Gene: NPTX2

4885
NARP|NP-II|NP2
neuronal pentraxin 2
protein-coding
7q22.1
Ensembl:ENSG00000106236 MIM:600750 Vega:OTTHUMG00000154369 UniprotKB:P47972
NG_009905.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.730e-1 (AD)  8.146e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BDNF0.825
GPR680.811
SCG20.791
VGF0.787
DUSP20.774
BEND50.757
CORO1A0.742
LAMB30.739
ARL4D0.736
EGR30.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3B-0.482
MYOM1-0.437
ACSS3-0.409
CDC14A-0.405
TGFBR3-0.4
RHOD-0.399
PELI2-0.398
ACOX2-0.396
DIAPH3-0.394
ACSF2-0.391

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NPTX2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NPTX2 protein20106945
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPTX2 mRNA16483693
D001151ArsenicArsenic affects the methylation of NPTX2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of NPTX2 mRNA26705709
C006632arsenic trioxidearsenic trioxide results in increased expression of NPTX2 mRNA15761015
C015001arsenitearsenite results in increased methylation of NPTX2 promoter23974009
D001280AtrazineAtrazine results in increased expression of NPTX2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPTX2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of NPTX2 mRNA22342234
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of NPTX2 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of NPTX2 mRNA17404688
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of NPTX2 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of NPTX2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of NPTX2 mRNA26079696
D004390ChlorpyrifosChlorpyrifos results in increased expression of NPTX2 mRNA26775027
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NPTX2 gene20938992
D003024ClozapineClozapine results in decreased expression of NPTX2 mRNA18208916
D003042CocaineCocaine affects the expression of NPTX2 protein20534846
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of NPTX2 mRNA24690739
D003300CopperCopper deficiency results in increased expression of NPTX2 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of NPTX2 mRNA19549813
C009160cyclonitecyclonite results in increased expression of NPTX2 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of NPTX2 mRNA27989131
C014347decitabinedecitabine affects the expression of NPTX2 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NPTX2 mRNA21266533
D002945CisplatinCisplatin affects the expression of NPTX2 mRNA23300844
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NPTX2 mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of NPTX2 mRNA26033743
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of NPTX2 mRNA24690739
C118739entinostatentinostat results in increased expression of NPTX2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
D005473FluoxetineFluoxetine results in increased expression of NPTX2 mRNA18301726
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NPTX2 gene20938992
D004397FonofosFonofos results in increased methylation of NPTX2 promoter22847954
C419708gefitinibgefitinib results in decreased expression of NPTX2 mRNA16685379
D006220HaloperidolHaloperidol results in decreased expression of NPTX2 mRNA18208916
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NPTX2 mRNA25307878|2675264
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of NPTX2 mRNA20843944
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of NPTX2 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of NPTX2 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NPTX2 gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of NPTX2 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NPTX2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NPTX2 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NPTX2 mRNA26924002
D019829NevirapineNevirapine results in increased expression of NPTX2 mRNA23947594
D010278ParathionParathion results in increased methylation of NPTX2 promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPTX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NPTX2 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of NPTX2 mRNA21061450
D010862PilocarpinePilocarpine results in increased expression of NPTX2 mRNA14656328
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NPTX2 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of NPTX2 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of NPTX2 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of NPTX2 mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of NPTX2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of NPTX2 mRNA24780913
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of NPTX2 mRNA19564919
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NPTX2 mRNA23806026
C012568terbufosterbufos results in increased methylation of NPTX2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NPTX2 mRNA20106945|2615948
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of NPTX2 gene26756918
D014212TretinoinTretinoin results in decreased expression of NPTX2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of NPTX2 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NPTX2 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of NPTX2 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NPTX2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NPTX2 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NPTX2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPTX2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of NPTX2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0030246carbohydrate binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-NAS8530029  
GO:0008306associative learning-IEA-  
GO:0031175neuron projection development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0009898cytoplasmic side of plasma membrane-IBA21873635  
GO:0030175filopodium-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0030426growth cone-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22414467Preliminary study analyzing the methylated genes in the plasma of patients with pancreatic cancer. (2012)Park JWScand J Surg