Gene: NPPB

4879
BNP
natriuretic peptide B
protein-coding
1p36.22
Ensembl:ENSG00000120937 MIM:600295 Vega:OTTHUMG00000002389 UniprotKB:P16860
NC_000001.11
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.610e-1 (AD)  6.722e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBED20.699
GPR1010.662
ENTHD10.658
TNFRSF80.657
DGKK0.653
SLC35D30.652
AMBN0.651
SLC18A30.651
TMPRSS60.645
SAG0.644

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.357
SOHLH1-0.331
NXPH3-0.326
NEUROD6-0.314
ALDH1A1-0.309
GALNT9-0.298
TRIB2-0.29
NTNG2-0.29
SYTL2-0.286
TESPA1-0.282

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01136CarvedilolSmall Molecule72956-09-3Approved|InvestigationalTarget
DB06412OxymetholoneSmall Molecule434-07-1Approved|IllicitTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of NPPB mRNA"19502547
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Benzo(a)pyrene results in increased expression of NPPB mRNA]21383588
C0374131,3-dinitropyrene"1,3-dinitropyrene results in increased expression of NPPB mRNA"28186253
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased expression of NPPB mRNA"25600587
C0333101,8-dinitropyrene"1,8-dinitropyrene results in increased expression of NPPB mRNA"28186253
C5054562-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]18806606
C4867842-methyl-3-(4-(2-(5-methyl-2-thiophen-2-yloxazol-4-yl)ethoxy)phenyl)-2-phenoxypropionic acid2-methyl-3-(4-(2-(5-methyl-2-thiophen-2-yloxazol-4-yl)ethoxy)phenyl)-2-phenoxypropionic acid results in increased expression of NPPB mRNA20044590
C4867842-methyl-3-(4-(2-(5-methyl-2-thiophen-2-yloxazol-4-yl)ethoxy)phenyl)-2-phenoxypropionic acid2-methyl-3-(4-(2-(5-methyl-2-thiophen-2-yloxazol-4-yl)ethoxy)phenyl)-2-phenoxypropionic acid results in increased expression of NPPB protein20044590
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NPPB mRNA"23196670
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NPPB mRNA"20512997
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]"20177073
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]"20177073
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NPPB protein"26116029
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of NPPB mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C0220225-hydroxy-6,8,11,14-eicosatetraenoic acid"5-hydroxy-6,8,11,14-eicosatetraenoic acid results in increased expression of NPPB mRNA"25600587
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
D000319Adrenergic beta-Antagonists[Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of NPPB protein21697605
D000319Adrenergic beta-Antagonists[Adrenergic beta-Antagonists co-treated with Angiotensin Receptor Antagonists] results in decreased expression of NPPB protein21697605
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NPPB mRNA27153756
D000450AldosteroneNPPB affects the abundance of Aldosterone20339970
D000450AldosteroneNPPB protein results in decreased abundance of Aldosterone16333235
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPPB mRNA16483693
D000806Angiotensin-Converting Enzyme Inhibitors[Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of NPPB protein21697605
D000806Angiotensin-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme Inhibitors results in decreased expression of NPPB mRNA15667801
D057911Angiotensin Receptor Antagonists[Adrenergic beta-Antagonists co-treated with Angiotensin Receptor Antagonists] results in decreased expression of NPPB protein21697605
D001241Aspirin[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein21378469
D001241AspirinAspirin affects the expression of NPPB mRNA12800193
D001241AspirinAspirin results in increased expression of NPPB mRNA12800193
D001262AtenololAtenolol results in increased expression of NPPB protein18192850
D001262Atenolol[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA15969258
D001262Atenolol[Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA15969258
D001262AtenololAtenolol results in decreased expression of NPPB mRNA15969258
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of NPPB protein18360054
D001374AzacitidineAzacitidine results in increased expression of NPPB15005238
C051019BAEC protocolBAEC protocol affects the expression of NPPB protein16856907
C044946benazeprilbenazepril results in decreased expression of NPPB mRNA11136700
C044946benazepril[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA11136700
C061004benidipinebenidipine affects the expression of NPPB mRNA15721868
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of NPPB mRNA19969063
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPPB mRNA22316170
D001564Benzo(a)pyrene1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Benzo(a)pyrene results in increased expression of NPPB mRNA]21383588
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPPB mRNA19889059|2138358
D001564Benzo(a)pyreneN-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [Benzo(a)pyrene results in increased expression of NPPB mRNA]19889059
D015784BetaxololBetaxolol results in decreased expression of NPPB mRNA12693380
