Gene: NPAT

4863
E14|E14/NPAT|p220
nuclear protein, coactivator of histone transcription
protein-coding
11q22.3
Ensembl:ENSG00000149308 MIM:601448 Vega:OTTHUMG00000166385 UniprotKB:Q14207
NC_000011.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.353e-3 (AD)  2.057e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IREB20.909
CTDSPL20.898
DIS30.895
ZNF7910.893
TMEM161B0.88
WDFY10.878
SEC24B0.877
NUP1530.877
DHX360.874
LYST0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.424
OR4F29-0.385
S100A1-0.29
HIGD1B-0.29
PLA2G5-0.283
FOXJ1-0.277
TMEM253-0.263
C7orf61-0.255
ADAMTSL5-0.252
MTRNR2L6-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of NPAT protein26194647
D000082AcetaminophenAcetaminophen results in increased expression of NPAT mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of NPAT mRNA28959563
D001280AtrazineAtrazine results in increased expression of NPAT mRNA25929836
C006780bisphenol Abisphenol A results in increased expression of NPAT mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NPAT mRNA26079696
D003010ClorgylineClorgyline results in increased expression of NPAT mRNA19691856
C000944dicrotophosdicrotophos results in decreased expression of NPAT mRNA28302478
D005557FormaldehydeFormaldehyde results in decreased expression of NPAT mRNA20655997
C039281furanfuran results in decreased expression of NPAT mRNA25539665
D019833GenisteinGenistein results in increased expression of NPAT protein24552547
C544151jinfukangjinfukang results in decreased expression of NPAT mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NPAT mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NPAT mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NPAT mRNA"20188158
D010634PhenobarbitalPhenobarbital affects the expression of NPAT mRNA23091169
D011374ProgesteroneProgesterone results in increased expression of NPAT mRNA23012394
C017947sodium arsenitesodium arsenite results in increased expression of NPAT mRNA12016162
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPAT mRNA19465110|2405805
D013849ThimerosalThimerosal results in increased expression of NPAT mRNA16870260
C012589trichostatin Atrichostatin A affects the expression of NPAT mRNA28542535
D014635Valproic AcidValproic Acid results in decreased expression of NPAT mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of NPAT gene29154799
C025643vinclozolinvinclozolin affects the expression of NPAT mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of NPAT mRNA20566332
C025643vinclozolinvinclozolin results in increased expression of NPAT mRNA23555832
C111237vorinostatvorinostat results in increased expression of NPAT mRNA22083351
C088658zoledronic acidzoledronic acid results in increased expression of NPAT mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IDA14585971  17974976  
GO:0003713transcription coactivator activity-IMP15988025  17163457  
GO:0003714transcription corepressor activity-IMP17163457  
GO:0005515protein binding-IPI18850719  
GO:0008022protein C-terminus binding-IPI15988025  
GO:0047485protein N-terminus binding-IPI19170105  
GO ID GO Term Qualifier Evidence PubMed
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-IMP15988025  
GO:0006351transcription, DNA-templated-IEA-  
GO:0010468regulation of gene expression-IMP15988025  
GO:0045893positive regulation of transcription, DNA-templated-IDA18850719  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15988025  19170105  
GO:0005654nucleoplasm-IDA17068332  
GO:0005737cytoplasm-IDA17068332  
GO:0015030Cajal body-IDA15988025  17068332  17577209  19170105  
GO:0097504Gemini of coiled bodies-IDA17068332  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29191063Changes in DNA methylation induced by multi-walled carbon nanotube exposure in the workplace. (2017 Nov - Dec)Ghosh MNanotoxicology
28346444Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. (2017 May)Wright DJNat Genet