Gene: NPM1

4869
B23|NPM
nucleophosmin 1
protein-coding
5q35.1
Ensembl:ENSG00000181163 MIM:164040 Vega:OTTHUMG00000130465 UniprotKB:P06748
NG_016018.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.502e-1 (AD)  9.699e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11927233chr5:170816542NPM18.400e-22Smoking27651444
cg11927233chr5:170816542NPM14.450e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTF30.958
SBDS0.951
CNBP0.951
EIF3H0.947
RPL150.941
HNRNPR0.936
MRFAP10.933
HNRNPD0.933
EIF10.932
SNW10.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.837
OR4F5-0.824
MTRNR2L6-0.151
RNF223-0.146
HOXD4-0.134
SEC14L3-0.133
MTRNR2L9-0.131
C16orf97-0.127
LCE3B-0.125
TTLL10-0.122

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NPM1 mRNA"20056577
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NPM1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NPM1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NPM1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NPM1 mRNA"15215175
C0194992-nitrofluorene2-nitrofluorene results in increased expression of NPM1 mRNA15890375
C4388683,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide"3,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide affects the metabolism of NPM1 protein"14534293
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of NPM1 mRNA12958071
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NPM1 mRNA"18648102
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NPM1 mRNA15890375
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of NPM1 mRNA"22745752
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in decreased expression of NPM1 protein"22745752
D000082AcetaminophenAcetaminophen affects the expression of NPM1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [NPM1 protein mutant form results in increased susceptibility to arsenic trioxide]23877794
D000111AcetylcysteineAcetylcysteine inhibits the reaction [NPM1 protein mutant form results in increased susceptibility to Bortezomib]23877794
C016601afimoxifeneafimoxifene results in decreased expression of NPM1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPM1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NPM1 mRNA15890375
C103303alitretinoinalitretinoin results in decreased expression of NPM1 protein28886987
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPM1 mRNA16483693
D001151ArsenicArsenic affects the methylation of NPM1 gene25304211
D001151ArsenicArsenic results in increased expression of NPM1 mRNA19818359
D001151ArsenicArsenic results in increased expression of NPM1 protein19818359
C006632arsenic trioxideAcetylcysteine inhibits the reaction [NPM1 protein mutant form results in increased susceptibility to arsenic trioxide]23877794
C006632arsenic trioxidearsenic trioxide results in increased expression of NPM1 mRNA20458559|2252195
C006632arsenic trioxideNPM1 protein affects the susceptibility to arsenic trioxide23877794
C006632arsenic trioxideNPM1 protein mutant form results in increased susceptibility to arsenic trioxide23877794
D001205Ascorbic AcidAscorbic Acid results in increased expression of NPM1 mRNA22139585
D001280AtrazineAtrazine results in increased expression of NPM1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPM1 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPM1 mRNA22228805
D004958EstradiolEstradiol results in decreased phosphorylation of NPM1 protein27026707
D004958EstradiolEstradiol results in increased expression of NPM1 mRNA16514628
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone affects the localization of NPM1 protein27998958
C006780bisphenol Abisphenol A affects the localization of NPM1 protein27998958
C006780bisphenol Abisphenol A analog affects the localization of NPM1 protein27998958
C006780bisphenol Abisphenol A results in decreased expression of NPM1 mRNA28079927
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NPM1 promoter23359474
C006780bisphenol Abisphenol A results in increased expression of NPM1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of NPM1 protein22174045
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of NPM1 mRNA17553608
D001761BleomycinBleomycin results in increased expression of NPM1 protein25933445
D000069286BortezomibAcetylcysteine inhibits the reaction [NPM1 protein mutant form results in increased susceptibility to Bortezomib]23877794
D000069286BortezomibNPM1 protein affects the susceptibility to Bortezomib23877794
D000069286BortezomibNPM1 protein mutant form results in increased susceptibility to Bortezomib23877794
C032036bromobenzenebromobenzene results in increased expression of NPM1 mRNA12628495
C515564bromovaninbromovanin results in decreased expression of NPM1 protein21419150
D002066BusulfanNPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin]20172040
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NPM1 mRNA18804290
D020148Butyric AcidButyric Acid results in decreased expression of NPM1 mRNA12800193
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NPM1 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NPM1 mRNA15963342
D002392CatechinCatechin results in decreased expression of NPM1 mRNA15465739
C099555CD 437CD 437 results in decreased expression of NPM1 mRNA12958071
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NPM1 mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NPM1 mRNA18804290
