Gene: NPAS2

4862
MOP4|PASD4|bHLHe9
neuronal PAS domain protein 2
protein-coding
2q11.2
Ensembl:ENSG00000170485 MIM:603347 Vega:OTTHUMG00000130675 UniprotKB:Q99743
NG_023259.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.555e-1 (AD)  1.328e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STK240.909
LASP10.907
DLGAP40.906
CELF20.896
VPS26B0.889
DNAJC50.888
CLIP30.884
TMEM1270.883
C11orf950.882
CMIP0.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.649
OR4F29-0.597
ANXA13-0.416
CTNNA3-0.397
SH2D1A-0.383
MYL3-0.367
SNHG18-0.365
TRPV5-0.358
POU2AF1-0.357
VRK2-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NPAS2 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NPAS2 mRNA"27291303
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of NPAS2 mRNA"21920950
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of NPAS2 mRNA25088246
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPAS2 mRNA22129741
D020106AcrylamideAcrylamide results in decreased expression of NPAS2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPAS2 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NPAS2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NPAS2 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of NPAS2 mRNA20678512
C006780bisphenol Abisphenol A affects the methylation of NPAS2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of NPAS2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of NPAS2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of NPAS2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NPAS2 mRNA24988533
C006780bisphenol Abisphenol A results in increased methylation of NPAS2 gene28505145
C584509C646 compoundC646 compound results in decreased expression of NPAS2 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NPAS2 mRNA17484886
D002330CarmustineNPAS2 mRNA affects the susceptibility to Carmustine16365179
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NPAS2 mRNA16934159
D002737ChloropreneChloroprene results in decreased expression of NPAS2 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of NPAS2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of NPAS2 mRNA24386269
D003042CocaineCocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]23776671
D003042CocaineCocaine promotes the reaction [NPAS2 protein binds to PER2 promoter]23776671
D003042CocaineCocaine promotes the reaction [NPAS2 protein binds to PER3 promoter]23776671
D003042CocaineCocaine results in decreased expression of NPAS2 mRNA15994025
D003042CocaineCocaine results in increased expression of NPAS2 mRNA23776671
D003042CocaineNPAS2 affects the susceptibility to Cocaine23776671
D016572CyclosporineCyclosporine results in increased expression of NPAS2 mRNA25562108|2798913
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NPAS2 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NPAS2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of NPAS2 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of NPAS2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of NPAS2 mRNA23537522
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPAS2 mRNA22129741
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of NPAS2 mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of NPAS2 mRNA25380136
D004610Ellagic AcidEllagic Acid results in increased expression of NPAS2 mRNA12002526
D000431EthanolEthanol results in decreased expression of NPAS2 mRNA29018328
D005473FluoxetineFluoxetine affects the expression of NPAS2 mRNA15994025
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of NPAS2 mRNA20846436
C039281furanfuran results in decreased expression of NPAS2 mRNA25539665|2619464
D005897GlafenineGlafenine results in decreased expression of NPAS2 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of NPAS2 mRNA26846883
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPAS2 mRNA22129741
C544151jinfukangjinfukang results in increased expression of NPAS2 mRNA27392435
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of NPAS2 mRNA26378955
C025340manganese chloridemanganese chloride results in decreased expression of NPAS2 mRNA28511934
C005219methyl cellosolvemethyl cellosolve results in decreased expression of NPAS2 mRNA21061450
D008752Methylene ChlorideMethylene Chloride results in decreased expression of NPAS2 mRNA28392392
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NPAS2 mRNA"26251327
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of NPAS2 mRNA25380136
D019829NevirapineNevirapine metabolite results in decreased expression of NPAS2 mRNA23947594
D019829NevirapineNevirapine results in decreased expression of NPAS2 mRNA23947594
C029938nickel sulfatenickel sulfate results in increased expression of NPAS2 mRNA17382205|2271453
D052638Particulate MatterParticulate Matter results in increased expression of NPAS2 mRNA22178795
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of NPAS2 mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of NPAS2 mRNA23091169
D010672PhenytoinPhenytoin results in increased expression of NPAS2 mRNA20345932
D010795Phthalic AcidsPhthalic Acids results in decreased expression of NPAS2 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NPAS2 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NPAS2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NPAS2 mRNA27413110
D011374ProgesteroneProgesterone results in increased expression of NPAS2 mRNA21795739
D011441PropylthiouracilPropylthiouracil results in decreased expression of NPAS2 mRNA24780913
C059514resveratrolresveratrol results in increased expression of NPAS2 mRNA12002526|1256957
C059514resveratrolresveratrol results in decreased expression of NPAS2 mRNA25905778
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NPAS2 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of NPAS2 mRNA25879800
C017947sodium arsenitesodium arsenite results in increased expression of NPAS2 mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of NPAS2 mRNA25993096
D013311StreptozocinStreptozocin results in decreased expression of NPAS2 mRNA25905778
D020058StyreneStyrene results in decreased expression of NPAS2 mRNA28951217
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of NPAS2 mRNA26378955
C047246temozolomideNPAS2 mRNA affects the susceptibility to temozolomide16365179
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of NPAS2 mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of NPAS2 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPAS2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPAS2 mRNA24058054|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPAS2 mRNA19933214|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPAS2 mRNA20159946
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of NPAS2 mRNA28973375
D013853ThioacetamideThioacetamide results in decreased expression of NPAS2 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NPAS2 mRNA28973375
D014635Valproic AcidValproic Acid results in decreased methylation of NPAS2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of NPAS2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NPAS2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of NPAS2 mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of NPAS2 mRNA"24525044
D019287Zinc SulfateZinc Sulfate results in decreased expression of NPAS2 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IDA11441146  
GO:0003677DNA binding-IPI9576906  
GO:0003700DNA-binding transcription factor activity-TAS9012850  
GO:0005515protein binding-IPI14645221  
GO:0046872metal ion binding-IEA-  
GO:0046983protein dimerization activity-IEA-  
GO:0051879Hsp90 protein binding-IDA9079689  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006974cellular response to DNA damage stimulus-IEA-  
GO:0007417central nervous system development-TAS9012850  
GO:0007623circadian rhythm-TAS-  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0045739positive regulation of DNA repair-IMP18819933  
GO:0045893positive regulation of transcription, DNA-templated-IDA11441146  
GO:0045893positive regulation of transcription, DNA-templated-IMP18819933  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI9576906  
GO:0051775response to redox state-IDA11441146  
GO:0060548negative regulation of cell death-IMP18819933  
GO:2001020regulation of response to DNA damage stimulus-IMP18819933  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA14645221  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IPI9576906  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionTAS
R-HSA-1430728MetabolismIEA
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionIEA
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)IEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockIEA
R-HSA-400253Circadian ClockTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29144171Circadian gene methylation in rotating-shift nurses: a cross-sectional study. (2018 Jan)Reszka EChronobiol Int
28412756Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One