Gene: NPC1

4864
NPC|POGZ|SLC65A1
NPC intracellular cholesterol transporter 1
protein-coding
18q11.2
Ensembl:ENSG00000141458 MIM:607623 Vega:OTTHUMG00000131873 UniprotKB:O15118
NG_012795.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.761e-1 (AD)  5.036e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CERS20.897
TTYH20.878
RFFL0.865
LAMP20.864
VEZF10.849
CRTC30.845
CDC42EP10.843
ATP11A0.843
ICOSLG0.843
ZDHHC90.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.354
OR4F29-0.344
PRTN3-0.341
FBLN7-0.317
CRH-0.309
IGF1-0.307
FREM3-0.296
HAPLN1-0.295
NPBWR1-0.294
FAM163A-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NPC1 mRNA"28903501
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NPC1 mRNA"28433925
C07699627-hydroxycholesterolNPC1 protein affects the abundance of 27-hydroxycholesterol18483620
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of NPC1 protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NPC1 mRNA"18648102
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NPC1 mRNA19038236
D000082AcetaminophenAcetaminophen results in increased expression of NPC1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of NPC1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NPC1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NPC1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPC1 mRNA16483693
C519728archazolid Barchazolid B results in increased expression of NPC1 mRNA25218289
C006632arsenic trioxidearsenic trioxide results in decreased expression of NPC1 protein25419056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NPC1 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NPC1 mRNA"18687144
D001554BenzeneBenzene results in increased expression of NPC1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NPC1 mRNA19131362
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NPC1 protein19131362
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NPC1 mRNA19131362
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NPC1 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of NPC1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of NPC1 mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of NPC1 mRNA29275510
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NPC1 mRNA"28433925
C006780bisphenol Abisphenol A results in increased expression of NPC1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA28628672
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of NPC1 mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NPC1 mRNA15336504
D002104CadmiumCadmium results in decreased expression of NPC1 mRNA24067728
D002104CadmiumCadmium results in increased expression of NPC1 mRNA12890491
D002211CapsaicinCapsaicin results in increased expression of NPC1 mRNA18533110
C100187chloropicrinchloropicrin results in increased expression of NPC1 mRNA26352163
D002784CholesterolNPC1 protein results in increased secretion of Cholesterol16174794
D002784CholesterolProgesterone inhibits the reaction [NPC1 protein results in increased secretion of Cholesterol]16174794
D002784CholesterolNPC1 affects the localization of Cholesterol12183525
D002784CholesterolNPC1 protein affects the abundance of Cholesterol18483620
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of NPC1 mRNA16197558
C018021cobaltous chloridecobaltous chloride results in increased expression of NPC1 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NPC1 mRNA20971185
D003300CopperCopper deficiency inhibits the reaction [NPC1 gene mutant form results in increased expression of CP mRNA]24901380
D003300CopperCopper deficiency inhibits the reaction [NPC1 gene mutant form results in increased expression of MT1 mRNA]24901380
D003300CopperNPC1 affects the abundance of Copper22216111
D003300CopperNPC1 gene mutant form results in increased abundance of Copper24901380
D003300CopperNPC1 protein affects the abundance of Copper22526561
D003300CopperNPC1 protein affects the secretion of [CP protein binds to Copper]19007772
D019327Copper SulfateCopper Sulfate results in increased expression of NPC1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of NPC1 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of NPC1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in increased expression of NPC1 mRNA23830897
D003630DaunorubicinNocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]16174794
D003630DaunorubicinNPC1 affects the susceptibility to Daunorubicin16174794
D003630DaunorubicinNPC1 protein results in increased secretion of Daunorubicin16174794
D003630DaunorubicinProgesterone inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]16174794
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA28628672
C016366dibenzothiophenedibenzothiophene results in increased expression of NPC1 mRNA23656968
D004026DieldrinDieldrin results in decreased expression of NPC1 mRNA23041725
D004041Dietary FatsDietary Fats results in decreased expression of NPC1 mRNA18042831
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NPC1 mRNA"28433925
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased expression of NPC1 protein20056921
D000068876Fingolimod HydrochlorideNPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]20056921
C082360fipronilfipronil results in decreased expression of NPC1 mRNA23962444
D017261GlycosylphosphatidylinositolsNPC1 affects the localization of Glycosylphosphatidylinositols12183525
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of NPC1 mRNA26846883
C027185indirubinindirubin results in increased expression of NPC1 mRNA15056799
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NPC1 mRNA25613284
D007501IronNPC1 gene mutant form results in decreased abundance of Iron24901380
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA28628672
D007559IvermectinIvermectin results in decreased expression of NPC1 mRNA26471037
C544151jinfukangjinfukang results in increased expression of NPC1 mRNA27392435