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of NPM1 mRNA28472532
C031180chrysenechrysene results in increased expression of NPM1 mRNA26377693
D002995Clofibric AcidClofibric Acid affects the expression of NPM1 mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NPM1 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of NPM1 mRNA19549813
C030973cupric oxidecupric oxide results in increased phosphorylation of NPM1 protein25470785
C014347decitabinedecitabine results in decreased methylation of NPM1 promoter18055864
C107676deguelin[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein25242579
C107676deguelin[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein25242579
C107676deguelin[deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein25242579
C107676deguelinNPM1 protein mutant form results in increased susceptibility to deguelin25242579
C107676deguelin[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein25242579
C107676deguelin[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein25242579
C107676deguelin[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein25242579
C107676deguelin[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein25242579
C107676deguelin[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein25242579
C107676deguelin[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein25242579
D015255IdarubicinNPM1 gene mutant form results in increased susceptibility to [Busulfan co-treated with Idarubicin]20172040
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of NPM1 protein23811945
D003976DiazinonDiazinon affects the expression of NPM1 mRNA22546817
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NPM1 promoter23359474
D002945CisplatinCisplatin results in increased expression of NPM1 protein19818359
D002945CisplatinNPM1 protein results in decreased susceptibility to Cisplatin24736981
C000944dicrotophosdicrotophos results in decreased expression of NPM1 mRNA28302478
D004026DieldrinDieldrin affects the expression of NPM1 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of NPM1 mRNA25016146
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NPM1 promoter23359474
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NPM1 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of NPM1 mRNA28943392
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NPM1 mRNA15890375
C039060dihydroartemisinindihydroartemisinin analog binds to NPM1 protein26340163
D002117CalcitriolCalcitriol results in decreased expression of NPM1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of NPM1 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of NPM1 mRNA15890375
D004147DioxinsDioxins affects the expression of NPM1 mRNA20463971
C067311docetaxelNPM1 protein results in decreased susceptibility to docetaxel24736981
D004317DoxorubicinNPM1 protein results in decreased susceptibility to Doxorubicin24736981
D004391DustDust results in decreased expression of NPM1 mRNA17805423
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NPM1 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of NPM1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NPM1 mRNA17108234
D005419FlavonoidsFlavonoids results in decreased expression of NPM1 mRNA15465739
D005472FluorouracilNPM1 protein results in decreased susceptibility to Fluorouracil24736981
D005485FlutamideFlutamide results in increased expression of NPM1 mRNA24136188
C070081fulvestrantfulvestrant results in decreased expression of NPM1 mRNA16514628
C039281furanfuran results in increased methylation of NPM1 gene22079235
C056507gemcitabineNPM1 protein results in decreased susceptibility to gemcitabine24736981
D019833GenisteinESR1 promotes the reaction [Genistein results in increased expression of NPM1 protein]20884965
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of NPM1 protein]20884965
D019833GenisteinGenistein results in increased expression of NPM1 protein20884965
D005839GentamicinsGentamicins results in increased expression of NPM1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of NPM1 mRNA24136188
D006046GoldGold results in decreased expression of NPM1 mRNA25523186
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of NPM1 protein17569113
D007213IndomethacinIndomethacin results in decreased expression of NPM1 mRNA10619186
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NPM1 mRNA25613284
D007529IsoflavonesIsoflavones results in decreased expression of NPM1 protein19818359
D007545IsoproterenolIsoproterenol results in decreased expression of NPM1 mRNA21335049
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NPM1 mRNA25961927
C410337K 7174K 7174 results in decreased expression of NPM1 mRNA24086573
C008261lead acetatelead acetate results in increased expression of NPM1 mRNA22641619
D008701MethapyrileneMethapyrilene results in increased expression of NPM1 mRNA15890375
D008727MethotrexateMethotrexate results in increased expression of NPM1 mRNA24736981
D008727MethotrexateMethotrexate results in increased expression of NPM1 protein24736981
D008727MethotrexateNPM1 protein results in decreased susceptibility to Methotrexate24736981
D008748MethylcholanthreneMethylcholanthrene results in increased expression of NPM1 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NPM1 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of NPM1 mRNA29191790
