Gene: NPY1R

4886
NPY1-R|NPYR
neuropeptide Y receptor Y1
protein-coding
4q32.2
Ensembl:ENSG00000164128 MIM:162641 Vega:OTTHUMG00000161371 UniprotKB:P25929
NC_000004.12
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.539e-1 (AD)  4.651e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RUNX1T10.865
FAM117B0.859
ACVR2A0.858
SORBS20.85
RPAP20.85
NAALAD20.845
SIMC10.844
PLEKHA10.844
HOOK10.843
SLC30A40.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPKAPK3-0.435
ASB4-0.424
S100A14-0.419
MYL3-0.403
S100A1-0.4
AQP5-0.397
LRAT-0.389
ENDOU-0.38
MBNL3-0.38
KLRB1-0.38

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05004AC162352Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NPY1R mRNA"26377693
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in decreased expression of NPY1R mRNA"20519331
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NPY1R mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NPY1R mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPY1R mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPY1R mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY1R mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPY1R mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPY1R mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY1R mRNA"27188386
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of NPY1R mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NPY1R protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPY1R gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NPY1R mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of NPY1R mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPY1R mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NPY1R mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of NPY1R mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NPY1R mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NPY1R mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NPY1R mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NPY1R mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPY1R mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPY1R mRNA19619570
D004958EstradiolEstradiol results in increased expression of NPY1R mRNA19146866|1961957
D004958EstradiolMedroxyprogesterone Acetate inhibits the reaction [Estradiol results in increased expression of NPY1R mRNA]19146866
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of NPY1R mRNA]21185374
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NPY1R mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NPY1R mRNA27685785
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NPY1R mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of NPY1R gene28505145
C006780bisphenol Abisphenol A results in decreased expression of NPY1R mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NPY1R promoter22457795
D002211Capsaicin"neuropeptide Y, Leu(31)-Pro(34)- inhibits the reaction [NPY1R protein results in increased susceptibility to Capsaicin]"16714086
D002211CapsaicinNPY1R protein results in increased susceptibility to Capsaicin16714086
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NPY1R mRNA12734012
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NPY1R mRNA27858113
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NPY1R mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of NPY1R mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of NPY1R mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of NPY1R mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NPY1R mRNA]18310284
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPY1R mRNA]11007951
D016572CyclosporineCyclosporine results in decreased expression of NPY1R mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of NPY1R mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NPY1R mRNA15620428
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NPY1R mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of NPY1R mRNA26924002
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of NPY1R mRNA]21233418
D004967EstrogensEstrogens affects the expression of NPY1R mRNA15473135
D004967EstrogensEstrogens results in increased expression of NPY1R mRNA21233418
D004967EstrogensEstrogens affects the expression of NPY1R mRNA15473135
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NPY1R mRNA17555576
C024565ethylene dichlorideethylene dichloride results in increased expression of NPY1R mRNA28189721
D005473FluoxetineFluoxetine affects the expression of NPY1R mRNA9729278
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of NPY1R gene28505145
D007069IfosfamideIfosfamide results in increased expression of NPY1R mRNA25596134
D007649KetamineKetamine results in decreased expression of NPY1R mRNA20080153
C008261lead acetatelead acetate results in increased expression of NPY1R mRNA11578147
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate inhibits the reaction [Estradiol results in increased expression of NPY1R mRNA]19146866
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of NPY1R mRNA18497975
D008627Mercuric ChlorideMercuric Chloride results in increased expression of NPY1R mRNA16507785
D008694MethamphetamineNPY1R gene SNP results in increased susceptibility to Methamphetamine19566775
D008694MethamphetamineMethamphetamine affects the expression of NPY1R mRNA15930374
D008694MethamphetamineNPY1R protein affects the reaction [NPY protein results in decreased susceptibility to Methamphetamine]15930374
