Gene: NPY5R

4889
NPY5-R|NPYR5|NPYY5-R
neuropeptide Y receptor Y5
protein-coding
4q32.2
Ensembl:ENSG00000164129 MIM:602001 Vega:OTTHUMG00000161353 UniprotKB:Q15761
NC_000004.12
PubMed
0   ANCO-SNPs
CD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.418e-1 (AD)  4.676e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGKI0.905
RAB9B0.904
CDH120.904
STYK10.897
LRRTM30.896
FRY0.894
XK0.893
NBEA0.892
CDH80.892
MTMR70.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.583
MYL3-0.571
ROM1-0.566
S100A16-0.527
TMEM176A-0.523
YES1-0.519
EMP3-0.519
MAPKAPK3-0.516
TGIF1-0.516
PXDC1-0.515

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05004AC162352Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NPY5R mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NPY5R mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPY5R gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NPY5R mRNA21298039
D0150812-Naphthylamine2-Naphthylamine analog binds to and results in decreased activity of NPY5R protein10937714
D0150812-Naphthylamine2-Naphthylamine analog binds to NPY5R protein10937714
D000639AmitriptylineAmitriptyline results in increased expression of NPY5R mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPY5R mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of NPY5R mRNA"22863853
C014353benzimidazolonebenzimidazolone analog binds to and results in decreased activity of NPY5R protein10937714
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPY5R mRNA19619570
D004958EstradiolEstradiol results in increased expression of NPY5R mRNA19619570|2118537
C006780bisphenol Abisphenol A results in decreased expression of NPY5R mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NPY5R gene28505145
D002101Cacodylic AcidCacodylic Acid results in decreased expression of NPY5R mRNA22246474
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NPY5R mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NPY5R mRNA]17585979
D003300CopperCopper results in increased expression of NPY5R mRNA24403277
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NPY5R mRNA15620428
D004041Dietary FatsDietary Fats results in increased expression of NPY5R mRNA18721800
C039281furanfuran results in increased methylation of NPY5R gene22079235
C004312glycidolglycidol results in decreased expression of NPY5R mRNA24915197
D010656PhenylephrineNPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]10660688
D010656PhenylephrineNPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]10660688
D011441PropylthiouracilPropylthiouracil results in increased expression of NPY5R mRNA24780913
C012526quercitrinquercitrin results in increased expression of NPY5R mRNA25193878
D012999SomanSoman results in decreased expression of NPY5R mRNA19281266
C515547spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-"spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans- binds to and results in decreased activity of NPY5R protein"17712121
D013619TacrineTacrine results in increased expression of NPY5R mRNA12832660
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPY5R mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPY5R mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPY5R mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of NPY5R mRNA15977195
D014212TretinoinTretinoin results in increased expression of NPY5R mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of NPY5R mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of NPY5R mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of NPY5R mRNA24935251

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001601peptide YY receptor activity-IBA21873635  
GO:0001601peptide YY receptor activity-IEA-  
GO:0001602pancreatic polypeptide receptor activity-IBA21873635  
GO:0004983neuropeptide Y receptor activity-TAS8824284  
GO ID GO Term Qualifier Evidence PubMed
GO:0002675positive regulation of acute inflammatory response-IEA-  
GO:0002865negative regulation of acute inflammatory response to antigenic stimulus-IEA-  
GO:0003151outflow tract morphogenesis-IMP19593212  
GO:0003214cardiac left ventricle morphogenesis-IMP19593212  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007568aging-IEA-  
GO:0014050negative regulation of glutamate secretion-IEA-  
GO:0032229negative regulation of synaptic transmission, GABAergic-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0060112generation of ovulation cycle rhythm-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8824284  
GO:0016020membrane-IBA21873635  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16198492Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas. (2005)Wittmann WNeuroscience
18828811Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (2008 Dec)Wetherill LAlcohol Clin Exp Res