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of NPM1 protein20553848
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NPM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NPM1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of NPM1 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of NPM1 mRNA17616710
D015739NocodazoleNocodazole affects the phosphorylation of NPM1 protein15190079
C025589ochratoxin Aochratoxin A results in increased expression of NPM1 protein19445961
C025589ochratoxin Aochratoxin A results in increased expression of NPM1 mRNA23358140
C025589ochratoxin Aochratoxin A results in increased expression of NPM1 mRNA14994279
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NPM1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of NPM1 mRNA25729387
D017239PaclitaxelNPM1 protein results in decreased susceptibility to Paclitaxel24736981
C530734p-aminophenylarsine oxidep-aminophenylarsine oxide binds to NPM1 protein22422341
D000068437PemetrexedNPM1 protein results in decreased susceptibility to Pemetrexed24736981
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NPM1 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NPM1 mRNA19162173|2131816
D010578PetroleumPetroleum affects the expression of NPM1 mRNA25208076
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of NPM1 mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of NPM1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of NPM1 mRNA15890375|1916217
D010936Plant ExtractsPlant Extracts results in decreased expression of NPM1 mRNA15465739
D059808PolyphenolsPolyphenols results in decreased expression of NPM1 mRNA15465739
D011372ProgestinsProgestins results in increased expression of NPM1 mRNA19609016
D011794QuercetinQuercetin results in decreased expression of NPM1 protein19207037
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of NPM1 mRNA16514628
D012176RetinoidsRetinoids results in increased expression of NPM1 protein28886987
C410733scriptaidscriptaid affects the expression of NPM1 mRNA18813790
D012643Selenium[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of NPM1 mRNA11444866
D012715Sesame OilSesame Oil results in increased expression of NPM1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of NPM1 protein25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NPM1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of NPM1 mRNA22431001
C080703SK&F 83959SK&F 83959 results in decreased expression of NPM1 protein25852303
C017947sodium arsenitesodium arsenite results in increased expression of NPM1 protein21925251
C016104sodium bichromatesodium bichromate results in increased expression of NPM1 mRNA22561333|2599309
D012999SomanSoman results in increased expression of NPM1 mRNA19281266
D013605T-2 ToxinT-2 Toxin affects the expression of NPM1 protein26141394
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of NPM1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of NPM1 mRNA21592394
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of NPM1 mRNA20189893
C020806tetrabromobisphenol Atetrabromobisphenol A affects the localization of NPM1 protein27998958
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPM1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of NPM1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPM1 mRNA16962184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPM1 protein16548065
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NPM1 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of NPM1 protein"25852303
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of NPM1 mRNA28943392
C009495titanium dioxidetitanium dioxide results in increased phosphorylation of NPM1 protein21439344
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NPM1 mRNA25729387
D014212TretinoinTretinoin promotes the reaction [NPM1 protein binds to TFAP2A protein]17318229
D014212TretinoinTretinoin promotes the reaction [[NPM1 protein binds to TFAP2A protein] which binds to NPM1 promoter]17318229|1731822
D014212TretinoinTretinoin results in decreased expression of NPM1 mRNA17318229
D014212TretinoinTretinoin results in decreased expression of NPM1 protein28886987
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NPM1 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NPM1 mRNA19042947
C057693troglitazone[RARA gene mutant form co-treated with NPM1 gene mutant form] affects the susceptibility to troglitazone14508522
C000602704UF010 compoundUF010 compound results in increased acetylation of NPM1 protein25699604
D014635Valproic AcidValproic Acid results in decreased expression of NPM1 mRNA23179753|2718838
D014640VancomycinVancomycin results in decreased expression of NPM1 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of NPM1 mRNA22570695
C025643vinclozolinvinclozolin results in increased expression of NPM1 mRNA23034163
C030852vinorelbineNPM1 protein results in decreased susceptibility to vinorelbine24736981
D014810Vitamin E[Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of NPM1 mRNA11444866
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of NPM1 mRNA"25208076
D015032ZincZinc deficiency results in increased expression of NPM1 mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of NPM1 mRNA]16140947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001047core promoter binding-IDA19160485  
GO:0003682chromatin binding-IBA21873635  