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of NPPB mRNA25912373
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]17257893
C006780bisphenol Abisphenol A results in increased expression of NPPB mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of NPPB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NPPB gene28505145
D001786Blood GlucoseNFE2L2 gene mutant form promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NPPB mRNA]28373008
D001786Blood Glucose[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NPPB mRNA28373008
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NPPB mRNA15336504
D020148Butyric AcidButyric Acid results in increased expression of NPPB mRNA12800193
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NPPB mRNA20061341
D002110CaffeineCaffeine results in increased expression of NPPB mRNA25093688
D002110CaffeineDantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]25093688
C077793candesartan cilexetilcandesartan cilexetil results in decreased expression of NPPB mRNA15667801
C043211carvedilol[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein21378469
C043211carvedilolcarvedilol results in decreased expression of NPPB protein19367012|2041302
C043211carvedilolcarvedilol inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]26036690
C043211carvedilolcarvedilol results in decreased expression of NPPB mRNA19650993|1969226
C043211carvedilolcarvedilol results in decreased expression of NPPB protein19650993
C043211carvedilolcarvedilol results in increased expression of NPPB mRNA11206715
D017272CeliprololCeliprolol results in decreased expression of NPPB mRNA15262839
C469298CEP-11004CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]20067472
C469298CEP-11004CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]20067472
C469298CEP-11004CEP-11004 inhibits the reaction [EDN1 protein results in increased secretion of NPPB protein]20067472
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of NPPB mRNA26272509
C034587CHOP protocolCHOP protocol results in increased expression of NPPB protein16247790
C034587CHOP protocolValsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]16247790
D002857ChromiumChromium results in increased expression of NPPB mRNA21437242
C007095cobaltiprotoporphyrincobaltiprotoporphyrin affects the expression of NPPB protein24708733
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin affects the expression of NPPB protein]24708733
C018021cobaltous chloridecobaltous chloride results in increased expression of NPPB mRNA19502547
C026305cobalt sulfatecobalt sulfate results in increased expression of NPPB mRNA19502547
D003300CopperCopper results in increased expression of NPPB mRNA19747488
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of NPPB mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of NPPB mRNA19549813
C038106cucurbitacin Icucurbitacin I results in increased expression of NPPB mRNA27836799
D003520CyclophosphamideCyclophosphamide results in increased expression of NPPB protein17562616|1854819
D016572CyclosporineCyclosporine results in decreased expression of NPPB mRNA27989131
D016572CyclosporineCyclosporine inhibits the reaction [LIF protein results in increased expression of NPPB protein]11073891
D003561CytarabineCytarabine results in increased expression of NPPB mRNA21198554
D003561CytarabineCytarabine results in increased expression of NPPB protein16151589
D003620DantroleneDantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]25093688
D003630DaunorubicinDaunorubicin results in increased expression of NPPB protein11279304
D003630DaunorubicinDaunorubicin results in decreased expression of NPPB mRNA17673002
D003630DaunorubicinDaunorubicin results in decreased expression of NPPB protein17673002
D003630DaunorubicinDaunorubicin results in increased expression of NPPB mRNA26328012|2709088
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NPPB mRNA23914054
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of NPPB mRNA15364798
D015255IdarubicinIdarubicin results in increased expression of NPPB protein16151589
D003907Dexamethasone[Thalidomide co-treated with Dexamethasone] results in increased expression of NPPB protein18414984
D002945CisplatinCisplatin results in decreased expression of NPPB mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NPPB protein26042203
D004041Dietary FatsGPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NPPB protein]26042203
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NPPB protein26042203
D019422Dietary SucroseGPX4 gene mutant form promotes the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of NPPB protein]26042203
D004077DigoxinDigoxin results in increased expression of NPPB protein16032632
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of NPPB mRNA21853993|2893901
D004176DipyridamoleDipyridamole results in increased expression of NPPB protein18037770
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of NPPB mRNA24690739
C067311docetaxeldocetaxel results in increased expression of NPPB protein11454849