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NPY1R mRNA28001369
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NPY1R mRNA26924002
D009020MorphineMorphine results in decreased expression of NPY1R mRNA20144693
D009151Mustard GasMustard Gas results in increased expression of NPY1R mRNA15674844
D015544Inositol 1,4,5-Trisphosphate"NPY1R protein affects the abundance of Inositol 1,4,5-Trisphosphate"7742479
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NPY1R mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NPY1R mRNA"25554681
C062259neuropeptide Y, Leu(31)-Pro(34)-"neuropeptide Y, Leu(31)-Pro(34)- binds to and results in increased activity of NPY1R protein"16714086
C062259neuropeptide Y, Leu(31)-Pro(34)-"neuropeptide Y, Leu(31)-Pro(34)- inhibits the reaction [NPY1R protein results in increased susceptibility to Capsaicin]"16714086
C062259neuropeptide Y, Leu(31)-Pro(34)-"neuropeptide Y, Leu(31)-Pro(34)- binds to and results in increased activity of NPY1R protein"18809749
D009532NickelNickel results in decreased expression of NPY1R mRNA24768652|2558310
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NPY1R mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of NPY1R mRNA25596134
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPY1R mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of NPY1R mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of NPY1R mRNA22178795
D010424PentobarbitalNPY1R protein affects the reaction [NPY protein results in increased susceptibility to Pentobarbital]11454027
D010424PentobarbitalNPY1R protein results in increased susceptibility to Pentobarbital11454027
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPY1R mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NPY1R mRNA26272509
D010665PhenylpropanolamineNPY1R protein affects the reaction [Phenylpropanolamine results in decreased expression of NPY protein]23052195
D010665PhenylpropanolamineNPY1R protein affects the susceptibility to Phenylpropanolamine23052195
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of NPY1R protein23052195
D010852PicrotoxinPicrotoxin results in increased expression of NPY1R mRNA15170462
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NPY1R mRNA27935865
D011188PotassiumNPY1R protein affects the reaction [NPY protein affects the abundance of Potassium]10737671
D011374ProgesteroneProgesterone results in increased expression of NPY1R mRNA18070364
D011441PropylthiouracilPropylthiouracil results in increased expression of NPY1R mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of NPY1R mRNA]21185374
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of NPY1R mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NPY1R mRNA25895662
D053260SootSoot results in decreased expression of NPY1R mRNA26551751
D013629TamoxifenTamoxifen affects the expression of NPY1R mRNA17555576
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPY1R mRNA]11007951
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPY1R mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPY1R mRNA11007951|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPY1R mRNA19933214
D014212TretinoinTretinoin results in increased expression of NPY1R mRNA21934132
C062527tribromoethanolNPY1R protein results in increased susceptibility to tribromoethanol11454027
C012589trichostatin Atrichostatin A results in decreased expression of NPY1R mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of NPY1R mRNA24935251
D014269Trifluoroacetic AcidTrifluoroacetic Acid binds to and results in decreased activity of NPY1R protein16714086
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of NPY1R mRNA23537331
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPY1R mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NPY1R mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NPY1R mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of NPY1R mRNA19136453
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NPY1R gene25560391
D014801Vitamin ANPY1R protein results in increased susceptibility to Vitamin A17400914

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001601peptide YY receptor activity-IEA-  
GO:0001602pancreatic polypeptide receptor activity-IBA21873635  
GO:0004983neuropeptide Y receptor activity-TAS1317848  
GO:0005515protein binding-IPI23597562  
GO ID GO Term Qualifier Evidence PubMed
GO:0003151outflow tract morphogenesis-IMP19593212  
GO:0006006glucose metabolic process-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS1317848  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS1321422  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0008217regulation of blood pressure-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0040014regulation of multicellular organism growth-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1317848  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24845178Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. (2014 Jul)Levran OPsychoneuroendocrinology
22309839Association study of 45 candidate genes in nicotine dependence in Han Chinese. (2012 May)Wei JAddict Behav
18828811Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (2008 Dec)Wetherill LAlcohol Clin Exp Res
21822476Modulation of tyrosine hydroxylase, neuropeptide y, glutamate, and substance p in Ganglia and brain areas involved in cardiovascular control after chronic exposure to nicotine. (2011)Ferrari MFInt J Hypertens
16198492Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas. (2005)Wittmann WNeuroscience