activity-IDA3029074  9305962  16930574  16964310  18938130  
GO:0008144drug binding-IDA18938130  
GO:0042301phosphate ion binding-IDA18938130  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-IDA3029074  
GO:0006148inosine catabolic process-IDA16964310  
GO:0006195purine nucleotide catabolic process-TAS-  
GO:0006738nicotinamide riboside catabolic process-IDA19001417  
GO:0006955immune response-IMP16930574  
GO:0034356NAD biosynthesis via nicotinamide riboside salvage pathway-IGI19001417  
GO:0034418urate biosynthetic process-IDA16964310  
GO:0042102positive regulation of T cell proliferation-IDA16964310  
GO:0042493response to drug-IDA18938130  
GO:0042493response to drug-IMP15047506  
GO:0043101purine-containing compound salvage-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0046638positive regulation of alpha-beta T cell differentiation-IDA16964310  
GO:0070970interleukin-2 secretion-IMP16930574  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005622intracellular-IDA15047506  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA3029074  16930574  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-74217Purine salvageTAS
R-HSA-74259Purine catabolismTAS
R-HSA-8956319Nucleobase catabolismTAS
R-HSA-8956321Nucleotide salvageTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22503604Diabetic polyneuropathy relates to bone metabolism and markers of bone turnover in elderly patients with type 2 diabetes: greater effects in male patients. (2012 Jun)Rasul SGend Med
29291904Opioid Use Dependency in the Mother Who Desires to Breastfeed Her Newborn: A Case Study. (2018 May - Jun)Busch DJ Pediatr Health Care