C012301domoic aciddomoic acid results in increased expression of NPPB mRNA25691335
C076946donepezildonepezil results in decreased expression of NPPB protein19879468
D017292DoxazosinDoxazosin results in increased expression of NPPB protein18551024
D017292Doxazosin[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA15969258
D017292Doxazosin[Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA15969258
D017292Doxazosin[Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA15969258
D004317DoxorubicinDoxorubicin results in increased expression of NPPB protein11466716|1172464
D004317DoxorubicinDoxorubicin results in decreased expression of NPPB mRNA17531194
D004317DoxorubicinDoxorubicin results in increased expression of NPPB mRNA16770644
D004317Doxorubicincarvedilol inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]26036690
D004317DoxorubicinDoxorubicin inhibits the reaction [phenylhydrazine results in increased expression of NPPB mRNA]22908232
D004317DoxorubicinDoxorubicin results in decreased expression of NPPB mRNA19796650
D004317DoxorubicinDoxorubicin results in increased expression of NPPB protein14745153|2603669
D004317DoxorubicinFebuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]26036690
D004656EnalaprilEnalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]18806606
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of NPPB mRNA25198161
D004837EpinephrineEpinephrine results in increased expression of NPPB mRNA19300450
D000431EthanolEthanol results in decreased expression of NPPB protein25598224
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NPPB mRNA23550701
C049347fasudilfasudil results in decreased expression of NPPB mRNA22465603
D000069465FebuxostatFebuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]26036690
D011345FenofibrateFenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]22198280
D011345FenofibrateFenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]22198280
D011345FenofibratePPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]]22198280
D005557FormaldehydeFormaldehyde results in increased expression of NPPB mRNA12679049
C039281furanfuran results in increased expression of NPPB mRNA27387713
C419708gefitinibgefitinib results in increased expression of NPPB mRNA27084042
C419708gefitinibgefitinib results in increased expression of NPPB protein27084042
D005839GentamicinsGentamicins results in increased expression of NPPB mRNA17312373
D006108GraphiteGraphite results in increased expression of NPPB mRNA27440207
D006152Cyclic GMPNPPB protein results in increased abundance of Cyclic GMP9194512
C425931GW 501516[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18701451
C529376GYY 4137GYY 4137 inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]28503736
C529376GYY 4137SIRT3 protein affects the reaction [GYY 4137 inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]]28503736
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in increased expression of NPPB mRNA"25600587
C072551HS 142-1HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]10642269
C072551HS 142-1HS 142-1 results in increased secretion of NPPB protein10642269
D006830HydralazineHydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]16326922
D006852HydrochlorothiazideHydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]16326922
D006859HydrogenHydrogen inhibits the reaction [Oxygen deficiency results in increased expression of NPPB mRNA]25281567
D007200IndicanIndican results in increased expression of NPPB mRNA25703824
D007545IsoproterenolIsoproterenol results in increased expression of NPPB mRNA11804996
D007545Isoproterenol2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]18806606
D007545IsoproterenolEnalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]18806606
D007545IsoproterenolIsoproterenol results in increased expression of NPPB mRNA25045214|9043801
D007545IsoproterenolIsoproterenol results in increased expression of NPPB protein18806606
D007545IsoproterenolSirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]25045214
D007545IsoproterenolTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]25045214
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NPPB mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]23939492
C063302KN 62KN 62 inhibits the reaction [LIF protein results in increased expression of NPPB protein]11073891
C031895lead chromatelead chromate results in increased expression of NPPB mRNA23584427
C017461lead nitratelead nitrate results in increased expression of NPPB mRNA23391631
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NPPB mRNA21873422
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB mRNA]21873422
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NPPB protein22224641
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB protein]22224641
D019808Losartan[Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA15969258
D019808Losartan[Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA15969258
D019808Losartan[Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA17666919
D019808LosartanLosartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]12198334