C410337K 7174K 7174 results in increased expression of NPC1 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NPC1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NPC1 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NPC1 protein26558463
D005677G(M1) GangliosideNPC1 affects the localization of G(M1) Ganglioside12183525
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NPC1 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NPC1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NPC1 mRNA"25554681|2562005
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of NPC1 mRNA15878706
D015739NocodazoleNocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]16174794
C570896NSC305787NSC305787 results in increased expression of NPC1 mRNA27137931
C570897NSC668394NSC668394 results in increased expression of NPC1 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NPC1 mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in increased expression of NPC1 mRNA"18204070
D000073878Palm OilPalm Oil results in decreased expression of NPC1 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of NPC1 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of NPC1 mRNA19159669
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of NPC1 mRNA27756839
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NPC1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of NPC1 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of NPC1 mRNA28903501
D011374ProgesteroneProgesterone inhibits the reaction [NPC1 protein results in increased secretion of Cholesterol]16174794
D011374ProgesteroneProgesterone inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin]16174794
D011441PropylthiouracilPropylthiouracil affects the expression of NPC1 mRNA24780913
C059514resveratrolresveratrol results in increased expression of NPC1 mRNA19371625
D015474IsotretinoinIsotretinoin results in decreased expression of NPC1 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NPC1 mRNA25895662
D013467SulindacSulindac results in increased expression of NPC1 mRNA11906190
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein]19131362
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein]19131362
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPC1 mRNA19131362
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPC1 protein19131362
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPC1 mRNA15056799
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of NPC1 mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of NPC1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NPC1 gene]21762485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPC1 mRNA21724226
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NPC1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of NPC1 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NPC1 mRNA28111298
C012589trichostatin Atrichostatin A affects the expression of NPC1 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NPC1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of NPC1 mRNA28973697
D014520UrethaneUrethane results in increased expression of NPC1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NPC1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NPC1 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NPC1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of NPC1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of NPC1 mRNA26682919
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of NPC1 mRNA18593933
D019287Zinc SulfateZinc Sulfate results in increased expression of NPC1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0004888transmembrane signaling receptor activity-TAS10521290  
GO:0005515protein binding-IPI16757520  19583955  25285302  26771495  
GO:0015248sterol transporter activity-TAS9927649  
GO:0015485cholesterol binding-IDA18772377  
GO:0038023signaling receptor activity-TAS9211849  
GO ID GO Term Qualifier Evidence PubMed
GO:0006486protein glycosylation-IDA10821832  
GO:0006897endocytosis-IEA-  
GO:0006914autophagy-IGI19074461  
GO:0007041lysosomal transport-ISS-  
GO:0007165signal transduction-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0008203cholesterol metabolic process-IEA-  
GO:0008206bile acid metabolic process-ISS-  
GO:0016242negative regulation of macroautophagy-IEA-  
GO:0030301cholesterol transport-IDA18772377  
GO:0031579membrane raft organization-IMP23360953  
GO:0033344cholesterol efflux-IDA16141411  
GO:0034383low-density lipoprotein particle clearance-TAS-  
GO:0042493response to drug-IEA-  
GO:0042632cholesterol homeostasis-IDA12719428  
GO:0042632cholesterol homeostasis-IMP9927649  
GO:0042632cholesterol homeostasis-ISS-  
GO:0046686response to cadmium ion-IEA-  
GO:0046718viral entry into host cell-IMP21866101  21866103  
GO:0060548negative regulation of cell death-IEA-  
GO:0071383cellular response to steroid hormone stimulus-IEA-  
GO:0071404cellular response to low-density lipoprotein particle stimulus-IEA-  
GO:0090150establishment of protein localization to membrane-IDA23360953  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-ISS-  
GO:0005635nuclear envelope-IDA12554680  
GO:0005764lysosome-ISS-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005765lysosomal membrane-TAS-  
GO:0005783endoplasmic reticulum-IDA12554680  
GO:0005794Golgi apparatus-IEA-  
GO:0005887integral component of plasma membrane-IDA10821832  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-TAS10521290  
GO:0031902late endosome membrane-IEA-  
GO:0045121membrane raft-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA12554680  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8964038LDL clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20955564Interaction of functional NPC1 gene polymorphism with smoking on coronary heart disease. (2010 Oct 18)Ma WBMC Med Genet