GO:0003713transcription coactivator activity-IDA15087454  19160485  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-IDA12058066  
GO:0004860protein kinase inhibitor activity-IDA12882984  
GO:0005515protein binding-IPI12080348  12882984  15144954  15161933  15184379  15989956  
16376884  16648475  16957780  17015463  17318229  17438371  
17475909  17602943  18259216  18420587  19160485  19188445  
19410545  20075868  20159986  20618440  21326211  21822216  
22510990  22528486  22712502  22720776  23019224  23892143  
24462683  24857377  25416956  25956029  
GO:0008134transcription factor binding-IPI25956029  
GO:0019901protein kinase binding-IPI20352051  
GO:0030957Tat protein binding-IDA9094689  
GO:0033613activating transcription factor binding-IPI19160485  
GO:0042393histone binding-IBA21873635  
GO:0042393histone binding-IDA11602260  
GO:0042803protein homodimerization activity-IDA9121481  
GO:0043023ribosomal large subunit binding-IDA18809582  
GO:0043024ribosomal small subunit binding-IDA18809582  
GO:0046982protein heterodimerization activity-IMP12080348  
GO:0051059NF-kappaB binding-IDA15087454  
GO:0051059NF-kappaB binding-ISS-  
GO:0051082unfolded protein binding-IDA10211837  
GO:0051082unfolded protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000055ribosomal large subunit export from nucleus-IBA21873635  
GO:0000056ribosomal small subunit export from nucleus-IBA21873635  
GO:0006281DNA repair-IDA19188445  
GO:0006334nucleosome assembly-IDA11602260  
GO:0006338chromatin remodeling-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0006407rRNA export from nucleus-IBA21873635  
GO:0006886intracellular protein transport-TAS12080348  
GO:0006913nucleocytoplasmic transport-IDA16041368  
GO:0006913nucleocytoplasmic transport-TAS12080348  
GO:0007098centrosome cycle-IMP11051553  
GO:0007098centrosome cycle-ISS-  
GO:0007165signal transduction-NAS16130169  
GO:0007569cell aging-IMP12080348  
GO:0007569cell aging-ISS-  
GO:0008104protein localization-IDA18420587  
GO:0008284positive regulation of cell proliferation-IDA22528486  
GO:0008285negative regulation of cell proliferation-IMP12080348  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0010824regulation of centrosome duplication-IBA21873635  
GO:0010826negative regulation of centrosome duplication-IMP16041368  
GO:0016032viral process-IEA-  
GO:0032071regulation of endodeoxyribonuclease activity-IDA19188445  
GO:0034080CENP-A containing nucleosome assembly-TAS-  
GO:0034644cellular response to UV-IDA19160485  
GO:0042255ribosome assembly-TAS12080348  
GO:0042273ribosomal large subunit biogenesis-IBA21873635  
GO:0042274ribosomal small subunit biogenesis-IBA21873635  
GO:0043066negative regulation of apoptotic process-IDA12882984  
GO:0043066negative regulation of apoptotic process-NAS16130169  
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation-IDA12882984  
GO:0045727positive regulation of translation-IDA12882984  
GO:0045893positive regulation of transcription, DNA-templated-IDA22528486  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA19160485  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP25956029  
GO:0046599regulation of centriole replication-IMP20352051  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP15087454  
GO:0051259protein complex oligomerization-IDA18809582  
GO:0060699regulation of endoribonuclease activity-IDA19188445  
GO:0060735regulation of eIF2 alpha phosphorylation by dsRNA-IDA12882984  
GO:1902629regulation of mRNA stability involved in cellular response to UV-IMP12080348  
GO:1902751positive regulation of cell cycle G2/M phase transition-IDA22528486  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA12080348  22720776  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA12058066  19160485  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA11420665  12080348  16041368  17475909  18809582  19160485  19188445  19208757  22528486  25956029  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9121481  
GO:0005737cytoplasm-ISS-  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA11051553  
GO:0005813centrosome-ISS-  
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA19946888  
GO:0031616spindle pole centrosome-IDA16041368  
GO:0032991protein-containing complex-IDA19160485  
GO:0032993protein-DNA complex-IDA19160485  
GO:1990904ribonucleoprotein complex-IDA18809582  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162906HIV InfectionTAS
R-HSA-162906HIV InfectionIEA
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-162909Host Interactions of HIV factorsIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-1643685DiseaseIEA
R-HSA-177243Interactions of Rev with host cellular proteinsTAS
R-HSA-177243Interactions of Rev with host cellular proteinsIEA
R-HSA-180746Nuclear import of Rev proteinTAS
R-HSA-180746Nuclear import of Rev proteinIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5663205Infectious diseaseIEA
R-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromereTAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804115TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-774815Nucleosome assemblyTAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8869496TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27565936Autoantibodies against tumor-associated antigens in the early detection of lung cancer. (2016 Sep)Dai LLung Cancer