D019808LosartanLosartan results in decreased expression of NPPB mRNA15969258
D019808LosartanLosartan results in decreased expression of NPPB protein12198334
C105338makatoxin Imakatoxin I results in increased expression of NPPB mRNA27687165
C105338makatoxin Imakatoxin I results in increased expression of NPPB protein27687165
D008550Melatonin"Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]"17198541
D008558MelphalanMelphalan results in increased expression of NPPB protein18548196
C042720mercuric bromidemercuric bromide results in increased expression of NPPB mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of NPPB mRNA24472606
D008727MethotrexateMethotrexate results in increased expression of NPPB mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NPPB mRNA28001369
D008790MetoprololMetoprolol results in decreased expression of NPPB mRNA20353484
D008790MetoprololMetoprolol results in decreased expression of NPPB protein11181074
D016686MonocrotalineMonocrotaline results in increased expression of NPPB mRNA16936438
D016686MonocrotalineMonocrotaline results in increased expression of NPPB protein16936438
C523799MRK 003NPPB results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of NPPB mRNA27617619
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPPB mRNA]24658325
D000068577NebivololNebivolol results in increased expression of NPPB protein18192850
C433446N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidineN-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [Benzo(a)pyrene results in increased expression of NPPB mRNA]19889059
C022838nickel chloridenickel chloride results in increased expression of NPPB mRNA24612858
C029938nickel sulfatenickel sulfate results in decreased expression of NPPB mRNA22714537
D009543Nifedipine[Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA17666919
D009569Nitric OxideHydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]16326922
D009569Nitric OxideHydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]16326922
D009569Nitric OxideLosartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]12198334
D009569Nitric OxideNitric Oxide deficiency results in increased expression of NPPB mRNA12198334|1632692
D009569Nitric OxideNitric Oxide deficiency results in increased expression of NPPB protein12198334
D009599NitroprussideNitroprusside results in decreased expression of NPPB protein20339970
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of NPPB mRNA17616710
D009638NorepinephrineNPPB affects the abundance of Norepinephrine20339970
D009638NorepinephrineNPPB protein results in decreased abundance of Norepinephrine16333235
D000068557Olmesartan MedoxomilOlmesartan Medoxomil results in decreased expression of NPPB mRNA16336959
D010100OxygenOxygen deficiency results in increased expression of NPPB mRNA19502547|1954249
D010100OxygenOxygen deficiency results in increased secretion of NPPB protein19542490
D010100OxygenRotenone inhibits the reaction [Oxygen deficiency results in increased secretion of NPPB protein]19542490
D010100OxygenHydrogen inhibits the reaction [Oxygen deficiency results in increased expression of NPPB mRNA]25281567
D010100OxygenOxygen deficiency results in increased expression of NPPB mRNA25281567
D010100OxygenNFE2L2 gene mutant form promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NPPB mRNA]28373008
D010100Oxygen[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NPPB mRNA28373008
D010100OxygenOxygen deficiency results in increased expression of NPPB mRNA17193925
D010100OxygenOxygen deficiency results in increased expression of NPPB mRNA24492474
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NPPB mRNA]24492474
D052638Particulate MatterParticulate Matter results in decreased expression of NPPB mRNA23085030
D010431PentoxifyllinePentoxifylline results in decreased expression of NPPB protein14970111
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NPPB mRNA27153767
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NPPB mRNA22237054
D015232DinoprostoneDinoprostone results in increased expression of NPPB mRNA18030065
D010656PhenylephrineANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18502941
D010656PhenylephrineHEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]16603706
D010656PhenylephrinePhenylephrine results in increased expression of NPPB mRNA11804996|1660370
D010656Phenylephrinebisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]17257893
D010656PhenylephrinePhenylephrine results in increased expression of NPPB mRNA17257893
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]17257893
D010656PhenylephrineCEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]20067472
D010656PhenylephrineCEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]20067472
D010656PhenylephrineEP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094368
D010656PhenylephrineGRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]28759639
D010656Phenylephrine[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18701451
D010656PhenylephrineHS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]10642269
D010656Phenylephrine(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]23939492
D010656PhenylephrineJUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]11799083
D010656PhenylephrineMOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]11854500
D010656PhenylephrineMYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]16556869
D010656PhenylephrinePDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]18790048
D010656PhenylephrinePhenylephrine results in increased expression of NPPB mRNA11754973|1179908
D010656PhenylephrinePhenylephrine results in increased expression of NPPB protein28822817
D010656PhenylephrinePhenylephrine results in increased secretion of NPPB protein10642269|1175497
D010656Phenylephrine[pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18701451
D010656PhenylephrinePRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094369
D010656PhenylephrineSildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18790048
D010656Phenylephrine[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094368
D010656PhenylephrineSIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094368
C030299phenylhydrazineDoxorubicin inhibits the reaction [phenylhydrazine results in increased expression of NPPB mRNA]22908232
C030299phenylhydrazinephenylhydrazine results in increased expression of NPPB mRNA22908232
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NPPB mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of NPPB mRNA16985257
C006253pirinixic acid[pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18701451
D010936Plant ExtractsPlant Extracts results in decreased expression of NPPB mRNA23557933
D010936Plant ExtractsPlant Extracts affects the expression of NPPB mRNA17645561
D010936Plant ExtractsPlant Extracts affects the expression of NPPB protein18097624
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NPPB mRNA22714537
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]17257893
D011374ProgesteroneProgesterone results in increased expression of NPPB mRNA20726854
D011433PropranololPropranolol affects the activity of NPPB protein modified form1363893
D000527AlprostadilAlprostadil results in decreased expression of NPPB protein16084762
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the expression of NPPB mRNA17457379
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB mRNA]21873422
D011794QuercetinPPARG protein affects the reaction [Quercetin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]]24039778
D011794QuercetinQuercetin affects the expression of NPPB mRNA18178720
D011794QuercetinQuercetin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]24039778
D017257RamiprilRamipril results in decreased expression of NPPB mRNA15667801
C059514resveratrolresveratrol results in decreased expression of NPPB mRNA25394648
C059514resveratrolresveratrol inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]18543488
C059514resveratrolresveratrol inhibits the reaction [AGT protein results in increased expression of NPPB protein]18543488
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NPPB mRNA]24492474
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPPB mRNA]19969063
C059514resveratrolresveratrol results in decreased expression of NPPB mRNA17499237|2616781
C059514resveratrolresveratrol results in decreased expression of NPPB protein24535859
C059514resveratrolresveratrol results in decreased secretion of NPPB protein17499237
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of NPPB mRNA21127053
C089730rosiglitazonerosiglitazone results in decreased expression of NPPB mRNA21515302
C089730rosiglitazonerosiglitazone results in increased expression of NPPB mRNA19397913
C089730rosiglitazonerosiglitazone results in increased expression of NPPB protein28822817
D012402RotenoneRotenone inhibits the reaction [Oxygen deficiency results in increased secretion of NPPB protein]19542490
C093642SB 203580SB 203580 affects the expression of NPPB protein21084678
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB protein]22224641
C093642SB 203580SB 203580 results in decreased expression of NPPB mRNA21084678
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of NPPB mRNA"24160326
D000068677Sildenafil CitrateSildenafil Citrate affects the expression of NPPB protein19179780
D000068677Sildenafil CitrateSildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]18790048
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NPPB mRNA25895662
D012834SilverSilver results in increased expression of NPPB mRNA28959546
D012834SilverSilver results in increased expression of NPPB mRNA27131904
C076731simendansimendan results in decreased expression of NPPB protein16084762
D019821SimvastatinSimvastatin results in decreased expression of NPPB16628357
D019821SimvastatinSimvastatin results in decreased expression of NPPB protein21124329
D020123SirolimusSirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]25045214
D020123SirolimusTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]25045214
C016104sodium bichromatesodium bichromate results in increased expression of NPPB mRNA24612858
C025451sodium bisulfideSIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]]28503736
C025451sodium bisulfideSIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPB protein]]28503736
C025451sodium bisulfidesodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]28503736
C025451sodium bisulfidesodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPB protein]28503736
D053260SootSoot results in increased expression of NPPB mRNA26551751
D013148Spironolactone[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein21378469
D013148SpironolactoneSpironolactone results in decreased expression of NPPB protein11300427
D013311StreptozocinStreptozocin results in increased expression of NPPB mRNA10828832
C473478sunitinibsunitinib results in increased expression of NPPB mRNA24247421
D016559TacrolimusTacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPB mRNA]15939815
C084178telmisartantelmisartan affects the expression of NPPB protein16671338
C084178telmisartantelmisartan results in decreased expression of NPPB protein18712048
C055603temocapril hydrochloride[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein21378469
D013749TetrachlorodibenzodioxinN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPPB mRNA]24658325
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPPB mRNA24658325
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPPB mRNA26139165
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NPPB mRNA]19969063
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPPB mRNA19969063
D013792Thalidomide[Thalidomide co-treated with Dexamethasone] results in increased expression of NPPB protein18414984
D013827ThiabendazoleThiabendazole results in increased expression of NPPB mRNA18539377
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin affects the expression of NPPB protein]24708733
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NPPB mRNA23038017
D014212TretinoinTretinoin results in increased expression of NPPB mRNA21934132
D014212TretinoinTretinoin results in increased expression of NPPB protein20098333
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of NPPB protein]26385185
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NPPB mRNA24935251|2627250
D014285Triiodothyronine, Reverse"Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]"17198541
D014285Triiodothyronine, Reverse"Triiodothyronine, Reverse results in increased expression of NPPB mRNA"17198541
D014285Triiodothyronine, Reverse"Vitamin E affects the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]"17198541
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NPPB mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NPPB mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of NPPB mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NPPB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NPPB mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of NPPB mRNA23179753|2438349
D000068756ValsartanValsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]16247790
D000068756ValsartanValsartan results in decreased expression of NPPB protein12417542
D000068756Valsartan[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA11136700
D000068756ValsartanValsartan results in decreased expression of NPPB mRNA11136700
D014807Vitamin DVitamin D results in decreased expression of NPPB25488441
D014810Vitamin E"Vitamin E affects the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA]"17198541
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPPB mRNA"27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of NPPB mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IDA1672777  
GO:0005102signaling receptor binding-IPI12727915  16870210  
GO:0005179hormone activity-NAS7601467  
GO:0005515protein binding-IPI25416956  
GO:0008613diuretic hormone activity-TAS14960748  
GO:0051427hormone receptor binding-IPI1660465  
GO ID GO Term Qualifier Evidence PubMed
GO:0006182cGMP biosynthetic process-IDA1672777  
GO:0006457protein folding-IDA16870210  
GO:0007166cell surface receptor signaling pathway-NAS12727915  
GO:0007168receptor guanylyl cyclase signaling pathway-IDA1672777  
GO:0007589body fluid secretion-TAS14960748  
GO:0008217regulation of blood pressure-NAS12727915  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016525negative regulation of angiogenesis-TAS14737067  
GO:0030308negative regulation of cell growth-NAS12727915  
GO:0035810positive regulation of urine volume-TAS14737067  
GO:0035815positive regulation of renal sodium excretion-TAS14960748  
GO:0043114regulation of vascular permeability-TAS14737067  
GO:0097746regulation of blood vessel diameter-NAS7601467  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS14960748  
GO:0005615extracellular space-NAS7601467  
GO:0032991protein-containing complex-IDA16870210  23382219  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics
21514286Natriuretic peptide precursor B gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia. (2011 Jul 15)Szabo GClin Chim Acta